
Idania RodeiroInstitute Marine Sciences, ICIMAR · Pharmacology
Idania Rodeiro
PhD
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Publications (138)
Citation: García, T.H.; Spengler, I.; Fernández, A.; Rodeiro, I.; Hernández-Balmaseda, I.; Céspedes, I.; Garrido, G.; dos Santos, L.C.; Vilegas, W.; Celano, R.; et al. Traditional Use, Chemical Constituents, and Pharmacological Activity of Maytenus elaeodendroides Stem Bark. Diversity 2024, 16, 694. Abstract: Plants belonging to the genus Maytenus...
Background/Objectives: Research on pharmacogenetic variability in response to prescribed drugs and across ethnic groups is essential for personalized medicine, particularly in admixed and unstudied populations. For the first time, this study examines CYP2D6, CYP2C9, and CYP2C19 alleles and genotypes in 197 healthy volunteers from the Dominican Repu...
Introduction
The Cuban population is genetically diverse, and information on the prevalence of genetic variants is still limited. As complex admixture processes have occurred, we hypothesized that the frequency of pharmacogenetic variants and drug responses may vary within the country. The aims of the study were to describe the frequency distributi...
In this paper, the lipid classes, compositions of the neutral lipids, phospholipids and fatty acids, acetylcholinesterase inhibition and cytotoxic activity of two brown algae Lobophora tsengii D. Tien & Z. Sun and Lobophora australis Z. Sun, F. C. Gurgel & H. Kawai have been investigated. The polar lipid class had the highest content in total lipid...
The chemical composition of the essential oil from the aerial parts (leaves and flowers) of Tagetes filifolia Lag. grown in the Peruvian Andes was examined throughout the gas chromatography and gas chromatography-mass spectrometry techniques. Fifty-seven compounds were identified representing more than 99% of the essential oil. Phenylpropanoids had...
Herpes viruses (HSV) are among the most common viruses that infect humans. They cause blisters and inflammation of the oral and genital mucosa as well as severe symptoms such as blindness, hearing impairment and fatal encephalitis. Although acyclovir (ACV) and its derivatives are highly effective in treating recurrent lytic infections, the emergenc...
Introduction: Maytenus buxifolia subsp. cajalbanica Borhidi & O. Muñiz, Ageratina havanensis (Kunth) R. M. King & H. Rob, mucuna (Mucuna pruriens [L] DC. vc. utilis, Stizolobium niveum y Stizolobium aterrimum), Coccoloba cowellii Britton plants and the brown algae Sargasssum fluitams present potential for their use in medicinal chemistry and agricu...
Context: Marine ecosystems are sources of bioactive compounds. Thirty-eight microorganism strains from the Cuban platform were screened, which allowed us to identify an extract from Bacillus amyloliquefaciens, strain CBM-116, as a source for obtaining bioproducts with biomedical applications.
Aims: To physiologically characterize the culture of Ba...
Metalloproteinase-9 (MMP-9) is a key protein in cancer advancement and metastasis owing to its ability to degrade some extracellular matrix components. Mangiferin, a natural polyphenolic compound, has demonstrated through experimental and theoretical studies to be a great anticancer agent for the selective inhibition of MMP-9. This work aimed to ev...
Context: Marine organisms are sources of compounds with anti-inflammatory activity, many of them derived from the secondary metabolites produced by microorganisms.
Aims: To evaluate the possible anti-inflammatory effect of M116, an extract obtained by fermentation from the CBM-116 strain of the marine bacterium Bacillus amyloliquefaciens, which wa...
Join to ImmunoPharmacology 2023
Despite the large amount of experimental evidence and the development of some products, to date the vast majority of viral diseases lack therapeutic and prophylactic treatment and continue to be a serious health problem. Several sources have been described as
reservoirs of compounds with antiviral activity against a wide spectrum of viruses. This...
This unique volume draws on the rich culture, folklore and environment of medicinal plants in Ecuador, which includes the important rain forest region. This country has rich plant resources and a large diversity of plants. In particular, the Biotechnological Research Center of Ecuador, CIBE, is an important center of plant research and biodiversity...
