Igor Tomašković

Igor Tomašković
University Clinical Hospital Center "Sestre Milosrdnice" · Department of Urology

Ph.D

About

62
Publications
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168
Citations

Publications

Publications (62)
Article
Background: Patient factors associated with urinary tract cancer can be used to risk stratify patients referred with haematuria, prioritising those with a higher risk of cancer for prompt investigation. Objective: To develop a prediction model for urinary tract cancer in patients referred with haematuria. Design, setting, and participants: A p...
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p>This review aims to emphasize new insights into the diagnosis, classification, and therapy of bladder cancer (BC). Bladder cancer is a heterogeneous, complex disease on a morphological, molecular, diagnostic, and prognostic level. Cancer stage is still the most important attribute for prognosis and treatment, while early detection with optimal an...
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Objective: To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer (UTUC) and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. Patients and methods: This was an international multicentre prospectiv...
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Adherence to national and international clinical practice guidelines is suboptimal throughout Europe. The European Association of Urology Guidelines Office project "IMAGINE" (IMpact Assessment of Guidelines Implementation and Education) has been developed to measure baseline adherence to urological guideline recommendations across Europe and to ide...
Article
Prostate cancer treatment during the COVID-19 pandemic underwent, as was the case with other diseases, significant changes. The uniqueness of this situation is reflected in the fact that the whole world has been affected and that healthcare systems, including care for cancer patients, was forced to adapt to the new situation. The availability of fa...
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Changes in the diagnostic pathway for prostate cancer advised in the most recent Guidelines of the European Association of Urology bring many endeavors for everyday practice. Availability, costs and radiological expertise are still representing a challenge for the adoption of these guidelines in everyday clinical practice. In this article we discus...
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This study investigated the influence of refugee status on the occurrence of enuresis. It was performed among school children aged 6 to 11 years and their parents in the Vukovarsko-srijemska County (eastern Croatia), which had many displaced persons and refugees (mostly women and children) in the 1990s due to the wars in Croatia and Bosnia and Herz...
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The Department of Urology at the Sestre milosrdnice University Hospital Center is the oldest urological institution in the Republic of Croatia and this part of Europe. Today, the Department is a modern tertiary healthcare institution, where the most complex methods of urological practice are performed using modern medical devices and highly sophist...
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Multiparametric magnetic resonance is assuming an increasingly important role in the diagnosis, initial assessment and monitoring of patients with prostate cancer. This paper offers a more complex insight into the application of magnetic resonance imaging with prostate cancer, with a current literature overview. The focus is on the problem of initi...
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The aim of this prospective clinical study was to determine the detection rate of prostate cancers by multiparametric magnetic resonance and transrectal ultrasound (mpMRI-TRUS) cognitive fusion biopsies in patients with a previously negative TRUS-guided biopsy. Between 1 October 2016 and 1 July 2017, in 101 consecutive patients with elevated antige...
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The history of Croatian urology clearly shows its affiliation to the medical and civilizational circle of the Western world. The Department of Urology at the Sestre milosrdnice University Hospital Center is the oldest urology institution in the Republic of Croatia. The Department was established in 1894, when the new Sestre milosrdnice Hospital was...
Article
The aim of this study was to determine the incidence of incidental prostate cancer and its clinical significance among patients who underwent transurethral prostate resection or transvesical adenomectomy for benign prostate hyperplasia at the Department of Urology in Sestre milosrdnice University Hospital Center from January 1997 to December 2017....
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Pelvic lymph node dissection (PLND) during radical prostatectomy (RP) is the most accurate staging modality for lymph node assessment in patients with prostate cancer. It is recommended in all patients with intermediate or high-risk disease undergoing radical prostatectomy. The goal of our study was to assess unfavorable clinicopathological charact...
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One of the main reasons for the introduction of a new grading system was Gleason sum 7, which differed significantly in the prognosis of the disease depending on the primary Gleason. The aim of this study was to compare grade group 2 and grade group 3, and the impact of cancer percentages in final pathology reports after radical prostatectomy on th...
