
Igor SaveljicInstitute for information technologies Kragujevac
Igor Saveljic
PHD
About
120
Publications
15,083
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586
Citations
Introduction
Additional affiliations
October 2010 - present
Position
- Scientific Associate
Education
December 2010 - September 2016
Faculty of engineering, University of Kragujevac
Field of study
- Applied mechanics
October 2002 - April 2009
Faculty of engineering, University of Kragujevac
Field of study
- Applied mechanics
Publications
Publications (120)
Background:
Fractional flow reserve (FFR) determined invasively has been globally accepted as the gold standard for determining the functional significance of coronary artery stenoses. However, despite its great importance, the invasive method has certain disadvantages, including the risk of vascular injuries, the need for vasodilation, and signif...
Cardiovascular diseases (CVDs) are a leading cause of death. If not treated in a timely manner, cardiovascular diseases can cause a plethora of major life complications that can include disability and a loss of the ability to work. Globally, acute myocardial infarction (AMI) is responsible for about 3 million deaths a year. The development of strat...
Invasively determined Fractional Flow Reserve (FFR) has been recognized as a reliable tool for assessing coronary artery stenosis severity. Since the invasive method is associated with a risk of vessel injury due to pressure wire manipulation several non-invasive techniques have been developed. The objective of this paper is to propose an alternati...
Background
To assess the effectiveness of inhalation therapy, it is important to evaluate the lungs' structure; thus, visualization of the entire lungs at the level of the alveoli is necessary. To achieve this goal, the applied visualization technique must satisfy the following two conditions simultaneously: (1) it has to obtain images of the entir...
Driving comfort is one of the important factors for vehicle users. There is a lot of research related to comfort or discomfort in a vehicle but there is still no well-defined way to assess it accurately. In this paper, an assessment of vehicle comfort during fore-and-aft random vibrations was made based on measured and predicted r.m.s. acceleration...
Background:
The fractional flow reserve (FFR) index has been widely accepted as a standard diagnostic method for identifying functional relevance of coronary stenosis. Since the invasive techniques used for its determination are associated with a certain risk of vascular injury, as well as with an increased cost, several non-invasive procedures ha...
Hypertrophic cardiomyopathy is a congenital or acquired disorder of the heart muscle, which is clinically manifested by symmetrical or asymmetric hypertrophy of the left and/or right ventricle in the absence of any other cause of hypertrophy. The goal of this research was to develop a finite element model of the electrical activity of the heart emb...
The human body, as a complex biomechanical system, is daily exposed to oscillatory movements. Vibrations are observed as small displacements of points compared to the dimensions of the system. The body's sensitivity to vibration depends on many factors, such as body position, muscle tension, frequency, amplitude, and direction of vibration. Comfort...
Heart diseases are the leading cause of death in both developed and developing countries. Practically, they are so widespread that it is increasingly difficult to find the part of the planet where the population is protected from these diseases. Aortic dissection is a serious medical condition in which the inner layer of the aortic wall ruptures. T...
Stent implanation is one of the clinical treatments of stenotic arteries. This clinical procedure requires careful planning that considers the geometry of the artery of the particular patient. The numerical simulation can be very useful to analyze the state of the arterial wall during and after this intervention. The numerical model considered with...
Vibrations and vehicles reduce the comfort of drivers and passengers, causing stress, fatigue and discomfort. Chronic exposure to whole body vibration can affect the lumbar spine, the gastrointestinal system, the peripheral veins and the vestibular system. Until recently, it was possible to study the semicircular canals geometry only in cadaveric s...
Background and Objectives
: Stent implantation procedure should be carefully planned and adapted to the particular patient in order to minimize possible complications. Numerical simulations can provide useful quantitative data about the state of the artery after the implantation, as well as information about the benefits of the intervention from th...
Arterial stenosis is the obstruction of normal blood flow that is caused by atherosclerosis. One of the endovascular treatment procedures in this case is the implantation of a stent to restore the blood flow. This study presented an improved numerical model that can precisely simulate the deformation of human arterial wall in coronary arteries, dur...
