Igor Otavio Minatel

Igor Otavio Minatel
São Paulo State University | Unesp · Department of Chemistry and Biochemistry

PhD

About

83
Publications
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Publications

Publications (83)
Article
Bioactive amines present in grapes and their derivatives are used as quality markers and have important physiological functions in plants and humans. We quantified the biogenic amines and antioxidant activity in whole juices of Vitis labrusca and hybrid grapes developed in Brazil. The grapes used were V. labrusca (‘Bordô’ and ‘Isabel’) and Brazilia...
Article
The growth of peach orchards in subtropical regions depends on the minimal requirements for chilling accumulation, and crop loading requires sprays of chemical compounds to overcome dormancy, induce bud break, and allow adequate flowering and fruiting. The ability of hydrogen cyanamide, nitrogen fertilizer and calcium nitrate to break the dormancy...
Article
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Purpose This study aimed to evaluate the effect of rice bran (RB) supplementation to a high-sugar fat (HSF) diet on cardiac dysfunction in an experimental obesity model. Methods Male Wistar rats were distributed into three groups: control, high-sugar fat, and high-sugar fat supplemented with 11% RB for 20 weeks. Results HSF diet promoted obesity...
Article
The identification and quantification of different contaminants in natural waters have been widely disseminated in scientific journals. In the last two decades, removal from aqueous samples of drugs and their metabolites, also called emerging contaminants, have been highlighted. The problem of their existence in the environment, besides its persist...
Article
Grapes and sweet potatoes are two different plant species that have distinct bioactive composition and the use of both in a non-alcoholic mixed beverage may be an interesting source of phytochemicals. Physicochemical and sensory characteristics, profile of phenolic compounds and biogenic amines of mixed juices of grapes (‘BRS Violeta’, ‘BRS Cora’ a...
Article
Background Skeletal muscle is the most important organ for whole-body glucose homeostasis. However, it has been suggested that obesity-related inflammation could be involved in insulin resistance and diabetes mellitus type 2 (DM2) development due several mechanisms, among them, the reduced expression of the glucose transporter type 4 (GLUT-4). Gamm...
Article
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Introduction: The receptor for AGEs (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface receptors expressed in many organs, among them, the kidneys. When activated, RAGE leads to a sequence of signaling that results in inflammation and oxidative stress, both involved in kidney disease pathogenesis. Gamma-oryzanol (γOz)...
Article
The ‘Niagara Rosada’ (Vitis labrusca) grape is widely consumed for its nutritional qualities and flavor, in addition to presenting a great diversity of phytochemical compounds, mainly polyphenols. ‘Niagara Rosada’ has a limited shelf life, especially when kept at room temperature, a common form used by markets in Brazil. Salicylic acid (SA) is a lo...
Article
Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this stu...
Article
The literature has reported a higher prevalence of negative clinical outcomes due to Coronavirus disease 19 (COVID-19) in obese individuals. This can be explained by the cytokine storm, result from the cytokine production from both obesity and viral infection. Gamma-oryzanol (γOz) is a compound with anti-inflammatory and antioxidant activities. How...
Article
Full-text available
Introduction: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The a...
Article
A sífilis é uma infecção sexualmente transmissível (IST), causada pela bactéria Treponema pallidum, que acomete homens e mulheres. Apesar da relação sexual sem o uso de preservativos ser a principal forma de infecção, a transmissão congênita durante a gestação ou parto têm crescido nos últimos anos. O diagnóstico da sífilis pode ser realizado pelos...
Chapter
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Vegetarian and vegan consumers have increased in the last years. However, the food industry is facing problems responding to this growing market, since the food safety of several plant-based products is not well established. Fruits, vegetables and fermented products, such as nut and grains milks and cheeses, may be rich sources of biogenic amines;...
Article
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Purpose The consumption of products containing fructose is associated with metabolic disorders and nonalcoholic fatty liver disease (NAFLD). Several pathways have been described associating the fructose intake and liver damage, among them the reduced peroxisome proliferator-activated receptor alpha (PPAR-α) expression, insulin resistance, inflammat...
