Innocentmary Ejiofor

Nnamdi Azikiwe University, Awka | Unizik · Department of Pharmaceutical Biology and Traditional Medicine

In this paper, a novel distribution was proposed for modeling data on Leukemia and median effective dose (ED50) of Artemether-Lumefantrine against Plasmodium falciparum. Plasmodium falciparum or P. falciparum is one of the protozoan species that causes malaria. In the treatment of malaria, especially in sub-Saharan Africa Artemether-Lumefantrine do...

Drug repurposing is a term applied to finding a new therapeutic and pharmacological indication for an existing drug molecule with a known indication. Repurposing existing drugs to treat both rare and widespread ailments is more and more compelling due to the use of less risky compounds, which may result in lower entire development costs and quicker...

Picralima nitida the only species in the genus Picralima belongs to the Apocyanaceae family. It is widely known for its medicinal purposes. The aim of the study was to investigate pharmacognostic parameters of the leaf and evaluate the hepatoprotective activity against carbon tetrachloride induced hepatotoxicity using Swiss Albino mice. The physico...

Due to the complexity of cancer treatment, there is a need to embrace more advanced approaches in cancer therapy. Targeted therapies are cancer treatment that targets proteins and enzymes that affect how cancer cells grow, divide, and disseminate. The specificity of targeted therapies is essential in understanding the most effective way to treat ca...

The prevalence of Diabetes mellitus (DM) is continuously rising worldwide. Among its types, type I is characterized by the destruction of beta cells triggered by various mechanisms, including the activation of Caspase 3. Studies have demonstrated the crucial role of Caspase 3 in initiating the apoptosis of beta cells in DM. Our research aims to ide...

Citation Igbokwe MC et al. (2022) In-silico study for African plants with possible beta-cell regeneration effect through inhibition of DYRK1A. Sciences of Phytochemistry. 1(2): 1-16. Abstract The continuous destruction of normal insulin-producing pancreatic beta-cells is a contributing factor in all common forms of diabetes, due to insufficient pro...

The continuous destruction of normal insulin-producing pancreatic beta-cells is a contributing factor in all common forms of diabetes, due to insufficient production of insulin, especially in type 1 diabetes. There are attempts at beta-cells transplantation, but the cost and availability of donors pose a great challenge to the process. Dual-Specifi...

Drug repurposing involves reusing an active pharmaceutical ingredient that is already in the market and drugs that were unsuccessful in their clinical phases of development for a new indication. It has numerous benefits in drug development. Therapeutic inhibitors are agents that could be of synthetic or natural source with the ability to trigger th...

Resistance to Pyrimethamine, an antimalarial medicine has been reported to be due to mutations in Dihydrofolate reductase-thymidylate synthase (DHFR-TS). Phytochemicals, particularly from plants that been used in ethnomedicine, have been reported to have privileged structures that might bind strongly to the mutants of DHFR-TS. The aim of this study...

Resistance to Pyrimethamine, an antimalaria medicine has been reported to be due to mutations in Dihydrofolate reductase-thymidylate synthase (DHFR-TS). Phytochemicals, particularly from plants that been used in ethnomedicine, have been reported to have privileged structures that might bind strongly to the mutants of DHFR-TS. The aim of this study...

Flavonoids are polyphenolic compounds and are one of the most abundant secondary metabolites present in plants. They are found in almost all vegetables and fruits. Flavonoids are of essence to plants and to man as well, due to their Medicinal and Pharmaceutical importance. Explicit understanding of the biosynthetic pathway of flavonoids is very ess...

The use of plants for the treatment of diseases in Africa is attracting more attention. This use of plants calls for more researches towards the validation of the healing claims by herbalist and the users of these herbs. Vernonia amygdalina Delile (Asteraceae) is one of the widely used plants in Nigeria by herbalists for the treatment of different...

We investigated the binding affinities of antiviral of ethno medicinal origin to five Ebola viral proteins by in silico molecular docking simulations. One hundred and seventy three compounds were obtained from literature, extracted from ZINC® database as mol2 files and further prepared for docking simulations using Auto Dock tools v. 1.5.6. Five Eb...

Ebola Viral Disease (EVD) ravaged parts of West Africa in 2014. Management of EVD was hinged on supportive care with rehydration etc. since no drug or vaccine was proven to be effective against the disease. Drug repurposing is the discovery and development of existing therapeutic agent for condition(s) other than those for which they were first dev...