Inmaculada Failde

• MD.PhD
• Professor (Full) at Universidad de Cádiz

Objective: To identify the factors associated with the pain-related functional interference level in people with chronic low back pain. Design: Cross-sectional. Subjects/Patients: Chronic low back pain patients. Methods: Sociodemographic data, pain intensity, pain-related functional interference, physical functioning and fitness, sleep quality, anx...

Objectives To analyse the effectiveness of a physical exercise programme guided by a mobile health technology system (COVIDReApp) for patients with post-acute COVID-19 syndrome. This syndrome is a multisystem disease that occurs in people with a history of COVID-19 between 1 and 3 months after the onset of the disease. This study will assess the im...

Background Chronic pain (CP) is a public health problem worldwide. Aim To update the prevalence of CP and compare the clinical and social characteristics of people with CP with those with non‐chronic continuous pain and a group without pain. Methods An observational cross‐sectional study was carried out in a representative sample of 7058 adults f...

Objective To determine the prevalence and related factors of diagnosed osteoarthrosis (DO) and undiagnosed osteoarthrosis (UO) in the general Spanish adult population. Setting Cross-sectional study with data from the Spanish National Health Survey 2017. Participants N = 23,089 adults. Three groups of people were defined: DO, UO, and no osteoarthr...

Objectives: To identify factors related to patients' feeling of safety during prehospital emergencies. Material and methods: Descriptive, multicenter cross-sectional study in the context of "061" emergency response services of Andalusia, Spain. Data were collected from April 2021 to March 2022. Patients attended and transported by emergency resp...

Gait and dynamic balance are two main goals in neurorehabilitation that mHealth systems could address. To analyze the impact of using mHealth systems on gait and dynamic balance outcomes in subjects with neurological disorders. Randomized controlled trials (RCT) published in PubMed, Web of Science, Scopus, and PEDro databases were searched up to Ap...

Background: Chronic pain (CP) is 1 of the leading causes of disability worldwide and represents a significant burden on individual, social, and economic aspects. Potential tools, such as mobile health (mHealth) systems, are emerging for the self-management of patients with CP. Objective: A systematic review was conducted to analyze the effects o...

Objective: To identify and compare physical activity levels in the Spanish population with chronic low back pain and their associated factors. Design: Cross-sectional national study. Subjects: A total of 3,220 adults with chronic low back pain from the 2017 Spanish National Health Survey. Methods: Three groups were defined according to physi...

The aim of this study was to analyse the differences in cognitive function between women and men with type-2 diabetes mellitus (DMT2) and diabetic peripheral neuropathy (DPN) with and without diabetic neuropathic pain (DNP), and the factors associated with cognitive function in each sex. A cross-sectional study of 149 patients with DMT2 and DPN was...

Introduction The physical limitations experienced by people with chronic pain (CP) produce a greater need for care and assistance, most of which is provided by an informal caregiver (IC). Despite the key role ICs play in the everyday lives of individuals living with CP, knowledge about their experiences and needs is limited. We aimed to address thi...

Objective To analyse the COVID-19-related lockdown impact on University workers, to identify groups based on this information, and to study the factors associated with each group. Study design Cross-sectional study. Methods A survey was conducted 3.5 weeks after COVID-19-related lockdown in University workers in Spain. Sociodemographic variables,...

Aims To systematically describe the factors influencing the perception of feeling safe among patients receiving pre‐hospital emergency care. Background Patient safety is a top priority worldwide. Little is known about how patients perceive safety during emergency health care and what the related factors are. Design A mixed‐methods systematic revi...

Introduction The knowledge of COVID-19 and the recommended preventive measures for controlling the disease have been widely studied in the general population, but little is known about whether the University workers as educators and transmitters of knowledge have appropriate knowledge and take preventive measures for COVID-19. This study aims to an...

To compare cognitive function in patients with diabetes mellitus type-2 (T2DM) both with and without diabetic neuropathic pain (DNP). To analyse the relationship between mood and sleep disorders, quality of life and cognitive function in patients with DNP. Cross-sectional study conducted in patients with T2DM and neuropathy. The presence of DNP, co...

Objectives: The aim of this study is to improve our knowledge of cognitive function in individuals with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus and with peripheral diabetic neuropathy (DPN). Methods: A systematic review and meta-analysis was performed of publications included in PubMed, Scopus, PsycInfo and Web of Science databases unti...

