Ilja Mihatovic

Heinrich-Heine-Universität Düsseldorf | HHU · Poliklinik für Zahnärztliche Chirurgie und Aufnahme

Objectives: To assess the clinical performance of an equine-derived collagen-containing bone block (CXBB) for lateral alveolar ridge augmentation and staged implant placement. Material and methods: A total of n = 16 patients (16 implants) had received a modified surgical protocol for lateral ridge augmentation using a size-adapted rigidly fixed...

Background To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy. Material and Methods A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino‐bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZ...

Objectives Previous research revealed that autogenous tooth roots may be biologically equivalent to conventional bone grafts for lateral ridge augmentation. However, these analyses were limited to two dimensions, whereas healing is a volumetric process. The present study aimed at volumetrically assessing the microstructure following lateral ridge a...

Background: Whereas stationary stability of implants has been postulated for decades, recent studies suggested a phenomenon termed implant migration. This describes a change in position of implants as a reaction to applied forces while maintaining stability. The underlying biological phenomenon and thus both time- and tension-depending bone remode...

Objectives This study seeks to assess the bone tissue response at experimental zirconia implants in comparison with titanium implants by means of descriptive histology and histomorphometry in a dog model. Materials and methods Experimental zirconia implants with three different surface roughnesses (Z1 < Z2 < Z3) and conventional sandblasted large g...

The cover image, by Ilja Mihatovic et al., is based on the Animal Experiment Periodontally diseased tooth roots used for lateral alveolar ridge augmentation. A proof-of-concept study, DOI: 10.1111/jcpe.12579.

Objectives: To assess the clinical safety and performance of collagenated xenogeneic bone block (CXBB) for lateral alveolar ridge augmentation and two-stage implant placement. Material & methods: In ten patients exhibiting a single-tooth gap, the surgical procedure included the preparation of mucoperiosteal flaps, a rigid fixation of CXBB (Geist...

Objectives: To assess the efficacy of periodontally diseased tooth roots used as autografts for lateral ridge augmentation and two-stage early osseointegration of titanium implants. Material & methods: Ligature-induced periodontitis lesions were established at the maxillary premolars in n=8 foxhounds. Extracted, scaled and root planned premolar...

Objectives: To assess biomechanical, micro-computed tomographic (micro CT) and immunohistochemical characteristics of early osseous integration at titanium implants placed following lateral ridge augmentation using autogenous extracted tooth roots. Material & methods: The roots of healthy maxillary premolars (PM) and retromolar cortical autogeno...

Jüngste experimentelle Daten haben gezeigt, dass extrahierte Zähne/Zahnwurzeln ein strukturelles und biologisches Potenzial besitzen, um als alternative Autotransplantate für die lokalisierte Kiefer-kammaugmentation und zweizeitige Osseointegration von zahnärztlichen Implantaten zu dienen. Dieser Artikel bewertet das biologische Potenzial dieses ne...

Objectives: To assess the efficacy of tooth roots used as autografts for lateral ridge augmentation and two-stage early osseointegration of titanium implants. Material & methods: The maxillary premolars were randomly assigned to either endondontic therapy (PM-E) or were left untreated (PM-C). Retromolar cortical autogenous bone (AB) blocks serve...

The success of ridge preservation techniques in reducing bone resorption is well documented, but no clear guidelines have been provided regarding the type of the biomaterial or technique to be used. This experimental animal study aimed at comparing the effectiveness of two ridge preservation techniques. Following the extraction of the distal roots...

Objectives The present study was conducted to evaluate the bone tissue response after the application of an oily calcium hydroxide suspension (OCHS) into defects created in the tibial bone of minipigs. Materials and methods Standardized defects (2ccm) were created into the tibia of 4 Goettinger minipigs. Defects in the test group (n=4) were filled...

Objective: To assess the superficial cellular population at the healing site after gingival augmentation using a 3D collagen matrix. Method: Primary cell cultures of human gingival tissue from 10 adults with keratinized tissue deficit, which underwent gingival apically positioned flap and coverage with a 3Dcollagen matrix(Geistlich Mucograft,Geis...

Objectives: To histologically evaluate the effectiveness of a porcine derived collagen matrix (CM) and a subepithelial connective tissue graft (CTG) for coverage of localized gingival recessions. Materials and methods: Chronic single Miller Class I-like recessions were created at the buccal at the canines and at the third and fourth premolars in...

