Imourana Alassane-Kpembi

Université de Montréal | UdeM · Faculty of Veterinary Medicine

The foodborne mycotoxin deoxynivalenol (DON) produced by Fusarium species threats animal and human health through disruption of the intestinal barrier. Targeting the gut microbiota and its products appears as a promising strategy to mitigate DON intestinal toxicity. In this study, we investigated whether the bacterial metabolite butyrate could alle...

The Fusarium mycotoxin deoxynivalenol (DON) is one of the most frequently occurring food contaminants. Nearly all individuals are exposed to DON, due to it widespread presence in grains and grain-based products. Chronic DON poisoning is associated with growth retardation, immunotoxicity as well as impaired reproduction and fetal development. At the...

Microbial biotransformation of Zearalenone (ZEN) is a promising deactivation approach. The residual toxicity and stability of Zearalenone-14-phosphate (ZEN-14-P) and Zearalenone-16-phosphate (ZEN-16-P), two novel microbial phosphorylation products of ZEN, remain unknown. We investigated the cytotoxicity, oxidative stress, pro-inflammatory, and estr...

Cattle are deemed less susceptible to mycotoxins due to the limited internal exposure resulting from rumen microbiota activity. However, the significant amounts of Fusarium mycotoxins deoxynivalenol (DON) and zearalenone (ZEN) frequently detected in bovine follicular fluid samples suggest that they could affect ovarian function. Both mycotoxins tri...

Cattle are deemed less susceptible to mycotoxins due to the limited internal exposure resulting from rumen microbiota activity. However, the significant amounts of Fusarium mycotoxins deoxynivalenol (DON) and zearalenone (ZEN) frequently detected in bovine follicular fluid samples suggest that they could affect ovarian function. Both mycotoxins tri...

Scope: The food contamination by mycotoxins is of increasing public health concerns. Deoxynivalenol (DON), a mycotoxin contaminating cereals has been associated with the exacerbation of inflammatory bowel diseases (IBD), thereby raising the question of its role in the development of IBD. Moreover, the effect of DON on the colon is poorly described...

The effects of low doses of toxicants are often subtle and information extracted from metabolomic data alone may not always be sufficient. As end products of enzymatic reactions, metabolites represent the final phenotypic expression of an organism and can also reflect gene expression changes caused by this exposure. Therefore, the integration of me...

Résumé L’exposition alimentaire humaine aux mycotoxines est une préoccupation croissante pour la sécurité sanitaire des aliments et la santé publique. Très répandues dans nos aliments, ces toxines ont des modes d’action différents et de nombreux effets sur la santé. Des réglementations, basées sur leur occurrence et/ou leur toxicité chez l’Homme et...

Humans are exposed to multiple exogenous substances, notably through food consumption. Many of these compounds are suspected to impact human health, and their combination could exacerbate their harmful effects. We previously observed in human cells that, among the six most prevalent food contaminant complex mixtures identified in the French diet, s...

Low-level contamination of food and feed by deoxynivalenol (DON) is unavoidable. We investigated the effects of subclinical treatment with DON, and supplementation with probiotic yeast Saccharomyces cerevisiae boulardii I1079 as a preventive strategy in piglets. Thirty-six animals were randomly assigned to either a control diet, a diet contaminated...

Aflatoxin B1 (AFB1) is the most potent carcinogen among mycotoxins. Its biosynthesis involves the formation of versicolorin A (VerA), whose chemical structure shares many features with AFB1. Our data revealed significant levels of VerA in foodstuff from Central Asia and Africa. Given this emerging food risk, it was of prime interest to compare the...

Co-occurrence of mycotoxins in food and feed represents the rule rather than the exception. Information about combinatory toxic effects of co-occurring mycotoxins is scarce, in particular the effects that mixtures of mycotoxins in feed may have on farm animals. This review focusses on studies on the combined effects of moniliformin and co-occurring...

The gastrointestinal tract is the first physiological barrier against food contaminants, as well as the first target for these toxicants [...]

