Indraneel Bhattacharyya

Indraneel Bhattacharyya
University of Florida | UF · College of Dentistry

Doctor of Dental Surgery

About

339
Publications
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3,491
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Publications

Publications (339)
Article
Blue nevus is a benign melanocytic tumor that commonly occurs on the skin. It appears as a solitary, well-demarcated, dark blue nodule or smooth-surfaced macule. Blue nevus has been reported in the lymph nodes, parotid, and prostate glands. In the oral cavity, blue nevus accounts for one-third of all oral mucosal melanocytic nevi, with the palate b...
Article
Introduction Gingival growths are mostly reactive and seldom exhibit significant true neoplastic potential. The typical etiology is local irritation from dental plaque/calculus, trauma as well as medication-related overgrowth. Such lesions are easily distinguished and categorized into diagnoses such as pyogenic granuloma, peripheral ossi- fying fib...
Article
Introduction Secretory carcinomas (SC) of minor and major salivary gland (SG) are rare neoplasms that demonstrate microscopic overlap with acinic cell carcinomas (ACC), adenocarcinoma NOS (AdNOS), and mucoepidermoid carcinomas (MEC) respectively. Recently alternative translocations of ETV6-RET gene locus have been recognized in a small group of SC....
Article
Introduction HPV-related benign papillary epithelial neoplasms are common lesions affecting any region of the oral cavity. This study evaluated the trends in frequency, location, and demographics of these lesions over 20 years. Materials and Methods Following IRB approval, the archives of UF Oral Pathology Biopsy Service between 19952015 were quer...
Article
Objective Neurofibromatosis type 1 is an autosomal dominant disorder caused by mutations in the NF1 gene at chromosomal location 17q11.2. We present a patient with bone abnormalities and a myriad of lesions secondary to his redeveloping renal failure and NF1. Clinical Presentation A 21-year-old male renal transplant recipient with NF1 presented wi...
Article
Background Verrucous gingival lesions are common within the spectrum of proliferative verrucous leukoplakia (PVL), and the gingiva is not an unusual location for oral carcinoma. However, non-PVL associated dysplastic gingival lesions appear to be less common and may not progress directly to malignancy. In addition, it appears HPV likely plays a lim...
Article
Introduction Vesiculobullous disorders encompass several rare conditions with varying pathology and morbidity, but similar signs and symptoms. Materials and Methods With IRB approval, the record systems of the UF Oral Medicine and UF Dermatology Clinics were searched for cases diagnosed between 2011 and 2020 of the following disorders: pemphigus v...
Article
Introduction Carcinomatous transformation in odontogenic cysts is rare, with few cases described in the literature. Squamous cell carcinoma (SCC) is the most common form of malignant transformation in odontogenic cysts. Radicular and dentigerous cysts are the most common odontogenic cysts to undergo malignant transformation. We present three cases...
Article
Objective We present a case series of adenomatoid odontogenic tumor (AOT), a benign odontogenic tumor from a large biopsy service. AOT has a limited growth potential and is often seen in children and young adults, between the ages of 10-19 years. AOT has uncertain pathogenesis and studies suggest enamel organ, reduced enamel epithelium, and rests o...
Article
Oral contact stomatitis (OCS) may be caused by oral hygiene products, common foods, and topical agents. OCS is of- ten a diagnostic challenge to health care providers. The purpose of this report is to present a rare case of reversible OCS related to components of electronic cigarettes (EC) not previously reported in the literature. A 55-year-old fe...
Article
Introduction Oral cavity sarcomas are rare and account for 1% of all malignancies in this site. This study aims to evaluate the prevalence, variety and distribution of soft tissue and gnathic sarcoma in the oral cavity. Methods An IRB approved retrospective review encompassing years 2010-2020 of the University of Florida Oral Pathology Biopsy Serv...
Article
Introduction Ameloblastic carcinoma (AC) is a rare malignant primary epithelial odontogenic tumor demonstrat- ing histologic features of ameloblastoma with signs of overt malignancy. In this case series, we describe the clinical, radiographic and histologic features of 3 cases of AC. Methods Three cases of AC were identified from the University of...
Article
Introduction Papillon-Lefèvre syndrome (PLS) is an unusual health condition manifested by pre-pubertal extensive periodontal disease that results in early tooth loss and palmoplantar keratosis. The etiology of PLS is loss-offunction mutations in the cathepsin C gene. This gene is a lysosomal protease that plays an essential role in immune and infla...
Article
Background Extragnathic xanthomas are rare benign tumors associated with excess lipid production. Its gnathic counterpart was first reported in 1964. Only 45 cases of central xanthoma of jaw (CXJ) have been reported in the English literature. The etiopathogenesis of CXJ is highly suggestive of a reactive process or a metabolic condition. Materials...
