Inés Sánchez-Sellero

• PhD
• Professor (Full) at University of Santiago de Compostela

Background/Objectives: The association between vestibular symptoms and psychological distress has been previously studied, mainly with the use of questionnaires. The purpose of this study is to compare the consumption of psychotropic drugs between a group of patients with vertigo and a control group. Methods: A prospective cross-sectional, observat...

Background/Objectives: It is known that balance disorders involve occupational hazards. However, the inverse relationship (between certain occupations and an increased incidence of vertigo or dizziness) has been scarcely studied. The objective of this work was to analyze the occupation of a group of patients with vertigo compared to the economicall...

Background/Objectives: It is known that balance disorders involve occupational hazards. However, the inverse relationship (between certain occupations and an increased incidence of vertigo or dizziness) has been scarcely studied. The objective of this work was to analyze the occupation of a group of patients with vertigo, compared to economically a...

The use of z-drugs has increased worldwide since its introduction. Although the prescribing patterns of hypnotics differ among countries, zolpidem is the most widely used z-drug in the world. Zolpidem may be involved in poisoning and deaths. A simple and fast HPLC-PDA method was developed and validated. Zolpidem and the internal standard chloramphe...

Purpose Therapeutic drug monitoring of plasma lamotrigine (LTG) has customarily been carried out in order to prevent some its adverse effects. For forensic purposes, determination of LTG in plasma is an useful tool in cases of accidental overdose or suicidal attempts. Currently, there are several analytical methods available including some based on...

Some South American countries have ancient traditions that may pose legal problems, such as the consumption of coca leaves, as this can provide positive results for cocaine use after the analysis of biological samples. For this reason, it is necessary to find specific markers that help differentiate legal from illegal consumption, such as tropacoca...

Hygrine and Cuscohydrine, two coca leaf alkaloids, have been previously proposed as markers to differentiate legal and illegal cocaine consumption. This is a very common problem in some countries of...

Objectives: Dietary changes are useful in the management of Menière’s disease; regarding alcohol, many clinicians recommend to avoid or reduce its consumption. However, there are no researches aimed to evaluate whether habitual alcohol consumption is more prevalent and/or more intense in patients with Menière’s disease. Methods: Cross-sectional, ob...

Objectives: Although it is commonly recognized that dietary restrictions may improve the clinical course of Menière's disease, their effectiveness has not been definitely demonstrated. The aim of this study was to examine whether caffeine consumption could be involved in Menière's disease. Methods: Cross-sectional, observational, case-control study...

OBJECTIVE: The therapeutic use of ototoxic drugs is relatively common, particularly in patients with severe diseases. It is likely that disturbances of balance in these patients are underestimated by clinicians. MATERIALS and METHODS: The purpose of this study was to identify drugs involved in the vestibulotoxic origin of instability in a group of...

The purpose of the study was to evaluate self-perceived handicap in patients with definite Menière's disease (MD). A cross-sectional study was conducted. To examine the self-perception of disability, participants completed a DHI (Dizziness Handicap Inventory). Parameters compared with DHI scores: sex, age, unilateral/bilateral affectation, time ela...

A prospective study of patients diagnosed with 'single-canal' benign paroxysmal positional vertigo (BPPV) was performed. Demographic, etiological and prognostic differences between patients with posterior, horizontal and superior canal BPPV were studied. A total of 614 patients diagnosed in a period of 11 years and with a follow-up period of at lea...

Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vestibular vertigo. BPPV can be diagnosed by clinical examination and its treatment is based on particle repositioning manoeuvres, and specialized equipment is not required. Therefore, most patients could be diagnosed and treated by their general practitioner. Unfortunately,...

Introduction: Dimethyl sulfoxide is an amphiphilic compound whose miscibility with water and its ability to dissolve lipophilic compounds make it an appreciated solvent in biomedical research. However, its reported antioxidant properties raise doubts about its use as a solvent in evaluating new antioxidants. The goal of this investigation was to e...

J. Neurochem . (2009) 109 , 879–888. Abstract The ability of aluminium to affect the oxidant status of specific areas of the brain (cerebellum, ventral midbrain, cortex, hippocampus, striatum) was investigated in rats intraperitoneally treated with aluminium chloride (10 mg Al ³⁺ /kg/day) for 10 days. The potential of aluminium to act as an etiolo...

Tetrahydropapaveroline (THP) is a compound derived from dopamine monoamine oxidase-mediated metabolism, particularly present in the brain of parkinsonian patients receiving L-dopa therapy, and is capable of causing dopaminergic neurodegeneration. The aim of this work was to evaluate the potential of THP to cause oxidative stress on mitochondrial pr...

