Inês Mahú

Inês Mahú
Max Planck Institute for Metabolism Research | NF · Group of Neuronal Control of Metabolism

Doctor of Philosophy

About

20
Publications
2,851
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360
Citations
Introduction
Skills and Expertise
Education
January 2014 - November 2020
Instituto Gulbenkian de Ciência (IGC)
Field of study
  • Integrative Biology and Biomedicine

Publications

Publications (20)
Preprint
Full-text available
Hypoglycemia is a clinical hallmark of severe malaria, the often-lethal presentation of Plasmodium falciparum infection of humans. Here we report that mice reduce blood glucose levels in response to Plasmodium infection via a coordinated response whereby labile heme, an alarmin produced via hemolysis, induces anorexia and represses hepatic glucose...
Article
Full-text available
Signals from sympathetic neurons and immune cells regulate adipocytes and thereby contribute to fat tissue biology. Interactions between the nervous and immune systems have recently emerged as important regulators of host defence and inflammation1,2,3,4. Nevertheless, it is unclear whether neuronal and immune cells co-operate in brain–body axes to...
Article
Full-text available
Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH or...
Article
Full-text available
The ‘Crosstalks of immunity and metabolism’ Symposium was focused on how the intercommunication between different organs and the immune system affects organismal health. At this meeting, experts in immunology and metabolic research provided novel insights into the growing field of immunometabolism. This report attempts to review and integrate views...
Article
Full-text available
Objective The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism. Here we tested the hypothesis that ferritin regulates organismal Fe metabolism in a manner that impacts energy balance and thermal homeostasis....
Article
Full-text available
The cellular mechanism(s) linking macrophages to norepinephrine (NE)-mediated regulation of thermogenesis have been a topic of debate. Here we identify sympathetic neuron–associated macrophages (SAMs) as a population of cells that mediate clearance of NE via expression of solute carrier family 6 member 2 (SLC6A2), an NE transporter, and monoamine o...
Article
Full-text available
Nature Communications 8 : Article number: 14967 10.1038/ncomms14967 ( 2017 ); Published 3 April 2017 ; Updated 17 May 2017 The financial support for this Article was not fully acknowledged.
Data
Shivering of sympathectomized mice after cold challenge (related to Figure 4).
Data
Supplementary Figures, Supplementary Table.
Data
Mice phenotype after 8 injections once a day of 0.02 pmol per gram of body weight of DT (related to Figure 3).
Data
Mice phenotype after 8 injections once a day of 0.02 pmol per gram of body weight of PEGyDT (related to Figure 3)
Data
Shivering of control mice after cold challenge (related to Figure 4).
Article
Full-text available
Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, diphtheria toxin (DT) crosses the blood–brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are also expressed in the central nervous system (CNS). Here we report the development of a brai...
Article
Full-text available
Taking into account all the aspects referred above, leptin resistance may also involve decreased sympathetic local activity, within the adipose organ. In this regard, and before the leptin era, George Bray and others proposed the “MONA LISA” hypothesis (Most Obesities kNown Are Low In Sympathetic Activity). This hypothesis was built up from studies...
Article
In recent decades, obesity has become a global public health crisis irrespective of age or gender [21]. But according to historic records, concerns over appropriate maintenance of body size have been long established. For more than to 2 millennia, the main therapeutic approach to curb excess weight has been to recommend dietary restrictions and reg...

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