Ines Zimbarra Cabrita

University of Lisbon | UL · Faculty of Medicine

Raised tricuspid regurgitant velocity (TRV) occurs in approximately 30% of adults with sickle cell disease (SCD), and has been shown to be an independent risk factor for death. TRV was assessed in 164 SCD patients who were subsequently followed up for survival. Raised pulmonary pressures were defined as a TRV jet ≥2·5 m/s on echocardiography. Eleva...

Cabergoline is a highly effective medical treatment for patients with hyperprolactinaemia. There is an increased risk of valvular heart disease in patients receiving cabergoline for Parkinson's disease. This study examined whether cabergoline treatment of hyperprolactinaemia is associated with a greater prevalence of valvulopathy. Cross-sectional,...

Myocardial performance index (MPI) measured by conventional Doppler is routinely used to assess right ventricular (RV) systolic function in patients with pulmonary hypertension (PH). Our aim was to determine whether MPI measured by Doppler tissue imaging (tMPI) is effective in assessing RV function in these patients. Retrospectively, we have studie...

Cardiovascular disease represents the leading cause of death worldwide. Different imaging methods are available to aide in both the diagnosis of coronary artery disease and monitoring of the disease processes, including ultrasound/echocardiography, nuclear imaging, hybrid imaging, molecular imaging, and invasive imaging. Over the last few years, de...

In this study, we looked at the prognostic value of echocardiographic and hemodynamic measures in a large cohort of patients with precapillary pulmonary hypertension before and after initiation of treatment. Data were collected prospectively in a cohort of consecutive patients with precapillary pulmonary hypertension referred between 2002 and 2011....

Aims The aim of this study was to assess the papillary muscle strain as a contributor to recurrent mitral regurgitation (MR) after mitral valve repair for fibroelastic deficiency. Methods and results Sixty-four patients with isolated posterior mitral valve prolapse and severe MR referred for surgery were prospectively recruited between 2008 and 20...

Introduction: The spectrum of hypertensive heart disease is wide, and can include left ventricular dysfunction. The development of echocardiographic parameters to improve patient stratification and to identify early adverse changes could be clinically useful. Aim To identify subclinical left ventricular dysfunction in hypertensive subjects with pr...

Introduction: The aim of the study was to examine right ventricular (RV) longitudinal strain in idiopathic pulmonary arterial hypertensive (IPAH) patients during 2 year follow up and associate strain with 3-dimensional echocardiographic (3DE) and cardiac magnetic resonance (CMR) volumetry. Strain was also associated with clinical deterioration. Cli...

Raised tricuspid regurgitant velocity (TRV) occurs in approximately 30% of adults with sickle cell disease (SCD), and has been shown to be an independent risk factor for death. TRV was assessed in 164 SCD patients who were subsequently followed up for survival. Raised pulmonary pressures were defined as a TRV jet ≥2.5 m/sec on echocardiography. Ele...

Background: The hypothesis of the study was whether any of the indices at the initial visit-prior to treatment initiation-could suficiently predict clinical deterioration. Clinical deterioration was deined as death or admission to the hospital with signs of heart failure.

The impact of cardiovascular imaging on cardiovascular prevention and risk assessment has substantially increased over the last few years, mainly due to the amount of relevant information that imaging modalities now provide. This review discusses different aspects of cardiovascular imaging with respect to prevention and risk assessment, including:...

The impact of cardiovascular imaging on cardiovascular prevention and risk assessment has substantially increased over the last few years, mainly due to the amount of relevant information that imaging modalities now provide. This review discusses different aspects of cardiovascular imaging with respect to prevention and risk assessment, including:...

Topic(s): Hypertension, other Citation: European Heart Journal (2012) 33 (Abstract Supplement), 5 Purpose: To characterize the segmental longitudinal deformation of the left ventricle (LV) in patients (pts) with arterial hypertension and preserved ejection fraction, using 2 dimensional strain imaging. Methods: Comparative study of a group of 229 pt...

Purpose: The aim of this study was to assess the way the right ventricle and tricuspid valve remodel in patients with post-capillary pulmonary hypertension who are undergoing mitral valve repair for degenerative mitral valve disease. The functional and morphological changes of the right ventricle (RV) as well as tricuspid apparatus in post-capillar...

Right ventricular (RV) remodelling may be an important determinant of clinical outcome in patients undergoing mitral valve surgery for mitral regurgitation. In the present study we hypothesised that, compared to valve replacement, mitral valve repair for degenerative mitral regurgitation may result in better RV remodelling, as assessed by real-time...

Aims: Transthoracic echocardiography is a useful technique for non-invasive detection of pulmonary arterial systolic pressure (PASP). Isovolumic relaxation time (IVRT) measured by Doppler tissue imaging (DTI) is a sensitive measurement of changes in pulmonary vasculature. Our aim was to validate IVRT in the echocardiographic assessment of pulmonar...

Right atrial (RA) dilatation may be important for patients' outcome in pulmonary arterial hypertension (PAH). The aim of this study was to examine the longitudinal RA and right ventricular (RV) remodelling in PAH patients using real-time three-dimensional echocardiography (3DE) and their relation to clinical outcome. Sixty-two consecutive PAH patie...

The authors investigated the safety of oral tetrahydrobiopterin (BH4), a cofactor for nitric oxide synthesis, as a novel treatment for pulmonary hypertension (PH). Eighteen patients with pulmonary arterial hypertension or inoperable chronic thromboembolic PH received sapropterin dihydrochloride (6R-BH4), the optically active form of BH4, in additio...

Background: Elevated filling pressures is the dominant feature in diastolic dysfunction with functional and prognostic implications. Transmitral E to annular Ea velocity ratio (E/Ea) reliably predicts left ventricular(LV) filling pressures. Strain and strain rate deformation parameters are able to quantify regional LV function. Aim: To investigate...