Ilaria Cuomo

Ilaria Cuomo
Sapienza University of Rome | la sapienza · Department of Neuroscience, Mental Health and Sense Organs NESMOS

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38
Publications
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291
Citations

Publications

Publications (38)
Article
Background Treatment-resistance in schizophrenia is 30–40%. Its neurobiology remains unclear; to explore it, we conducted a combined spectrometry/tractography/cognitive battery and psychopathological rating study on patients with treatment-resistant schizophrenia (TRS), dividing the sample into early-onset (N = 21) and adult-onset TRS (N = 20). Pre...
Article
Background: Age-at-onset (AAO) affects psychiatric disorder outcome; substance (SUDs) or alcohol use disorders (AUDs) may influence their onset. Affective temperaments may affect early AAO and drug-use proneness. Objectives: To investigate whether SUD/AUD moderated temperamental effects in determining AAO of mental disorders. Methods: We included...
Article
Background Major Depressive Episodes (MDEs) may characterise many psychiatric disorders. Its pharmacotherapy is laid with unmet needs, rendering the testing of new drugs necessary. Objective To compare the effects of vortioxetine with those of other antidepressants (OADs) in a 1-year naturalistic setting. Methods We included 126 adult patients wi...
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Background: Long-acting injectable (LAI) aripiprazole was found to be efficacious in schizophrenia. In common clinical practice, the use of LAIs is often restricted to chronic patients with frequent relapses and poor adherence. Recently, some investigators advanced the idea of early LAI use also in young people with schizophrenia at their first psy...
Article
Background Several second-generation antipsychotics (SGAs) are available in long-acting injectable (LAI) formulations. Objective To systematically review the effects of the two formulations, Monohydrate and Lauroxil, of Aripiprazole LAI in patients with schizophrenia and bipolar disorder during an acute episode or during maintenance treatment. Me...
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Background: Placebo response appears to be increasing in antidepressant, antipsychotic and various internal medicine trials. A similar trend has been reported for OCD during 1989-1999. Placebo response is generally considered as the extent to which placebo treatment is associated with core symptom improvement. In this analysis we used Joinpoint re...
Article
Aim Bipolar disorder (BD) is often treated with anticonvulsants. Lacosamide has not been tested in BD. We assessed its effects in a hospital setting in patients with BD without epilepsy. Method We treated with lacosamide 50‐300 mg/day 102 consecutive hospitalised patients with acute BD. We compared this sample with a retrospective sample treated w...
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Background: To overcome nonadherence in patients with psychosis switch to long-acting injectable (LAI) antipsychotic formulations is adopted. Most oral versus LAI comparisons showed similar antipsychotic responses. Psychoses often overlap with substance use disorder (SUD). Head-to-head LAI comparisons have hitherto focused only on non-comorbid pop...
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Background and aim of the work: Mood disorders are often complicated by comorbidity with epilepsy. Anxiety and personality disorders may worsen prognosis and treatment outcome. Lacosamide has been recently introduced as adjunctive treatment for partial epilepsy. Its mechanism consists of selective slow inactivation of voltage-gated sodium channels...
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Background: Asenapine is a second-generation antipsychotic approved in Europe for treating moderate-to-severe manic episodes in adults affected by type I bipolar disorder (BD-I). We aimed to compare its efficacy in psychiatric inpatients with BD-I, with or without substance use disorder (SUD). Methods: We administered flexible asenapine doses ra...
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Background: Athanasios Koukopoulos proposed the primacy of mania hypothesis (PoM) in a 2006 book chapter and later, in two peer-reviewed papers with Nassir Ghaemi and other collaborators. This hypothesis supports that in bipolar disorder, mania leads to depression, while depression does not lead to mania. Objective: To identify evidence in liter...
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A 24-year old woman with multisubstance use since the age of 13, including opioids and cocaine, and long-standing HIV/HCV seropositivity status, presented with psychosis, agitation, and insomnia at the emergency department of a university hospital. She had been abusive and physically aggressive frequently without specific reasons and was involved i...
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Objectives: The aim of this study was to identify hiccup cases among patients hospitalized in a psychiatric ward and focus on their treatment, so to establish intervention risk. Methods: We reviewed records of 354 consecutively admitted patients during the year 2013 to identify hiccup cases. Results: Hiccup occurred in 7 patients on both aripi...
Article
