Ioan Simon

Ioan Simon
Iuliu Haţieganu University of Medicine and Pharmacy | UMF Cluj · Department of Surgery IV

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49
Publications
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294
Citations

Publications

Publications (49)
Article
A biomimetic electrochemical sensor based on molecularly imprinted polymer (MIP) containing chitosan and graphene oxide was designed for direct highly sensitive and selective detection of serotonin, an important neurotransmitter, with a significant role in various body functions, in real samples such as serum, tears and saliva. The composite MIP fi...
Article
Background The bioactive glasses (BGs) are very attractive materials increasingly used in healing skin lesions due to their antibacterial effect and stimulation of collagen deposition and angiogenesis. In this study, three specimens of bioactive glasses (BG1, BG2 and BG3) have been synthesized and characterized. Methods In order to evaluate theiri...
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Optimizing the diagnosis of lung cancer represents a challenge, as well as a necessity, for improving the low survival of these patients. Flexible bronchoscopy with forceps biopsy is one of the key diagnostic procedures used for lung tumors. The small sample size and crush artifacts are several factors that can often limit access to a complete diag...
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Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a commonly used minimally invasive method for the diagnosis and staging of lung cancer. In order to improve its diagnostic accuracy, rapid on-site cytologic evaluation (ROSE) is being utilized in some institutions. ROSE, performed by a cytopathologist in th...
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We present the clinical observation of a female patient with cystic peritoneal malignant mesothelioma developed in the thickness of the abdominal wall. The diagnosis included several steps: tumor classification as mesothelioma, tumor differentiation from reactive mesothelial hyperplasia, establishment of the malignant nature and differentiation fro...
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The development of rapid and sensitive devices for the simultaneous detection of neurotransmitters has critical implications for the clinical field and for the management of several diseases. Parkinson’s, Alzheimer’s disease, autism, schizophrenia, depression and anxiety are major healthcare challenges for which early diagnostics and personalized t...
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Lung cancer represents a genetically heterogeneous disease with low survival rates. Recent data have evidenced key roles of noncoding RNAs in lung cancer initiation and progression. These functional RNA molecules that can act as both oncogenes and tumor suppressors may become future biomarkers and more efficient therapeutic targets. In the precisio...
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An important class of biosensors is immunosensors, affinity biosensors that are based on the specific interaction between antibodies and antigens. They are classified in four classes based on the type of employed transducer: electrochemical, optical, microgravimetric, and thermometric and depending on the type of recognition elements, antibodies, a...
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Background: The objective of this prospective study was to evaluate whether soluble programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) and serum amyloid A1 (SAA1) are potential diagnostic, predictive or prognostic biomarkers in lung cancer. Methods: Lung cancer patients (n=115) with advanced metastatic disease, 101 with non-small c...
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Background: The objective of this prospective study was to evaluate whether soluble programmed cell death- 1/programmed cell death-ligand 1 (PD-1/PD-L1) and serum amyloid A1 (SAA1) are potential diagnostic, predictive or prognostic biomarkers in lung cancer. Methods: Lung cancer patients (n=115) with advanced metastatic disease, 101 with non-small...
Article
A novel magnetoimmunosensor, designed for sensitive and selective quantification of interleukin 6, is herein reported. The experimental design involves the covalent immobilization of anti‐interleukin 6 antibody through an amidic bond formed with the carboxyl functionalities provided at the surface of protein G‐functionalized magnetic microparticles...
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Lung cancer continues to be the leading topic concerning global mortality rate caused by cancer; it needs to be further investigated to reduce these dramatic unfavorable statistic data. Noncoding RNAs (ncRNAs) have been shown to be important cellular regulatory factors and the alteration of their expression levels has become correlated to extensive...
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Background and aims Colorectal cancer is one of the most frequent digestive malignancies, being the third cause of death by cancer, despite early diagnosis and therapeutic progress made over the past years. Standard treatment in these patients is to preserve the anal sphincter with restoration of intestinal function by mechanical colorectal anastom...
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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive method for diagnosing and staging of lung cancer. EBUS-TBNA obtained small specimens. Rapid on-site examination (ROSE) is a rapid, real-time examination method. The aim of our study is to evaluate the impact of ROSE on adequate specimen sampling, ra...
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Background and aims. Endometriosis is a commonly found disorder in women of reproductive age, consisting in the presence of active ectopic endometrial tissue outside of the endometrial cavity. Surgical scar endometriosis is a rare condition representing about 2% of all endometriosis cases. The purpose of this study was to assess the main characteri...
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A rare neuroendocrine tumor, the pheochromocytoma (PCC) raises problems due both the limited experience of the researchers in this field and its pathogenic mechanisms, still not fully elucidated. The malignant potential of this tumor cannot be predicted based on its macro-or microscopic aspects, but on the presence of metastases. The aims of this s...
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Background and aim: Endobronchial ultrasound (EBUS) is a recent minimally invasive, safe examination method for the mediastinum, with a good diagnostic precision. This method makes possible real time examination with transbronchial fine needle aspiration, diagnostic transbronchial needle aspiration (TBNA) and staging of non-small pulmonary tumors,...