Food and feed commodities are often contaminated by more than one mycotoxin. Among the several combinations that frequently occur, fusariotoxins are often mentioned. The multi-mycotoxins contamination is a serious threat for health. In the present study we investigated the toxic interactions between deoxynivalenol (DON), nivalenol (NIV), and fusare...

Type B trichothecene mycotoxin deoxynivalenol (DON) is one of the most frequently occurring food contaminants. By inducing trans-activation of a number of pro-inflammatory cytokines and increasing the stability of their mRNA, trichothecene can impair intestinal health. Several yeast products, especially Saccharomyces cerevisiae, have the potential...

Type B trichothecene mycotoxins (TCT B) are secondary metabolites produced by Fusarium fungi. Deoxynivalenol (DON), nivalenol (NIV) and their acetylated derivatives (3-acetyldeoxynivalenol: 3-ADON, 15-acetyldeoxynivalenol: 15-ADON, and 4-acetylnivalenol or fusarenon-X: FX) frequently co-occur in cereals following fungal infection by Fusarium specie...

Cadmium (Cd), a common and widespread toxic heavy metal, and mycotoxins such as deoxynivalenol (DON) are frequent contaminants of the food supply. Most of the data on their toxicity concern their effects when present alone. However, consumers can be exposed to a cocktail of DON and Cd. To improve the understanding of their combined toxicity, the ef...

The few data available on fusarenon-X (FX) do not support the derivation of health-based guidance values, although preliminary results suggest higher toxicity than other regulated trichothecenes. Using histo-morphological analysis and whole transcriptome profiling, this study was designed to obtain a global view of the intestinal alterations induce...

The global incidence of Fusarium head blight and attendant cereal grains multi-contamination by the trichothecene mycotoxins deoxynivalenol (DON) and nivalenol (NIV) are increasing as a possible result of climate change and inadequate agricultural practices. At the molecular level, these mycotoxins bind to the ribosome, activate the mitogen-activat...

Patulin is the main mycotoxin contaminating apples. During the brewing of alcoholic beverages, this mycotoxin is degraded to ascladiol, which is also the last precursor of patulin. The present study aims (1) to characterize the last step of the patulin biosynthetic pathway and (2) to describe the toxicity of ascladiol. A patE deletion mutant was ge...

Mycotoxins are secondary metabolites of fungi that grow on a variety of substrates. Due to their high consumption of cereals and their sensitivity, pigs are highly impacted by the presence of mycotoxins. At the European level, regulations and recommendations exist for several mycotoxins in pig feed. Among these toxins, fumonisin B1 (FB1), and deoxy...

Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represents an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the “native” mycotoxins. The main derivates o...

Traditionally, toxicology studies have used rodent bioassays to perform the identification and characterization of potentially hazardous substances. It is intended that these bioassays will be the first step, and then different extrapolation methods and safety factors will be applied to the data to generate the health-based guidance values for huma...

Humans and animals are exposed to several toxins at the same time. The toxicity of combinations of mycotoxins cannot always be predicted based upon their individual toxicities. Interactions between concomitantly occurring mycotoxins can be antagonistic, additive, or synergistic. Several approaches have been used to determine the interaction between...

Humans and animals are exposed to several toxins at the same time. The toxicity of combinations of mycotoxins cannot always be predicted based upon their individual toxicities. Interactions between concomitantly occurring mycotoxins can be antagonistic, additive, or synergistic. Several approaches have been used to determine the interaction between...

Abstract Mycotoxins are fungal secondary metabolites detected in many agricultural commodities, especially cereals. Due to their high consumption of cereals, pigs are exposed to these toxins. In the European Union regulation and/or recommendation exist in pig feed for aflatoxins, ochratoxin A, fumonisins, zearalenone, and trichothecenes, deoxynival...

Mycotoxins are fungal secondary metabolites detected in many agricultural commodities, especially cereals. Due to their high consumption of cereals, pigs are exposed to these toxins. In the European Union, regulations and/or recommendations exist in pig feed for aflatoxins, ochratoxin A, fumonisins, zearalenone, and trichothecenes, deoxynivalenol a...