RESUMEN Las infecciones virales continúan siendo una de las principales causas a nivel mundial de morbilidad y mortalidad. De manera alarmante, la cantidad de pacientes diagnosticados con infecciones virales aumenta cada año. La inmensa mayoría de las enfermedades virales carecen de tratamiento terapéutico y profiláctico a pesar del desarrollo de a...
Mangiferin is a glycosylated xanthone widely distributed in nature, which exhibits wide pharmacological activities, highlighting its anti-cancer properties. Mangiferin interferes with inflammation, lipid, and calcium signaling, which selectively inhibits multiple NFkB target genes as interleukin-6, tumor necrosis factor, plasminogen, and matrix met...
The chemical composition and antioxidant activity of the essential oil from the leaves of Ambrosia arborescens Miller grown in the Peruvian Andes were studied. One hundred and thirteen compounds were identified, which represents 94.7% of the total composition of the essential oil. Sesquiterpene hydrocarbons and oxygenated monoterpenes were the most...
Introducción:
El cáncer de pulmón es uno de los principales problemas de salud en Cuba y el mundo. Las diferencias genéticas a causa de polimorfismos de un solo nucleótido, son factores importantes involucrados en la susceptibilidad genética a esta enfermedad. En Cuba son escasos los datos disponibles sobre los polimorfismos de un solo nucleótido y...
Objectives:
ABCB1 gene polymorphisms can modify P-glycoprotein function with clinical consequences.
Methods:
The 3435C>T polymorphism prevalence was analyzed using oligonucleotide probes and next-generation sequencing in 421 unrelated healthy individuals living in Cuba. Data were stratified by gender, ethnic background and residence. The genotyp...
In spite of the current advances and achievements in cancer treatments, colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in both men and women worldwide. Drug resistance, adverse side effects and high rate of angiogenesis, metastasis and tumor relapse remain one of the greatest challenges in long-term management...
Enteroviruses cause human diseases such as Mouth, Hand and Foot Syndrome, hemorrhagic conjunctivitis, aseptic meningitis, and viral meningoencephalitis. As yet, there is not specific therapy for most enteroviruses infections. The brown seaweeds of Sargassum genus synthesize a great variety of metabolites, which make them potential sources of compou...
Introducción:
Las plantas son una parte fundamental de los sistemas de medicina. Para contar con una fuente vegetal como alternativa terapéutica, es indispensable demostrar científicamente su utilidad. Las especies Clusia minor L., Caesalpinia bahamensis Lam., Murraya paniculata L, Phania matricarioides (Spreng.) Griseb. y Lippia alba Mill, que cre...
Marine plants have become an inexhaustible reservoir of new phytopharmaceuticals for cancer treatment. We demonstrate in vitro/in vivo antitumor efficacy of a standardized polyphenol extract from the marine angiosperm Thalassia testudinum (TTE) in colon tumor cell lines (RKO, SW480, and CT26) and a syngeneic allograft murine colorectal cancer model...
Osteosarcoma (OS) is a malignant bone tumor and its occurrence is associated with high levels of microRNAs (miRNAs) and critical protein sinvolved on intracellular signaling pathways. Cisplatin and Doxorubicin are employed on chemotherapy, but their use cause side effects and contributes to multidrug resistance. Since several tripodal amines have b...
Marine plants are important sources of pharmacologically active metabolites. The aim of the present work was to evaluate the cytotoxic and antitumor activity of a polyphenolic fraction obtained from Thalassia testudinum marine plant and thalassiolin B in human colorectal cancer cells. Human cancer cell lines, including HCT15, HCT116, SW260, and HT2...
The aim of the present work was to evaluate the effects of Thalassia testudinum hydroethanolic extract, its polyphenolic fraction and thalassiolin B on the activity of phase I metabolizing enzymes as well as their antimutagenic effects. Spectrofluorometric techniques were used to evaluate the effect of tested products on rat and human CYP1A and CYP...