Introduction Asenapine is a second-generation antipsychotic approved in Europe for the treatment of moderate to severe manic episodes in adults affected by Bipolar Disorder I (BD I). Aims We aimed to assess the efficacy of asenapine in controlling manic, mixed and/or depressive symptoms in an inpatient psychiatric population. Methods A total of 1...
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Full-text available
Recent literature based on peripheral immunity findings speculated that neuroinflammation, with its connection to microglial activation, is linked to bipolar disorder. The endorsement of the neuroinflammatory hypotheses of bipolar disorder requires the demonstration of causality, which requires longitudinal studies. We aimed to review the evidence...
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To review the role of Wnt pathways in the neurodevelopment of schizophrenia. SYSTEMATIC PUBMED SEARCH, USING AS KEYWORDS ALL THE TERMS RELATED TO THE WNT PATHWAYS AND CROSSING THEM WITH EACH OF THE FOLLOWING AREAS: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action. Neuro...
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To assess acute efficacy and safety of 9.75 mg of intramuscular (IM) injections of the atypical antipsychiatric aripiprazole in patients with schizophrenia or bipolar disorder and acute agitation. Open-label trial of IM injections of aripiprazole and 24-hour monitoring of clinical response in patients with major psychoses and acute agitation. Parti...
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Pathological gambling behaviour is a side effect of dopaminergic drugs used in Parkinson's disease, but has seldom been reported with selective serotonin reuptake inhibitors. A 58-years-old woman with somatisation disorder since the age of 20 and recent-onset major depression (at 54 years) received 40 mg/day intravenous citalopram, thereafter switc...
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A young woman with bipolar I disorder and comorbid catatonia on enteral nutrition from several months, developed a form of near-lethal catatonia with weight loss, pressure sores, muscle atrophy, electrolyte imbalance, and depression of vital signs. A compulsory treatment was necessary, and informed consent was obtained from her mother for electroco...
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A Caucasian, male, young adult with recurrent agitated depression and suicidal ideation received lithium and oral olanzapine. His white blood cell count was normal at that time. Due to unsatisfactory response, he received 4 mg/day risperidone. While symptoms improved, leukopenia emerged, specifically directed towards neutrophils. Upon risperidone d...
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Current liquid chromatographic tandem mass spectrometry (LC-MS/MS) methods to measure serum levels of aripiprazole (Ar) and dehydroaripiprazole (DHAr) are sensitive, but difficult to use in a hospital context. We aimed to develop a rapid LC-MS/MS method allowing reliable level measurement in the presence of co-administered drugs, withdrawing sample...
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Suicidal behavior in peacekeepers is not well documented because only a few articles have investigated this field. These articles suggest that mental health problems represent the most important risk factor for suicide. The risk factors for suicide in peacekeepers can be divided into: (1) before deployment, such as parental psychosocial problems an...
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Congestive heart failure (CHF) and hypertension are prevalent diseases with high mortality and morbidity rates. Depression and anxiety are frequently associated with cardiovascular diseases. This observational cross-sectional study assessed depression, anxiety, suicidality, and quality of life in 240 patients with CHF (with or without hypertension)...
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Objective: The aims of this study were to assess the personal and clinical features of a sample of patients with schizophrenia who had made highly lethal suicide attempts. Method: Participants were 39 inpatients with schizophrenia, 18 of whom had made a high lethality suicide attempt in the six month period before assessment, while the others had n...
Chapter
Depression strongly affects the quality of life of patients with heart diseases. Mood disorders in general, together with chronic medical conditions, result in a unique and additional impairment of patient functioning. Depression also increases the risk of morbidity and mortality related to cardiac disorders and may play an important role in the de...
Chapter
Suicidal behavior in peacekeepers is not well documented because only a few articles have investigated this field. These articles suggest that mental health problems represent the most important risk factor for suicide. The risk factors for suicide in peacekeepers can be divided into: (1) before deployment, such as parental psychosocial problems an...
Article
Full-text available
The goals of this study were to assess the validity and usefulness of a new scale and to assess disability in a sample of patients with chronic daily headache. Participants were a convenience sample of 61 adult outpatients admitted to the Department of Medical Sciences of the Sant’Andrea Hospital in Rome, between September 2007 and May 2008. Inclus...

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