Iman Muhammad Higazy

Iman Muhammad Higazy
National Research Center, Egypt | NRC · Department of Pharmaceutical Technology

Doctor of Philosophy

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6
Publications
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197
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Publications (6)
Article
Full-text available
Targeted drug delivery o�ers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate...
Article
Full-text available
This study presents an alternative therapy to conventional anti-Parkinson’s treatment strategies; where motor and non-motor symptomatic complications are considered. Thus; providing sustainability, patient compliance, therapeutic safety and efficiency, based on triggering secretion of endogenous dopamine (DA). Exogenous DA has long been considered...
Article
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Background and purpose: Glioma is one of the most aggressive primary brain tumors and is incurable. Surgical resection, radiation, and chemotherapies have been the standard treatments for brain tumors, however, they damage healthy tissue. Therefore, there is a need for safe anticancer drug delivery systems. This is particularly true for natural pr...
Article
Management of epilepsy requires brain delivery therapy, therefore, this study was aimed to prepare lamotrigine loaded poly-ɛ-(d,l-lactide-co-caprolactone) (PLCL) nanoparticles using spontaneous emulsification solvent diffusion method. Nanoparticles for brain delivery required to have a particle size <200 nm, polydispesity index <0.2 and a sustained...
Article
Full-text available
The purpose of this study is to screen various preformulation studies in early stages of dosage form development, in order to reach a preliminary optimized group of lamotrigine (LTG) loaded polymeric nanoparticles, with certain characteristics that would permit brain targeting through parenteral administration. Various preformulation studies were c...

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