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A diet rich in antioxidants is a heath choice most people make when it comes to options in fighting free radicals, that are formed natural in the body, but that cause damage to DNA and are connected to aging. The study was done in order the evaluate fruit teas that are a sources of antioxidants that can be easily introduce in the diet and are found...
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Stir bar sorptive extraction (SBSE)-thermal desorption (TD) procedure combined with gas chromatography electron capture detection (GC-ECD) was applied to the determination of 20 organochlorine pesticides (OCPs) in six white Romanian grape varieties. Analyses were performed using stir bars coated with 1.0 mm polydimethylsiloxane. The method provided...
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The purpose of this study was to develop a quick procedure for the determination of α-phosphatidylcholine from soybean. The procedure is based on a simple solid-liquid extraction followed by a quick analytical method carried out with an LC-ESI-MS/MS system. A chromatographic column of 2×50 mm with a particle size of 2.5 µm was used. The LC-ESI-MS/M...
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Celery is recently the subject of various studies due to its role in human nutrition and for medicine purposes. One of the most speculated ideas is that celery contains high quantities of androsterone which makes it suitable for infertility treatments. Due to this trend, the purpose of this study was to develop an analytical method suitable to conf...
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The aim of this research was to establish whether all-trans lycopene extracted from fresh and frozen tomatoes is able to inhibit the in vitro proliferation of colon cancer cells, to trigger apoptosis by reactive oxygen species modulation and to reveal its influence on NF-kβ signalling, through the p65 transcription factor and expression of two TNF...
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Full-text available
The aim of this research was to establish whether all-trans lycopene extracted from fresh and frozen tomatoes is able to inhibit the in vitro proliferation of colon cancer cells, to trigger apoptosis by reactive oxygen species modulation and to reveal its influence on NF-kβ signalling, through the p65 transcription factor and expression of two TNF...
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Psammocarcinomas (PCas) are rare epithelial tumors, usually originating in the ovaries or the peritoneum. These tumors are morphologically characterized by extensive psammomatous calcifications, invasiveness and low-grade cytological features. We present the case of a 54-year-old woman who was referred to our department with an umbilical tumor and...
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Hypothesis. Gallstone disease increases slightly the risk for colorectal cancer. This association could lead to omission of the diagnosis of colorectal cancer in patients with gallstones in the situation of mistaken interpretation of clinical data and premature closure of diagnosis. Materials and methods. A retrospective study including 693 patient...
Article
REMARKS REGARDING THE RELATIONSHIP BETWEEN BILIARY LITHIASIS AND/OR CHOLECYSTECTOMY AND COLORECTAL CANCER (Abstract): PURPOSE: The aim of this study is to investigate the relationship between gallstones/cholecystectomy and colorectal cancer. MATERIAL AND METHODS: We designed a retrospective study including all the patients with different cancers tr...
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Rezumat Tuberculoza abdominală este o afecţiune rară, cu tablou clinic nespecific. Au fost studiaţi 7 pacienţi, cu o vârstă medie de 36,7 ani, diagnosticaţi cu tuberculoză abdominală în Clinica Chirurgie IV în perioada 2007-2008. Din cei 7 pacienţi cu tuberculoză abdominală, în 5 cazuri a fost tuberculoză peritoneală, 1 caz tuberculoză intestinală...
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This paper presents the anatomical principles behind preservation of inferior laryngeal nerve and of the external branch of superior laryngeal nerve during thyroidectomy. The embryological development of thyroid and recurrent laryngeal nerves explains the constant relationship between Zuckerkandl’s tuberculum and the recurrent laryngeal nerve, whil...
Article
This paper presents the anatomical principles behind preservation of inferior laryngeal nerve and of the external branch of superior laryngeal nerve during thyroidectomy. The embryological development of thyroid and recurrent laryngeal nerves explains the constant relationship between Zuckerkandl’s tuberculum and the recurrent laryngeal nerve, whil...
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Introducere Sistemul nervos enteric este esenţial pentru moti-litate, precum şi pentru alte funcţii importante ale tractului gastrointestinal. La alcătuirea acestuia iau parte atât neuroni aparţinînd inervaţiei intrinseci, cât şi extrinseci [1]. Inervaţia intrinsecă este alcătuită din plexurile nervoase Meissner (submucoasă) şi Auerbach (musculară)...
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Rezumat Prezentăm un caz operat de angiomiolipom formă sporadică, diagnosticat tardiv, la o pacientă fără antecedente patologice renale. Diagnosticul preoperator s-a pus prin ecografie şi CT abdominal. Tumora a fost de dimensiuni mari 28/18 cm, complicată cu hemoragie şi sindrom anemic sever, ceea ce a impus nefrectomia de urgenţă şi nu a permis un...
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We present some of digestive diseases: achalazia, esophageal diverticula and esophageal fistula, which in their evolution determine respiratory symptoms: dispnea, cough and imitate until confusion respiratory diseases. The diagnosis is most of the time difficult and it needs special investigations. A better knowledge of these diseases helps us to a...
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Bronchoscopy is a central technique in diagnosing lung cancer, but also in different therapeutic approaches. The most common indication for bronchoscopy is for tissue sampling and determining the extent of lung cancer. Established diagnostic techniques are forceps biopsy, aspiration or brush cytology sampling, or needle aspiration. Laser therapy, e...
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Cell surface HLA class I molecules present peptides derived from human cellular proteins to T cells. In the present study, we investigated the expression of HLA class I in human pancreatic carcinoma. The expression of HLA class I antigen and the extent of tumor infiltration by T cells were investigated in 46 primary tumors and in 14 metastases of p...

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