Inci F. Çilesiz

Inci F. Çilesiz
Istanbul Technical University · Department of Electronics and Communication Engineering

PhD BME

About

45
Publications
2,828
Reads
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503
Citations
Additional affiliations
September 2007 - December 2007
University of Minnesota Twin Cities
Position
  • Researcher
Description
  • Principal investigator in "Temperature dependence of tissue physical properties using spectral domain OCT techniques," a 2219-project fully supported by The Scientific and Technological Research Council of TURKEY
July 2000 - July 2002
Academisch Medisch Centrum Universiteit van Amsterdam
Position
  • Research Associate
Description
  • Participant in "Optical Coherence Tomography: Theoretical and Practical Limitations of Minimally-Invasive Imaging of Biological Tissues," a project supported by the Dutch Governmental Research Foundation of Fundamental Research on Matter (FOM) and Philips Research.
June 1998 - September 1998
Tel Aviv University
Position
  • Researcher
Description
  • Participated in two short projects: "Effect of Albumin Based Solder on Feedback Controlled Photothermal Skin Welding" and "Rate Process Kinetics of Photothermally Coagulated Egg White".
Education
August 1988 - December 1994
University of Texas at Austin
Field of study
  • Biomedical Engineering
September 1982 - October 1986
Istanbul Technical University
Field of study
  • Electronics and Communication Engineering