Monoamine oxidase (MAO) is an enzyme involved in brain catabolism of monoamine neurotransmitters whose oxidative deamination results in the production of hydrogen peroxide. It has been documented that hydrogen peroxide derived from MAO activity represents a special source of oxidative stress in the brain. In this study we investigated the potential...

1,2,3,4-Tetrahydroisoquinoline (TIQ) and 1,2,3,4-tetrahydro-beta-carboline (THbetaC) are two endogenous or exogenous dopaminergic proneurotoxicants supposedly involved in the etiology of Parkinson's disease. We investigated whether the chronic administration of a twice daily dose of a cigarette smoke solution might modify the endogenous concentrati...

Phosphotriesterase (PTE) activities in mammalian serum are typically found in the lipoprotein fraction. This PTE requires Ca++ for activity and is consequently inactivated by ethylenediaminetetraacetic acid (EDTA). There is also a little known PTE in mammal serum that is resistant to EDTA inactivation. In this work, the PTE activities for the subst...

A new method for detecting and quantifying 11-nor-9-carboxy-Δ-tetrahydrocannabinol (Δ-THC-COOH) in urine is proposed. The analyte is released as a glucuronide derivative into urine, so the glucuronide bond must be cleaved by alkaline hydrolysis prior to analysis. Subsequently, the sample is subjected to liquid-liquid extraction with n-hexane/ethyl...

The in vitro effects of cigarette smoke on catalase activity were investigated in biological preparations from rat liver and brain using a polarographic method. In both cases cigarette smoke solutions showed a potent ability to inhibit catalase activity with a slight time dependency. The reversibility of their inhibitory activity was demonstrated b...

1,2,3,4-Tetrahydro-beta-carboline (TH beta C) is an endogenous or environmental neurotoxic factor putatively involved in the development of Parkinson's disease (PD). As part of our efforts to characterize the mechanism of the reported protection of smoking against PD, we have examined the interaction between TH beta C and cigarette smoke. We found...

A new method for detecting and quantifying 11-nor-9-carboxy-Δ8- tetrahydrocannabinol (Δ8-THC-COOH) in urine is proposed. The analyte is released as a glucuronide derivative into urine, so the glucuronide bond must be cleaved by alkaline hydrolysis prior to analysis. Subsequently, the sample is subjected to liquid-liquid extraction with n-hexane/eth...

A series of adducts of 1,2,3,4-tetrahydroisoquinoline (TIQ) and some components of tobacco smoke were investigated for their ability to inhibit rat brain monoamine oxidase. 1-Cyano-TIQ (1CTIQ), N-(1'-cyanoethyl)-TIQ (CETIQ), N-(1'-cyanopropyl)-TIQ (CPTIQ), and N-(1'-cyanobutyl)-TIQ (CBTIQ) were found to act as competitive inhibitors for both MAO-A...

An HPLC method for the simultaneous determination of paraquat and diquat in aqueous solutions and biological fluids (plasma, urine and vitreous humour) was developed. This method is based on the initial ion-pair solvent extraction of both herbicides from plasma or urine. Vitreous humour samples required a protein precipitation and concentration pro...

Tetrahydroisoquinoline (TIQ), a presumed proneutrotoxin linked with Parkinson's disease (PD), was found to interact with some components of cigarette smoke to give N-(cyanomethyl)-TIQ (CMTIQ), N-(1'-cyanoethyl)-TIQ (CETIQ), N-(1'-cyanopropyl)-TIQ (CPTIQ), N-(1'-cyanobutyl)-TIQ (CBTIQ), and 1-cyano-TIQ (1CTIQ). The in vitro formation of these compou...

Two hundred and ninety three intoxications from the sanitary area of Santiago de Compostela throughout 1993 were reviewed. We only studied those adults with positive results for carbon monoxide, medicines and/or drugs of abuse. The most of the patients were treated in the Emergency Services (279 cases) and others in Intensive Care Units (10 cases)...

A sequential spectrophotometric method for the resolution of mixtures of cocaine, procaine and lidocaine in powder samples is proposed. The analytes are determined sequentially in the following order: 1st-Procaine, 2-Cocaine and 3-Lidocaine. The three determinations are carried out in phosphate buffer at pH 7.8. This solvent was selected as alterna...

A sequential spectrophotometric method for the simultaneous determination of paraquat and diquat in plasma using second-derivative spectroscopy after ion-pair liquid-liquid extraction was developed. The paraquat and diquat in the last extract are reduced with alkaline sodium dithionite to coloured complexes whose absorption peaks appear at a differ...

A third-derivative spectrophotometric method for measuring the carboxyhemoglobin (HbCO) percent content and the amount of hemoglobin not bound to the toxic gas and hence available for oxygen transport (functional Hb) is proposed. The method is quite straightforward, rapid and inexpensive and can be used to diagnose CO intoxications with a high prec...