Ingrid Y Liu

Ingrid Y Liu
Tzu Chi University · Institute of Medical Sciences

Ph.D. in Neuroscience University of Southern California

About

37
Publications
9,020
Reads
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1,194
Citations
Introduction
Research Overview 1. We use cytogenetic, molecular and genomic approaches to research patients with inherited or spontaneous brain disorders and screen for genes associated with these diseases. 2. We utilize mouse models to identify gene functions and molecular mechanisms underlying memory processing and formation. 3. We use mouse models to select promising drug candidates for treating Alzheimer's disease and PTSD.
Additional affiliations
January 2010 - present
Tzu Chi University
January 2004 - present
Education
September 2000 - June 2003
University of Southern California
Field of study
  • Neuroscience
September 1998 - June 2000
New York University
Field of study
  • Biology
September 1990 - June 1992
Indiana University Bloomington
Field of study
  • Microbiology

Publications

Publications (37)
Article
Peroxiredoxin 6 (PRDX6) is expressed throughout the brain, including the hippocampus, where it plays a potential role in synaptic regulation and forming emotional and spatial memories. PRDX6 is predominantly detected in the female mouse's hippocampus; thus, we investigate the effect of the Prdx6 gene on behavioral phenotypes and synaptic functions...
Article
Full-text available
Fear dysregulation is one of the symptoms found in post-traumatic stress disorder (PTSD) patients. The functional abnormality of the hippocampus is known to be implicated in the development of such pathology. Peroxiredoxin 6 (PRDX6) belongs to the peroxiredoxin family. This antioxidant enzyme is expressed throughout the brain, including the hippoca...
Article
Full-text available
Peroxiredoxin 6 (PRDX6) is expressed dominantly in the astrocytes and exerts either neuroprotective or neurotoxic effects in the brain. Although PRDX6 can modulate several signaling cascades involving cognitive functions, its physiological role in spatial memory has not been investigated yet. This study aims to explore the function of the Prdx6 gen...
Article
Full-text available
Stress can elicit glucocorticoid release to promote coping mechanisms and influence learning and memory performance. Individual memory performance varies in response to stress, and the underlying mechanism is not clear yet. Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme participating in both physiological and pathological conditions. Several s...
Article
The triple transgenic Alzheimer’s disease (3xTg-AD) strain is a common mouse model used for studying the pathology and mechanism of Alzheimer’s disease (AD). The 3xTg-AD strain exhibits two hallmarks of AD, amyloid beta (Aβ) and neurofibrillary tangles. Several studies using different gender and age of 3xTg-AD mice to investigate their behavior phe...
Article
Full-text available
Alzheimer's disease (AD) is a neurodegenerative disease characterized by an excessive inflammatory response and impaired memory retrieval, including spatial memory, recognition memory, and emotional memory. Acquisition and retrieval of fear memory help one avoid dangers and natural threats. Thus, it is crucial for survival. AD patients with impaire...
Article
Full-text available
Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as one of the early signs of AMD and was found in mor...
Article
Full-text available
The relationship between neuronal inflammation and impairment of memory retrieval is not well established, partially because of the lack of appropriate compound to test this hypothesis. Here we investigated effects of a novel coral‐derived compound on hippocampal inflammation markers and contextual fear memory retrieval using a triple‐transgenic AD...
Preprint
Full-text available
Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme expressed in many organs including the brain. It is known to participate in many psychiatric functions, but its role in fear memory is unknown. The present study demonstrates that PRDX6 plays a critical role in the regulation of fear response. Using Prdx6 knockout (Prdx6-/-) mice, we identified th...
Article
Full-text available
Depression is a life-threatening psychiatric disorder and a major public health concern worldwide with an incidence of 5% and a lifetime prevalence of 15%-20%. It is related with the social disability, decreased quality of life, and a high incidence of suicide. Along with increased depressive cases, health care cost in treating patients suffering f...
Article
Full-text available
Memory retrieval dysfunction is a symptom of schizophrenia, autism spectrum disorder (ASD), and absence epilepsy (AE), as well as an early sign of Alzheimer's disease. To date, few drugs have been reported to enhance memory retrieval. Here, we found that a coral-derived natural product, excavatolide-B (Exc-B), enhances contextual memory retrieval i...
Article
Full-text available
The genetic and molecular basis underlying fear memory formation is a key theme in anxiety disorder research. Because activating transcription factor 3 (ATF3) is induced under stress conditions and is highly expressed in the hippocampus, we hypothesise that ATF3 plays a role in fear memory formation. We used fear conditioning and various other para...
Article
Full-text available
Homozygous Cav3.2 knockout mice, which are defective in the pore-forming subunit of a low voltage activated T-type calcium channel, have been documented to show impaired maintenance of late-phase long-term potentiation (L-LTP) and defective retrieval of context-associated fear memory. To investigate the role of Cav3.2 in global gene expression, we...
