Ildikó Scheer

Ildikó Scheer

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12
Publications
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135
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Publications

Publications (12)
Article
Full-text available
Background: Elevated APOBEC3B expression in tumours correlates with a kataegic pattern of localised hypermutation. We assessed the cellular phenotypes associated with high-level APOBEC3B expression and the influence of p53 status on these phenotypes using an isogenic system. Methods: We used RNA interference of p53 in cells with inducible APOBEC...
Article
Full-text available
The role of uracil in genomic DNA has been recently re-evaluated. It is now widely accepted to be a physiologically important DNA element in diverse systems from specific phages to antibody maturation and Drosophila development. Further relevant investigations would largely benefit from a novel reliable and fast method to gain quantitative and qual...
Article
Full-text available
Nucleocytoplasmic trafficking of large macromolecules requires an active transport machinery. In many cases, this is initiated by binding of the nuclear localization signal (NLS) peptide of cargo proteins to importin- molecules. Fine orchestration of nucleocytoplasmic trafficking is of particularly high importance for proteins involved in maintenan...
Article
Full-text available
Next generation sequencing technologies led to the discovery of numerous new microbe species in diverse environmental samples. Some of the new species contain genes never encountered before. Some of these genes encode proteins with novel functions, and some of these genes encode proteins that perform some well-known function in a novel way. A tool,...
Article
Phosphorylation adjacent to nuclear localization signals (NLSs) is involved in the regulation of nucleocytoplasmic transport. The nuclear isoform of human dUTPase, an enzyme that is essential for genomic integrity, has been shown to be phosphorylated on a serine residue (Ser11) in the vicinity of its nuclear localization signal; however, the effect...
Article
The nuclear isoform of human dUTPase plays an important role in maintaining genomic integrity. Its expression is strictly cell cycle regulated and is known to be a phosphoprotein in vivo. However, the role of this phosphorylation remained unknown.Here we show regulation of the nuclear transport of human dUTPase via phosphorylation of a serine resid...

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