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My work focuses on development of propagation-based phase-contrast X-ray imaging, in particular with tomography. Current projects include simulations of clinical imaging and in vivo imaging with laboratory sources. I have also a strong interest in phase-retrieval and quantitative imaging.
Propagation-based phase-contrast X-ray imaging provides high-resolution, dose-efficient images of biological materials. A crucial challenge is quantitative reconstruction, referred to as phase retrieval, of multi-material samples from single-distance, and hence incomplete, data. In this work, the two most promising methods for multi-material sample...
Cellular-Resolution Imaging of Microstructures in Rat Bone using Laboratory Propagation-Based Phase-Contrast X-ray Tomography - Volume 24 Supplement - Ilian Haggmark, Jenny Romell, Susanne Lewin, Caroline Ohman, Hans M. Hertz
Propagation-based phase-contrast X-ray imaging is an emerging technique that can improve dose efficiency in clinical imaging. In silico tools are key to understanding the fundamental imaging mechanisms and develop new applications. Here, due to the coherent nature of the phase-contrast effects, tools based on wave propagation (WP) are preferred ove...
Phase-contrast X-ray lung imaging has broken new ground in preclinical respiratory research by improving contrast at air/tissue interfaces. To minimize blur from respiratory motion, intubation and mechanical ventilation is commonly employed for end-inspiration gated imaging at synchrotrons and in the laboratory. Inevitably, the prospect of ventilat...
Respiratory X-ray imaging enhanced by phase contrast has shown improved airway visualization in animal models. Limitations in current X-ray technology have nevertheless hindered clinical translation, leaving the potential clinical impact an open question. Here, we explore phase-contrast chest radiography in a realistic in silico framework. Specific...
We present a straight-forward strategy for how to process anthropomorphic phantoms to enable simulations of propagation-based phase-contrast X-ray imaging (PBI). PBI requires sampling of a few micrometers which results in few TB of storage for a centimeter-sized model. With long propagation distances the thickness of each material in the X-ray dire...
Biomedical Applications of Multi-Material Phase Retrieval in Propagation-Based Phase-Contrast Imaging - Volume 24 Supplement - Ilian Haggmark, William Vagberg, Hans M. Hertz, Anna Burvall