
Ine DecuyperInstitute of Tropical Medicine | ITM · Department of Clinical Sciences
Ine Decuyper
Pediatrician MD PhD
focusing on pediatric infectious diseases and allergy/immunology looking for answers through clinical work and research
About
44
Publications
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Introduction
Ine Decuyper has a research position at the Department of HIV and tuberculosis, Institute of Tropical Medicine, Antwerp. She combines this part-time activity with clinical work as a paediatrician at the ZNA Queen Paola Hospital in Antwerp where she focusses on general pediatrics, pediatric infectious diseases and allergy.
Additional affiliations
May 2023 - present
October 2019 - present
September 2019 - September 2020
Education
April 2019 - August 2019
August 2015 - March 2019
September 2008 - July 2015
Publications
Publications (44)
Cannabis allergy is a burgeoning field, consequently research is still in its infancy and allergists’ knowledge surrounding this topic is limited. As cannabis legalization expands across the world, it is anticipated there will be an increase in cannabis use. Thus, we hypothesize that a concomitant rise in the incidence of allergy to this plant can...
Introduction:
Cannabis is the most widely consumed illicit drug in the world and carries a risk of severe IgE-mediated allergic reactions, requiring appropriate diagnostic management. Currently available diagnostics are still relatively limited and require careful interpretation of results to avoid harmful over- and underdiagnosis.
Areas covered:...
Background
Uncertainties remain about the molecular mechanisms governing clonal mast cell disorders (CMCD) and anaphylaxis.
Objective
This study aims at comparing the burden, phenotype and behavior of mast cells (MCs) and basophils in patients with CMCD with wasp venom anaphylaxis (CMCD/WVA⁺), CMCD patients without anaphylaxis (CMCD/ANA⁻), patient...
Cannabis is the most widely used recreational drug in the world. Cannabis sativa and Cannabis indica have been selectively bred to develop their psychoactive properties. The increasing use in many countries has been accelerated by the COVID‐19 pandemic. Cannabis can provoke both type 1 and type 4 allergic reactions. Officially recognized allergens...
Drug allergy has been a research topic within the allergy field for decades. However, many drug reactions presumed to be of allergic nature, are not and originate from different mechanisms. Drug-induced reactions can affect numerous organ systems, present with a variety of symptoms, and have more than one mechanism of action. In this rostrum articl...
Background
Studies on the mechanisms that govern mast cell (MC) functions are hindered by the difficulties in isolating sufficient numbers of these tissue-resident cells. Therefore, many research groups use cultured human MCs obtained out of progenitor cells. However, these culture methods significantly differ regarding primary source material, cul...
Within the last decade there has been a significant expansion in access to cannabis for medicinal and adult nonmedical use in the United States and abroad. This has resulted in a rapidly growing and diverse workforce that is involved with the growth, cultivation, handling, and dispensing of the cannabis plant and its products. The objective of this...
Background
Recent studies show that nsLTP sensitization is not limited to the Mediterranean basin and can present diverse clinical phenotypes. It remains challenging to predict clinical outcome when specific IgE antibodies (sIgE) to nsLTPs are present. This study compares both clinical and in vitro allergy characteristics but also diagnostic perfor...
Background:
Expatriates (expats) from European countries regularly migrate to low-income countries where infectious diseases are more prevalent. Little evidence exists however on pediatric expatriates' compliance with preventive measures related to infectious diseases. This study aims to evaluate compliance in Belgian expat-children.
Methods:
Da...
Introduction: Although the use of cannabis dates back millennia, the first description of cannabis allergy is relatively recent (1971). Recent large-scale data show that cannabis allergy can manifest severe and generalized symptoms with extensive cross-reactions. Thus, it is essential to become familiarized with its clinical presentation, diagnosti...
Background:
Despite numerous efforts to describe the clinical manifestations and the epidemiology of perioperative hypersensitivity (POH), there remains room to increase awareness among anesthetists and immunologists/allergists.
Objective:
To report the findings of a 17-year survey of suspected POH in Antwerp, Belgium.
Methods:
We analyzed cli...
Objectives:
Cannabis allergy has mainly been described following recreational use but some cases also point to cannabis sensitisation as a result of occupational exposure. As a consequence, little is known on the prevalence and clinical phenotype of occupational cannabis allergy. Therefore, this study aims to explore the allergy-associated health...
