Ilka Fuchs

Ilka Fuchs
Center for Prenatal Diagnosis and Human Genetics, Kudamm-199 · Center of prenatal diagnosis

About

68
Publications
3,242
Reads
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1,623
Citations
Citations since 2016
2 Research Items
571 Citations
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100

Publications

Publications (68)
Article
Introduction Doppler sonography of the uterine artery (UA) is done to monitor pregnancies, because the detected flow patterns are useful to draw inferences about possible disorders of trophoblast invasion. Increased resistance in the UA is associated with an increased risk of preeclampsia and/or intrauterine growth restriction (IUGR) and perinatal...
Article
The aim of this study was to visualize levator trauma by three-dimensional (3D) ultrasound performed during labor and soon after the crowning of the fetal head and to determine how often levator trauma occurs. This was a prospective, observational study of 66 women enrolled during the first stage of labor. The women underwent intrapartum 3D transpe...
Article
Mirror syndrome, also referred to as Ballantyne's syndrome, is normally defined as the development of maternal edema in association with fetal hydrops. The incidence of mirror syndrome is low and few cases have been published. We describe a case report in association with fetal Ebstein anomaly and provide a systematic review on the fetal associated...
Article
The aim of this pilot study was to perform a preliminary investigation into the predictive values of the position of the fetal spine and of the occiput measured during the first and second stages of labor by intrapartum ultrasound for persistent occiput posterior (OP) position. This was a prospective, cohort study, in which 100 women with singleton...
Article
To study the impact of circulating vascular endothelial growth factors (VEGF) -A, -C and -D and their soluble receptors VEGFR-1/-2 on disease invasion and progression in patients with pre-invasive (CIN), invasive (PCC) and recurrent (RCC) cervical cancer. Blood samples were obtained from 125 women, including 50 cases of CIN, 51 of PCC and 24 of RCC...
Article
Full-text available
This prospective study evaluates the predictive value of preoperative staging by transvaginal sonography (TVS) in ovarian cancer. In 39 patients presenting with clinical signs and symptoms of ovarian cancer, preoperative systematic staging regarding tumor size (T), presence of ascites (A), peritoneal carcinomatosis (PC), bladder invasion (BI), inte...
Article
The assessment of the cervix by transvaginal ultrasound represents a modern diagnostic tool for various indications during pregnancy. The measurement of the cervical length allows a reliable risk assessment in threatened preterm labour by differentiating between true and false preterm contractions. Prior to the induction of labour the cervical leng...
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Full-text available
The oral fluoropyrimidine carbamate, capecitabine, is a highly active and well-tolerated treatment for metastatic breast cancer. In patients treated previously with anthracyclines and taxanes, capecitabine is an approved single-agent therapy. Trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER-2), is also...
Article
Full-text available
The aim of this study was to investigate the expression and prognostic influence of HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3) and HER4 (cerb-B4) in squamous cell cervical carcinomas (SCC) and the importance of receptor correlations. 78 SCC were stained immunohistochemically for HER1-HER4. HER2 gene amplification was determined using fluorescenc...
Article
To compare the immediate postinterventional and long-term outcomes of children with a prenatal and those with a postnatal diagnosis of isolated congenital heart defects. This was a retrospective study of 257 children admitted over a 10-year period to our pediatric cardiology unit with one of four different cardiac lesions: transposition of the grea...
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Full-text available
Since the anti-HER2 monoclonal antibody trastuzumab made its triumphant advance into breast cancer therapy, new selective agents, including pan-HER inhibitors are entering clinical practice. This study investigates the expression of the four HER-family members, HER1-4, in 48 primary breast carcinomas (PBC) and corresponding distant metastases (CDM)...
Article
Having studied intrapartum translabial ultrasound (ITU) to define easily obtainable sonographic criteria during maternal pushing, we used it dynamically immediately before vacuum extraction to determine its use in predicting successful operative vaginal delivery. In a pilot study, maternal and fetal landmarks were determined sonographically during...
Article
Purpose: To investigate the application of intrapartum infrapubic ultrasound using a typical transabdominal probe to determine fetal head station and descent and to describe ultrasound criteria to predict successful intrumental delivery. Methods and Materials: 20 patients in labor >37 weeks' gestation with normal singleton cephalic-presenting fetu...
Article
Purpose: Congenital heart defects represent one of the major causes of infant morbidity and mortality. Intrauterine identification of congenital heart defects allows optimal postnatal management of the neonates including delivery in a tertiary centre permitting immediate early interventions. However the impact of prenatal diagnosis on the long-term...
Article
To predict when delivery will occur, within 48 h and 7 days of presentation and before 35 weeks' gestation in women presenting with threatened preterm labor. Sonographic measurement of cervical length was carried out in 510 women with singleton pregnancies presenting with threatened preterm labor and intact membranes at 24 to 33 + 6 weeks of gestat...
Article
Less than 10% of women presenting with preterm contractions progress to active labor and delivery. This study investigates whether cervical length measurements by ultrasound can discriminate between true and false labor in women presenting with threatened preterm labor. Cervical length was measured by transvaginal ultrasound in 253 women with singl...
Article
