Ingeborg Stalmans

Ingeborg Stalmans
KU Leuven | ku leuven · Department of Neurosciences

About

131
Publications
22,968
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3,293
Citations
Citations since 2016
36 Research Items
1177 Citations
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2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200

Publications

Publications (131)
Article
Full-text available
In this study, we report the results of a comprehensive phenotyping of the retina of the AppNL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities...
Article
Full-text available
Objective Pain in fibromyalgia (FM) and chronic fatigue syndrome (CFS) is assumed to originate from central sensitization. Perineural cysts or Tarlov cysts (TCs) are nerve root dilations resulting from pathologically increased cerebrospinal fluid pressure. These cysts initially affect sensory neurons and axons in dorsal root ganglia and produce sen...
Article
PRéCIS:: Intraocular pressure measurement differences with Goldmann applanation tonometry and Dynamic contour tonometry are affected by atmospheric pressure inside a hyperbaric chamber. Purpose: To compare intraocular pressure measurements obtained with Goldmann applanation tonometry (GAT) and Dynamic contour tonometry (DCT) in 22 normal individu...
Article
Full-text available
Purpose: Increasing evidence suggests that fibromyalgia most likely represents a neurological dysfunction. We previously hypothesized that at least some fibromyalgia cases may be caused by irritation of nerve root fibers and sensory neurons due to moderately increased cerebrospinal pressure. Because of the rostro-caudal hydrostatic pressure gradie...
Article
The crystalline lens plays an important role in the pathophysiology of primary angle closure (PAC) and primary angle-closure glaucoma (PACG). The aging process is associated with a progressive enlargement of the lens, resulting in greater iridolenticular and iridotrabecular contact, which exacerbates both pupillary block and appositional angle clos...
Article
Purpose Bimatoprost SR (BimSR), a biodegradable intracameral (IC) implant that slowly releases bimatoprost to lower intraocular pressure (IOP), is in Phase III development for glaucoma treatment. The effect of BimSR treatment on the VF (visual field) MD (mean difference) in glaucoma patients was evaluated in a Phase 1/2 clinical trial. Methods Pha...
Article
Since its inception, OCT angiography has moved from pretty images that were subjectively judged to a source of quantifiable vascular data. It has already proven itself as being able to detect glaucoma and it also shows promise as a useful tool for progression analysis. However, there is still controversy in published literature. This might be happe...
Article
Full-text available
Purpose Tarlov cysts (TCs) are dilations of nerve roots arising from pathologically increased hydrostatic pressure (HP) in the spinal canal. There is much controversy regarding whether these cysts are a rare source of pain or often produce symptoms. The aim of this review was to identify the reasons that symptomatic TCs (STCs) are easily overlooked...
Article
Full-text available
PRéCIS:: Noninferiority of efficacy was demonstrated for a preservative-free latanoprost-timolol fixed combination compared with a BAK-containing formulation at 84 days after treatment in patients with open-angle glaucoma or ocular hypertension. Purpose: The purpose of this study was to compare the effect on intraocular pressure and safety of pre...
Article
Tarlov cysts (TCs) consist of dilated nerve root sheaths filled with cerebrospinal fluid (CSF) and are most frequently found in the sacrum. It is estimated that 25% of detected TCs cause chronic pain and intestinal and urogenital symptoms due to compression of the sacral nerve root fibers inside the TC. Unfortunately, symptomatic TCs are frequently...
Article
Full-text available
Purpose: Idiopathic intracranial hypertension (IICH) is a condition characterized by raised intracranial pressure (ICP), and its diagnosis is established when the opening pressure measured during a lumbar puncture is elevated >20 cm H2O in nonobese patients or >25 cm H2O in obese patients. Papilledema is caused by forced filling of the optic nerve...
Article
Full-text available
The surgical management of glaucoma offers the potential to lower intraocular pressure (IOP) independent of patients’ compliance with their medication regimen. Procedures such as trabeculectomy and tube shunt placement often yield large magnitudes of IOP reduction, but may be associated with short- and long-term complications. Microinvasive glaucom...
Article
Full-text available
Fibromyalgia (FM) is a debilitating, widespread pain disorder that is assumed to originate from inappropriate pain processing in the central nervous system. Psychological and behavioral factors are both believed to underlie the pathogenesis and complicate the treatment. This hypothesis, however, has not yet been sufficiently supported by scientific...
