Ida Kristin Haugen

Ida Kristin Haugen
Diakonhjemmet Hospital (Norway) · Department of Rheumatology

MD, PhD

About

211
Publications
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Introduction
Skills and Expertise
Additional affiliations
January 2006 - present
Diakonhjemmet Hospital (Norway)
Position
  • PostDoc Position

Publications

Publications (211)
Article
Objectives The IMI-APPROACH knee osteoarthritis study used machine learning (ML) to predict structural and/or pain progression, expressed by a structural (S) and pain (P) predicted-progression score, to select patients from existing cohorts. This study evaluates the actual 2-year progression within IMI-APPROACH, in relation to the predicted progres...
Article
Objective To examine whether psychological symptoms and cognitive patterns are associated with self-reported pain and pain sensitization in people with hand osteoarthritis (OA). Design In the Nor-Hand study (n = 300), people with hand OA self-reported psychological symptoms (Hospital Anxiety and Depression Scale), cognitive patterns (Pain catastro...
Article
Objective To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function. Design We used baseline data from the APPROACH cohort, comprising persons with knee OA fulfilling the clinical American College of Rheumatology classification criteria. Radi...
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Background There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units (IMUs), might be a user-friendly and objective method to assess function. This study evaluates the validity and responsiveness of GaitSmart®...
Article
Objectives Osteoarthritis (OA) patient stratification is an important challenge to design tailored treatments and drive drug development. Biochemical markers reflecting joint tissue turnover were measured in the IMI-APPROACH cohort at baseline and analysed using a machine learning approach in order to study OA-dominant phenotypes driven by the endo...
Article
Objective: To examine the association of body mass index (BMI) with pain in people with hand osteoarthritis, and explore whether this association, if causal, is mediated by systemic inflammatory biomarkers. Methods: In 281 Nor-Hand study participants, we estimated associations between BMI and hand pain by Australian/Canadian Osteoarthritis Hand...
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Objectives: In Phase 1 of developing new hand osteoarthritis (OA) classification criteria, features associated with hand OA were identified in a population with hand complaints. Radiographic findings could better discriminate patients with hand OA and controls than clinical examination findings. The objective of Phase 2 was to achieve consensus on...
Article
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Objective To examine associations of pain sensitisation with tender and painful joint counts and presence of widespread pain in people with hand osteoarthritis (OA). Methods Pressure pain thresholds (PPT) at a painful finger joint and the tibialis anterior muscle, and temporal summation (TS) were measured in 291 persons with hand OA. We examined w...
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Objectives Osteoarthritis (OA) patients with a neuropathic pain (NP) component may represent a specific phenotype. This study compares joint damage, pain and functional disability between knee OA patients with a likely NP component, and those without a likely NP component. Methods Baseline data from the Innovative Medicines Initiative Applied Publ...
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Objective To examine the frequency of Complementary and Alternative Medicine (CAM) in a hand osteoarthritis (OA) population, and to compare demographic and clinical characteristics between persons with hand OA visiting vs. not visiting CAM providers. Methods 300 persons with hand OA from the Nor-Hand study responded to questionnaires concerning de...
Article
Objective Pain sensitization is associated with pain severity in persons with hand osteoarthritis (OA). What contributes to pain sensitization is unclear. This study explores whether hand OA pathologies and symptom duration are related to central sensitization. Method Participants with hand OA in the Nor-Hand study underwent bilateral hand radiogr...
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Objective: Physical function is one of the Outcome Measures in Rheumatology (OMERACT) core outcome domains for hand osteoarthritis studies. Our aim was to select appropriate instrument(s) to measure this domain, as part of the development of a core outcome measurement set. Methods: Following the OMERACT Filter 2.1 instrument selection process, t...
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Context: Repetitive joint use is a risk factor for osteoarthritis, which is a leading cause of disability. Sports requiring a bat or racket to perform repetitive high-velocity impacts may increase the risk of thumb-base osteoarthritis. However, this hypothesis remains untested. Objective: To determine if a history of participation in racket or bat...
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Objectives To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted probabilities for knee osteoarthritis (OA) structural (S) progression and/or pain (P) progression. Methods Baseline clinical characteristics o...
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Objective To standardize and assess the reliability of ultrasonographic assessment of inflammatory and structural lesions in patients with hand osteoarthritis (OA). Methods The Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group selected synovial hypertrophy (SH), joint effusion (JE), and power Doppler (PD) signals as the main infl...
Article
