Inez Myin-Germeys

Inez Myin-Germeys
KU Leuven | ku leuven · Department of Neurosciences

About

571
Publications
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Introduction
Inez Myin-Germeys is psychologist, professor of Contextual Psychiatry and head of the Center for Contextual Psychiatry, Department of Neurosciences, KU Leuven. Inez does research on person-environment interactions in the development of psychopathology in general and psychosis specifically. She is an international expert in the field of Experience Sampling Methodology. Main research lines are: 1) statistical and methodological development of Experience Sampling Methodology and integration of passive and active remote monitoring 2) SIGMA, a longitudinal cohort study in adolescence 3) stress, reward, and alterations in social interaction as mechanisms underlying psychosis 4) ecological momentary interventions 5) first-person accounts of psychosis

Publications

Publications (571)
Article
Full-text available
Childhood adversity is associated with psychopathology. First evidence in adults suggests that threat anticipation, i.e., an enhanced anticipation of unpleasant events creating an enduring sense of threat, may be a putative mechanism linking childhood adversity to psychopathology. This study aimed to test the indirect effect of childhood adversity...
Preprint
Full-text available
BACKGROUND Stress-related mental disorders are highly prevalent and pose a significant burden on individuals and society. Improving strategies of their treatment and prevention requires knowledge about risk and resilience. This multi-center study aims to contribute to this endeavor by investigating psychological resilience in healthy, but vulnerabl...
Preprint
Recently, cross-sectional relationships between psycho-social resilience factors (RFs) and resilience, operationalized as an outcome of low reactivity of mental health to stressor exposure (low ‘stressor reactivity’) during the first wave of the COVID-19 pandemic, were reported. Extending these findings, we here examine prospective relationships an...
Article
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Restrictive COVID-19 measures can have significant mental health impacts, particularly on young people. How such measures may influence day-to-day momentary affect, nonetheless, remains to be explored. Experience sampling data were collected from 165 young people (aged 15-24) as part of a larger epidemiological youth mental health study in Hong Kon...
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Childhood adversity is a major risk factor for psychiatric disorders and has especially been associated with an admixture of depressive, anxiety and psychosis symptoms. Identity formation, a main developmental task during adolescence, may be impacted by these adverse experiences. We investigated the association between childhood adversity, identity...
Preprint
Background Changes in lifestyle, finances and work status during COVID-19 lockdowns may have led to biopsychosocial changes in people with pre-existing vulnerabilities such as Major Depressive Disorders (MDD) and Multiple Sclerosis (MS). Methods Data were collected as a part of the RADAR-CNS (Remote Assessment of Disease and Relapse – Central Nerv...
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Contextual factors influence how people regulate their everyday emotions. While daily life is rich with situations that evoke emotion regulation, few studies have broadly investigated the role of context in regulating emotions in response to naturally occurring negative events. In this study, we use a structured diary technique - the Experience Sam...
Preprint
Background Remote Measurement Technologies (RMTs) have the potential to revolutionise major depressive disorder (MDD) disease management by offering the ability to assess, monitor and predict symptom changes. However, the promise of RMT data depends heavily on sustained user engagement over extended periods of time. Here we report a longitudinal qu...
Article
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Social withdrawal is often presented as overall negative, with a focus on loneliness and peer exclusion. However, social withdrawal is also a part of normative adolescent development, which indicates that groups of adolescents potentially experience social withdrawal differently from one another. This study investigated whether different groups of...
Article
Background Remote sensing for the measurement and management of long-term conditions such as Major Depressive Disorder (MDD) is becoming more prevalent. User-engagement is essential to yield any benefits. We tested three hypotheses examining associations between clinical characteristics, perceptions of remote sensing, and objective user engagement...
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Background: Adolescence is a period of both great social change, and of vulnerability to psychiatric distress. However, little is known about the associations between early psychopathology and social interactions at the fundamental level of daily life. To better understand the social correlates of subclinical psychopathology in adolescence, we ass...
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Recent growth in remote studies has shown the effectiveness of digital health technologies in recruiting and monitoring the health and behavior of large and diverse populations of interest in real-world settings. However, retaining and engaging participants to monitor their long-term health trajectories has remained a significant challenge. Uneven...
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Reduced positive future thinking has been associated with suicidal ideation and behaviour in adults, and appears to be exacerbated by negative affect. Yet, this has received little attention in youth. Prior research has also focussed on longer-term future thinking, e.g. months and years, and relied on lab-based assessments. Using the experience sam...
Article
The Perceptual Crossing Experiment (PCE) captures the capacity for social contingency detection using real-time social interaction dynamics but has not been externally validated. We tested ecological and convergent validity of the PCE in a sample of 208 adolescents from the general population, aged 11 to 19 years. We expected associations between P...