Article
Introduction Sjogren syndrome (SS) is a chronic autoimmune rheumatic disease characterized by lymphocytic infiltration of exocrine glands and other organs. The spectrum of clinical manifestations suggests that SS clinical phenotype in children is more heterogeneous than that in adults. The objective of this study was to perform histopathological an...
Article
Introduction Odontogenic keratocyst (OKC) represents approximately 11% of all odontogenic cysts and may be an early sign of Nevoid Basal Cell Carcinoma syndrome (NBCCS). We aim to identify histologic variations in syndromic OKC in patients under 30 years of age that correlate with the protein patched homolog-1 (PTCH-1) immunohistochemical (IHC) sta...
Article
Introduction Primary head and neck mucosal melanomas (HNMMs) are rare and exhibit aggressive biologic behavior, dismal prognosis, and elevated mutational loads. The molecular mechanisms responsible for high genomic instability observed in HNMMs remain elusive. The DNA cytosine deaminase APOBEC3B constitutes a major endogenous source of mutation in...
Article
Introduction p53 overexpression is well documented in premalignant lesions of the oral cavity. However, recent studies have shown increased expression of podoplanin (D2-40) in oral dysplasia. This study aims to evaluate the efficacy of both markers in predicting malignant transformation in cases of proliferative verrucous leukoplakia (PVL), a recal...
Article
The calcifying epithelial odontogenic tumor (CEOT), also known as the Pindborg tumor, is a rare benign neoplasm which makes up less than 1% of all odontogenic tumors. The purpose of this study is to describe a series of cases of CEOT spanning 25 years. METHODS: With IRB approval, all cases diagnosed as CEOT between 1994 and 2019 were retrieved from...
Article
Background Oral Melanoacanthoma (OM) is an unusual, likely reactive heavily pigmented, benign epithelial proliferation. OM often grows rapidly mimicking melanoma and leading to anxiety for both the patient and the clinician. We present a large series of OM including demographics, description of clinical appearance and characteristics, histology, an...
Article
Background Burning mouth syndrome (BMS) is a relatively common condition defined as a relentless, idiopathic burning sensation of the oral mucosa after exclusion of other underlying causes of burning. Currently effective treatment is limited mostly to pharmacologic interventions. The use of non-pharmacologic therapy, specifically the use of protect...
Article
Introduction Oral squamous cell carcinoma (OSCC) is typically associated with older adults often with established relationship to tobacco and/or alcohol abuse. OSCC is rare in children and young adults without traditional risk factors. This case series encompasses an archival review of OSCC affecting patients under 30 years of age with analyses of...
Article
Full-text available
Human papillomavirus (HPV)-related benign papillary epithelial neoplasms are common lesions affecting any region of the oral cavity. This study evaluated the trends in frequency, location, and demographics of these lesions over 20 years in a large biopsy service. Following IRB approval, the archives of UF Oral Pathology Biopsy Service between 1995...
Article
Introduction: Buccal bifurcation cyst is an inflammatory odontogenic cyst and constitutes up to 5% of all odontogenic cysts. The aim of this study was to report a series of cases, review the recent literature, and facilitate recognition and proper treatment of this entity. Methods: With institutional review board approval, the authors retrieved...
Article
Objective: Adenomatoid odontogenic tumor (AOT) is a benign odontogenic tumor with an excellent prognosis, often seen in children and young adults. The aim was to examine the spectrum of clinical, radiographic, and histologic attributes of AOT and assess clinician recognition of this entity. In addition, diagnostic considerations and treatment moda...
Article
Angina bullosa hemorrhagica (ABH) is a rare benign condition that affects the oral and oropharyngeal mucosa. It is characterized by a rapid eruption of one or more red or magenta blood-filled bullae, which typically involves the soft palate. ABH is a self-limiting condition that heals spontaneously usually within 2 weeks without scarring. ABH is no...
Article
Full-text available
Oral hairy leukoplakia (OHL) is an Epstein-Barr virus (EBV) related lesion seen in severely immunocompromised patients especially, those with concomitant human immunodeficiency virus (HIV) infection. It has been rarely reported in immunocompetent patients. OHL most often presents on the lateral border of the tongue as an asymptomatic, white, and co...
Article
Full-text available
Secretory carcinoma (SC) is an uncommon salivary gland neoplasm of the oral cavity that microscopically may mimic acinic cell carcinoma (ACC) and mucoepidermoid carcinoma (MEC). This study describes a series of SC in minor glands with a literature review. We performed a retrospective search for oral SC, within the archives of the University of Flor...
Article
Full-text available
Gingival growths, barring a few are mostly reactive and seldom exhibit significant true neoplastic potential. The common etiology is local irritation from dental plaque/calculus, trauma as well as medication-related overgrowth. Such lesions are easily distinguishable and categorized into diagnoses such as pyogenic granuloma, peripheral ossifying fi...