Objectives To assess the impact of microgrooved abutments and the insertion depth on crestal bone changes at titanium implants with platform switch.Materials and MethodsA total of n = 3 titanium implants (conical abutment connection) were inserted in each hemimandible of n = 6 foxhounds with the implant shoulder (IS) located at either epicrestal, s...

Objectives To evaluate the impact of plaque accumulation on osseointegration at surface enhanced modified hydrophilic titanium–zirconium (TiZr) alloy and titanium (Ti) implants.Materials and methodsTiZr and Ti implants with a sand-blasted, acid etched, and chemically modified endosseous and a machined (M) transmucosal portion were bilaterally (i.e....

The atrophic alveolar ridge in the posterior mandible remains a challenge for an implant-supported prosthetic rehabilitation due to the location of the inferior alveolar nerve. To ensure implants are placed within bone of sufficient dimension, vertical ridge augmentation is frequently necessary. The presented case discusses an extensive alveolar ri...

The soft tissues around dental implants are enlarged compared with the gingiva because of the longer junctional epithelium and the hemidesmosonal attachments are fewer, suggestive of a poorer quality attachment. Inflammatory infiltrates caused by bacterial colonization of the implant-abutment interface are thought to be one of the factors causing e...

To histologically and immunologically assess experimental peri-implant mucositis at surface enhanced modified (mod) hydrophilic titanium implants. In a split-mouth design (n=6 foxhounds), 4 different implants were inserted on each side of the maxilla: 3 titanium-zirconium alloy implants (TiZr) with either modSLA (sand-blasted, acid etched and chemi...

This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis. At ligature-induced peri-implantitis defects, the intrabony component was filled with a natural bone mineral (NBM), and the supracrestal component was treated by either an equine...

The objective of this study is to evaluate the effects of a paste-like bone substitute material with easy handling properties and improved mechanical stability on periodontal regeneration of intrabony defects in dogs. Mandibular and maxillary first and third premolars were extracted, and three-wall intrabony defects were created on second and fourt...

Aim: The aim of the present study was to investigate the impact of proangiogenic factors [erythropoetin (EPO), human growth hormone (HGH), fibroblast growth factor (FGF), and platelet derived growth factor (PDGF-BB)] on the organization and biodegradation of a porcine-derived collagen matrix (CM) in rats. Material and methods: Collagen matrix sp...

The aim of the present study was to investigate the impact of pen-implant soft tissue dimensions, especially keratinized mucosa, and the occurrence of soft tissue recession after implant uncovering by means of a buccal advancement flap. In the present investigation, 26 patients (14 women and 12 men) between the ages of 35 and 60 years in need of im...

Objectives: This study aimed to immunohistochemically evaluate staged guided bone regeneration and osseointegration of titanium implants using two bone graft substitutes in combination with a polyethylene glycol (PEG) membrane in a dog model. Materials and methods: Saddle-type alveolar ridge defects were prepared in the lower jaws of 12 foxhound...

To histologically evaluate and compare the performance of healing abutments with either hydrophobic or hydrophilic surface properties in humans. According to a parallel-group design, titanium implants placed in the posterior mandible and maxilla of 30 patients were randomly assigned to either (1) hydrophobic machined (M), (2) chemically modified hy...

Aim: The aim of the present study was to evaluate bone formation in vertical ridge augmentations using particulate bone grafting material stabilized by a resorbable polymer. Material and methods: Three vertical defects were created in the maxillary alveolar ridge of six Beagle dogs 3 months after the removal of all premolars. One defect in each...

Objectives To assess the safety and efficacy of a rigid synthetic barrier system in a shell technique for localized alveolar ridge augmentation. Materials and methodsSaddle-type defects (n=4 each) were prepared in the lower jaws of six fox hounds. At two defects, the outer contours were reconstructed using polylactic acid (D and L isomers) (PDDL) p...

Purpose: This case illustrates a pulp tissue-induced dentointegration of a titanium implant. Materials and methods: One commercially available titanium implant with a sand-blasted and acid-etched surface was placed in the maxilla of a foxhound where the palatinal root of the previously (i.e., 8 weeks) removed first molar was unintentionally reta...

