Ida Safitri Laksono

Universitas Gadjah Mada | UGM · Department of Pediatrics

Background: Transmission within families and multiple spike protein mutations have been associated with the rapid transmission of SARS-CoV-2. We aimed to: 1) describe full genome characterization of SARS-CoV-2 and correlate the sequences with epidemiological data within family clusters, and 2) conduct phylogenetic analysis of all samples from Yogya...

Latar belakang. Risiko kematian pada anak dengan sindrom syok dengue (SSD) tinggi. Obesitas diduga sebagai faktor risiko SSD tetapi hasil penelitian sebelumnya masih kontroversial. Tujuan. Mengevaluasi overweight atau obes sebagai faktor risiko SSD pada anak. Metode. Penelitian case control pada anak (0-18 tahun) yang dirawat di RSUP Dr. Sardjito Y...

Latar belakang. Infeksi virus dengue (IVD) bersifat akut dan dinamis, perjalanan klinisnya terkadang sulit diprediksi sehingga berakibat keterlambatan pengelolaan. Maka perlu diteliti parameter klinis dan laboratoris di fase kritis / defervescence untuk memprediksi derajat keparahan infeksi dengue. Tujuan. Mengetahui parameter klinis dan laboratori...

Latar belakang. Pemberian antibiotik sangat penting untuk menurunkan angka kematian pasien demam neutropenia. Di sisi lain, penggunaan antibiotik jangka panjang akan mengubah pola patogen dan uji sensitivitas terhadap antibiotik. Tujuan. Mencari pola patogen, menilai sensitivitas cefotaxime dan gentamicin sebagai antibiotik lini pertama, dan mendap...

Latar belakang. Infeksi virus dengue merupakan mosquito borne disease yang sering dijumpai di dunia. Demam pada awal sakit karena infeksi dengue dan bukan dengue sangat sulit dibedakan. Di fasilitas kesehatan dengan sumber daya terbatas diperlukan pemeriksaan darah sederhana untuk membantu mendiagnosis dengue. Jumlah leukosit, neutrofil, limfosit,...

Background: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ imp...

Dengue virus (DENV) infection is a significant burden in Indonesia and other tropical countries. DENV infection have wide spectrum of clinical manifestations i.e. asymptomatic, dengue fever, dengue hemorrhagic fever and dengue shock syndrome. The difference of clinical manifestation may due to the deversity of genetic constitution of the host. The...

Cellular immunity plays an important role in viral infection. The activation of effector T-lymphocytes and the release of cytokines define the course of dengue viral infection. CD4⁺ T-lymphocyte induces the immunopathology via various mechanisms; however, its kinetics in different onset of fever and disease severity are not fully understood. This s...

Background: Inactivated poliovirus vaccine (IPV) is rarely used in tropical developing countries. To generate additional scientific information, especially on the possible emergence of vaccine-derived polioviruses (VDPVs) in an IPV-only environment, we initiated an IPV introduction project in Yogyakarta, an Indonesian province. In this report, we...

Background Clinical and biochemical impacts on liverdysfunction, as manifested by an increase in serum transaminaselevels, are common in dengue infection. Howevei; an association ofelevated serum transaminase and dengue shock syndrome (DSS)has n ot been well-established.Objective To assess for an association between serum transaminaselevels and the...

Background Clinical and biochemical impacts on liver dysfunction, as manifested by an increase in serum transaminase levels, are common in dengue infection. However, an association of elevated serum transaminase and dengue shock syndrome (DSS) has not been well-established. Objective To assess for an association between serum transaminase levels a...

18 Apr 2014: The PLOS Neglected Tropical Diseases Staff (2014) Correction: Dengue Research Funded by the European Commission-Scientific Strategies of Three European Dengue Research Consortia. PLOS Neglected Tropical Diseases 8(4): e2883. https://doi.org/10.1371/journal.pntd.0002883 View correction

In his recent perspective entitled Dengue: the Syndromic Basis to Pathogenesis Research, Inutility of the 2009 WHO Case Definition, Halstead expresses concern that adoption of the 2009 World Health Organization (WHO) classification scheme will compromise the “analytic clarity needed to understand mechanisms underlying dengue pathophysiology, pathog...

Dengue clinical scenarios. (DOC)

Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage. As a result of this prophylactic platelet transfusions ar...

In view of the long term discussion on the appropriateness of the dengue classification into dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), the World Health Organization (WHO) has outlined in its new global dengue guidelines a revised classification into levels of severity: dengue fever with an intermediary grou...

Overview table of opinions regarding revised dengue classification and treatment algorithm

A prospective study on dengue (DEN) viruses was initiated in October 1995 in Gondokusuman kecamatan, Yogyakarta, Indonesia. This report presents data from the first year of the study. The studied cohort included all children 4-9 years of age living in the kecamatan. Blood samples for serology were collected from 1,837 children in October 1995 and a...