Les mycotoxines "masquées" : un nouveau risque en production porcine ? Les mycotoxines sont des métabolites secondaires de moisissures qui peuvent contaminer différentes céréales et par conséquent l’alimentation du porc. Au niveau européen, des réglementations et des recommandations pour l'alimentation animale ont été édictées pour six mycotoxines...

Mycotoxins are secondary fungal metabolites produced mainly by Aspergillus, Penicillium and Fusarium. As evidenced by large-scale surveys, humans and animals are simultaneously exposed to several mycotoxins. Simultaneous exposure could result in synergistic, additive or antagonistic effects. However, most toxicity studies addressed the effects of m...

Humans and animals are exposed to several toxins at the same time. The toxicity of combinations of mycotoxins cannot always be predicted based upon their individual toxicities. Interactions between concomitantly occurring mycotoxins can be antagonistic, additive, or synergistic. Several approaches have been used to determine the interaction between...

Abstract Trichothecenes raise increasing concern for food safety issues, given the growing body of evidences of their potential to cause toxicity in humans and animals and their frequent and global worldwide occurrence. The trichothecene mycotoxin fusarenon X (4-Acetylnivalenol) (FX) can be found in cereal commodities including rice, corn, barley a...

The mycotoxins deoxynivalenol (DON) and nivalenol (NIV), worldwide cereal contaminants, raise concerns for animal and human gut health, following contaminated food or feed ingestion. The impact of DON and NIV on intestinal mucosa was investigated after acute exposure, in vitro and in vivo. The histological changes induced by DON and NIV were analyz...

The mycotoxins deoxynivalenol (DON) and nivalenol (NIV), worldwide cereal contaminants, raise concerns for animal and human gut health, following contaminated food or feed ingestion. The impact of DON and NIV on intestinal mucosa was investigated after acute exposure, in vitro and in vivo. The histological changes induced by DON and NIV were analyz...

As the most extensively exposed surface in the body, the intestinal mucosa has to face important chemical and biological challenges. The intestinal mucosa has three main physiological functions. It establishes a physical barrier between the internal milieu and the luminal content. The intestinal mucosa is also responsible for luminal nutrients dige...

In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly sensitive to mycotoxins. The aim...

The issue of toxicological interactions in in vitro assessment of the combined toxicity of mycotoxins 2 nd FOODSEG Symposium 14-15 june 2013 Bucharest, Romania

Deoxynivalenol (DON) is the most prevalent trichothecene mycotoxin in crops in Europe and North America. DON is often present with other type B trichothecenes such as 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV) and fusarenon-X (FX). Although the cytotoxicity of individual mycotoxins has been widely studied, d...

The type of interaction between type B trichothecenes on the intestine varies with the dose 12 th European Fusarium Seminar 12-16 may 2013 Bordeaux, France

Enniatins, the most prevalent emerging mycotoxins, represent an emerging food safety issue, because of their common co-occurrence with other fusariotoxins such as trichothecenes co-produced by Fusarium spp on field grains and because of their extensive prevalence in grains. In this study, the intestinal toxicity of enniatin B1 (ENN) alone and mixed...

Abstract Les mycotoxines sont des métabolites secondaires produits par les champignons qui peuvent contaminer de nombreuses denrées alimentaires. La plupart des champignons produisent simultanément plusieurs mycotoxines, et les aliments peuvent êtres contaminés par différentes souches fongiques. L’homme et l’animal sont donc exposés à un cocktail d...

Abstract Les trichothécènes B sont des époxides de la famille des sesquiterpenes produits par des moisissures du genre Fusarium. Le deoxynivalenol (DON) est le représentant le mieux connu et le plus répandu de cette famille de mycotoxines. Le DON et ses dérivés acétylés 3-acetyldeoxynivalenol (3-ADON) et 15-O-acetyl-4-deoxynivalenol (15-ADON) sont...