The aim of the present work was to evaluate the effects of Thalassia testudinum hydroethanolic extract, its polyphenolic fraction, and thalassiolin B on the activity of phase I metabolizing enzymes as well as their antimutagenic effects. Spectrofluorometric techniques were used to evaluate the effect of tested products on rat and human CYP1A and CY...
Ageratina havanensis (Kunth) R. M. King & H. Robinson is a species of flowering shrub in the family Asteraceae, native to the Caribbean and Texas. The aim of this work was to compare the quantitative chemical composition of extracts obtained from Ageratina havanensis in its flowering and vegetative stages with the antioxidant potential and to deter...
Thalassia testudinum a sea grass, is highly abundant along the Cuban coasts and has been characterized. The extract obtained from Thalassia testudinum has anti-inflammatory, antioxidant, photoprotective, antinociceptive, hepatoprotective and neuroprotective properties. Nevertheless, there are very few reports of its safety evaluation. The aims of t...
We present the distribution of CYP2D6, CYP2C9 and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero‐America (n>6,000) in the context of genetic ancestry (n=3,387). Continental ancestries are the major determinants of frequencies of the increased‐activity allele CYP2C19*17 and CYP2C19 gUMs (negatively associat...
Advanced metastatic melanoma, one of the most aggressive skin malignancies, is currently without reliable therapy. The process of angiogenesis is crucial for progression and metastasis of the majority of solid tumors including melanomas. Therefore, new therapies are urgently needed. Mangiferin is a naturally occurring glucosylxanthone which exerts...
p> Clusia minor L. is traditionally used to treat many disorders that including pain and inflammation such as sores and warts. Four extracts from the leaves of plant were prepared: hexane (CMH-A), ethyl acetate (CMH-B), methanol (CMH-C) and ethanol (CMH-E) and the pharmacological (antioxidant and anti-inflammatory properties) and toxicity effects w...
The protective effect of the supplementation with an aqueous‐ethanolic extract obtained from Ulva lactuca (Delile) green seaweed on benzo[a] pyrene‐induced damage in mice was evaluated. Animals were treated with oral doses of U. lactuca extract (100 and 400 mg/kg) for 9 weeks. They were exposed to 50 mg/kg of oral doses of benzo(a)pyrene starting f...
Medium and high polarity extracts from Maytenus species are known to contain polyphenolic compounds such as proanthocyanidins. The high polarity and structural complexity of these compounds make very difficult their isolation even by modern chromatographic techniques. Maytenus cajalbanica (Borhidi & O. Muñiz) Borhidi & O. Muñiz is endemic from Cuba...
The chemical composition and antioxidant activity of the essential oil from the stems of Bursera graveolens (Kunth) Triana et Planch grown in Manabí (Ecuador) were studied. Ninety-nine compounds were identified in the essential oil. Monoterpene hydrocarbons and oxygenated monoterpenes were the most represented classes of volatiles with 35.4% and 30...
Resumen Context: The search of new substances with analgesic properties has grown in the last years. Brazil and Cuba have a big biodiversity allowing the study of several plants with potential pharmacological activities. Aims: To evaluate the chemical composition and potential antinociceptive effect of the ethanolic extract from Clusia minor L. lea...
Context: Caesalpinia bahamensis Lam. is a medicinal plant used by the Cuban population to treat renal and hepatic diseases. However, this species lacks scientific studies that support its biological applications. Aims: To evaluate the chemical composition and the antioxidant capacity of fractions obtained from the stem of Caesalpinia bahamensis Lam...
Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations in CYP2D6, CYP2C9, and CYP2C19 drug metabolizing enzyme genotypes, which were subsequently utilized to cata...
The chemical composition of the essential oil from leaves of Croton wagneri Müll. Arg. grown in Ecuador was studied. A total of 135 volatile compounds were identified in the essential oil, of which the most prominent were cis-chrysanthenol (27.5%) and myrcene (19.2%). Furthermore, we assessed the antioxidant properties using the DPPH and the ferric...
Context: Sacha Inchi has been consumed for years by indigenous peoples. Meanwhile, its toxicological potential has not been sufficiently studied.