Article
Purpose To correlate structural and vascular optical coherence tomography (OCT) parameters with cerebral amyloid burden in cognitive intact (Control) and mild cognitive impairment patients (MCI). Methods Controls and MCI patients were recruited from an ongoing longitudinal cohort of cognitively intact older adults and a memory clinic‐based cohort...
Article
Purpose The role vascular factors play in glaucoma is still not fully understood. We aim to understand if advanced vascular exams can improve our ability to distinguish primary open angle glaucoma (POAG) from normal tension glaucoma (NTG) patients. Methods We applied multivariate logistic regression on the Leuven Eye Study data (182 NTG and 202 PO...
Article
Purpose To compare the efficacy, safety, and risk factors for failure of standalone ab interno gelatin microstent implantation with mitomycin C (MMC) versus trabeculectomy with MMC. Design International, multicenter, retrospective interventional cohort study. Participants Three hundred fifty-four eyes of 293 patients (185 microstent and 169 trabe...
Article
Objective: The clinical entity “Symptomatic Tarlov Cysts” is a highly under reported condition. We aimed to perform an electrophysiologic evaluation in patients with Tarlov cysts to determine whether the cysts create electrical abnormalities that could translate into clinical symptoms. The findings are correlated with the data currently available i...
Article
Full-text available
Objective: The clinical entity “Symptomatic Tarlov Cysts” is a highly under reported condition. We aimed to perform an electrophysiologic evaluation in patients with Tarlov cysts to determine whether the cysts create electrical abnormalities that could translate into clinical symptoms. The findings are correlated with the data currently available i...
Article
Purpose To evaluate the efficacy and safety of the Ultrasound Ciliary Plasty (UCP) procedure with a second generation probe. Methods Fifty-two eyes of 52 patients with primary open-angle glaucoma were treated between April 2015 and August 2015 in 4 University Hospitals with a second generation therapy probe comprising 6 piezoelectric transducers w...
Article
Trabeculectomy is till the gold standard in glaucoma surgery because it is an effective technique to lower intra-ocular pressure. However, this surgical technique is associated with a risk of vision-threatening complications. Therefore, great efforts have been made in the past decade to develop a safer alternative. A plethora of surgical implants h...
Article
Purpose Mean retinal venous oxygen saturation (VSatO2) has been found to be different from normal in several retinal diseases. There are speculations that metabolic imaging of the retina could be helpful in monitoring such diseases and perhaps help with diagnosis. The aim of the study was to characterize normal range of retinal VSatO2 and to furthe...
Article
Purpose To contrast systemic and ocular vascular parameters in patients with normal-tension glaucoma (NTG) versus primary open-angle glaucoma (POAG). Methods Sub-analysis of a prospective, cross-sectional, case–control hospital-based study investigating ocular blood flow in glaucoma patients (Leuven Eye Study). Systemic and ocular vascular paramet...
Article
The ocular pulse amplitude (OPA) measured by dynamic contour tonometry is one of the vascular parameters often used in glaucoma research. Probably measuring the pressure wave caused by the shifting volume of blood inside the eye in accordance to the cardiac cycle, this measurement gives information about extra- as well as intraocular hemodynamics....
Article
Purpose Preserved latanoprost eyedrops efficacy have been demonstrated in intraocular pressure lowering. New marketed first formulation of a preservative-free (PF) latanoprost (Monoprost®) was a further step to improve tolerance. Relatively little is known about newly diagnosed patient's tolerance to their first prostaglandin treatment. That's why...
Article
Purpose During posterior vitreous detachment (PVD) the posterior hyaloid remains, for a certain period, attached to the posterior pole. At the macula, the vitreomacular interface and its associated disease has been studied extensively. The opposite is true for the vitreopapillary interface, especially in glaucoma patients. As glaucoma affects the s...
Article
Purpose To evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) cyclocoagulation in reducing intraocular pressure (IOP) in patients with glaucoma by using a novel miniaturized delivery device (EyeOP1) after 6 months of follow up. Methods This was an interventional study of 61 eyes of 61 patients with glaucoma. The first ser...
Article
Purpose To investigate the correlation between mixed venous (SvO2) and retinal vessel (SrO2) oxygen saturation, using non-invasive spectroscopy in pre- and post- heart transplant patients. Methods Retinal oxygen saturation and vessel caliber were measured in dark-adapted patients, breathing ambient air in a seated position, using dual wavelength r...
Chapter
Purpose: To provide an overview of the antifibrotic strategies that are currently in use or under evaluation for the enhancement of filtering surgery. Methods: A literature research was done and the available evidence was summarized. Results: A summary of the available antiscarring agents is provided, going from the well-established antimitotic age...
