Immo Weber

Immo Weber
Philipps University of Marburg | PUM · Klinik für Neurologie (Marburg)

Dr. rer. nat.

About

32
Publications
3,184
Reads
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125
Citations
Citations since 2016
30 Research Items
125 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Additional affiliations
January 2017 - present
University Hospital Gießen & Marburg
Position
  • Researcher
June 2013 - December 2016
University of Cologne
Position
  • PhD Student
October 2011 - July 2012
University of Rostock
Position
  • Student
Description
  • Diploma Thesis
Education
October 2006 - August 2012
University of Rostock
Field of study
  • Biology

Publications

Publications (32)
Article
Full-text available
The vagus nerve constitutes a key link between the autonomic and the central nervous system. Previous studies provide evidence for the impact of vagal activity on distinct cognitive processes including functions related to social cognition. Recent studies in animals and humans show that vagus nerve stimulation is associated with enhanced reward-see...
Article
Full-text available
In many scientific fields including neuroscience, climatology or physics, complex relationships can be described most parsimoniously by non-linear mechanics. Despite their relevance, many neuroscientists still apply linear estimates in order to evaluate complex interactions. This is partially due to the lack of a comprehensive compilation of non-li...
Article
Full-text available
Bimanual coordination is impaired in Parkinson’s disease affecting patients’ ability to perform activities of daily living and to maintain independence. Conveyance of information between cortical and subcortical areas is essential for bimanual coordination and relies on the integrity of cerebral microstructure. As pathological deposition of alpha-s...
Article
Full-text available
Rhythmic neural activity, so-called oscillations, plays a key role in neural information transmission, processing, and storage. Neural oscillations in distinct frequency bands are central to physiological brain function, and alterations thereof have been associated with several neurological and psychiatric disorders. The most common methods to anal...
Preprint
Full-text available
In many scientific fields like e.g. neuroscience, climatology or physics, complex relationships can be described most parsimoniously by nonlinear mechanics. Despite their relevance, many scientists still apply linear estimates in order to evaluate complex interactions. This is partially due to the lack of a comprehensive compilation of nonlinear me...
Preprint
Full-text available
Rhythmic neural activity, so called oscillations, play a key role for neural information transmission, processing and storage. Neural oscillations in distinct frequency bands are central to physiological brain function and alterations thereof have been associated with several neurological and psychiatric disorders. The most common methods to analys...
Article
Full-text available
Timed picture naming is a common psycholinguistic paradigm. In this task, participants are asked to label visually depicted objects or actions. Naming performance can be influenced by several picture and verb characteristics which demands fully characterized normative data. In this study, we provide a first German normative data set of picture and...
Article
Full-text available
Bimanual motor control declines during ageing, affecting the ability of older adults to maintain independence. An important underlying factor is cortical atrophy, particularly affecting frontal and parietal areas in older adults. As these regions and their interplay are highly involved in bimanual motor preparation, we investigated age-related conn...
Article
Full-text available
Whereas the effect of vagal nerve stimulation on emotional states is well established, its effect on cognitive functions is still unclear. Recent rodent studies show that vagal activation enhances reinforcement learning and neuronal dopamine release. The influence of vagal nerve stimulation on reinforcement learning in humans is still unknown. Here...
Article
Full-text available
Psychosis is the most common neuropsychiatric side-effect of dopaminergic therapy in Parkinson’s disease (PD). It is still unknown which factors determine individual proneness to psychotic symptoms. Schizotypy is a multifaceted personality trait related to psychosis-proneness and dopaminergic neurotransmission in healthy subjects. We investigated w...
Preprint
Full-text available
Bimanual motor control declines during healthy ageing, affecting the ability of older adults to maintain independence. Age-related changes in neural dynamics of movement preparation that underlie reduced bimanual motor control, however, remain largely elusive. Here, we assessed effective connectivity within a prefrontal-premotor network of 19 young...
Article
Full-text available
Despite advances in symptomatic treatment options, the pathomechanism of idiopathic Parkinson's disease (PD) remains poorly understood. Animal studies from recent years suggest pathological information processing in the basal ganglia network to be responsible for major movement deficits observed in patients, which, according to the information lesi...