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Prostate cancer represents a significant public health burden in Croatia, as well as in other developed countries. The aim of this paper was to present the current epidemiological situation in Croatia in comparison to other similar countries, using basic indicators such as incidence, mortality, prevalence and survival, and to discuss future possibi...
Article
Prostatic artery embolization is a minimally invasive endovascular treatment that improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Although further randomized studies and long-term evidence is still needed for this method to be fully incorporated into treatment guidelines for benign prostatic hyperplasia, current stud...
Article
The objective of this study was to determine differential expression of TFF1, TFF2 and TFF3 genes and proteins in breast tumor subtypes. In addition, we investigated the correlation between TFF genes within tumor subgroups, and TFF genes with clinical and pathologic characteristics of the tumor. Study group included 122 patients with surgically rem...
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Percutaneous ablative techniques under imaging guidance have become a frequently used treatment method in the therapy of primary T1a or secondary renal tumours, especially in patients who were burdened with comorbidities and are not surgical candidates. Radiofrequency ablation with single or multiple electrodes has been the primary ablative techniq...
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INTRODUCTION & OBJECTIVES: Bellini duct carcinoma represents one of the most aggressive carcinomas in urology. High percentage of metastatic disease at time of diagnosis and very poor outcomes have been reported in several studies. Primary treatment remains, as with all kidney cancers, surgical but adjuvant therapy is needed more often than in kidn...
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Introduction: The interchanged stromal-epithelial relations and altered expression profiles of various extracellular matrix (ECM) proteins creates a suitable microenvironment for cancer development and growth. We support the opinion that remodeling of the extracellular matrix (ECM) plays an important role in the cancer progression. The aim of this...
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The aim of this study was to assess the Croatian urologists’ management of non-neurogenic male lower urinary tract symptoms (LUTS) and their compliance with the European Association of Urology (EAU) guidelines. A cross-sectional survey included 51/179 Croatian urologists. We developed a questionnaire with questions addressing compliance with EAU gu...
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The widely used screening for prostate cancer with prostate specific antigen has resulted in identification of potentially lethal prostate cancers at a much more curable stage and has been associated with significant falls in prostate cancer mortality. In spite of the fact that prostate cancer is one of the deadliest malignancies in men, the advent...
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Endometrial cancer is the most common gynecological cancer but there is no economically justified screening method. Although we can detect endometrial cells in the sample using PAP test, many studies show low sensitivity and positive predictive value of PAP test for the diagnosis of endometrial cancer. The goal of this research was to determine sig...
Article
Only few reports validated contemporary Epstein criteria for insignificant prostate cancer, and only one being from Europe. Patients with insignificant prostate cancer should be offered active surveillance and spared radical treatment. In our study we tested Epstein biopsy criteria for predicting unfavorable final pathology and biochemical relapse...
Article
In this prospective study we examined the utility of parameters obtained on prostate needle biopsy and prostate specific antigen-alpha(1)-antichymotripsine complex (PSA-ACT) to predict adverse pathologic findings after radical prostatectomy. 45 consecutive patients assigned for radical prostatectomy due to clinically localized prostate cancer were...
Article
The aim of our study was to evaluate the impact of margin positivity in clinically and pathologically localized prostate cancer (pT2) after radical prostatectomy on biochemical recurrence and time to adjuvant treatment. We analyzed data from 371 patients who underwent radical prostatectomy. At the mean follow up of 36 (25-54) months, impact of marg...
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Conference Paper
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Liječenje lokaliziranog raka prostate radikalnom prostatektomijom doživjelo je posljednjih dvadesetak godina dramatičan porast. Unatoč napretku u kirurškoj tehnici i smanjenju ranih i kasnih postoperativnih komplikacija i dalje je prisutan dio bolesnika u kojih perzistira stresna inkontinencija urina. Većina pacijenata podvrgnutih radikalnoj prost...
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According to WHO tumor classification histological subtypes of renal cell carcinoma are clear cell, papillary and chromophobe carcinoma. Carcinomas that do not fit readily into one of the categories should be assigned as unclassified. In recent literature new and emerging entities are described; follicular, clear cell papillary and cystic, oncocyti...
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There is a well-documented relationship between urinary bladder diverticula and intradiverticular neoplasms. The great majorities of these tumors are urothelial carcinomas, but may also be of glandular or squamous type. Sarcomas occurring within bladder diverticula are exceptionally rare and highly malignant lesions, with only 20 well documented ca...
Article