Aims: To assess the acute, sub-chronic toxicity and genotoxicity evaluation of Sacha Inchi powder obtained from Plukenetia volubilis L.
Methods: A dose of 2000 mg/kg was orally administered to rats and...
Resumen Context: Caesalpinia bahamensis Lam. is a medicinal plant used by the Cuban population to treat renal and hepatic diseases. However, this species lacks scientific studies that support its biological applications. Aims: To evaluate the chemical composition and the antioxidant capacity of fractions obtained from the stem of Caesalpinia bahame...
P-glycoprotein (P-gp) is a transmembrane active efflux pump for a variety of drugs and the most extensively studied ATP-binding cassette (ABC) coded by MDR1 gene. The importance of P-gp in drug-drug interactions is being identified. ABCB1 polymorphisms also contribute to variability in P-gp function. Single-nucleotide polymorphisms (SNPs) in MDR1 g...
Introduction: Cancer is a multigenic disease associated to chronic inflammation, which in turn is associated to oxidative stress and neuropathic pain. The main problems of the anti-cancer chemotherapy are their lack of specificity and their serious adverse effects. The identification of biologically active compound from natural products has been a...
Background:
The aqueous extract of the Allophylus cominia (L) Sw (Sapindaceae) leaves has shown anti-diabetic, anti-obesity and anti-inflammatory properties. In the Caribbean region, it is typically used for the treatment of type-2 diabetes.
Methods:
Considering the herb–drug interaction, the aim of this study was to evaluate the potential effects...
The effects of an extract from the marine plant Thalassia testudinum on rat liver cytochrome P450s were investigated. Male Wistar rats were administered for 10 days with 20, 200 or 400 mg/kg oral doses of the extract. The activities of CYP1A1/A2, CYP2B1/B2, CYP2E1 and CYP3A were evaluated. CYP1A1 activity and protein content increased after 200 mg/...
Syringodium filiforme Kützing (Cymodoceaceae) is a marine seagrass abundant in Caribbean Sea, rich in phenolic compounds which have antioxidant properties and can provide new opportunities for treatment and prevention of diseases mediated by ultraviolet radiation like photoaging and skin cancer. The aim of this study was to evaluate the phytochemic...
CYP2C9, CYP2C19 and CYP2D6 metabolize around 40 % of drugs and their genes vary across populations. The Costa Rican population has a trihybrid ancestry and its key geographic location turns it into a suitable scenario to evaluate interethnic differences across populations. This study aims to describe the diversity of CYP2C9, CYP2C19 and CYP2D6 poly...
The chemical composition, antioxidant or anti-proliferative activities of essential oils from leaves of Schinus areira L. and Minthostachys spicata (Benth.) Epl. grown in Cuzco (Peru) was studied. Fifty-six and fifty-eight compounds were identified in the essential oils from S. areira and M. spicata leaves, respectively. In S. areira essential oil,...
The chemical composition and biological properties of
Ulva fasciata
aqueous-ethanolic extract were examined. Five components were identified in one fraction prepared from the extract by gas chromatography-mass spectrometry, and palmitic acid and its ethyl ester accounted for 76% of the total identified components. Furthermore, we assessed the extra...
Background:
The aqueous ethanolic extract from leaves of the marine plant Thalassia testudinum has shown antioxidant, cytoprotective, and neuroprotective properties. The chemical composition of this extract, rich in polyphenols, could interfere with active transport of drugs out of the cell and circumvent the phenomenon of multidrug resistance (MD...
Context: Pharmacological properties of mangiferin have been reported, but few studies have investigated mangiferin toxicity.
Aims: To study the acute and 28-day toxicity effects of mangiferin in rodents.
Methods: Single doses of mangiferin were administered by oral or i.p. route or were applied dermally to Sprague-Dawley rats and Balb/C mice. Cli...
La aproximación multimodal mediante terapias combinadas concebidas con racionalidad farmacodinámica y farmacocinética ofrecen mayor balance eficaciaseguridad en el tratamiento farmacológico del dolor crónico. La evaluación del efecto antihipernociceptivo del extracto de la corteza del árbol del mango (ECAM) y lamangiferina (MG) aislada de este, en...