Article
Parents are known to provide a lasting basis for their children's social development. Understanding parent-driven socialization is particularly relevant in adolescence, as an increasing social independence is developed. However, the relationship between key parenting styles of care and control and the microlevel expression of daily-life social inte...
Article
Introduction Emotional dysfunction and dysregulation are defining features of affective disorders. People differ in their beliefs about how controllable and useful negative and positive emotions are, and the process model of emotion regulation postulates that such beliefs play a central role in determining how people progress from emotion generatio...
Preprint
Background Remote sensing for the measurement and management of long-term conditions such as Major Depressive Disorder (MDD) is becoming more prevalent. User-engagement is essential to yield any benefits. We tested three hypotheses examining associations between clinical characteristics, perceptions of remote sensing, and objective user engagement...
Article
b> Introduction/Objective: This study aimed to investigate efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL), combining face-to-face therapy with an Ecological Momentary Intervention (EMI), in addition to treatment as usual (TAU) for psychotic distress, in comparison to TAU. Methods : Individuals aged 15–65 years with clinically...
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Objective: The aim of this study is to investigate the time to affective recovery from daily-life stressors between healthy controls (HC) and two groups with an increased risk for developing depression: individuals with subclinical symptoms of depression (SSD), and individuals remitted from a depressive episode with residual symptoms of depression...
Article
Purpose Early detection and intervention of mental health problems in youth are topical given that mental disorders often start early in life. Young people with emerging mental disorders however, often present with non-specific, fluctuating symptoms. Recent reports indicate a decline in social functioning (SF) as an early sign of specific emerging...
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BACKGROUND Identifying momentary risk and protective mechanisms may enhance our understanding and treatment of mental disorders. Affective stress reactivity is one mechanism that has been reported to be altered in individuals with early and later stages of mental disorder. Additionally, initial evidence suggests individuals with early and enduring...
Article
Full-text available
Background Major Depressive Disorder (MDD) is prevalent, often chronic, and requires ongoing monitoring of symptoms to track response to treatment and identify early indicators of relapse. Remote Measurement Technologies (RMT) provide an opportunity to transform the measurement and management of MDD, via data collected from inbuilt smartphone senso...
Preprint
Introduction: Robust sensitivity to reward may help preserve positive emotions in the face of adversity and has been proposed as a key resilience factor. We describe the development, feasibility, and efficacy of an mHealth application, Imager, which targets reward sensitivity by training individuals to create mental images of future rewarding exper...
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Accurately recognizing health-related conditions from wearable data is crucial for improved healthcare outcomes. To improve the recognition accuracy, various approaches have focused on how to effectively fuse information from multiple sensors. Fusing multiple sensors is a common scenario in many applications, but may not always be feasible in real-...
Article
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The experience sampling method (ESM) has revolutionized our ability to conduct psychological research in the natural environment. However, researchers have a large degree of freedom when preprocessing ESM data, which may hinder scientific progress. This study illustrates the use of multiverse analyses regarding preprocessing choices related to data...
Preprint
Full-text available
Stress-related mental disorders are highly prevalent and pose a significant burden on individuals and society. Improving strategies of their treatment and prevention requires knowledge about risk and resilience. This multi-center study aims to contribute to this endeavor by investigating psychological resilience in healthy, but vulnerable young adu...
Preprint
Full-text available
BACKGROUND Gait is an essential manifestation of depression. Laboratory gait characteristics have been found to be closely associated with depression. However, the gait characteristics of daily walking in real-world scenarios and their relationships with depression are yet to be fully explored. OBJECTIVE This study aimed to explore associations be...
Preprint
Background We investigated treatment effects of Acceptance and Commitment Therapy in Daily Life (ACT-DL) on psychological flexibility (PF) and the moderating role of the therapeutic working alliance on these effects in patients with early psychosis. Methods ACT-DL is an ecological momentary intervention (EMI) combining face-to-face ACT with a smar...
Article
Digital technology in mental health care: a narrative review and vision on the road to personalised care Mental health problems are prevalent and are associated with a huge societal cost. Therefore, there is an urgent need for improvements in mental health care focusing on a person-centered approach. Digital technology offers a unique opportunity t...
Article
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Background There is evidence for a polygenic contribution to psychosis. One targetable mechanism through which polygenic variation may impact on individuals and interact with the social environment is stress sensitization, characterized by elevated reactivity to minor stressors in daily life. The current study aimed to investigate whether stress re...
Preprint
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Multiple sclerosis (MS) is a progressive inflammatory and neurodegenerative disease of the central nervous system affecting over 2.5 million people globally. In-clinic six-minute walk test (6MWT) is a widely used objective measure to evaluate the progression of MS. Yet, it has limitations such as the need for a clinical visit and a proper walkway....
