Ines Leila Paraiso

Oregon State University | OSU · Department of Pharmaceutical Sciences

Xanthohumol (XN) improves cognition of wild-type rodents on a high-fat diet (HFD). Bile acids and ceramide levels in the liver and hippocampus might be linked to these effects. XN modulates activity of the nuclear farnesoid X receptor (FXR; also known as NR1H4), the primary receptor for bile acids. To determine the role of FXR in the liver and inte...

Consumption of a high fat diet (HFD) is linked to metabolic syndrome and cognitive impairments. This is exacerbated in age-related cognitive decline (ACD) and in individuals with a genetic risk for Alzheimer’s disease (AD). Apolipoprotein E (apoE) is involved in cholesterol metabolism. In humans, there are three major isoforms, E2, E3, and E4. Comp...

The farnesoid X receptor (FXR) plays a critical role in the regulation of lipid and bile acid (BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression from hepatic steatosis to nonalcoholic steatohepatitis (NASH). This study aimed to evaluate the effects of xanthohumol (XN), a hop-derived compound mitigating metaboli...

The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern. The rising number of cases of this highly transmissible infection have stressed the urgent need to find a potent drug. Although repurposing of known drugs currently provides an accelerated route to approval, there is no satisfactory treatment. Polyphenols...

Mol. Nutr. Food Res . 2020, 64 , 2000341 DOI: 10.1002/mnfr.202000341 Xanthohumol (XN), a flavonoid from hops (Humulus lupulus), and its hydrogenated derivatives, α,β‐dihydroxanthohumol (DXN) and tetrahydroxanthohumol (TXN) decrease hepatic cholesterol by enhancing de novo synthesis of bile acids and decrease ceramide content in liver and hippocampu...

Scope Sphingolipids including ceramides are implicated in the pathogenesis of obesity and insulin resistance. Correspondingly, inhibition of pro‐inflammatory and neurotoxic ceramide accumulation prevents obesity‐mediated insulin resistance and cognitive impairment. Increasing evidence suggests the farnesoid X receptor (FXR) is involved in ceramide...

Mol. Nutr. Food Res. 2019, 63, 1800923 DOI: 10.1002/mnfr.201800923 Gut microbial metabolism of xanthohumol produces estrogenic metabolites, notably 8‐prenylnaringenin. In article number 1800923, Jan F. Stevens and co‐workers show that 8‐prenylnaringenin is not the end product of metabolism by gut microbes, shedding new light on the perceived pro‐es...

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydr...