Ildefonzo Arocha

claret outpatient clinic · medical

La prediabetes es reconocida como un estado metabólico y como un factor predisponente individual a una alta probabilidad de progresar a diabetes en el futuro, personas con prediabetes tienen un riesgo elevado de desarrollar patologías asociadas con esa enfermedad, como retinopatía diabética, neuropatías, nefropatías y complicaciones macrovasculares...

Objectives: Sleep disturbances, including disrupted sleep and short sleep duration, are highly prevalent and are prospectively associated with an increased risk for various chronic diseases, including cardiometabolic, neurodegenerative, and autoimmune diseases. Material and methods: This is a narrative review of the literature based on numerous...

Sedentary behavior is spreading in society, a phenomenon especially aggravated by the rise of modern technology. Sedentary lifestyle habits are being adopted by young people, who increase the time they spend in stationary activities like video games, TV and, most recently handheld digital devices like smartphones and tablets. Today many daily activ...

Sedentary behavior is spreading among society, especially since the rise of technology and progress. The sedentary lifestyle habits are being transmitted to young people, who increase the time they spend in sedentary activities like video games or TV. It has been demonstrated that both sedentary behavior and physical inactivity have negative cardio...

Atherosclerotic cardiovascular disease (ACVD) is the major adverse outcome in the evolution of several metabolic conditions. For around several decades, the cardiovascular continuum has been used as a fantastic tool to explain the evolution of ACVD from the onset of risk factor, to clinical outcomes, and to death. Nowadays, metabolic diseases such...

Resumen La enfermedad cardiovascular aterosclerótica (ECVA) es el principal desenlace de la evolución en una serie de condiciones metabólicas. Desde hace varias décadas, el continuo cardiovascular es una herramienta extraordinaria para explicar la evolución de la ECVA desde el inicio de los factores de riesgo hasta los desenlaces clínicos y la muer...

Cardiovascular risk factors such as arterial hypertension, type 2 diabetes mellitus (DM2) and dyslipidemia are commonly involved with chronic kidney disease (CKD) and its contribution to long-term cardiovascular morbidity. Diffuse endothelial dysfunction and atherosclerosis are believed to be part of the common pathophysiology in diabetic and non-d...

Sedentarism and physical inactivity is highly prevalent globally, and are associated with a wide range of chronic diseases and premature deaths. The interest in sedentary behaviour is justified by a growing body of evidence that points to a relationship between this lifestyle and the increase in the prevalence of obesity, diabetes and cardiovascula...

In the vast majority of cardiovascular diseases (CVDs), there are well-described differences between women and men in epidemiology, pathophysiology, clinical manifestations, effects of therapy, and outcomes. These differences arise on one hand from biological differences among women and men, which are called sex differences, due to differences in g...

Resumen El sedentarismo y la inactividad física son altamente prevalentes globalmente y están asociados a un amplio rango de enfermedades crónicas y muerte prematura. El interés en la conducta sedentaria está justificado por la creciente evidencia que apunta hacia una relación entre esta conducta y el incremento en la prevalencia de obesidad, diabe...

Prevention and treatment of dyslipidemia should therefore be considered as an integral part of individual cardiovascular prevention interventions, which should be addressed primarily to those at higher risk who will benefit most. Statins are the most commonly used options for the pharmacologic treatment of dyslipidemia. In recent decades, numerous...

El tratamiento actual dirigido a retardar la progresión de la enfermedad renal diabética, incluye un control intensivo de la glucemia con control óptimo de la hipertensión arterial, bloqueo del sistema renina-angiotensina-aldosterona junto a otras intervenciones multifactoriales. Sin embargo, la protección renal, a pesar de éstas medidas, no se alc...

El déficit de hierro con o sin anemia está siendo reconocido cada vez más como una comorbilidad importante en los pacientes con insuficiencia cardíaca (IC). Aunque la deficiencia de hierro es fácilmente diagnosticada por medio de dos marcadores (ferritina sérica y saturación de transferrina), es subdiagnosticada en estos pacientes y pudiera afectar...

The current approach to the management of hypertension has not provided us with the desired results. The use of combination therapy as frst line treatment, or much earlier treatment in the course of treating hypertension, appears to be much more effcient than the stepped care approach. The use of combination therapy will provide greater effcacy, fe...

Effective blood pressure therapy is a central health goal, although several studies worldwide show inacceptable control rates. Lack of patient compliance is a major factor responsible for the differences between clinical trials results and real effectiveness in daily medical practice, contributing to an insuffcient control of the cardiovascular ris...