A unique feature of COVID-19 interstitial pneumonia is an abrupt progression to respiratory failure. Our calculation shows that this abrupt deteriorate may be caused by a sudden shift in the spread of virus-laden bioaerosols through the airways to many different regions of the lungs from the initial site of infection.
With a fast progression of computational methods and medical imaging techniques, the advanced simulations of carotid arteries can be approached aiming to address different medical conditions and support the clinical practice. Within this context, the main purpose of this study was to computationally model the biological and mechanical processes rel...
The main purpose of this study was to computationally examine the hemodynamic parameters of plaque progression within carotid artery, such as wall shear stress and plaque concentration. The 3D finite element mesh was created for a patient-specific anatomical geometry which was reconstructed on the basis of computed tomography (CT) scan images. The...
Today, endovascular prosthesis—stents are used as a solution for treating many health disorders and diseases. Their major application is found in treating cardiovascular diseases. One of the problems in stent implantation is a process called in stent restenosis (ISR). In the pre-stent era, the occurrence of restenosis ranged between 32 and 55% of a...
Atherosclerosis is a disease of arterial blood vessels characterized by the accumulation of lipids in the arterial wall, starting with endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. In this study, using DICOM images, a numerical model of atherosclerosis progression was developed. Fluid domain (blood...
The balance system is called a labyrinth and it consists of three mutually orthogonal canals, called semicircular canals (SCCs). The SCCs are filled with a fluid called endolymph, and each canal has a cupula that is deformed by the endolymph flow. One of the balance disorders is called benign paroxysmal positional vertigo, and one of the pathologic...
Background and objective:
One of the most widely adopted endovascular treatment procedures is the stent implantation. The effectiveness of the treatment depends on the appropriate stent expansion. However, it is difficult to accurately predict the outcome of such an endovascular intervention. Numerical simulations represent a useful tool to study...
In this chapter we described predictive model for plaque formation and progression in the coronary and carotid artery. A full three-dimensional model for plaque formation and progression, coupled with blood flow and LDL concentration is analysed. The Navier-Stokes equations together with the Darcy law for model blood filtration and Kedem-Katchalsky...
In this study a patient-specific computer model of stent deployment into the human stenosed coronary arteries is developed. The model is also able to predict atherosclerosis growing in the artery after stent deployment. We analyse shape post-implantation, possible damages to the endothelium as well as the effects of the stenting on the vessel wall,...
Coronary artery disease or coronary atherosclerosis (CATS) is the most common type of cardiovascular disease and the number one cause of death worldwide. Early identification of patients who will develop progression of disease is beneficial for treatment planning and adopting the strategy for reduction of risk factors that could cause future cardia...
The inflammation and lipid accumulation in the arterial wall represents a progressive disease known as atherosclerosis. In this study, a numerical model of atherosclerosis progression was developed. The wall shear stress (WSS) and blood analysis data have a big influence on the development of this disease. The real geometry of patients, and the blo...
Geometry of the bioreactor was created on the basis of the existing literature. Flow of the fluid, containing the monocyte cells, through the bioreactor was analysed. The model was created with open solver PAK and solved with the finite element method, as well as with commercial software ANSYS. The obtained results were compared between the solvers...
Atherosclerosis is a leading cause of mortality in the all developed countries. This disease begins with endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. Interaction between the blood and the plaque can lead to plaque rupture. An important hemodynamic parameter in interaction between fluid and vessel...
Atherosclerosis is a disease of arterial blood vessels characterized by the accumulation of lipids in the arterial wall. Mechanical forces such as low shear stress are implicated in plaque formation and development. Using DICOM images, 3D models of human right coronary artery (RCA) were developed. This paper studies influence of wall shear stress (...
In this study we analysed computational model
for plaque development and validation with clinical study.
Mass transfer within the blood lumen and through the arterial
wall was coupled with the blood flow. Plaque progression was
modeled using three additional reactiondiffusion partial differential
equations. The results for plaque concentration for...
Benign Paroxysmal Positional Vertigo (BPPV) is the most common vestibular disorder. In this paper we tried to investigate a model of the semi-circular canal (SCC) with parametrically defined dimension and full 3D three SCC from patient-specific 3D reconstruction. Full Navier-Stokes equations and continuity equations are used for fluid domain with A...
