Inmaculada Suarez Gonzalez

University of Granada | UGR · Department of Analytical Chemistry

Bevacizumab (BVZ), cetuximab (CTX) and trastuzumab (TTZ) are monoclonal antibodies (mAbs) used worldwide for the treatment of several widespread kinds of cancer. They are marketed as medicines under their respective tradenames: Avastin®, Erbitux® and Herceptin®. The aim of this research was to develop in-house specific enzyme-linked immunosorbent a...

Background Trastuzumab (TRZ) (Herceptin) is a humanised monoclonal antibody IgG1 that acts against human epidermal growth factor receptor 2 (HER2). It is indicated in the treatment of early and metastatic breast cancer and metastatic gastric cancer. Purpose To evaluate the biological activity (BA) that remains in Herceptin after single-use vials h...

Background The use of an alternative liquid anaesthetic sevoflurane has recently been reported in the literature on vascular ulcers. Topical application for management of analgesia appears to be successful. Purpose To evaluate the stability of sevoflurane in pure polypropylene amber syringes. Material and methods Commercial solutions of sevoflurane...

Background Cetuximab (CTX) (Erbitux) is a chimeric mouse-human monoclonal antibody IgG1 targeting epidermal growth factor receptor (EGFR). It is approved for use as treatment for metastatic colorectal cancer and squamous cell carcinoma of the head and neck. Purpose To evaluate the biological activity (BA) that remains in Erbitux after opening singl...

Background Bevacizumab (BVZ), the active substance of Avastin (25 mg/mL BVZ), is a humanised anti-vascular endothelial growth factor (VEGF) monoclonal antibody indicated in the treatment of several cancers. Purpose To evaluate the biological activity (BA) that remains in the medicine Avastin after opening single-use vials in a long-term study. Mate...

Background Cetuximab (CTX) (Erbitux) is a chimeric mouse-human monoclonal antibody IgG1 targeting epidermal growth factor receptor (EGFR). It is approved for use as treatment for metastatic colorectal cancer and squamous cell carcinoma of the head and neck. Purpose To access the stability of CTX during storage (in dark glass bottles at 4°C refriger...

Background Tumour necrosis factor alpha (TNF-α) is a proinflammatory cytokine, the main mediator in inflammatory and autoimmune diseases, as well as during various attacks on cells such infections. It is therefore involved in the course of a large number of pathologies such as rheumatoid arthritis, Crohn’s disease, psoriatic arthritis, ankylosing s...

Background Infliximab (Remicade®) is a chimeric human-murine antihuman tumour necrosis factor (TNF) monoclonal antibody (75% human; 25% murine). It is composed of human constant and murine variable regions. It is produced by a recombinant cell line cultured by continuous perfusion. Infliximab binds to the soluble and transmembrane forms of tumour n...