Article
Full-text available
Various biological effects are associated with radiation exposure. Irradiated cells may elevate the risk for genetic instability, mutation, and cancer under low levels of radiation exposure, in addition to being able to extend the postradiation side effects in normal tissues. Radiation-induced bystander effect (RIBE) is the focus of rigorous resear...
Data
miRNA-gene interaction predicted by miRTar; the complete gene list is provided by our array original data.
Article
Full-text available
Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterat...
Data
Full-text available
Gene ontology enrichment analysis results are given in Table 2 and supplementary table 1. It appears that, starting at a dosage of 0.5 Gy 60Co radiation, cells may have already been affected in terms of nucleotide metabolism and signaling pathways responsive to external apoptotic signals. Beginning at 1 Gy, increasing radiation exposure induces cha...
Article
Objective This study aims to investigate whether single-nucleotide polymorphisms (SNPs) CYP2C9 and VKORC1 can be used to adjust effective warfarin treatment for aboriginal Taiwanese population. Materials and Methods This study investigates the association of SNPs CYP2C9 and VKORC1 and clinical factors [gender, age, and body mass index (BMI)] with...
Article
MicroRNA-132 (miR-132) has been demonstrated to affect multiple neuronal functions, including dendritic growth and spinogenesis in cultured neurons and brain slices, as well as learning behavior of animals. However, its role in acquisition of temporal-associated memory remains unclear. In this study, we demonstrated that the mature miR-132 level in...
Article
Full-text available
Background Approximately 30 sex-chromosome discordant chimera cases have been reported to date, of which only four cases carried trisomy 21. Here, we present an additional case, an aborted fetus with a karyotype of 47,XX, +21/46,XY. Case Presentation Autopsy demonstrated that this fetus was normally developed and had male genitalia. Major characte...
Article
Full-text available
Among all voltage-gated calcium channels, the T-type Ca2+ channels encoded by the Cav3.2 genes are highly expressed in the hippocampus, which is associated with contextual, temporal and spatial learning and memory. However, the specific involvement of the Cav3.2 T-type Ca2+ channel in these hippocampus-dependent types of learning and memory remains...
Data
Paired-pulse ratio. No significant difference was recorded for paired-pulses ratio of WT (indicated in solid circle) and KO −/− (a1H−/−; indicated in open circle). (TIF)
Data
Raw traces of field excitatory post synaptic potential (fEPSP). No significant difference was observed for raw traces of fEPSP of WT (indicated in solid circle) and KO −/−(a1H−/−; indicated in open circle). (TIF)
Data
TEA-induced fEPSP. No significant difference was observed for TEA-induced fEPSP of WT (indicated in solid circle) and KO −/− (a1H−/−; indicated in open circle). (TIF)
Article
Full-text available
Clinical and molecular cytogenetic investigations of a newborn girl exhibiting facial dysmorphism with developmental delay. Phenotypic evaluation was first applied to examine the proband's developmental status. Computed tomography and colour transcranial Doppler were used then to investigate her brain structure and function. Subsequently, chromosom...
Article
Full-text available
Treatments for chronic musculoskeletal pain, such as lower back pain, fibromyalgia, and myofascial pain syndrome, remain inadequate because of our poor understanding of the mechanisms that underlie these conditions. Although T-type Ca2+ channels (T-channels) have been implicated in peripheral and central pain sensory pathways, their role in chronic...
Article
Luteolin (3',4',5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to possess antioxidant, anti-inflammatory, and anticancer activities. In this work, we assessed whether luteolin has neurotrophic activity, namely, the ability to induce neurite outgrowth and to attenuate serum withdrawal-induced cytotoxicity in PC12 cells. Our re...
Article
The brain regions involved with trace fear conditioning (TFC) and delayed fear conditioning (DFC) are well-characterized, but little is known about the cellular representation subsuming these types of classical conditioning. Previous evidence has shown that activation of the amygdala is required for both TFC and DFC, while TFC also involves the hip...
Article
Full-text available
In this study, brain-derived neurotrophic factor (BDNF) heterozygous knock-outs were tested on fear conditioning, and their wild-type littermates were used as controls. Results showed that BDNF(+/-) mice are impaired in contextual learning, whereas tone learning remains intact. Because BDNF is involved in synaptic transmission and contextual learni...
Article
Full-text available
Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of a variety of antioxidants might be beneficial for pre...
Article
Full-text available
Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of a variety of antioxidants might be beneficial for pre...

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Projects

Projects (4)
Project
We use peroxiredoxin 6 knockout mice to investigate its role in memory formation.
Project
To investigate the Cav3.2 gene function in memory formation
Project
To investigate the function of the ATF3 gene in memory formation