In this study stent deployment modeling with plaque formation and pro- gression for specific patient in the coronary arteries are described. State of the art method for the reported investigations of blood flow in the stented arteries is described. In the met- hod section, image segmentation method for arteries with stent is shortly described. Bloo...
In this study, experimental electroporation model with human aorta tissue is compared with computational modeling. The segments in native state of the aorta are treated by electroporation method through a series of electrical impulses from 50 to 2500 V/cm. The Pennes Bioheat equation is used to solve heat transfer problems. Different conductivity v...
In this chapter a complex problem of stent deployment with plaque formation and progression for specific patient in coronary arteries is described. Stent enables widening of the stenosed part of the blood vessel. We firstly describe state of the art for blood flow in the stented arteries. Blood flow simulation is described by Navier-Stokes and cont...
Benign Paroxysmal Positional Vertigo (BPPV) is most common vestibular disorder which becomes from the presence of basophilic particles in the semicircular canals (SCC). Three-dimensional biomechanical model of the SCC is described with full 3D fluid-structure interaction of particles, wall, cupula deformation and endolymph fluid flow. The model of...
Atherosclerosis is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall. Determination of plaque location and plaque volume for a specific patient is very important for prediction of atherosclerotic disease progression. In this study coupled computer modeling of at...
In this study computer model of atherosclerosis progression was developed. Additional to mechanics approach with wall shear stress a biomolecular parameters Cholesterol, LDL, HDL and Triglycerides are also included for patient specific analysis. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the inti...
Regional deposition effects are important in the pulmonary delivery of drugs intended for the topical treatment of respiratory ailments. They also play a critical role in the systemic delivery of drugs with limited lung bioavailability. In recent years, significant improvements in the quality of pulmonary imaging have taken place, however the resol...
Anatomy of frontal sinuses varies individually, from differences in volume and shape to a rare case when the sinuses are absent. However, there are scarce data related to influence of these variations on impact generated fracture pattern. Therefore, the aim of this study was to analyse the influence of frontal sinus volume on the stress distributio...
Determination of plaque location and plaque volume for a specific patient is very important for prediction of atherosclerotic disease progression. Atherosclerosis is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall.
In this study we compared computer simulation of plaque development and Fractional Flow Reserve (FFR) with real clinical data from a specific patient. The Navier-Stokes and continuity equations were used for blood flow and pressure distribution for FFR. The Darcy law was used for model blood filtration, Kedem-Katchalsky equations for the solute and...
Research presented at 44th European Calcified Tissue Society Congress in section Bone biomechanics and quality
The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs suc...
Computational study for plaque formation and development for the patient specific coronary arteries was performed. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the intimal area was implemented. Mass transport of LDL through the wall and the simplified inflammatory process was firstly solved. The Na...
In this review we presented scientific results from three EC FP7 projects: ARTREAT, SIFEM and EMBALANCE. The title of FP7 ARTREAT project was: Multi-level patient-specific artery and atherogenesis model for outcome prediction, decision support treatment, and virtual hand-on training. Researchers from University of Kragujevac and BioIRC participated...
In this study, experimental and numerical stent modelling with plaque formation and progression for specific patient in the coronary arteries is described. In the method, section experimental stent testing is firstly described. Then numerical methods with finite element methods are given. Blood flow simulation is described with Navier-Stokes and co...
Due to the important biological role of red blood cells (RBCs) in vertebrates, the analysis of reshaping and dynamics of RBCs motion is a critical issue in physiology and biomechanics. In this paper the behavior of RBCs within the immature capillary plexus during embryonic development of zebrafish has been analyzed. Relying on the fact that zebrafi...
Benign paroxysmal positional vertigo (BPPV) is the most common type of vertigo. The symptoms of BPPV typically appear after angular movements of the head. BPPV leads to dizziness, nausea and imbalance. In this study, we examined a model of the semi-circular canal (SCC) with fully 3D three dimensional anatomical data from specific patient. A full Na...
There are a lot of studies regarding modeling of the middle and inner ear. The models of middle ear are simple mechanical models, because three ossicles and supported ligaments which are placed in the middle ear have only role to transmit mechanical vibrations of tympanic membrane. These mechanical vibrations are caused by acoustical excitations fr...