Article
Purpose: To compare funduscopic and confocal scanning vertical cup-disc ratio (VCDR) assessments and their respective predictive value for estimating functional glaucomatous damage. Methods: Data from a single eye of open angle glaucoma patients from the Leuven Eye Study were included: age, gender, intra-ocular pressure, visual acuity, refractiv...
Article
Objective: This study compared the efficacy, safety, and pharmacokinetics of a preservative-free latanoprost formulation to an established, benzalkonium chloride (BAK)-containing formulation for the treatment of open-angle glaucoma or ocular hypertension. Methods: Phase II, randomized, cross-over, investigator-masked, multi-center, pilot study (...
Article
Full-text available
Purpose The aim of this study was to investigate the efficacy and safety of Bimatoprost Unit Dose Preservative Free (BUDPF) and Latanoprost Unit Dose Preservative Free (LUDPF). Methods A prospective, randomized, investigator-masked, cross-over comparison was used. Inclusion criteria were ocular hypertension (OHT) or open-angle glaucoma (OAG) with...
Article
IntroductionWith the increasing use of intravitreal administration of corticosteroids in macular edema, steroid-induced intraocular pressure (IOP) rise is becoming an emergent issue. However, for patients in whom intravitreal steroids are indicated, there are no specific recommendations for IOP monitoring and management after intravitreal administr...
Article
The European Glaucoma Society stands for Innovation, Education and Communication. The EGS website www.eugs.org content reflects these goals. The fourth edition of the EGS Guidelines is now downloadable free of charge. The Tip of the Month and Journal club contain clinical tips and tricks and relevant highlights from the literature which are monthly...
Article
Glaucoma patients are known to have an underlying vascular dysfunction and General anesthesia (GA) significantly decreases blood pressure, which might decrease ocular perfusion. This study was conducted to investigate the effects of GA on ophthalmic flow velocities and blood pressure.
Article
To evaluate the degree of surgically induced corneal astigmatism (SIA) following trabeculectomy and to investigate the relation of SIA with long-term reduction of intraocular pressure (IOP).
Article
The authors have no conflict of interest Abstract Purpose: Elevated intra-ocular pressure (IOP) has been identified as a major risk factor for glaucoma, and therefore treatment is mainly focused on lowering IOP. Additionally, extensive literature depicts a vascular dysfunction to exist in these patients. However, integrating this knowledge in the c...
Article
Purpose: The aim of this study was to investigate the efficacy and safety of Bimatoprost Unit Dose Preservative Free (BUDPF) and Latanoprost Unit Dose Preservative Free (LUDPF). Methods: A prospective, randomized, investigator-masked, cross-over comparison was used. Inclusion criteria were ocular hypertension (OHT) or open-angle glaucoma (OAG) w...
Article
To evaluate the difference in assessment between fundoscopic and confocal scanning vertical cup-disc-ratio (VCDR) in open angle glaucoma patients.
Article
To investigate the correlation between cerebral tissue oxygenation (SctO2) and retinal vessel oxygen saturation (SO2) using non-invasive spectroscopy in healthy individuals.
Article
The high prevalence of ocular surface diseases (OSD) in patients treated for OHT/glaucoma is expected to displease them. To evaluate this, a survey was conducted in three European countries: the Netherlands, Belgium and United Kingdom.
Conference Paper
Aqueous humor outflow resistance depends on a complex equilibrium of extracellular matrix biosynthesis versus proteolysis in the trabecular meshwork. Several members of the MMP family, including MMP-9, are essential to the regulation of aqueous humor outflow resistance, i.e. to intraocular pressure (IOP) homeostasis. Here, we characterized the base...
Article
We previously showed that inhibition of placental growth factor (PlGF) was more effective than anti-VEGF-R2 treatment in improving surgical ouctome of glaucoma filtration surgery (GFS). In this study, we investigated the complementary effects of mitomycin-C (MMC) and anti-PlGF therapy and compared it to the combined administration of MMC with aflib...
Article
During posterior vitreous detachment (PVD) the posterior hyaloid remains, for a certain period, attached to the optic disc. It can exert traction with development of optic nerve head hemorrhages (ONHH). ONHH are known to be associated with glaucomatous progression and retinal nerve fiber layer (RNFL) defects. Therefore this study aims at investigat...