The association of triglycerides with the incidence of cardiovascular disease remains controversial; however, the evidence that elevated serum triglyceride levels are associated with increased risk for atherosclerotic events is increasing. Elevated nonfasting triglyceride levels indicate the presence of residual lipoproteins, which may promote athe...

N-3 polyunsaturated fatty acids (n-3 PUFA) have effects on diverse physiological processes impacting normal health and chronic disease, such as regulation of plasma lipid levels, cardiovascular and immune function. During the past 20 years there has been renewed interest in fish meat and fish oil, rich sources of n-3 PUFA, which have sparked intens...

Omega -3 fatty acids have demonstrated risk reduction of coronary artery disease. However, it is not clear if this effect is only associated to the antiatherogenic properties of this kind of essential fatty acids. Potential mechanisms of action of omega-3 fatty acids are the following: antiarrythmic effect, reduction of thrombogenesis, endothelial...

First studies concerning long chain fatty acids: elcosapentanolc (EPA) and docosahexanoic (DHA) were done in Greenland Esquimos, because this population showed a low incidence of coronary heart disease. Omega-3 fatty acids are polyunsaturated and can not be synthetized by human cells. Omega-6 fatty acids, such as linoleic, are regularly found In oi...

Introduction and objectives Moderate-to-severehypertension is less prevalent than mild hypertension,but it is responsible for more incidences ofcomplications. Its complex treatment requires severaldrugs, and is often inadequate. This studyassessed the efficacy and safety of nifedipine GITS(oral release osmotic system) as monotherapy, inaddition to...

Moderate-to-severe hypertension is less prevalent than mild hypertension, but it is responsible for more incidences of complications. Its complex treatment requires several drugs, and is often inadequate. This study assessed the efficacy and safety of nifedipine GITS (oral release osmotic system) as monotherapy, in addition to the effects on left v...

Dopamine is synthetized and excreted by kidneys, this amine exerts its natriuretic and diuretic effects by inhibition of sodium reabsorption on kidney convoluted tubules. The objective of this study was to verify the changes of dopamine urinary excretion induced by nifedipine-LP treatment in hypertensive patients. Twenty four patients with essentia...

To determine whether the calcium channel blocker nitrendipine improves glucose tolerance, lowers circulating insulin, and raises serum dehydroepiandrosterone sulfate (DHEA-S) levels in insulin-resistant men, a total of 15 obese and hypertensive men were enrolled in a single blind, placebo-controlled study. A nitrendipine group (n = 8) and a placebo...

To determine whether the calcium channel blocker nitrendipine improves glucose tolerance, lowers circulating insulin, and raises serum dehydroepiandrosterone sulfate (DHEA-S) levels in insulin-resistant men, a total of 15 obese and hypertensive men were enrolled in a single blind, placebo-controlled study. A nitrendipine group (n = 8) and a placebo...

The purpose of the study was to define the relationship between the salt intake and the levels of arterial blood pressure in adolescent people. Seventy-eight youngs between 12 and 18 years old with diastolic/systolic blood pressure above 95 percentile formed the hypertensive group; a similar population with the same characteristic (age, sex, race,...

Nitrendipine (NIT), a new potent calcium channel blocking agent, was administered to a patient with essential severe (191/119 mm Hg), refractory, and resistant hypertension (HT) to conventional triple drug regime. Three previous pregnancies had been unsuccessful in the past 4 years because of uncontrollable HT and repeated hypertensive crises. NIT...

The antihypertensive efficacy of once-daily nitrendipine was studied in 18 patients with severe, resistant, refractory, and complicated hypertension. The dose range was 20-120 mg/day adjusted weekly for a total treatment period of 3 years. Nitrendipine produced a significant reduction in blood pressure compared to pretreatment baseline values with...

The antihypertensive efficacy of once-daily nitrendipine was studied in 18 patients with severe. resistant. refractory. and complicated hypertension. The dose range was 20-120 mg/day adjusted weekly for a total treatment period of 3 years. Nitrendipine produced a significant reduction in blood pressure compared to pretreatment baseline values with...

RESUMEN En este articulo de revisión se exponen los planteamientos del uso e indicaciones actuales de las pruebas de cardiología nuclear. Siendo un método incruento, por la fidelidad de sus resultados y fácil reproducibilidad ha ganado un amplio prestigio en el campo de la investigación clínica. Se revisan los procedimientos y sus resultados. SUMMA...

Incluye bibliografía

Mecanografiado Tesis (Dr. en Medicina)-- Universidad de Los Andes, Facultad de Medicina, Escuela de Medicina, Mérida, [196?]