Publications

Publications (45)
Preprint
Precise investigation of the temperature and the duration for collagen denaturation is critical for a number of applications, such as adjustment of temperature and duration during a laser assisted tissue welding or collagen based tissue repair products (films, implants, cross linkers) preparation procedures. The result of such studies can serve as...
Article
Full-text available
Knowledge about the changes in optical properties is needed for planning safer and more accurate laser treatments. A monitoring system was developed to study how the optical properties of a lipid emulsion are affected by temperature changes. A double-integrating-sphere system is modified with a controlled heating apparatus to measure the temperatur...
Conference Paper
Full-text available
In this work, Ultra-wide band Ground Penetrating Radar system is purposed for detection of human respiratory movement through obstacle. As background subtraction methods, Principal Component Analysis, Singular Value Decomposition and Frame Differencing Techniques are applied for reducing clutter effect. After background subtraction, human breathing...
Conference Paper
Todays, Ground Penetrating Radar (GPR) System is used for civil applications such as detection of buried pipes, mine and military fields. One of the recent applications of GPR in civil and defense industry is detection of human vital signs through obstacles such as wall, rubble etc. In this study, we aim to set ultra-wideband ground penetrating rad...
Conference Paper
Todays, Ground Penetrating Radar (GPR) System is used for civil applications such as detection of buried pipes, mine and military fields. One of the recent applications of GPR in civil and defense industry is detection of human vital signs through obstacles such as wall, rubble etc. In this study, we aim to set ultra-wideband ground penetrating rad...
Conference Paper
Todays, Ground Penetrating Radar (GPR) System is used for civil applications such as detection of buried pipes, mine and military fields. One of the recent applications of GPR in civil and defense industry is detection of human vital signs through obstacles such as wall, rubble etc. In this study, we aim to set ultra-wideband ground penetrating rad...
Conference Paper
Amaç: Bu projenin amacı çok ilaca dirençli (ÇİD) hastane enfeksiyonu etkenlerinin, gerçek zamanlı polimeraz zincir reaksiyonu (qPCR) tabanlı bir yöntemle tespitinin otomatize yapılabildiği Moleküler Patojen Analiz Sistemi (MOPAS)ın geliştirilmesidir. MOPAS kapsamındaki cihaz ve sarfların bu proje kapsamında geliştirilerek, (1) düşük maliyetli yerli...
Article
Laser exposure time and irradiance are crucial parameters governing the process of thermal damage. The goal of our in vitro study was to study and determine optimal parameters for the onset of coagulation and carbonization at three different wavelengths (980, 1070 and 1940 nm). We also compared photothermal effects at these three wavelengths by var...
Conference Paper
Full-text available
As they are directly related to people's health and social progress, food safety and quality are important issues in food industry. A rapid nondestructive sensing technique will be very useful to monitor and manage different working steps in horticultural production, at harvest as well as in pre-harvest and postharvest processing. Due to fast respo...
Article
Full-text available
We experimentally investigate propagation of laser beams with Gaussian, Bessel and Airy transverse profles in turbid media. We evaluate and compare the self-healing properties of these beams. © 2011 by the Author(s); licensee Accademia Peloritana dei Pericolanti, Messina, Italy.
Article
of Airy beams in turbid media has not yet been explored comprehensively. In this study, propagation of Gaussian, Bessel and Airy beams in turbid media was investigated experimentally. In experiments, we used variable concentration intralipid emulsion as turbid media. Intralipid emulsion samples diluted in distilled water at different densities were...
Article
Factors like, (i) noise and (ii) artifacts, that occur depending on acoustical properties of tissues, (iii) wrong selection of system variables, like (a) wrong operation frequency, (b) poor calibration, and (c) improper location of focal points, may cause high amount of image degradation during ultrasound imaging. This, in return, may lead to misdi...
Article
Full-text available
Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n and the attenuation coefficient mu(t) using optical coherence tomography (OCT) of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properti...
Article
Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n, and the attenuation coefficient mut using optical coherence tomography of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is w...
Article
Early diagnosis of esophageal cancer limited to the mucosa allows local endoscopic treatment and thereby improves prognosis. Optical coherence tomography images of normal human esophageal tissue obtained with 2 systems with light sources that provide different wavelengths (800 nm and 1275 nm) were compared with histology to determine which waveleng...
Article
Background: Early diagnosis of esophageal cancer limited to the mucosa allows local endoscopic treatment and thereby improves prognosis. Optical coherence tomography images of normal human esophageal tissue obtained with 2 systems with light sources that provide different wavelengths (800 nm and 1275 nm) were compared with histology to determine wh...
Article
Early diagnosis with esophageal cancer limited to the mucosa will allow for local endoscopic treatment and improve prognosis. We compared with histology OCT images of healthy human esophageal tissue from two systems operating at 800 and 1275 nm to investigate which wavelength was best suited for detailed OCT imaging of the esophageal wall, and to l...
Article
Background and objective: Laser soldering of tissues is based on the application of a biological solder on the approximated edges of a cut. Our goal was to use laser soldering for sealing cuts in skin under temperature feedback control and compare the results with ones obtained using standard sutures. Study design/materials and methods: Albumin...
Article
Temperature feedback control during laser-assisted tissue coagulation was investigated and demonstrated with the egg-white model. We observed the dynamics of photothermal denaturation during CO2 laser irradiation by simultaneously controlling surface temperature and monitoring He-Ne laser transmission of egg-white samples. Once a quasi-constant sur...
Article
With the availability of suitable fibres, the Er:YAG laser has become an indispensable tool for invasive neurosurgical applications as a source of precise ablation. The aim of this study was to investigate the ablative effects of the Er:YAG laser on brain tissue. The response of neuronal tissue to 2.94 microns Er:YAG laser irradiation was investiga...
Article
The use of 980 nm diode laser irradiation within cortical tissue was investigated by the author's previous work. In the present study the lesions created in cortical and subcortical tissues and lesioning effects of diode laser applied in continuous and pulsed regimes were compared. In vivo stereotaxic neurosurgical procedure was performed on female...