Article
To establish the safety and efficacy of an ab-interno gelatin stent, as a stand-alone procedure, in combination with a preoperative mitomycin C injection in reducing IOP and anti-glaucoma medications in patients presenting with primary open angle glaucoma. Mean IOP, IOP change, reduction in medications, and safety were recorded in 70 subjects throu...
Article
PurposeTo determine the optimum administration route of bevacizumab after glaucoma filtering surgery (GFS) and to investigate whether a reduced dose of mitomycin-C (MMC) in combination with bevacizumab could improve surgical outcome with a reduced incidence of side-effects.Methods Plasma levels of bevacizumab were determined via ELISA after intraca...
Article
Purpose: First, to elucidate the effect of Rho kinase inhibitor, AMA0526, on Human Tenon Fibroblast (HTF) proliferation and transdifferentiation to myofibroblasts. Second, the effects of ROCK inhibition on the wound healing process and surgical outcome were investigated in a rabbit model of glaucoma filtration surgery. Methods: After exposure of...
Article
Purpose To investigate the correlation between the peripapillary choroidal thickness (CT) and the retinal vessel oxygen saturation (SO2) in young healthy individuals.Methods Young healthy volunteers were recruited in this observational, cross-sectional study. Peripapillary CT was obtained using enhanced depth imaging optical coherence tomography (E...
Article
Purpose Rho kinase (ROCK) is associated with VEGF-driven angiogenesis and is involved in inflammation and fibrosis. Therefore, the effect of a locally acting ROCK inhibitor, AMA0428, was studied in wet age-related macular degeneration (AMD).Methods The effect of AMA0428 on human brain microvascular endothelial cells (HBMEC), human brain vascular pe...
Article
Purpose The aim of this study was to investigate the effect of AMA0526, a selective and locally acting ROCK inhibitor on endothelial cells in vitro and in vivo by using a mouse corneal neovascularization (NV) model.Methods In vitro, the effect of AMA0526 (0.1; 1 and 10 µM) on endothelial cell proliferation and FBS-stimulated migration was investiga...
Article
Purpose Vitreomacular adhesion can lead to vitreomacular traction (VMT) and macular hole (MH) formation. Intravitreal ocriplasmin provides a non-surgical solution to release VMT with or without macular hole. A series of 37 patients treated with ocriplasmin is presented. Since ocriplasmin was used in a non-reimbursed setting, the injection was only...
Article
To explore the combined inhibition of VEGF and PlGF, by the use of VEGF-Trap, as a new therapeutic strategy to prevent filtration failure: 1) To investigate the most optimal administration route for VEGF-Trap 2) To compare the effects of VEGF-Trap to those of the gold standard in clinical practice, mitomycin-C (MMC) 3) To investigate the potential...
Article
Failure of glaucoma filtration surgery due to excessive post operative wound healing is still a major problem in the treatment of glaucoma. With this project we want to examine if Xiaflex® is able to reduce fibrosis after glaucoma filtration surgery and in this way may improve surgical outcome.
Article
Purpose The aim of this study was to evaluate the therapeutic potential of α5β1-integrin inhibitor (CLT-28643) to improve the outcome of filtering surgery in a mouse model. Different dose regimen and administration routes of the inhibitor were compared to mitomycin C (MMC), the gold standard in clinical practice.Methods The efficacy of CLT-28643 on...
Article
Purpose The aim of this study was to investigate the efficacy of a locally active ROCK-inhibitor AMA0526 (Amakem NV) on corneal wound healing induced by alkali burn in an in vivo mouse model. Methods Swiss mice were divided randomly into 3 groups after chemical cauterization of the cornea by alkali. Topical treatment was initiated after the injury...
Article
Purpose Glaucoma filtration surgery (GFS) frequently leads to surgical failure due to excessive postoperative wound healing. The current study was designed to investigate the effect on postoperative scarring of a single subconjunctival (SC), intracameral (IC) or intravitreal (IV) injection of bevacizumab. Methods The effect of bevacizumab (AvastinT...
Article
Purpose We first compared the effect of mitomycin-C (MMC) versus bevacizumab on the surgical outcome of glaucoma filtration surgery (GFS). Secondly, the complementary effects of MMC and anti-VEGF therapy were investigated. Methods The effect of bevacizumab and MMC on surgical outcome was investigated in a mouse model of GFS. The 1st group received...
Article
Purpose To investigate IOP lowering efficacy of rho kinase (ROCK) inhibitors, AMA0076 and Y-39983, after subchronic treatment. Methods Dutch Belted rabbits (5 rabbits/concentration) were treated daily with a single topical dose of AMA0076 (0.05, 0.1 and 0.4%) or Y-39983 (0.025, 0.05 and 0.1%) in a masked fashion for 14 days. Saline was used as cont...