Article
Full-text available
An important prerequisite for the analysis of spike synchrony in extracellular recordings is the extraction of single-unit activity from the multi-unit signal. To identify single units, potential spikes are separated with respect to their potential neuronal origins ('spike sorting'). However, different sorting algorithms yield inconsistent unit ass...
Preprint
Full-text available
An important prerequisite for the analysis of spike synchrony in extracellular recordings is the extraction of single unit activity from the recorded multi unit signal. To identify single units (SUs), potential spikes are detected and separated with respect to their potential neuronal origins ('spike sorting'). However, different sorting algorithms...
Poster
Full-text available
Objective: To identify the significance of dopaminergic depletion in Parkinson’s disease (PD) on interhemispheric crosstalk using a complex bimanual tapping task. Background: Dopamine deficiency in PD patients causes abnormal neuronal processing within the basal ganglia subsequently impeding functional integration of distinct areas of the cerebral...
Poster
Full-text available
Objective: To identify age-related changes of bimanual coordination and characterize the underlying alterations of effective connectivity within the cortical motor system. Background: Exact signal processing within the sensorimotor system is essential for bimanual coordination. Cortical areas involved comprise supplementary motor area (SMA), later...
Article
Bimanual coordination is impaired in Parkinson's disease (PD), affecting patients' quality of life. Besides dysfunction of the basal ganglia network, alterations of cortical oscillatory coupling, particularly between prefrontal and (pre-)motoric areas, are thought to underlie this impairment. Here, we studied 16 PD patients OFF and ON medication an...
Article
Full-text available
Transfer entropy (TE) provides a generalized and model-free framework to study Wiener-Granger causality between brain regions. Because of its nonparametric character, TE can infer directed information flow also from nonlinear systems. Despite its increasing number of applications in neuroscience, not much is known regarding the influence of common...
Data
FNDC for the Kus-model as a function of filter order for an 80 Hz causal low-pass Butterworth filter. (TIFF)
Data
Comparison of FP for causal and non-causal Butterworth filter using the Kus-model. (TIFF)
Data
Comparison of FNDC for causal and non-causal Butterworth filter using the Kus-model. (TIFF)
Data
FP for the Kus-model including detected indirect connection as a function of filter order for a causal 80 Hz low-pass Butterworth filter. (TIFF)
Data
Computation time for 100 datasets of the Kus-model each with 20 trials for different Butterworth low-pass filter applications. Computation was done on two Dell precision tower 7910 XCTO base each with two Intel Xeon processors E5-2670 v3 (12 cores HT, 30 MB cache, 2.3 GHz) and 64 GB RAM. (TIFF)
Data
FNIC for the Kus-model as a function of filter order for an 80 Hz causal low-pass Butterworth filter. (TIFF)
Data
FP for the Kus-model as a function of filter order for an 80 Hz causal low-pass Butterworth filter. (TIFF)
Article
Full-text available
Although the clinical use of deep brain stimulation (DBS) is increasing, its basic mechanisms of action are still poorly understood. Platinum/iridium electrodes were inserted into the subthalamic nucleus of rats with unilateral 6-OHDA-induced lesions of the medial forebrain bundle. Six behavioral parameters were compared with respect to their poten...
Poster
Full-text available
Objective: To assess influences of dopamine deficiency on the causal interplay within the motor network during bimanual finger tapping in Parkinson's disease (PD) patients. Background: Bimanual coordination relies on a complex orchestration of neuronal information within distinct brain areas, including supplementary motor area (SMA), lateral premo...
Article
Bimanual finger coordination declines with age. However, relatively little is known about the neurophysiological alterations in the motor-system causing this decline. In the present study, we used 128-channel electroencephalography (EEG) to evaluate causal interactions of cortical, motor-related brain areas. Right-handed young and elderly subjects...
Poster
To identify mechanisms of physiological aging in the cerebral motor network and their effect on the causal interplay of motor related brain areas.
Poster
The aim of this study was to characterize the age related changes of effective connectivity within a cortical motor network during bimanual coordination.
Poster
To demonstrate how electrical brain activity and motor performance change during physiological aging.

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Projects

Projects (3)
Project
The aim of the project is to understand how information processing is disturbed in the motor system of Parkinson's patients by analyzing electrophysiological recordings of the subthalamic area.