Article
Background and objectives: Laser soldering of tissues is based on the application of a biological solder on the approximated edges of a cut. Our goal was to use laser soldering for sealing cuts in skin under temperature feedback control and compare the results with ones obtained using standard sutures. Materials and methods: Albumin solder was appl...
Conference Paper
Full-text available
The aim of the present study was to test the feasibility of the 980 nm diode laser for LEP (Laser Evoked Potentials) studies. Human subjects were exposed to laser stimulation. After the pain thresholds of the subjects were determined with respect to laser power level, 1.5 times the threshold value was applied and laser evoked potentials were record...
Article
Background and Objective Lasers have been used as stimulators for creating pain response without stimulating mechanoreceptive fibers. Various laser systems are still under investigation on the quest for best laser system. Our objective was to test the feasibility of the 980-nm diode laser for LEP (laser evoked potentials) studies.Study Design/Mater...
Chapter
As Barnes wrote in 1968 [1]: From the earliest days of medical practice, it has been known that thermal abnormalities or unusual localized areas of skin temperature, either elevated or depressed, usually denoted the presence of some underlying pathology or disease ... Until relatively recently, the physician who wished to examine his patient’s skin...
Article
Full-text available
With recent developments in laser technology, diode laser and optical delivery systems have become highly promising surgical devices with advantages of lower cost and higher precision. The aim of the study was to test the 980-nm diode laser for its potential use in stereotaxic surgery. In our dosimetric study, the response of cortical tissue to dif...
Article
The 980-nm diode laser has been under investigation for neurosurgery because of a local peak in the absorption spectra of water around this wavelength. This work was carried out to examine the extent of thermal changes and the recovery process of laser-induced brain lesions. In order to study the quality of the lesions, a conventional onopolar elec...
Article
Photothermal tissue welding has been investigated as an alternative surgical tool to improve bonding of a variety of severed tissues. Yet, after almost two decades of research, inconsistencies in interpretation of experimental reports and, consequently, mechanism of this photothermal process as well as control of dosimetry remain an enigma. Widespr...
Article
With recent developments in laser technology, high power diode laser and optical delivery systems have become highly promising surgical devices with advantages of lower cost and higher precision. The aim of the present study was to test the 980 nm wavelength laser (Opto Power OPC-D010-980-FCPS) for its potential use in neurosurgery. Response of neu...
Conference Paper
In this study, photon propagation is simulated by Monte Carlo algorithm, using absorption and scattering coefficients of histologically different human tissues (bone, brain white matter, liver, prostate, myocardium); fluence distribution is calculated by the convolved data, and comparisons are reported
Conference Paper
With recent developments in laser technology, high power diode laser and optical delivery systems have become highly promising surgical devices with advantages of lower cost and higher precision. The aim of the present study was to test the 980 nm wavelength laser (Opto Power OPC-D010-980-FCPS) for its potential use in neurosurgery. Response of neu...
Article
Thermal denaturation of proteins is recognized as a rate process governed by the local temperature-time response. Since rate processes are exponential with temperature, laser-assisted tissue welding was performed with and without temperature feedback control (TFC) to investigate the efficacy of temperature feedback in enhancing the photothermal wel...
Article
Temperature feedback control (TFC) during laser-assisted tissue welding was implemented to eliminate exponential increases in the rate of denaturation associated with rapidly increasing temperatures. This study was undertaken to investigate and compare the weld strengths and healing responses of laser welded enterotomies with and without TFC using...
Article
Temperature feedback control (TFC) of cw argon ion and cw Ho:YAG laser-assisted anastomoses of severed rat intestines increased wound stability during the first 72 hours after surgery when compared to laser anastomosies formed without temperature control. Comparisons of in vitro bursting pressures measurements and qualitative and quantitative histo...
Article
Thermal denaturation of proteins is recognized as a rate process governed by the local temperature-time response and is believed to be the principal mechanism for photothermal tissue welding. Since rate processes are exponential with temperature, feedback control of tissue surface temperature is hypothesized to create a quasi-constant rate of denat...
Article
Laser tissue welding has been applied successfully to several tissues using microscopic and macroscopic surgical techniques. The advantages of laser tissue welding include the formation of fluid tight bonds, decreased foreign body (suture) reaction scar formation, decreased anastomotic time and growth of the bond. The disadvantages compared to conv...
Article
Numerical modeling and experimental verification studies were conducted to compare continuous wave Ar, Tm:YAG, and Ho:YAG fusion characteristics in rat intestinal tissues. Spot sizes, powers, and activation times were varied according to laser characteristics. Exposed transected bowel wall was apposed and irradiated to obtain fusion in vivo. Tissue...
Article
This study examines the validity of optical property measurements by comparing surface temperatures rises predicted by a well-tested mathematical model with temperatures measured experimentally during laser irradiation. Analysis is based on the early temperature response that is proportional to the absorption coefficient. The results of the investi...
Article
This study was undertaken to investigate the effects of freezing upon the in vitro optical properties of human aorta from 300 nm to 800 nm. Freezing significantly decreased absorption coefficient over most of the spectrum from 300 nm to 800 nm. The only significant changes in the reduced scattering coefficient were from 300 nm to 335 nm.
Article
Laser assisted tissue welding (LTW) has been investigated at several institutions as a surgical tool to improve the anastomosis of severed blood vessels, nerves and a variety of hollow organs. LTW can provide immediate fluid-tight sealing and achieve successful anastomosis rates comparable to conventional suture techniques. It has also been reporte...
Article
The influences of dehydration and thermal damage on in vitro optical properties of human aorta were studied. The absorption coefficient increased by 20-50%, especially in the visible range when at least 40% of total tissue weight was lost as a result of dehydration. The reduced scattering coefficient increased by 10-45% in the visible and 30% to ov...

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