Article
Ameloblastic fibro-odontoma (AFO) is a rare benign mixed odontogenic tumor that affects children and young adults. AFO occurs mainly intraosseous. Extraosseous AFO is extremely rare. We report two cases of rare peripheral ameloblastic fibro-odontoma in 2 and 12-year-old females. Microscopic examination revealed a benign proliferation of odontogenic...
Article
Steatocystoma is a benign adnexal tumor that originates from sebaceous glands or ducts. Steatocystoma simplex presents as a solitary, noninherited tumor that affects adults with equal sex predilection. It can af- fect any part of the body and is seen most commonly on the skin of the face and neck. Involvement of the oral mucosa is extremely rare. T...
Article
Introduction Medulloblastoma is the most common tumor of the brain of neuroendocrine origin in children and typically demonstrates an aggressive, relentless clinical behavior and high recurrence rate. Extraneuraxial metastasis of medulloblastoma to the jaw is extremely rare, with fewer than 10 cases reported in the literature. Case Report A 10-yea...
Article
We present a patient with bone abnormalities and a myriad of lesions secondary to his redeveloping renal failure and neurofibromatosis type 1. A 21-year-old male renal transplant recipient with NF1 presented with painless masses and large, irregular radiolucent lesions in the maxilla and mandible. Following histological examination, the lesion was...
Article
Full-text available
The many diverse terms used to describe the wide spectrum of changes seen in proliferative verrucous leukoplakia (PVL) have resulted in disparate clinical management. The objective of this study was to produce an expert consensus guideline for standardized assessment and reporting by pathologists diagnosing PVL related lesions. 299 biopsies from 84...
Article
Full-text available
Objectives The aim of this study was to evaluate the clinical validity of early Sjögren’s syndrome (SS) autoantibodies (eSjA), which were originally marketed for early diagnosis of SS, for juvenile SS (JSS) in a recently identified pediatric cohort. Methods A total of 105 symptomatic subjects with eSjA results available were evaluated at the Cente...
Chapter
Sjögren’s syndrome (SS) is a chronic systemic autoimmune disease primarily affecting the lacrimal and salivary glands. It is broadly classified into primary SS and secondary SS. Primary SS occurs in 50% of cases and affects only the salivary and lacrimal glands leading to dry eyes and dry mouth. Secondary SS is characterized by presence of a second...
Article
Objectives: The role of Human papillomavirus (HPV) in the oral squamous cell carcinoma (OSCC) has not been completely elucidated. The purpose of the present study was to investigate the prevalence and localization of HPV-16 virus in OSCC and to correlate HPV-16 positivity and p16INK4A expression with the clinical and pathological features of OSCC....
Article
Objective Idiopathic pulmonary fibrosis (IPF) patients commonly present with sicca symptoms. This study aims to assess labial minor salivary glands (LMSG) in those patients to rule out Sjögren's syndrome (SS), in which sicca symptoms are the clinical hallmark. Study Design Cases of IPF patients with sicca symptoms referred to the Oral Medicine Cli...
Article
Objective The calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm that makes up less than 1% of all odontogenic tumors. This study aims to describe a case series of CEOT spanning 25 years and to review, and compare our results with, the existing literature. Study design With IRB approval, all CEOT archival cases from the UF Or...
Article
Oral squamous cell carcinoma (OSCC) is an extremely rare occurrence during pregnancy. OSCC accounts for less than 2% of all malignancies in pregnant women, with an average mortality rate of 36%. Understanding the features of this tumor during pregnancy is important; however, the paucity of reports in the literature makes this challenging. Case pres...
Article
Full-text available
The radicular cyst is the most common inflammatory odontogenic cyst in the jaws. It is a periapical lesion associated with non-vital teeth in the tooth-bearing regions of the jaws with a slight male predilection. A radicular cyst is typically asymptomatic, but if large or secondarily infected may cause swelling. The usual radiographic appearance of...
Preprint
Full-text available
Background: Evidence suggest periodontal bacterial infection can contribute to oral cancer initiation and progression. Aim: To investigate the effects of periodontal bacteria on oral cancer cell behavior using a cell-based system and a mouse carcinogenesis model. Methods: Oral cancer cell lines were polyinfected with four periodontal bacteria. Cyto...
Article
Full-text available
Salivary gland neoplasms of the buccal mucosa are relatively rare and often present with an unusual histopathologic profile when compared with other intraoral locations. We present a series of minor salivary gland neoplasms of the buccal mucosa and discuss demographics, clinical presentation, and histologic findings. An IRB approved retrospective s...