Objectives: To histologically assess the effectiveness of a porcine-derived collagen matrix (CM) and a subepithelial connective tissue graft (CTG) for the coverage of single mucosal recessions at osseointegrated dental implants. Materials and methods: Chronic-type mucosal Miller Class I-like recessions (mean clinical defect height: 0.67 ± 0.33-1...

To (i) investigate the influence of different extensions of a laser microgrooved abutment zone on connective tissue attachment and (ii) assess the impact of a repeated abutment dis-/reconnection on soft- and hard-tissue healing. Titanium implants were inserted epicrestally in the lower jaws of six dogs. Healing abutments with either partially (LP)...

To assess the impact of abutment material and dis-/re-connection on soft and hard tissue changes at implants with platform-switching. Titanium implants (n = 12), placed epicrestally in the upper jaws of three dogs, were connected with titanium (Ti) and zirconium dioxide (ZrO(2) ) abutments (horizontal mismatch of 0.4 mm) and randomly allocated in a...

Purpose This is a pilot study which aims to evaluate the accuracy of cone-beam computed tomography (CBCT) to assess the configuration and extent of ligature-induced peri-implantitis defects. Materials and methods Radiographic evaluation of advanced ligature-induced peri-implantitis defects (n = 9) in canine was performed using CBCT (central cross-s...

To evaluate radiological bone level (RBL) (i.e. cone-beam computed tomography) and histological bone levels (HBL) as well as re-osseointegration [bone-to-implant contact (BIC)] after surgical resective (i.e. implantoplasty) and/or regenerative therapy of advanced ligature-induced peri-implantitis in dogs. At all defect sites (n=6 dogs, n=48 implant...

To assess the influence of two barrier membranes and two bone graft substitutes on staged guided bone regeneration and osseointegration of titanium implants in dogs. Saddle-type defects were prepared in the lower jaws of 6 fox hounds and randomly filled with a natural bone mineral (NBM) and a biphasic calcium phosphate (SBC) and allocated to either...

Objectives: To assess the influence of two barrier membranes and two bone graft substitutes mixed with autogenous bone (AB) on staged guided bone regeneration and osseointegration of titanium implants in dogs. Materials and methods: Four saddle-type defects each were prepared in the upper jaw of six fox hounds and randomly filled with a natural bon...

To assess the influence of two barrier membranes and two bone graft substitutes mixed with autogenous bone (AB) on staged guided bone regeneration and osseointegration of titanium implants in dogs. Four saddle-type defects each were prepared in the upper jaw of six fox hounds and randomly filled with a natural bone mineral (NBM)+AB and a biphasic c...

Objectives: The aim of the present study was to histologically evaluate and compare a new prototype collagen type I/III- containing equine- (EB), and a bovine- (BB) derived cancellous bone block in a dog model. Materials and Methods: Four standardized box-shaped defects were bilaterally created at the buccal aspect of the alveolar ridge in the lowe...

To investigate (i) the impact of different titanium implant surfaces on soft tissue integration over 6 months, and (ii) the influence of frequent clinical probing during the healing phase on the established mucosal seal. Standardized clinical probing was randomly performed (12 dogs, probing versus control) at different transmucosal surfaces [machin...

To evaluate (i) the effects of rhPDGF-BB on localized ridge augmentation using a natural bone mineral (NBM), and (ii) the influence of a collagen membrane (CM) on factor activity. Chronic-type alveolar ridge defects (n = 4 dogs) were randomly allocated in a split-mouth design as follows: upper jaw: NBM + rhPDGF-BB + CM (test) vs. NBM + rhPDGF-BB (c...

The present study investigated the effects of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) on initial bone formation following lateral ridge augmentation using biphasic calcium phosphate (BCP) in combination with a native collagen membrane (CM) in dogs. Eight chronic-type mandibular lateral ridge defects in four beagle dogs (two...

To investigate the influence of platform switching on crestal bone level changes at non-submerged titanium implants over a period of 6 months. Titanium implants (n=72) were placed at 0.4 mm above the alveolar crest in the lower jaws of 12 dogs and randomly assigned to either matching or non-matching (circumferential horizontal mismatch of 0.3 mm) h...

The aim of the present study was to investigate the effects of surface hydrophilicity and microtopography on soft and hard tissue integration at non-submerged titanium implants. Implantation of conventional sand-blasted large grit and acid-etched (SLA) and chemically modified SLA (modSLA) titanium implants with differently structured transmucosal s...