Introduction
Hemodynamic parameters in zebrafish receive increasing attention because of their important role in cardiovascular processes such as atherosclerosis, hematopoiesis, sprouting and intussusceptive angiogenesis. To study underlying mechanisms, the precise modulation of parameters like blood flow velocity or shear stress is centrally impor...
Detailed methodology used for blood flow simulations.
(DOCX)
Examples of blood flow in the submental vein before and after treatment with 1 mmol/L sodium nitroprusside.
(MP4)
Human hearing system is very interesting for investigation. There are several parts in hearing system, but the most important parts in sense of conversion of audio signal in electrical impulse are cochlea and organ of Corti. The reason why scientists investigate mechanical behavior of human hearing system is hearing loss – a health problem that aff...
The semicircular canals (SCC) are fluid-filled inner ear structures designed to detect circular or angular motion. In this study we modeled three-dimensional biomechanical model of SCC and compared results with real patient case for the Benign Paroxysmal Positional Vertigo (BPPV) disease. Model consists of full 3D fluid-structure interaction incorp...
Purpose:
In this study the computational and experimental electroporation model with human aorta tissue is made in order to examine the reduction of smooth muscle cells.
Methods:
The segments in native state of the aorta are treated by electroporation method through a series of electrical impulses from 50 V/cm to 2500 V/cm. For each patient we a...
Vibration of the skull causes a hearing sensation. We call it Bone Conduction (BC) sound. There are several investigations about transmission properties of bone conducted sound. The aim of this study was to develop a software tool for easy generation of the finite element (FE) model of the human head with different materials based on human head ana...
Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vertigo syndrome that affects 15% of older persons. BPPV is characterized by sudden attacks of dizziness and nausea triggered by changes in head orientation, and primarily afflicts the posterior canal. We are modeling human semicircular canals (SSC) which considers the morph...
Atherosclerosis is a medical condition becoming the number one cause of death worldwide. For this reason, any developement that may help physicians in early diagnostic and selection of the most appropriate treatment strategy is of great importance. In this paper we describe three-dimensional computer model of plaque formation and development for hu...
Human hearing system in general, and particularly the cochlea, is very interesting for investigation. The most important reason for it is hearing loss - a health problem that affects a large part of the world's human population. The highest percentage of people with hearing problems are older people, but the problem also occurs in newborns. Experim...
This study describes computer simulation of blood flow and plaque progression pattern in a patient who underwent surgical treatment for infected carotid prosthetic tube graft using carotid-carotid cross-over bypass. The 3D blood flow is governed by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lu...
Vascular endothelial cells are continuously exposed to hemodynamic shear stress. Intensity and type of shear stress are highly relevant to vascular physiology and pathology. Here, we modeled shear stress distribution in a tissue culture well (R = 17.5 mm, fill volume 2 ml) under orbital translation using computational fluid dynamics with the finite...
The aim of the present study was to investigate the influences of the presence and position of a lower third molar (M3) on the fragility of mandibular angle and condyle, using finite element analysis. From computed tomographic scans of a human mandible with normally erupted M3, two additional virtual models were generated: a mandibular model with p...
Cochlea is part of the inner ear. The role of the cochlea is to transform outer acoustic signal into electrical impulse which is further transmitted to the brain. Two important phenomena taking place inside the cochlea: transformation of outer acoustic signal into mechanical vibration and transforming of mechanical vibration into electrical impulse...
In this study we investigated the hot caloric test response in the three semicircular canals using coupled fluid flow, natural convection and fluid-structure interaction with the finite element method. We demonstrated that the temperature distribution of the horizontal canal duct is more dominant and a longer period of irrigation time is required i...
In this chapter we described predictive model for plaque formation and progression in the coronary and carotid artery. A full Three-Dimensional model for plaque formation and progression, coupled with blood flow and LDL concentration is analysed. The Navier-Stokes equations together with the Darcy law for model blood filtration and Kedem-Katchalsky...
Braking system is one of the most important components of a vehicle on the road. This system has the task to bring the vehicle to stop or slow down. Friction brakes, during the braking process, convert the kinetic and potential energy into the thermal energy (heat). The basic components of braking systems, brake discs and brake pads, in a short per...