Aim To evaluate the effectiveness of PainReApp, an mHealth system, based on physical exercise recommendations for patients with chronic pain (low back pain, fibromyalgia and diabetic neuropathic pain) based on pain intensity, quality of life, anxiety and/or depression, and sleep quality. Design Single-blinded randomized controlled trial. Methods...

Resumen Introducción KnowPain-12 (KP12) y Nurses Pain Management Attitude Survey (NPMAS) son 2 herramientas que determinan el nivel de conocimiento y actitud frente al manejo del dolor crónico (DC). El objetivo de este trabajo es traducir y adaptar al castellano estos cuestionarios para determinar la actitud y el conocimiento sobre el manejo del D...

Migraine is a common neurological disorder considered the second most disabling condition worldwide. Its prevalence ranges from 2.6% to 21.7% in population studies. This study aimed to know the prevalence of diagnosed and undiagnosed migraine in the general Spanish adult population, their health care use, and factors related. A descriptive cross-se...

Introduction: The lack of adherence is frequent in chronic pain (CP) patients and the influence of psychological factors may play a relevant role. The aim of this study was to analyze the psychological factors related to the adherence to analgesic treatment in patients with CP.

In patients with coronavirus disease 2019 (COVID-19) infection, common drugs may exacerbate symptoms and negatively impact outcomes. However, the role of chronic medications on COVID-19 effects remains poorly understood. We hypothesized that certain chronic pain medications would influence outcomes in patients with COVID-19. The main aim is to asse...

This study aims to explore the psychological impact of the coronavirus disease (COVID-19)-related lockdown in university workers, and to analyse the factors related to their levels of stress, anxiety, and depression. A cross-sectional study was conducted between 8–22 April 2020, 3.5 weeks after the COVID-19-related lockdown in Spain. We collected s...

Objective: The aim of the study was to design and validate a new tool to measure the security perceived by witnesses of patient care and hospital transfers, after requesting urgent assistance via the "061" phone number. Methods: This is a descriptive observational, cross-sectional, design, and validation study of a scale conducted by telephone i...

Objectives: To determine the prevalence and factors associated with the use of opioids among patients with chronic non-cancer pain (CNCP). Methods: A systematic review and meta-analysis. Comprehensive literature searches in Medline-PubMed, Embase and SCOPUS databases. Original studies published between 2009 and 2019 with a cross-sectional design we...

This study aims to shed light on the frequency and associated factors of self-reported adherence to analgesic treatment among chronic pain (CP) patients in the Spanish population. A nationwide cross-sectional study was performed of 1066 Spanish adults, of whom 251 suffered from CP and 168 had been prescribed analgesic treatment. Adherence was asses...

This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2...

Purpose: To estimate the prevalence of diagnosed and undiagnosed chronic low back pain (CLBP-D and CLBP-UD respectively) in the general adult population in Spain and to compare the characteristics of these two groups with subjects without CLBP symptoms (No-CLBP). To establish CLBP-D patient subgroups according to their selfperceived health status,...

Aims and objectives To determine the feelings of safety among patients taken to hospital after requesting urgent care, based on their experiences and those of their carers and prehospital emergency care professionals. Background Little research has been performed into the perception of safety in prehospital emergency care settings worldwide, from...

Background Opioids are one of the most prescribed treatments for chronic pain (CP). However, their long‐term use (>3 months) has been surrounded by controversy, due to loss of beneficial effects. Objective To explore the experiences of people with chronic non‐malignant low back pain in Spain undergoing long‐term treatment with opioids. Design Qua...

Objective: To evaluate the national general prevalence of postoperative pain and the associated organizational/structural factors related to the provision of health care services. Design and setting: Observational prospective cohort study performed in 46 tertiary hospitals that were randomly selected from the Spanish National Inventory of Hospit...

Objective To compare cognitive function, mood and sleep status in patients with and without diabetic neuropathic pain (DNP) and their relationship with pain intensity, diabetes complications, and quality of life. To determine whether these relationships differ depending on the sensorial phenotype. Methods Cross-sectional study performed on patient...

Objective. To investigate the evolution of opioid-related mortality and potential years of life lost in Spanish general population from 2008 to 2017. To evaluate the differences between Spain and US. Methods. A descriptive study using retrospective annual data from 2008 to 2017 in Spanish and US general population. Information on the population and...

Background: Chronic pain (CP) is a major public health problem affecting patient's lives and reducing physical activity. The aim is to establish subgroups of people with chronic pain (PCP) according to limitations in activities of daily living (ADL), and to identify sociodemographic, pain related, and psychosocial variables associated to each subg...