Article
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Background/aims: Considering the importance of inflammation on obesity-related disorders pathogenesis, including cardiac dysfunction, the interest in natural anti-inflammatory therapeutic strategies has emerged. The lycopene is a carotenoid presents in tomato and red fruits that displays anti-inflammatory properties. In this sense, we will evaluat...
Article
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Aims: To test if the level of oxidative stress is different in women with overweight and with metabolic syndrome. Study Design: Cross-sectional. Place and Duration of Study: Endocrinology Clinic of the Botucatu Medical School-UNESP, between March 2013 and March 2014. Methodology: Eighty women (31.15 ± 7.91 years old) attended at the Endocrinology C...
Article
Full-text available
We have identified the best harvesting periods, related to higher bioactive compound content and post‐harvest quality, for minimally processed sweet potatoes with orange pulp and cream pulp. Quality loss in minimally processed sweet potatoes occurred due to browning in cv. Mãe de Familia and ESAM1 and to whitening in cv. Paraná. Both Mãe de Família...
Article
Grape pomace is the main residue from juice and wine industries, and their derived products such as flours, can be a rich source of phenolic compounds and antioxidants. The overall objective of this study was to assess the phenolic compounds, antioxidant capacity, biogenic amines, and amino acids in flours obtained from grape pomace. Four cultivars...
Article
Cauliflowers are generally associated with healthy diets due to their positive impact on health. This research aims to evaluate the effects of cooking processes (boiling, steaming and microwaving) and different preparation times, on the content of carotenoids and provitamin A and tocopherols, in cauliflowers and to verify the effect of the cooking...
Article
Full-text available
Some biogenic amines (BAs) are used as quality markers in grape-derived products. The prolife of 9 BAs was determined in juices and wines elaborated from hybrid grapes. Low levels of histamine, tyramine and cadaverine were found. Juices elaborated from ‘BRS Rúbea’ showed the highest tyramine levels (1.56 mg/L), while no histamine was found in wines...
Article
The aim of present study was evaluating the antioxidant activity and real content of phytochemicals of Spathodea campanulata from different climatic regions (two subtropical and one tropical area/cities) at Brazil. Samples of leaves, flowers and nectars from S. campanulata were tested for total phenolic content and in vitro antioxidant activity by...
Article
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Solanum paniculatum L. or popularly known as “jurubeba” is an herbal medicinal plant. A few studies have investigated its biological effects; however, research aimed at elucidating the redox balance effects from its fruits has not been reported so far. ROS interplays in various fields of medicine such as chemotherapy. Here, we evaluated antioxidant...
Article
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Biogenic amines are important indicators of food quality with recognized antioxidant capacity. Diets that are rich in these compounds promote several benefits for human health, although the consumption in excess may result in food poisoning. This study aims to screen the levels of biogenic amines in four colored cauliflowers, before and after cooki...
Poster
Full-text available
Negli ultimi anni, i viticoltori hanno cercato alternative per diversificare la produzione di uva e aumentare la qualità del succo introducendo nuove varietà. Le amine bioattive (AB) presenti nelle uve e nei loro derivati vengono utilizzate come marcatori di qualità, oltre ad avere importanti funzioni fisiologiche nell'organismo umano. La dopamina,...
Poster
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L'acido salicilico (AS) è un metabolita secondario importante nell'uva e svolge un ruolo essenziale nel determinare la qualità della bacca come colore, sapore, astringenza e amarezza. Questi effetti sono correlati alle sue prestazioni nella biosintesi dei composti fenolici e nella produzione di etilene, riducendo sia la respirazione che il decadime...
Article
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To verify if the bark of Passiflora edulis prevents obesity-related disorders and oxidative stress in db/db mice. Obese male db/db mice (n = 14 animals) were randomly divided into two groups to receive standard chow and water (obese, n = 7 (OB)) or standard chow with bark of Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 16 weeks. The...
Article
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The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement...
Article
Full-text available
Rice bran (RB) is a rice milling by-product and an interesting source of fibers and bioactive compounds as γ-oryzanol. These food compounds are capable of prevent and/or improve metabolic disorders associated to chronic diseases. To provide a good source of bioactive compounds and a better destination for RB, the aim of this study was to develop an...
Article
Bioactive amines are found in food and can be relevant for the assessment of fruits shelf life and nutritional quality. The pulp and peel of 20 banana and plantain were analyzed and the bioactive amine content varied according to the genotype, ripening stage, fruit tissue and thermal processing. In most of the analyzed genotypes, tyramine, histamin...
Article
Full-text available
ABSTRACT Nineteen genotypes of bananas and plantains were analysed in order to differentiate the subgroups and/or groups of consumption or industrial use. Genotypes of banana and plantain from different genomic groups and in three ripening stages (2, 5 and 7) were studied in relation to physical and physicochemical characteristics, including bioact...
Article
The presence of biogenic amines, such as histamine and tyramine, in pickled food can cause health problems, such as allergies. However, other bioactive amines may be present and can induce some diseases. Some biogenic amines can react with nitrate and form nitrosamines, compounds harmful to human health. In this research, we qualitatively and quant...
Article
A indução de efeitos fisiológicos benéficos após o uso de fungicidas sistêmicos em olerícolas tem sido descrito. Os efeitos incluem a promoção do crescimento e desenvolvimento vegetal, além de alterações de vias metabólicas relacionados com a defesa ao estresse biótico e abiótico. Neste sentido, objetivou-se avaliar a influência da aplicação de alg...
Article
Pharmaceutical industries have a demand for great amounts ofAchyrocline satureioides(Lam.) DC., however,most of the raw material commonly is extracted directly from the natural environment without any agronomicmanagement. Faced with this situation, the present study aimed to investigate the totalflavonoids and totalphenolic compounds, as well as th...
Article
This study investigated the effectiveness of cysteine in conservation of bioactive compounds and the antioxidant capacity of minimally processed red beet. After red beet minimal processing increasing cysteine concentrations were applied, corresponding to control, 2 mM, 4 mM, 8 mM and 16 mM. Assay was performed over 15 d to evaluate the polyphenols,...
Chapter
Grafting has been practiced to overcome yield problems associated to soil-borne diseases or declines in production. Usually this agricultural method involves the choice of better stock and scion species, procedures to improve the graft union and subsequent healing, and acclimation of the grafted plant to soil. Similarly, to agrochemicals used in ve...
Book
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Capítulo 13 A saúde como direito de cidadania e a questão das populações tradicionais em áreas ambientalmente protegidas Rodrigo Ceregatti Franco Cindy Carolina Benedetti Fedocci Lucas Pereira da Silva Freitas Duarcides Ferreira Mariosa Resumo: Fundamentado nas experiências e no conjunto de estudos publicados pelos pesquisadores do Grupo de Pesqu...
Article
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Adipose tissue dysfunction is a condition characterized by inflammation and oxidative stress able to lead metabolic disorders. Curcuma longa L. (Cl) is a rhizome commonly used in Indian culinary which presents anti-inflammatory and antioxidant compounds. The aim of this study was to evaluate the effect of in natura Curcuma longa L. on adipose tissu...
Article
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Anthurium cut flowers exposed to low temperatures may be subjected to chilling injury, whereas higher temperatures may accelerate their metabolism and induce premature senescence. Plant growth regulators, as gibberellic acid (GA3) and spermine (SPM), have been described to extend the postharvest life of flowers. In this study, both compounds were a...
Article
Full-text available
Isotopic analyses and chromatographic analysis (phenolic compounds and biogenic amines), can be applied to investigate the functional and nutritional quality in different grape juices and wines. These beverages when produced exclusively from grapes contain bioactive compounds. In this way, the isotopic analysis, as well as the determination of phen...