Context: Herbal drugs are a mixture of active compounds and the chemical complexity of each formulation increase with the possibility of interactions between them and conventional drugs. Many mechanisms are implicated in the interactions; scientific community has dedicated the attentions to enzymes as P-gp and CYP450. Aims: To investigate in the li...
Context: Herbal drugs are a mixture of active compounds and the chemical complexity of each formulation increase with the possibility of interactions between them and conventional drugs. Many mechanisms are implicated in the interactions; scientific community has dedicated the attentions to enzymes as P-gp and CYP450. Aims: To investigate in the li...
Context: Duroia macrophylla (Rubiaceae) is endemic from the Amazon Rainforest.
Aims: To perform phytochemical profile of Duroia macrophylla extracts and to evaluate them as antioxidant, insecticidal and cytotoxic.
Methods: Dichloromethane and methanol extracts of leaves and branches (collected three times) were subjected to phytochemical screening...
Context: BM-21 is a hydro-ethanolic extract obtained from the leaves of Thalassia testudinum marine plant, which is rich in polyphenols, and it has demonstrated antioxidant, anti-inflammatory, cytoprotective and neuroprotective properties.
Aims: To investigate the genotoxicity potential of BM-21.
Methods: Salmonella typhimurium Hist. - strains were...
The organisms are constantly exposed to a wide array of xenobiotics. Cytochrome P450 enzymes are involved in the phase I of xenobiotic metabolism, including pharmaceuticals, and in endogenous biosynthetic functions through oxidation, reduction reactions and hydrolysis. It is estimated that cytochrome P450 can metabolize up to two-thirds of drugs pr...
Introduction: Mangiferin has several pharmacological properties, but others remain to be deeply explored, such as antitumor activity since it may serve as adjuvant agent in conventional antitumoral chemotherapy in a combined treatment. Objective: to evaluate the antiproliferative effect of the use of mangiferin alone and in combination with low con...
The present study examines the possible effect of the glucosylxanthone mangiferin (MG) on pain-related behaviors in a tonic acute pain model (formalin test at 5%) and in a chronic constriction injury (CCI) model to clarify the underlying transient and long-term mechanisms. Acute administration of MG (10-100 mg/kg, i.p.) reduced licking/biting exclu...
We disclose here the effects over several P450 isoforms of one extract from Thalassia testudinum marine plant with cytoprotective and neuroprotective properties. Male Wistar rats were administered orally with 20, 200 and 400 mg/kg of the extract for 10 days. The activities of 7‐ethoxy, 7‐methoxy, 7‐penthoxy and 7‐benzoxyl resorufin‐O‐deethylases, 4...
Pharmacogenetics and Pharmacogenomics areas are currently emerging fields focused to manage pharmacotherapy that may prevent undertreatment while avoiding associated drug toxicity in patients. Large international differences in the awareness and in the use of pharmacogenomic testing are presumed, but not well assessed to date. In the present study...
The organisms are constantly exposed to a wide array of xenobiotics. Cytochrome P450 enzymes are involved in the phase I of xenobiotic metabolism, including pharmaceuticals, and in endogenous biosynthetic functions through oxidation, reduction reactions and hydrolysis. It is estimated that cytochrome P450 can metabolize up to two-thirds of drugs pr...
Mangifera indica L. (mango) stem bark aqueous extract (MSBE) that has antioxidant, anti-inflammatory and immunomodulatory properties, can be obtained in Cuba. It is rich in polyphenols, where mangiferin is the main component. In this study, we have tested DNA damage and protection effects of MSBE and mangiferin on primary human lymphocytes and lymp...
Mango (Mangifera indica L.) stem bark extract (MSBE) is a natural product with biological properties and mangiferin is the major component. This paper reported the evaluation of the protective effects of MSBE and mangiferin against the toxicity induced in HepG2 cells by tert-butyl hydroperoxide or amiodarone.
Nuclear morphology, cell viability, int...