Inderpal Singh Kochar

Inderpal Singh Kochar
Indraprastha Apollo Hospitals · Paediatric and adolescent endocrinology and diabetology

MD MAMS MRCPCH FELLOW PAEDIATRIC ENDOCRINOLOGY LON

About

29
Publications
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95
Citations
Citations since 2016
14 Research Items
62 Citations
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2016201720182019202020212022051015
2016201720182019202020212022051015
2016201720182019202020212022051015

Publications

Publications (29)
Article
Pancreas transplant, both whole pancreas and islet cell, is a known therapeutic option for treatment of type 1 diabetes mellitus. Islet cell transplant began as an experimental therapy but is emerging to be quite beneficial due to less surgical risk and fewer complications. It is also considered a promising option in pediatric patients. In this rev...
Article
Background To study the genetic profile of infants with neonatal diabetes and response to empirical glibenclamide.MethodA retrospective study, between 2014 and 2018, data retrieved from the records of infants admitted with neonatal diabetes and with genetic analysis. Started on insulin and given empirical glibenclamide in selected cases to evaluate...
Article
Skeletal dysplasias are the disorders of the skeletal and cartilaginous tissues. Short stature is the hallmark presentation. Achondroplasia is the commonest skeletal dysplasia. Growth hormone (GH) has been widely used in children with achondroplasia. Various studies have shown 1st year increase in height velocity is about 2-3cm. Apart from achondro...
Article
Full-text available
Objectives: Type 1 diabetes mellitus (T1DM) is one of the most common pediatric endocrine diseases. India alone is home to around 97,700 children with T1DM. This paper evaluates the efficacy, safety, and quality of life with continuous subcutaneous insulin infusion (CSII) in patients treated for a protracted time period of 1 year in a retrospective...
Article
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Pycnodysostosis is a rare genetic disorder with a prevalence of 1.7 per million births; it usually presents with short stature, osteosclerosis, increased bone fragility, and acro-osteolysis of distal phalanges. There are less than 200 cases reported worldwide and very few from South-East Asia. We present a case of pycnodysostosis who presented with...
Article
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Aims To evaluate the efficacy and safety of liraglutide in adolescents with obesity. Materials & Methods Patients (n=41) received injection liraglutide for at least 12 weeks and their pre‐ and post‐baseline characteristics were recorded and analysed. ‐ The key parameters analysed were: weight, height, BMI, Fasting insulin and sugar, one hour insul...
Article
Cushing’s syndrome (CS) or hypercortisolism results from disruption of the hypothalamus-pituitary-adrenal (HPA) axis with the resultant increase in the circulating serum and urinary cortisol levels and lack of cortisol circadian rhythm. The resultant effects cause the physical manifestation of hypercortisolism. The appearance of Cushing’s disease i...
Article
Full-text available
Background Insulin Degludec (IDeg) is a new ultra-long-acting basal insulin that has not been yet evaluated in Indian pediatric population. We aim to evaluate the efficacy and safety of IDeg as basal-bolus therapy in Indian pediatric patients affected by type 1 diabetes mellitus (T1DM). Methods A total of 30 pediatric and adolescent patients (17 b...
Article
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in adolescent girls and often over or under-diagnosed due to common features with normal puberty. Metformin an insulin sensitizer has been widely used in adult PCOS with benefits but the studies in adolescents are few. This use in adults has been translated to use in a...
Article
Abstract Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by end-organ resistance to 1α,25-dihydroxyvitamin D3 (1,25D3). Clinically, the syndrome is recognized by severe early onset rickets with bowing of the lower extremities, short stature, and often alopecia. Here, we report a case series on three s...
Article
Congenital hyperinsulinism (CHI), a clinically and genetically heterogeneous disease, characterized by the unregulated secretion of insulin from pancreatic β-cells, is the most common cause of persistent hypoglycemia in infancy. Early diagnosis and maintenance of normoglycaemia are essential to prevent adverse neurodevelopmental outcomes. The most...
Article
Full-text available
Blood glucose monitoring is a way of testing the concentration of glucose in the blood. The most recent advance is the development of continuous glucose monitoring system (CGMS) which gives 24 hour trend of blood sugar levels thus helping both the patient and the physician in achieving better glycemic control. CGMS in pediatric population is genera...
Article
Congenital adrenal hyperplasia is due to 21-hydroxylase deficiency in > 90% of cases. This is a very common genetic disorder for which biochemical screening is now performed. The classical form occurs in 1:15,000-16,000 live births, while the nonclassical form occurs in 1:1000. Congenital adrenal hyperplasia is the most common cause of primary adre...
Article
Wolfram syndrome is a progressive neurodegenerative disorder also known as DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness). The majority of cases are caused by mutations in the WFS1 gene. WFS1 is located at 4p16.1 and encodes wolframin, a transmembrane endoplasmic reticulum (ER) protein involved in the negative regulatio...
Article
Osteogenesis imperfecta (OI) often leads to severe lower limb (LL) deformities due to recurrent fractures that significantly hamper ambulation. We describe our management experience of correction of LL deformities in four children with OI. Medical management consisted of peri and postoperative pamidronate therapy, calcium supplementation and rehabi...
Article
Cushing's syndrome is an endocrine disorder caused by hypercortisolism. Despite its varied clinical spectrum of presentation, Cushing's disease has not been reported to present as arthritis. Moreover, keratilysis exfolitiva has not been described in Cushing disease. We report a 12 year old male child with pituitary micro adenoma initially presentin...
Article
Until the mid 1980's, Growth hormone(GH) therapy was only prescribed to treat children with severe growth hormone deficiency(GHD). Today, however, with abundance of recombinant human GH(rhGH), it is used to treat a wide range of conditions. rhGH can be used to treat short stature from GH deficiency(GHD), insufficiency and other disorders leading to...
Article
Newborns with intrauterine growth retardation (IUGR) have multiple risk factors for developing hypoglycaemia. Hyperinsulinism, both transient and prolonged, is one of the major risk factors responsible for the hypoglycaemia observed in some newborns with IUGR. Once the child has progressed beyond the infancy period, the most common cause of hypogly...

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