Introduction & objectives: The aim of the study was to determine whether the total percentage of carcinoma in needle core biopsy and localization of carcinoma in the prostate could be used as reliable predictors of biochemical relapse (BCR) in patients treated with radical prostatectomy.
Article
Unlabelled: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) represents the most common form of prostatitis. No known etiology factor in most cases can be found. It is possible that at least in some cases autoimmune response could be causative factor. Common treatment options include antibiotics, alpha blockers, myorelaxants, phytotherap...
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Serum levels of total prostate specific antigen (t-PSA) and PSA complexed to antichymotrypsin (PSA-ACT), as well as their corresponding density parameters were measured in prostate cancer (PC) candidates for radical prostatectomy. In these patients blood Chromogranin A (CgA) values were also recorded. The PSA-ACT recordings in presurgically charact...
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Arterial fibromuscular dysplasia (FMD) is a noninflammatory, nonatherosclerotic, occlusive condition of the systemic arteries, most frequently affecting renal arteries. Renal cell carcinoma (RCC) might be associated with arterial hypertension; however, there are no data in the literature regarding the relationship between RCC and associated renal a...
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Radical prostatectomy is a treatment of choice for localized prostatic adenocarcinoma. In most cases, radical prostatectomy is combined with pelvic lymph node dissection. During the last decade, the necessity to perform lymphadenectomy in all patients has been questioned. Lymph node dissection adds the risk of complications, and increases operation...
Article
To determine differences in systemic stress responses in patients undergoing three different types of surgery for benign prostatic hyperplasia (BPH), evaluated by measuring levels of stress variables, i.e. cortisol; acute-phase reactants, i.e. C-reactive protein (CRP) and fibrinogen; and antioxidants, i.e. total antioxidant status (TAS) and superox...
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The aim of the study was to analyze age distribution in patients undergoing early diagnosis procedures within the scope of the prostate cancer program, and to compare diagnostic accuracy of total prostate specific antigen (tPSA) test and age specific PSA range test in differentiating prostate cancer from benign prostate hyperplasia in order to redu...
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-Prostate cancer and its management have assumed increasing prominence amongst both urologists and the lay public over the past decades. fu a result of the heightened patient awareness of the disease, increased life expectancy, improved diagnostic techniques and screening procedures, prostate can-cer has become rhe mosr common neoplasm diagnosed in...
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Primary extragonadal germ cell tumors are rare neoplasms affecting young males. They usually present with abdominal retroperitoneal, mediastinal mass with varying symptoms. The rarest among these rare extragonadal germ cell tumors are embryonal cell carcinomas. Three cases of embryonal cell carcinomas are presented to show that the clinical present...
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Long term efficacy of transurethral incision of the prostate (TUIP) was evaluated in selected patients. A total of 50 patients with symptoms of bladder outlet obstruction caused by smaller benign prostates (estimated weight 30 g or less) were assigned to TUIP. Bilateral incision at "5 and 7" o'clock position was performed in all patients. Preoperat...
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The aim of the study was to compare Gleason scores obtained from sextant preoperative prostate biopsy and radical prostatectomy specimens in patients with localized prostate cancer. Seventy-three patients with prostate biopsy and operated on at our hospital from 2000 till 2002 were included in the study. Definitive postprostatectomy Gleason score w...
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A case is reported of metastatic renal cell carcinoma in the wall of the small bowel. The patient presented with abdominal pain, hematuria and fever. Exploration during radical nephrectomy revealed a metastatic tumor into the small bowel, which was resected at once. Pathologic examination showed stage T4N2M1 renal cell carcinoma, nuclear grade G4,...
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A patient with adenocarcinoma of the prostate metastatic to the left ureter, who had undergone bilateral orchiectomy six months before, is presented. His medical history included transurethral resection of the prostate gland two years before, when the histopathologic examination showed benign prostate hypertrophy. Dissection of the left ureter show...
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To analyze long-term effects of short and shallow incision of the prostate, a new modification of transurethral incision of the prostate (TUIP), as a method of resolving bladder outlet obstruction and preserving anterograde ejaculation and potency. Fifty patients with symptoms of bladder outlet obstruction caused by a small benign prostate tumor of...
Article
Objective: We report a case that we believe to be the largest example of a testicular mixed germ cell tumor with a clearly defined histology pattern. Clinical presentation and interventions: A 21-year-old patient consulted a urologist concerning a giant testicular mass. At the time of presentation the tumor measured 29 x 20 x 16 cm, with a weigh...

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