Introduction: Diabetic neuropathic pain (DNP) is a disabling complication suffered by patients with diabetic neuropathy. DNP coexists with different conditions, especially mental and sleep disorders, which seem to impair the management and course of the disease. However, there is a lack of accurate results about their prevalence. Consequently, the...

[This corrects the article on p. 1835 in vol. 11, PMID: 30254486.].

Background The objective of the study was to estimate the prevalence of pure central neuropathic pain (CNP) and peripheral neuropathic pain (PNP) among patients attending pain clinics in Spain. The study also aimed to analyze factors associated with pain intensity and quality of life (QoL). Methods A cross-sectional study was performed including 5...

Background: Chronic pain is a major health issue requiring an approach that not only considers medication, but also many other factors included in the Bio-Psycho-Social model of pain. New technologies, such as mobile applications, are tools to address these factors, although in many cases they lack proven quality or are not based on scientific evi...

BACKGROUND Chronic pain is a major health issue requiring an approach that not only considers medication, but also many other factors included in the biopsychosocial model of pain. New technologies, such as mobile apps, are tools to address these factors, although in many cases they lack proven quality or are not based on scientific evidence, so it...

Context: A lack of information has been found related to patients' perception towards pain management. Objectives: To analyze the point of view of the general Spanish population regarding the use of opioids in pain treatment. To identify groups of individuals based on this information. Methods: Nationwide cross-sectional study on a representat...

Objective. To compare sleep dimensions in patients suffering from chronic pain of different origins, and with a group of pain-free subjects. To analyze the relationship between depression and/or anxiety and sleep disorders in musculoskeletal, neuropathic and fibromyalgia patients. Methods. This cross-sectional study included patients diagnosed with...

Depressive Disorder, according to WHO will be one of the most disabling causes in the world. Depression includes psychological and somatic symptoms, like anhedonia or pain, and both have a bidirectional relationship, so that the presence and severity of one of them directly affects the other one, and both leads to a disruption in quality of life an...

Aims: To determine the use of clinical practice guidelines (CPGs) for chronic pain (CP) management; analyze the effects of training in pain and the attitudes of physicians towards pain and CP patients on the adherence to these CPGs; and assess the impact of adherence to CPGs on patient care. Method: This was a cross-sectional study in a sample o...

Objective.: To assess cognitive performance of chronic pain (CP) patients diagnosed with three types of pain-neuropathic pain (NP), musculoskeletal (MSK), and fibromyalgia (FM)-and to analyze the factors influencing cognitive difficulties in each group. Methods.: Two hundred fifty-four CP patients-104 NP, 99 MSK, 51 FM-and 72 pain-free subjects...

Objetivos: El sistema sanitario español ha sufrido muchos cambios como consecuencia de las políticas de austeridad llevadas a cabo durante la crisis económica, concretamente en lo que se refiere al gasto farmacéutico; medicamentos como los analgésicos, que previamente eran gratuitos para un sector de la población, se han visto afectados por la apli...

OBJECTIVES: to analyse the evolution of Health Related Quality of Life (HRQL) in coronary patients (CP) and to identify predictive factors influencing this evolution in a situation with missing data and time-dependent variables. DESIGN: prospective study with repeated measures. SETTING AND PARTICIPANTS: a total of 175 CP were included. General Esti...

Objectives To determine the prevalence and the factors related to sick leave and job loss among individuals suffering from chronic pain (CP), and to analyse specifically the effect of family and social support on the individual's employment. Design Observational cross-sectional study. Setting Data were collected using structured computer-assisted...

Background: The aim is to know the factors related to the evolution of Health Related Quality of Life (HRQL) in Coronary Patients (CP) from a longitudinal perspective using an appropriate method that handles missing data adequately when the mechanism of missingness is uncertain. Methods: Prospective study with repeated measures at baseline, 3 an...

Objective: To analyse the use of healthcare resources by chronic pain (CP) patients in Spain and their satisfaction thereof. Research design and methods: A nationwide, cross sectional study was carried out on a representative sample of 1,957 Spanish adults. A telephone survey was conducted with the aim of analysing the prevalence of CP, the char...

Introducción: Dadas las ventajas de metodologías de aprendizaje activo colaborativo se plantea establecer una enseñanza de Salud Pública basada en estas metodologías, evaluarla y detectar la satisfacción del alumno con este método. Material y métodos: Estudio descriptivo transversal en el que se aplicó aprendizaje activo colaborativo a alumnos de S...