Article
Full-text available
The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as dyslipidemia, hypertension, and cardiovascular disease. The aim of this study was to evaluate the association between dyslipidemia and cardiac dysfunction induced by western diet consumption. Wistar rats were randomly divided into two experim...
Article
Full-text available
In this study, we aimed to determine whether seasonality affects the content, chemical composition, and antimicrobial activity of essential oils (EOs) from the leaves of three species of Nectandra (Nectandra megapotamica, Nectandra grandiflora, and Nectandra lanceolata) native to the Atlantic rainforest, Sao Paulo state, Brazil. In addition, we ide...
Article
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The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol ( γ Oz) is a compound with antioxidant and anti-inflammatory...
Article
Full-text available
Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and...
Article
In bananas, the major carotenoids are α- and β-carotene, which give this fruit great potential in biofortification programs. The carotenoid content in pulp and peel of 22 banana and plantain genotypes was determined in order to evaluate the impact of ripening on the carotenoid content as well as its retention after different thermal processes. Frui...
Chapter
The bioavailability of dietary phytochemicals may be influenced by several factors as food matrix, cultivation conditions, host microbiota, and physiological state. Phenolic compounds and polyamines have been associated with various health benefits. However, their role in human health is dependent on interactions with the gut microbiota and convers...
Chapter
The bioavailability of dietary phytochemicals may be influenced by several factors as food matrix, cultivation conditions, host microbiota, and physiological state. Phenolic compounds and polyamines have been associated with various health benefits. However, their role in human health is dependent on interactions with the gut microbiota and convers...
Article
The aim of this study is to test the hypothesis that obesity induced by a diet rich in saturated fats and balanced in carbohydrates is associated with the development of systemic complications and comorbidities. Thirty-seven 60-day-old male Wistar rats were randomized into two groups: control (C, n = 18, standard diet) and obese (OB, n = 19, high-s...
Article
Full-text available
Background: The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as diabetes, and cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflamm...
Chapter
Current research in secondary metabolites from medicinal plants should take into account the prevalence and the healing properties of which plant. These compounds have been provided opportunities to development of new drugs leads against several diseases. However, to obtain compounds from edible medicinal plants as well as that used to prepare infu...
Chapter
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The metabolic syndrome (MetS) was defined as a condition characterized by disturbed glucose and insulin metabolism, central obesity, mild dyslipidemia, and hy-pertension. These conditions are important risk factors for diabetes, cardiovascular disease, and other chronic diseases. It etiology is a complex interaction between genetic , metabolic, and...
Article
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Obesity is associated with low-grade inflammation, triggered in adipose tissue, which may occur due to an excess of SFA from the diet that can be recognised by Toll-like receptor-4. This condition is involved in the development of components of the metabolic syndrome associated with obesity, especially insulin resistance. The aim of the study was t...
Article
The influence of cooking methods on chlorophyl, carotenoids, polyamines, polyphenols contents and antioxidant capacity were analyzed in organic and conventional green beans. The initial raw material had a higher content of chlorophyl and total phenolics in conventional green beans, whereas organic cultive favored flavonoid content and antioxidant c...
Chapter
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In this chapter, we discuss the influence of the processing methods on the content of phenolic compounds in fruits and vegetables. The intake of fruits and vegetables based‐foods are associated with delayed aging and a decreased risk of chronic disease development. Fruits and vegetables can be consumed in natura, but the highest amounts are ingeste...
Article
The growing demand for food has intensified the search for compounds of plant origin to protect field crops from predators and pathogens, as these compounds have less environmental impact and are considered healthier than synthetic compounds. Among plant species with insecticidal activity, Spathodea campanulata has been identified as a potential so...
Article
Full-text available
Metabolic syndrome (MetS) has a high prevalence around the world. Considering the components used to classify MetS, it is clear that it is closely related to obesity. These two conditions begin with an increase in abdominal adipose tissue, which is metabolically more active, containing a greater amount of resident macrophages compared to other fat...