Background:
Cannabis allergy (CA) has mainly been attributed to Can s 3, the nsLTP (non-specific lipid transfer proten) of Cannabis sativa. Nevertheless, standardized diagnostic tests are lacking and research on CA is scarce.
Objective:
To explore the performance of five cannabis diagnostic tests and the phenotypic profile of CA.
Methods:
120...
Secondary food allergies due to cross-reactivity between inhalant- and food allergens are a significant and increasing global health issue. Cross-reactive food allergies predominantly involve plant-derived foods resulting from a prior sensitization to cross-reactive components present in pollen (grass, tree, weeds) and natural rubber latex (NRL). B...
BACKGROUND
Sensitization to non-specific Lipid Transfer Proteins (ns-LTPs) is often associated with generalized allergic reactions (GR) to plant food(s), especially in the Mediterranean area. However, a recent study conducted in Western-European patients showed that the majority of the positive sIgE to ns-LTPs is clinically irrelevant, which hamper...
Background
For most physicians, quantification of drug-specific immunoglobulin E (drug-sIgE) antibodies constitutes the primary in vitro measure to document immediate drug hypersensitivity reactions (IDHR). Unfortunately, this is often insufficient to correctly identify patients with IgE-mediated IDHR and impossible for non-IgE-mediated IDHR that r...
IgE-mediated shellfish allergy constitutes an important cause of food-related adverse reactions. Shellfish are classified into molluscs and crustaceans, the latter belonging to the class of arthropoda. Among crustaceans, shrimps are the most predominant cause of allergic reactions and thus more extensively studied. Several major and minor allergens...
IgE-mediated Cannabis (C. sativa, marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may trigger a C. sativa sensitization and/or allergy. The clinical presentation of a C. sativa allergy varies from mild to life-threatening reactions and often seems to depend on the route of exposure. In addition, se...
Background:
For many physicians, quantification of serum drug-specific IgE (sIgE) antibodies constitutes the first measure in the diagnostic approach of immediate drug hypersensitivity reactions (IDHR).
Aim:
To review the accuracy and limitations of the main drug-sIgE tests, especially those that are commercially available.
Methods:
A literatu...
Background:
Mast cell progenitor cells, derived from CD34(+) hematopoietic stem cells, enter the circulation and subsequently mucosal or connective tissues where they mature to mast cells. Upon activation, mast cells increase the expression of activation markers, e.g. CD63, and release histamine amongst other mediators. Traditionally, release of t...
Opinion statement
IgE-mediated food allergy constitutes an important and increasing health issue with significant impairment of quality of life and significant morbidity and mortality. It affects children, as well as adolescents, and adults. Correct diagnosis of food allergy relies upon history supplemented by quantification of specific IgE (sIgE)...
Background:
Correct diagnosis of cefazolin hypersensitivity is not straightforward, mainly because of the absence of in vitro tests and uncertainties concerning the optimal cefazolin concentration for skin testing. Cross-reactivity studies suggest cefazolin hypersensitivity to be a selective hypersensitivity.
Objective:
The first objective was t...
The last two decades have witnessed that flow-assisted analysis of in vitro-activated basophils can constitute a valuable adjunct in the in vitro diagnostic approach of immediate drug hypersensitivity reactions (IDHR). This article summarises the current experience with the basophil activation test in the diagnosis of IDHR, with particular focus on...
Background:
Diagnosis of immediate drug hypersensitivity reactions (IDHRs) is based upon history taking, skin prick or intradermal tests and quantification of specific immunoglobulin E (IgE) antibodies. Unfortunately, this is often insufficient to correctly identify patients with IgE-mediated IDHRs and is impossible in the case of non-IgE-mediated...
Dans un grand nombre de cas, particulièrement chez les adolescents et les adultes, une allergie aux fruits et légumes repose sur une réactivité croisée. Les principales allergies croisées qui impliquent une allergie aux fruits et légumes sont le syndrome oral qui survient chez des patients sensibilisés à l’allergène majeur du bouleau, le « syndrome...
For about a decade, IgE-mediated cannabis (marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may lead to a cannabis sensitization and/or allergy. The clinical manifestations of a cannabis allergy can vary from mild to life-threatening reactions, often depending on the route of exposure. In addition,...