Chronic pain (CP) seriously affects the patient’s daily activities and quality of life, but few studies on CP have considered its effects on the patient’s social and family environment. In this work, through a review of the literature, we assessed several aspects of how CP influences the patient’s daily activities and quality of life, as well as it...

Patients with chronic pain often complain about cognitive difficulties, and since these symptoms represent an additional source of suffering and distress, evaluating the cognitive status of these patients with valid and reliable tests should be an important part of their overall assessment. Although cognitive impairment is a critical characteristic...

Exploratory Factor Analysis of the TYM (n = 254). (DOC)

Data Raw for PlosOne. (XLSX)

Missing data are a common problem in clinical and epidemiological research, especially in longitudinal studies. Despite many methodological advances in recent decades, many papers on clinical trials and epidemiological studies do not report using principled statistical methods to accommodate missing data or use ineffective or inappropriate techniqu...

According to the DSM5, Somatic Symptom Disorder (SSD) is characterized by somatic symptoms that are either very distressing or result in significant disruption of functioning. These criteria are significantly different compared with previous editions of DSM. For example, the DSM-IV diagnosis of somatization disorder required a specific number of co...

Objectives: to analyse the evolution of Health Related Quality of Life (HRQL) in coronary patients (CP) and to identify predictive factors influencing this evolution in a situation with missing data and time-dependent variables. Design: prospective study with repeated measures. Setting and participants: a total of 175 CP were included. General...

Objective: . We aimed to systematically review the methods and instruments used to evaluate cognitive function in chronic pain (CP) patients. Methods: A sensitive search strategy was designed using five databases. Based on the objectives and methodology, we selected cross-sectional studies on adults with chronic non-cancer pain in which cognitiv...

Study Design . Quasiexperimental study. Objective . To investigate whether radiofrequency treatment can preclude the need for spinal surgery in both the short term and long term. Background . Radiofrequency is commonly used to treat lumbosacral radicular pain. Only few studies have evaluated its effects on surgical indications. Methods . We conduct...

Objective This study aims to assess the prevalence of chronic pain, its characteristics, and its impact on the general Spanish population. Also, to establish chronic pain patient subgroups according to the characteristics of pain and to identify variables specifically associated with each subgroup.DesignTelephone-based, cross-sectional nationwide s...

To assess the impact of chronic pain on the family environment from the patient's, relative's and caregiver's perspective, we undertook cross-sectional study on a representative sample of Spanish adults who suffered pain at least 4 days a week for ≥3 months and on relatives and caregivers of patients that fulfilled these criteria. The characteristi...

The aim of this study is to investigate the attitudes towards mental illness and psychiatry among fifth year Spanish medical students. The study included 171 students from three medical schools located in different areas of Spain: Cádiz; UCA (n = 113), Madrid; San Pablo-CEU (n = 22), and Barcelona; UAB (n = 36). They responded, prior to their under...

The aim of this study was to determine the prevalence of painful musculoskeletal conditions and migraine headache or any other headache in a sample of Spanish adults with disabilities and their association with anxiety, depression, and sleep disorders. This cross-sectional study analyzed data from the Spanish national disability and dependence surv...

Background / Purpose: The association between pain and affective disorders is complex. Therefore, it is necessary to know other factors that may affect this relationship. In the present study we explored the effect of cognitive function and quality of sleep on affective disorder in chronic pain patients. Main conclusion: Sleep and cognitive fu...

Objective: The study aims to determine the prevalence of undiagnosed comorbid mood disorders in patients suffering chronic musculoskeletal pain in a primary care setting and to identify sleep disturbances and other associated factors in these patients, and to compare the use of health services by chronic musculoskeletal pain patients with and with...

Objective: Chronic pain and depression are frequent conditions in primary care patients. Depression is frequently overlooked in the presence of pain of uncertain origin. The aim is to measure the prevalence and clinical correlates of unrecognized comorbid mood disorders and chronic pain of uncertain origin in older primary care patients, and to el...

Background While pain is frequently associated with unipolar depression, few studies have investigated the link between pain and bipolar depression. In the present study we estimated the prevalence and characteristics of pain among patients with bipolar depression treated by psychiatrists in their regular clinical practice. The study was designed t...