Article
Objective Low self-esteem has been suggested as a putative mechanism in the development and maintenance of psychosis. Uncertainty still exists about how unstable self-esteem relates to psychotic experiences. The present study examines the potential (temporal) associations between momentary self-esteem, fluctuations in self-esteem, and psychotic exp...
Article
Full-text available
Much disagreement exists surrounding the relationship between digital communication and adolescent well-being. Micro-level insight into the direct effect of online interaction on affective experiences in daily life is crucial to advancing this discussion. In this registered study, we used experience sampling in 1705 general-population adolescents (...
Article
The capacity for dynamically coordinating behaviour is assumed to have largely matured in infancy. In adolescence—another sensitive period for social development—the primary focus on individual social cognition as the main driver of interaction has prevented the study of actual social interaction as behavioural coordination within dyads. From a dyn...
Article
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Background Stress plays an important role in the development of mental illness, and an increasing number of studies is trying to detect moments of perceived stress in everyday life based on physiological data gathered using ambulatory devices. However, based on laboratory studies, there is only modest evidence for a relationship between self-report...
Article
Full-text available
Background Negative symptoms occur in individuals at ultrahigh risk (UHR) for psychosis. Although there is evidence that observer ratings of negative symptoms are associated with level of functioning, the predictive value of subjective experience in daily life for individuals at UHR has not been studied yet. Objective This study therefore aims to...
Preprint
BACKGROUND The mobility of an individual measured by phone-collected location data has been found to be associated with depression in several recent studies. However, the longitudinal relationships (the temporal direction of relationships) between depressive symptom severity and phone-measured mobility are yet to be fully explored. OBJECTIVE To ex...
Article
Background COVID-19 and measures to contain it may have impacted college students’ behavior, including their drinking behavior. Students’ drinking may have decreased—for example, due to the closure of bars—but problematic drinking may have increased—for example, due to (solitary) drinking at home. Another behavior that has increased due to COVID-19...
Article
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Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes a clinical illness Covid-19, has had a major impact on mental health globally. Those diagnosed with major depressive disorder (MDD) may be negatively impacted by the global pandemic due to social isolation, feelings of loneliness or lack of acces...
Article
COVID-19 lockdown measures have profoundly impacted adolescent' daily life, with research suggesting an increase in irritability, stress, loneliness, and family conflict. A potential protective factor is parent-child relationship quality; however, no studies have investigated this. We used data from SIGMA, a longitudinal, experience sampling cohort...
Article
Full-text available
Background In a recent cross-sectional study, we highlighted psychosocial resilience factors associated with good mental health during the first COVID-19-lockdown. However, dynamic concepts of resilience suggest that people’s response to adversity can change over time. To better understand the emergence of resilience, we here examined individual dy...
Preprint
Full-text available
Since the introduction of the experience sampling method (ESM), there have been concerns that the repeated assessments typically related to this method may alter the behavior, thoughts, or feelings of participants. Previous studies have offered mixed results with some studies reporting reactive changes while others failed to find such effects. Our...
Article
Full-text available
Adolescence is a vulnerable period for psychopathology development, and certain parenting styles are consistent and robust predictors of a broad range of mental health outcomes. The mechanisms through which maladaptive parenting styles affect the development of psychopathology are assumed to be largely social in nature. Yet, the social mechanisms l...
Article
Background Delusions in schizophrenia are commonly approached as empirical false beliefs about everyday reality. Phenomenological accounts, by contrast, have suggested that delusions are more adequately understood as pertaining to a different kind of reality experience. How this alteration of reality experience should be characterised, which dimens...
Article
Full-text available
Background: Research in mental health has found associations between depression and individuals’ behaviors and statuses, such as social connections and interactions, working status, mobility, and social isolation and loneliness. These behaviors and statuses can be approximated by the nearby Bluetooth device count (NBDC) detected by Bluetooth sensor...
Preprint
While subjective measures have demonstrated an association between sleep duration, sleep quality, and symptoms of psychopathology in adolescents, findings from more reliable, objective measures remain limited. In this study, we investigate if objectively measured sleep duration and sleep quality are associated with symptoms of psychopathology in ad...
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Multimodal wearable physiological data in daily life settings have been used to estimate self-reported stress labels.However, missing data modalities in data collection make it challenging to leverage all the collected samples. Besides, heterogeneous sensor data and labels among individuals add challenges in building robust stress detection models....
Article
Full-text available
Schizophrenia and related disorders have heterogeneous outcomes. Individualized prediction of long-term outcomes may be helpful in improving treatment decisions. Utilizing extensive baseline data of 523 patients with a psychotic disorder and variable illness duration, we predicted symptomatic and global outcomes at 3-year and 6-year follow-ups. We...
Article
Background Less physical activity (PA) has been associated with the development of psychopathology in adolescence. Few studies, however, have focused on understanding the nature of the PA – psychopathology relationship and existing research relies mostly on self-report PA measures, which are less reliable. In this study, we investigated the nature...