To determine whether sonographic measurement of cervical length in pregnancies complicated by preterm prelabor amniorrhexis helps distinguish between those women who deliver within 7 days and those who do not. In 101 women with singleton pregnancies presenting with preterm prelabor amniorrhexis at 24-36 (median, 32) weeks of gestation cervical leng...
Article
Problemstellung: The purpose of this study was to evaluate the possible advantages, applications and usefulness of real-time transabdominal and transvaginal Extended Field of View (EFOV) ultrasound combined with Power Doppler in obstetrics and gynecology. Methode: 122 randomly selected pregnancies and preoperative gynecological patients referred...
Article
Rhabdoid tumors of the kidney are highly lethal malignancies of infancy. We report the prenatal detection of a renal rhabdoid tumor with mesoblastic components in a fetus at 27 weeks of gestation. The tumor presented as a large mass in the left renal area and there was concomitant massive polyhydramnios. Though the sonographic features alone did no...
Article
Fragestellung: 30% aller Fruhgeburten folgen auf einen vorzeitigem Blasensprung. Wir untersuchten, ob eine sonographische Zervixlangenmessung bei Frauen mit vorzeitigem Blasensprung eine Identifizierung der Frauen mit einem hohen Risiko einer Fruhgeburt innerhalb der nachsten sieben Tage ermoglicht. Methode: Bei 101 Einlingsschwangerschaften mit vo...
Article
To determine whether sonographic measurement of cervical length in twin pregnancies presenting with threatened preterm labor helps distinguish between true and false labor. In 87 women with twin pregnancies presenting with regular and painful uterine contractions at 24-36 (median, 30) weeks of gestation, cervical length was measured by transvaginal...
Article
When combined with anthracyclines, the humanized anti-HER2 monoclonal antibody trastuzumab (Herceptin) provides significant clinical benefit for women with HER2-overexpressing metastatic breast cancer. However, its use is limited by severe cardiotoxicity. To clarify whether myocardial HER2 and HER4 expression in response to anthracycline exposure a...
Article
The influence a job--including its physical and psychological aspects--has on pregnant woman's chances of delivering prematurely. Seven hundred and seven women who had given birth participated. Statements regarding her job and its stresses were obtained with a standardised questionnaire. Two hundred and thirty-seven of the 707 women delivered prema...
Article
We report the case of a 27-year-old pregnant woman in whom isolated mild fetal cardiomegaly, diagnosed prenatally on sonographic examination at 22 weeks' menstrual age, was the first sign of development of an arteriovenous malformation of the vein of Galen. The arteriovenous malformation was visualized on sonographic examination at 29 weeks' menstr...
Article
Congenital mesoblastic nephroma (CMN) is the most frequent renal tumor of early infancy. Usually benign, CMN is also referred to as leiomyomatous hamartoma or fetal renal hamartoma. However, local recurrence and distant metastasis have been reported, questioning the concept of CMN as a simple hamartoma. Initially, CMN was considered a congenital Wi...
Article
A pseudoaneurysm is an extraluminal collection of blood with turbulent flow that communicates with flowing arterial blood through a defect in the arterial wall. The development of an arterial pseudoaneurysm is a rare but reported complication of pelvic surgery or after vascular trauma. Hormonal and hemodynamic changes are considered the origins of...
Article
This study investigates the influence of epithelial-mesenchymal transition on prognosis in breast cancer. Eighty breast carcinomas as well as 6 breast cancer cell lines were analysed immunohistochemically for the expression of epithelial keratins (K) K8, K19 and mesenchymal vimentin. Protein expression was correlated with histopathological factors...
Article
To evaluate the possible advantages, applications, and usefulness of real-time transabdominal and transvaginal extended field-of-view sonography combined with power Doppler sonography in gynecology. A series of 63 gynecologic patients, referred for preoperative sonographic examination and for whom the examiner thought that extended field-of-view so...
Article
Placenta percreta is a rare obstetric condition associated with potentially life-threatening hemorrhage. Diagnosis in advance of delivery permits a planned delivery and preparation for blood transfusions and planned Cesarean hysterectomy, which is the common treatment. We report a case of placenta percreta in an HIV-positive patient which was diagn...
Article
Einleitung Der Verlust der epithelspezifischen Keratine (K) zugunsten des mesenchymalen Vimentins kennzeichnet einen strukturellen Wandel der Karzinomzelle, welcher zu einer Steigerung der Plastizität und Motilität der Tumorzelle führt. Die Bedeutung dieses Strukturproteinwechsels für die Metastasierung und die Prognose des Mammakarzinoms wurde in...
Article
Introduction: Herceptin™ comprises a powerful treatment option in the therapy of HER2 overexpressing metastatic breast cancer. Significant response rates and survival benefits have been established. Its effectiveness in patients with brain metastases (BM), however, is still questionable, since a considerable number of patients develop brain metasta...
Article
In vitro experiments as well as clinical studies revealed that the expression of keratin 18 (K18) in breast cancer tumors is associated with a favorable prognosis and a less aggressive phenotype of the carcinoma. To prove the principle we transfected the human K18 gene into the aggressive MDA-231 cell line and isolated a permanently overexpressing...
Article
This study was performed to determine the prognostic significance and the biological function of the structure protein keratin 18 (K18) in a group of patients with breast cancer. Paraffin sections from the primary tumors in 80 patients with breast cancer were examined for the expression of K18 by immunohistochemical staining with the monoclonal ant...
Article
Full-text available
This study was performed to determine if keratin 18 (K18) has prognostic significance in breast cancer cell lines and patients with breast carcinoma. Paraffin sections of primary breast carcinoma tumors and human breast carcinoma cell lines were examined for K18 expression by immunohistochemical staining with the monoclonal antibody CK2. K18 protei...

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