Background and aims: Epidemiological data about neuropathic pain are still scarce. A national survey, based on neurologic clinical diagnosis, was performed to determine its prevalence among patients attending pain clinics. Methods: An epidemiological cross-sectional study involving pain clinics across all regions in Spain was carried out. Pain s...

Introducción. El estigma social que persiste hacia la enfermedad mental puede estar presente en los estudiantes de medicina e impactar en la forma de considerar ésta y la psiquiatría como especialidad. Objetivo. Investigar la actitud hacia la enfermedad mental y la psiquiatría en una muestra de estudiantes. Sujetos y métodos. Se realizó una encuest...

Introduction. Medicine students could share that stigmatizing attitudes towards mental illness and Psychiatry as specialty. Aim. To investigate the attitudes of medical students towards the mental disease and the psychiatry. Subjects and methods. 27 medicine 5th course students from San Pablo-CEU University were interviewed with a structured interv...

To assess whether the methodological changes of this new algorithm improves the results of a previously presented strategy. We enhance the image and filter out the green channel of the digital color retinography. Multitolerance thresholding was applied to obtain candidate points and make a seed growing region by varying intensities. We took 15 char...

The Test Your Memory (TYM) scale is a screening tool, which assesses mild cognitive impairment (MCI). It has shown better psychometric outcomes than the Mini-Mental State Examination (MMSE). We aimed to translate and adjust into Spanish a conceptually equivalent version. Translation-back translation method, complemented with qualitative methods, an...

Chronic pain constitutes a serious public health problem due to its high prevalence and the social and personal consequences. The presence of chronic pain has been associated with mild cognitive impairment, especially in patients with fibromyalgia and neuropathic pain, and it has been also related with other disease like anxiety, depression, sleep...

Health-related quality-of-life (HRQL) tests used in sleep apnea-hypopnea syndrome (SAHS) are time-consuming, complicating their application in clinical practice. The objective was to examine the validity and responsiveness of a simple visual analogical well-being scale (VAWS) for the clinical use. The subjects proceed from a cohort of SAHS patients...

The role of gender differences in Health Related Quality Life (HRQL) in coronary patients is controversial, so understanding the specific determinants of HRQL in men and women might be of clinical importance. The aim of this study was to know the gender differences in the evolution of HRQL at 3 and 6 months after a coronary event, and to identify t...

Chronic pain constitutes a serious public health problem due to its high prevalence and the social and personal consequences. The presence of chronic pain has been associated with mild cognitive impairment, especially in patients with fibromyalgia and neuropathic pain, and it has been also related with other disease like anxiety, depression, sleep...

Background and objectivesThe Test Your Memory (TYM) scale is a screening tool, which assesses mild cognitive impairment (MCI). It has shown better psychometric outcomes than the Mini-Mental State Examination (MMSE). We aimed to translate and adjust into Spanish a conceptually equivalent version.

The need to assess the prevalence and characteristics of painful symptoms among depressed patients attended by psychiatrists in their regular clinical practice. A multi-centre, cross-sectional study was carried out in a large sample (n=3566) of patients attending out-patient psychiatric facilities in Spain. All types of DSM-IV-TR depressive disorde...

Patients with fibromyalgia (FM) often have associated mental disorders. As well as being very prevalent, the two conditions also have sociodemographic and clinical similarities. If both of these clinical conditions lead independently to a limitation of the health-related quality of life (HRQL) of the patients, it may be thought that their conjuncti...

The aim of the study was to determine the construct and criterion validity of the 12-item short-form questionnaire (SF-12) in coronary patients with either acute myocardial infarction or unstable angina in Spain. A total of 186 patients hospitalized with coronary heart disease have been studied. The construct validity has been analysed by means of...

Patients with chronic pain frequently display comorbid depression, but the impact of this concurrence is often underestimated and mistreated. The aim of this study was to determine the prevalence of unrecognized major depression and other mood disorders and comorbid unexplained chronic pain in primary care settings and to explore the associated fac...

Home mechanical ventilation (HMV) is a mode of ventilatory support for the treatment of chronic respiratory failure (CRF) which is carried out in the home of the patient. Ventilator-assisted individuals are composed of a mix of adult and pediatric patients with a variety of underlying medical conditions contributing to CRF. Current evidence about t...

ObjectivesTo determine the prevalence of neuropathic and mixed pain in the population treated in the Oncology Service of the catchment area (Cadiz-San Fernando) of the Puerta del Mar University Hospital. Patients with cancer reporting pain and who had not received prior oncological treatment that could have caused the pain were included. We also ai...