Objective To investigate the metabolic syndrome (MetS) association with radiographic and symptomatic hand osteoarthritis (OA). Methods Using 1:2 propensity-score-matching for relevant confounders, we included 2509 (MetS+896: MetS–1613) participants from the Osteoarthritis Initiative dataset. MetS and its components, according to the International...
Article
Objective To evaluate age, sex, race, osteoarthritis severity, metabolic factors, and bone health as risk factors for incident erosive hand osteoarthritis (EHOA) at baseline and over 48‐month period. Methods This study was a longitudinal cohort design including participants from the Osteoarthritis Initiative with complete hand radiographs from bas...
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Background Current health policy states that patients with osteoarthritis (OA) should mainly be managed in primary health care. Still, research shows that patients with hand OA have poor access to recommended treatment in primary care, and in Norway, they are increasingly referred to rheumatologist consultations in specialist care. In this randomiz...
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Objectives To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, and to evaluate if GaitSmart analysis is related to the presence and severity of radiographic knee OA. Methods GaitSmart analysis was p...
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Knee osteoarthritis (OA) is a heterogeneous disease associated with substantial effects on quality of life, and its clinical management is difficult. Among the several available guidelines for the management of knee OA, those from OARSI and ESCEO were updated in 2019. Here, we examine the similarities and differences between these two guidelines an...
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Background: Knowledge is lacking on patient goals and motivation for carpometacarpal joint osteoarthritis (CMCJ OA) surgery. The objective of this study was to explore patient goals and motivation for surgery, whether patient goals were reflected in self-reports of pain and function, and factors characterizing patients highly motivated for surgery...
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Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors. Patients and methods: The FOI scans we...
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Objective To compare levels of grip strength in persons with hand osteoarthritis (OA) with normative values, and examine how hand OA severity and other biopsychosocial factors are associated with grip strength. Methods Levels of grip strength across age groups were compared with normative values from the general population in sex‐stratified analys...
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Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using conventional and novel clinical, imaging, and biochemical markers, to support OA drug development. Participants APPROACH is a prospective c...
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Objectives Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. Methods In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) wer...
Article
Background Overweight and obesity are well-known risk factors for osteoarthritis (OA) in weight-bearing joints. However, the role of increased body mass index (BMI) and waist circumference in OA of the non-weight-bearing joints is more controversial. Few hand OA studies have explored the associations between increased BMI/waist circumference and pa...
Article
Background Pressure pain threshold (PPT) is a measure of pain sensitization; altered pain mechanisms in the peripheral and/or central nervous system causing increased pain sensitivity. PPT testing may be a useful tool to classify pain phenotypes but requires special equipment not available in the clinic. The Doyle index (DI) is a clinical measure o...
Article
Background Fluorescence Optical Imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. Objectives We wanted to assess the validity and diagnostic performance of FOI measuring synovitis, comparing it with Magnetic Resonance Imaging (MRI)- and ultrasound-detected synovitis in persons with hand osteoarthritis...
Preprint
Full-text available
Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors. Patients and Methods: The FOI scans were...
Preprint
Full-text available
Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors. Patients and Methods: The FOI scans were...
Article
Full-text available
Objective: Fluorescence optical imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in persons with hand OA, comparing it with magnetic resonance imaging (MRI)- and ultrasound-detected synovitis. Methods: Two hundre...
Preprint
Full-text available
Objective: Fluorescence Optical Imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in persons with hand OA, comparing it with magnetic resonance imaging (MRI)- and ultrasound-detected synovitis. Methods: 221 participa...
Preprint
Full-text available
Objective: Fluorescence Optical Imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in persons with hand OA, comparing it with magnetic resonance imaging (MRI)- and ultrasound-detected synovitis. Methods: 221 participa...
Article
Objectives: To determine the associations between race (black versus nonblack) and the presence of radiographic, symptomatic, and clinical hand osteoarthritis (OA). Methods: Using the Osteoarthritis Initiative cohort with available hand radiographs (n=4,699, black subjects n=849[18.1%], nonblack subjects n=3,850[81.9%]), propensity score-matchin...
Article
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Objectives: Pain sensitization contributes to the complex osteoarthritis (OA) pain experience. The relation between hand OA imaging features and clinically assessed pain sensitization is largely unexplored. We aimed to examine the association of structural and inflammatory features of hand OA with local pressure pain thresholds in the Nor-Hand stu...