Presentation
Purpose Purpose: to determine the correlation between ocular blood flow changes throughout the cardiac cycle on ocular pulse amplitude (OPA) in glaucoma patients and healthy subjects.
Article
Purpose To investigate the efficacy and safety of a single intracameral administration of bevacizumab to improve the outcome of trabeculectomy. Methods Between April 2009 and November 2010, 144 consecutive, medically uncontrolled glaucoma patients who were scheduled for primary trabeculectomy were included in this prospective, randomized, double‐bl...
Article
Full-text available
Purpose: To review and summarize the available literature on the effect of preservatives on the eye, to provide practical guidance for the clinical assessment of the ocular surface in glaucoma patients, and to define patient populations that might benefit from preservative-free topical intraocular pressure (IOP)-lowering agents. Methods: This manu...
Article
Full-text available
Purpose: To evaluate the long-term IOP-lowering effect of an initially successful switch from prostaglandine-analog (PGA) monotherapy to bimatoprosttimolol fixed combination (BTFC) METHODS: Prospective, monocentric, open-labeled clinical trial. 30 patients with insufficient intraocular pressure (lOP) control under PGA monotherapy were screened. Fo...
Article
Purpose To determine the intra ocular pressure (IOP) lowering efficacy of the local ROCK inhibitor, AMA0076, in Dutch Belted rabbits. Methods Dutch Belted rabbits (5 rabbits/group) received topically a single dose of AMA0076 in one eye. A concentration range of 0.031 - 0.625% AMA0076 was tested. The contralateral eye served as control and was treat...
Article
Collaborative studies between the Ophthalmology departments in Leuven and Reykjavik have shown that in glaucoma patients, venous oxygen saturation increases with increasing severity of disease (i.e. with worsening visual field). Patients with considerable visual field loss show higher venous oxygen saturation than healthy individuals, while glaucom...
Article
Clinical examples on the use of visual field and structural measurements in the management of glaucoma patients will be presented, and discussed with the audience.
Article
The Belgian Association for Glaucoma Patients was founded in 2010. Its goals are to inform about glaucoma, to improve early detection and follow-up of glaucoma, to promote interaction between the members and others, to promote the interests of the Belgian glaucoma patients and to enforce their position in the Belgian society. During this lecture, t...
Article
Purpose To elucidate the effect of Benzalkonium chloride (BAK) on the intraocular pressure (IOP) lowering efficacy of a local ROCK-inhibitor AMA0076 (Amakem NV) in the rabbit eye. Methods Topical administration of AMA0076 (0.1%, 0.3% and 0.5%) was tested in a normotensive New Zealand White rabbit model (5 rabbits/group). The IOP lowering efficacy o...
Article
Purpose The aim of this study was to investigate the efficacy of a local ROCK-inhibitor; AMA0076 (Amakem NV) for improving surgical outcome, after glaucoma filtration surgery in a rabbit model. Methods The in vivo effects of local ROCK-inhibition were investigated in a rabbit model of glaucoma filtration surgery (n=5 per histological analysis group...
Article
During this short introduction, the meaning and importance of measuring the rate of progression in glaucoma care will be explained and illustrated with a patient example.
Article
Purpose We checked the hypothesis that placental growth factor (PlGF) plays a role in scar formation after glaucoma filtration surgery (GFS), and that it may be a target for improvement of the outcome of this surgery. Methods The effect of the anti‐murine PlGF‐antibody (5D11D4) was investigated in a mouse model of GFS in C75Bl/6 mice. Immediately a...
Article
Purpose To determine whether retinal vessel oxygen saturation in glaucoma patients is associated with structural optic disc and retinal nerve fiber layer (RNFL) changes and visual field defects. Methods Retinal oxygen saturation was measured in glaucoma patients with a non‐invasive retinal oximeter (Oxymap ehf, Reykjavik, Iceland). Visuals fields a...
Article
Full-text available
Purpose: The present study is the first randomized clinical trial designed to evaluate the intraocular pressure (IOP)-lowering effect of anecortave acetate (AA) administered at 3 doses (3, 15, or 30 mg) as an anterior juxtascleral depot (AJD) in patients experiencing elevated IOP due to corticosteroid therapy. Methods: This was a double-masked,...
Presentation
Data that was published latter that year using the same title on Journal ”Acta Ophthalmologica”