Preprint
Early findings on the impact of the COVID-19 pandemic on adolescents, suggest that – despite being at the lowest physical health risk – both their mental health and day-to-day social lives are strongly affected. In this longitudinal study, we assessed changes in adolescent psychopathology symptoms, the quality and quantity of daily-life social inte...
Article
Full-text available
Intensive repeated momentary diary techniques, such as the experience sampling method (ESM), place considerable burden on study participants by repeatedly prompting them to fill in a questionnaire several times throughout the day. The objective of this study was to investigate the level of disturbance reported by participants and predictors thereof...
Article
22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder caused by a microdeletion on the long arm of chromosome 22. Sleep problems have been reported in this population, and psychiatric disorders and affect dysregulation are common to the behavioral phenotype of 22q11DS. Sleep and affect have been consistently linked across multiple st...
Preprint
Full-text available
Background Major Depressive Disorder (MDD) is prevalent, often chronic, and requires ongoing monitoring of symptoms to track response to treatment and identify early indicators of relapse. Remote Measurement Technologies (RMT) provide an exciting opportunity to transform the measurement and management of MDD, via data collected from inbuilt smartph...
Article
Background A psychosocial task that can induce comparable levels of stress repeatedly is fundamental to effectively study changes in stress reactivity over time or as a result of an intervention. However, existing tasks have struggled to provide consistent stress responses across repeated trials. Aim The goal was to assess the efficacy of two diff...
Preprint
BACKGROUND Acceptance and Commitment Therapy (ACT) is promising in the treatment of early psychosis. Augmenting face-to-face ACT with a mobile health (mHealth) ecological momentary intervention (EMI) may increase its treatment effects and empower clients to take treatment into their own hands. OBJECTIVE This study aimed to investigate treatment ad...
Article
Environmental and individual contextual factors profoundly influence how people regulate their emotions. The current article addresses the role of event intensity and psychopathology (an admixture of depression, anxiety, and psychoticism) on emotion regulation in response to naturally occurring events. For six days each evening, a youth sample (age...
Preprint
Full-text available
Importance Treatment in the early stages of psychosis is crucial to prevent poor clinical and social outcomes. Currently, no preventive interventions are available that reduce psychotic distress, or affective and negative symptoms as well as functioning, calling for more and dedicated treatments for these. Objective To investigate the efficacy of A...
Article
Full-text available
Aims Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes in individuals at ultra-high-risk (UHR) for psychosi...
Article
Full-text available
Background AVATAR therapy is a novel intervention targeting distressing auditory verbal hallucinations (henceforth ‘voices’). A digital simulation (avatar) of the voice is created and used in a three-way dialogue between participant, avatar and therapist. To date, therapy has been delivered over 6 sessions, comprising an initial phase, focusing on...
Preprint
Much disagreement exists surrounding the relationship between digital communication and adolescent well-being. Micro-level insight into the direct effect of online interaction on affective experiences in daily life is crucial to advancing this discussion. In this registered study, we used experience sampling in general-population adolescents (n = 1...
Preprint
BACKGROUND Negative symptoms occur in individuals at ultrahigh risk (UHR) for psychosis. Although there is evidence that observer ratings of negative symptoms are associated with level of functioning, the predictive value of subjective experience in daily life for individuals at UHR has not been studied yet. OBJECTIVE This study therefore aims to...
Preprint
Full-text available
Background: The Bluetooth sensor embedded in mobile phones provides an unobtrusive, continuous, and cost-efficient means to capture individuals’ proximity information, such as the nearby Bluetooth devices count (NBDC). The continuous NBDC data can partially reflect individuals’ behaviors and status, such as social connections and interactions, work...
Preprint
Adolescence is a vulnerable period for psychopathology development, and certain parenting styles are consistent and robust predictors of a broad range of mental health outcomes. The mechanisms through which maladaptive parenting styles affect the development of psychopathology are assumed to be largely social in nature. Yet, the social mechanisms l...
Article
Full-text available
Background: Sleep problems tend to vary accordingly to the course of the disorder in individuals with mental health problems. Research in mental health has implicated sleep pathologies with depression. However, the gold standard for sleep assessment, polysomnography (PSG), is not suitable for long-term, continuous, monitoring of daily sleep, and me...
Preprint
Full-text available
Background: Over half of all mental health conditions have their onset in adolescence. Large-scale epidemiological studies have identified relevant environmental risk factors for mental health problems. Yet, few have focused on potential mediating inter- and intrapersonal processes in daily life, hampering intervention development. Objectives: To i...
Preprint
Full-text available
Background Delusions in schizophrenia are commonly approached as empirical false beliefs about everyday reality. Phenomenological accounts, by contrast, have suggested that delusions are more adequately understood as pertaining to a different kind of reality-experience. To date, however, the specific nature ofdelusional reality-experience has not b...