Article
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Objective Fluorescence Optical Imaging (FOI) demonstrates indocyanine green (ICG)-enhanced microcirculation in wrist and finger joints, as a sign of inflammation. We wanted to assess the reliability of three FOI scoring methods from Berlin, Stockholm, and Copenhagen, to assess the validity of FOI with MRI as reference and to compare enhancement in...
Article
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Objective MicroRNAs (miRNAs) are being launched as biomarkers for various diseases, but a robust biomarker for articular cartilage pathology has yet to be discovered. Here we evaluate plasma extracellular vesicle (EV) miRNAs as possible biomarkers for osteoarthritis (OA). Method We compared miRNA levels found in plasma EVs from patients with OA wi...
Article
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Objectives To evaluate whether occupational therapy, provided in the period between referral and surgical consultation, might delay or reduce the need of surgery in thumb carpometacarpal joint (CMCJ) osteoarthritis and to explore predictors for CMCJ surgery. Methods This multicentre randomised controlled trial included patients referred for surgic...
Article
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Background: Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. Objective: To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration < 2 years) and active (DAS28 > 3.2) RA over a pe...
Article
Objectives: Joint swelling and tenderness are considered a proxy for inflammation in patients with rheumatoid arthritis (RA). With ultrasound-detected inflammation as reference, our objectives were to explore on patient and joint level the associations between ultrasound synovitis and joint swelling, tenderness and patient-reported joint pain (PRJ...
Article
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Objective: To explore whether ultrasound-detected grey-scale synovitis and power Doppler activity in the interphalangeal and 1st carpometacarpal (CMC-1) joints is associated with pain and physical function in patients with hand osteoarthritis (OA). Methods: 290 patients with hand OA underwent an ultrasound examination of the bilateral interphala...
Article
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Background: The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to compare the levels of arterial CVD risk markers between OA phenotypes and controls. Method: The "Musculoskeletal pain in Ullensak...
Article
Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from expert consensus and based on objective review of high-quality meta-analytic data. Methods:...
Conference Paper
Full-text available
Background The 2018 update of the EULAR recommendations for the management of hand osteoarthritis (OA) states that every patient with hand OA should be offered patient education, hand exercises and provision of assistive devices. Orthoses should be considered for symptom relief in patients with thumb carpometacarpal (CMC1) OA. Surgery should only b...
Conference Paper
Background Conditioned pain modulation (CPM) assesses adequacy of descending modulatory pathways. Temporal summation (TS) reflects ascending facilitation of nociceptive signals in the central nervous system (central sensitization). Inadequate CPM and enhanced TS of pain are both known to contribute to pain in chronic pain conditions. Different pain...
Conference Paper
Background Increased sensitivity to pain in the area around joints with osteoarthritis (OA), i.e., peripheral sensitization, is associated with higher pain severity. The mechanisms underlying peripheral sensitization in hand OA have not been substantially explored in previous studies. Objectives We aimed to explore whether the severity of structur...
Conference Paper
Background Fluorescence Optical Imaging (FOI) is an imaging technique demonstrating indocyanine (ICG)-enhanced microcirculation in wrist and finger joints, as a sign of inflammation. A reliable scoring method is essential in the assessment of these images. Objectives To assess inter-reader reliability of three FOI scoring methods from Berlin, Stoc...
Conference Paper
Background Despite no current knowledge of lesions or disease of the sensory nervous system in osteoarthritis (OA), subgroups of knee OA patients report neuropathic-like pain. The neuropathic-like pain component has been suggested to reflect central sensitization. Objectives To describe the prevalence of neuropathic-like pain in persons with hand...
Conference Paper
Background Pain in osteoarthritis (OA) causes significant physical, psychological and social limitations. Increased understanding of the pain experience is important for improved patient care. Objectives We aimed to assess the pain characteristics of hand OA using the McGill Pain Questionnaire, a multidimensional self-reporting questionnaire that...
Article
Objective: To compare direct evaluation of cartilage with high resolution MRI (hrMRI) to indirect cartilage evaluation using MRI inter-bone distance in hand OA patients and healthy controls. Design: 41 hand OA patients and 18 healthy controls underwent hrMRI of the 2nd and 3rd metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints....
Article
Full-text available
Background Osteoarthritis (OA) in the thumb carpometacarpal joint (CMCJ) is a prevalent disease which may lead to structural damage, severe pain and functional limitations. Evidence-based treatment recommendations state that all patients with hand OA should be offered non-pharmacological treatment. Surgery should be considered only when other treat...