Article
Full-text available
We present a report of bilateral mandibular radiolucent lesions that were diagnosed as synchronous ameloblastoma and odontogenic keratocyst (OKC) in a 75‐year‐old female patient. To the best of our knowledge, the simultaneous occurrence of ameloblastoma and OKC of the jaws, as contralateral lesions, has not been previously reported.
Article
Full-text available
Verruciform xanthoma (VX) of the oral cavity is an uncommon, reactive lesion of unknown etiology. In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Followi...
Article
Full-text available
Background: Potentially malignant lesions of the gingiva may frequently present as well-demarcated white lesions confined to the marginal gingiva. These lesions often become thick and verrucoid and spread along the marginal gingiva to encircle the tooth. Some cases of marginal gingival leukoplakia, over time, progress to extensively involve the gi...
Article
Full-text available
Purpose Squamous odontogenic tumor (SOT) is a rare benign, locally infiltrative odontogenic tumor of gnathic bones. It is comprised of islands of bland, well-differentiated squamous epithelium of varying shape and size. Due to histologic overlap, SOT has often been overdiagnosed as ameloblastoma and squamous cell carcinoma. It, thus, becomes import...
Article
Full-text available
CANDLE Syndrome (Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature) is an autoinflammatory disease. Clinical characteristics include recurrent fevers, organ inflammation, skin lesions, anemia, lipodystrophy, basal ganglion calcifications, and delayed physical development. Orofacial manifestations include facial li...
Article
Full-text available
Fibrous dysplasia (FD) is a rare condition commonly involving the jaws. While FD has a typical clinical and histological presentation, considerable variation exists. Moreover, overlap of features with other disorders is possible. This study serves to characterize the features of a large case series of FD of the jaws. With IRB approval, the Universi...
Article
New advances in cancer immunotherapy have been flooding the market at a rapid rate. Pembrolizumab (Keytruda®), a programmed cell death protein 1 (PD-1) inhibitor, introduced in 2014, has been used to treat several cancers. Immune-related adverse events associated with pembrolizumab and other immune checkpoint inhibitors are now well described compl...
Presentation
Introduction: p53 overexpression is well documented in premalignant lesions of the oral cavity. However, recent studies have shown increased expression of podoplanin (D2-40) in oral dysplasia. This study aims to evaluate the efficacy of both markers in predicting malignant transformation in cases of proliferative verrucous leukoplakia (PVL), a reca...
Article
Full-text available
The use of diverse terminology may lead to inconsistent diagnosis and subsequent mistreatment of lesions within the proliferative verrucous leukoplakia (PVL) spectrum. The objectives of this study were: (a) to measure inter-observer variability between a variety of pathologists diagnosing PVL lesions; and (b) to evaluate the impact of diverse termi...
Article
Full-text available
BACKGROUND Carcinosarcoma of the sinonasal tract is an extremely rare malignant neoplasm; it is often designated as carcinoma with spindle cell or sarcomatoid features. We report a case of carcinosarcoma arising in a pre-existing inverted Schneiderian papilloma in the left maxillary antrum and nasal cavity of a 72-year old male patient. CASE REPORT...
Article
Full-text available
Verrucous hyperkeratosis (VH), verrucous carcinoma (VC) and the relentless, truly pre-malignant variant proliferative verrucous leukoplakia often exhibit lichenoid histologic features that may create a diagnostic dilemma for pathologists. This study aims to evaluate and categorize the frequency and the histopathologic patterns of lichenoid features...
Article
Introduction: p16INK4a is a tumor suppressor protein that retards cell cycle progression from G1 to S phase. Prior studies have evaluated p16INK4a expression in odontogenic keratocyst and ameloblastoma, but data regarding other odontogenic cysts and tumors have been sparse. Methods: With IRB approval, cases from the following entities were ident...
Article
Objective: Angiogenesis inhibitors (AgI) are commonly used in combination chemotherapy protocols to treat cancer, and have been linked to osteonecrosis of the jaw (ONJ). However, it is unknown if AgI therapy alone is sufficient to induce ONJ. We have previously established an ONJ model in rice rats with localized periodontitis that receive zoledro...
Article
Full-text available
Chronic ulcerative stomatitis (CUS) is a poorly understood disease with clinical and histologic overlap with lichen planus (LP). Unlike classic LP, direct immunofluorescence (DIF) studies in cases of CUS exhibit a granular pattern of IgG in nuclei of basal and parabasal cells. This study assesses the demographic, clinical, histologic, and DIF featu...
Article
Background Enhancer of zeste homolog-2 (EZH2) is a member of the polycomb group PcG of proteins; the genes that are involved in transcriptional repression. Cell cycle regulation and cell proliferation is associated with EZH2 expression and EZH2 overexpression stimulates cell proliferation and invasiveness. Conversely, inhibition of EZH2 precludes c...