Iman Fathy

Ain Shams University · oral Biology

Root perforations may cause periodontitis, resulting in alveolar bone loss. This study compared the zirconia containing MTA Matreva ® (MAT group) to traditional MTA Angelus ® (ANG group) as root perforation repair materials regarding the cytotoxicity and the osteogenic potential. Bone marrow mesenchymal stem cells (BM-MSCs) were isolated from two a...

Background Dental tissue engineering is an alternative procedure for restoring damaged dental tissues. Adipose-derived stem cells are a new source of cells for regenerative endodontics in combination with scaffold materials. The descriptive data about this regenerative process is still insufficient. Objective To evaluate the regenerative potential...

Background Orthodontic relapse is a frequent problem that many patients experience. Although orthodontic therapy has advanced, recurrence rates can still reach 90%. We undertook a study to look at the possibilities of laser bio-stimulation and stem cells because they have showed promising outcomes in lowering recurrence rates. Objectives Our objec...

Background Dental regeneration benefits from improving the features of dental derived stem cells. Gallium-aluminum-arsenide laser had a significant role in modification of cell behavior in different cell lines and culture conditions. Hence, exploring its mechanism and effect on dental derived stem cells would benefit prospective regenerative dental...

Objectives: The present work was designed to evaluate the proliferation and differentiation potential of stem cells from the apical papilla (SCAP) seeded along with platelet rich fibrin (PRF) scaffolds prepared under two different centrifugation protocols. Materials and Methods: Standard and advanced PRF protocols were used. Cells were divided into...

Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects around 1% globally leading to joint inflammation and disability. Etorocoxib (ETR) is a potent COX-2 inhibitor traditionally used orally to alleviate RA induced inflammation, yet it causes hepatic side effects on prolonged use. This study aims for in silico optimization of ETR p...

Ciprofloxacin (CPFX ® ) is potent fluoroquinolone but has severe side effects. Cinnamon (CIN) and chia seeds are potent antioxidants. The current work aimed to compare the effect of CIN extract and chia seeds on CPFX ® -treated submandibular salivary glands (SMGs). Thirty-two male albino rats were divided into four groups: Group 1 : received saline...

Objective: Head and neck cancer is the sixth leading cancer by incidence worldwide and eighth by death. Recent reports revealed that, not only radiotherapy but also chemotherapy may induce xerostomia. The aim of this study was to compare the possible regenerative effect of BMSCs through systemic and local injections. Material and Methods: 52 male A...

Background: Cisplatin is a potent anti-carcinogenic agent; however, it has many dose-limiting side effects. The aim of our study was to determine and compare the effectiveness of adipose-derived stem cells (ADSCs) and platelet rich plasma (PRP) as a treatment modality against cisplatin-induced cytotoxicity in the submandibular glands of Albino rats...

Background: Relapse after orthodontic tooth development (OTM) happens through the rebuilding of the trans-shaped periodontal ligament (PDL), this rebuilding process involve the extracellular matrix (ECM), MMPs and tissue inhibitor metalloproteinases (TIMPs) may play a central role in regulating the production of ECM molecules. Some authors found th...

Background: Despite extensive efforts for the understanding and curative options for osteoporosis, it remains a critical public health threat. Alendronate sodium, an amino bisphosphonate, is a potent antiresorptive drug used in the treatment of osteoporosis in postmenopausal women. On the other hand, BMMSCS are considered one of the recent therapeu...

The current study was performed on adult human impacted third molars where aim of the study was to compare mesenchymal stem cells (MSCs) from cultures of periodontal ligament (PDL) and human dental pulp. The clonogenic potential of the isolated cells in both groups; group I (PDL) and group II (pulp) was assessed via Colony forming unit-fibrobla...