Ibrahim González-MarreroUniversidad de La Laguna | ULL · Department of Anatomy, Pathological Anatomy and Histology
Ibrahim González-Marrero
PhD
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86
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412
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Citations since 2017
Introduction
Additional affiliations
December 2009 - present
January 2006 - present
Education
September 1997 - June 2003
Publications
Publications (86)
The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β-amyloid metabolism and inflammatory processes. Cerebrospinal fluid (CSF) is a system linked to the...
Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Ab) peptides at the blood-CSF barrier (BCSFB), contribute to complications of Alzheimer’s disease (AD). The AD triple transgenic mouse model (3xTg-AD) at 16 month-old mimics critical hallmarks of the hum...
Aquaporin 1 (AQP1) and aquaporin 4 (AQP4) have been identified in the eye as playing an essential role in the formation of the aqueous humor along with the Na+/K+ ATPase pump. Different authors have described the relationship between blood pressure, aqueous humor production, and intraocular pressure with different conclusions, with some authors sup...
Hypertension is the leading cause of cardiovascular affection and premature death world- wide. The spontaneously hypertensive rat (SHR) is the most common animal model of hypertension, which is characterized by secondary ventricular dilation and hydrocephalus. Aquaporin (AQP) 1 and 4 are the main water channels responsible for the brain’s water bal...
Introduction:
The relationship between the entorhinal cortex (EC) and the hippocampus has been studied by different authors, who have highlighted the importance of grid cells, place cells, and the trisynaptic circuit in the processes that they regulate: the persistence of spatial, explicit, and recent memory and their possible impairment with agei...
The neuropeptide neurotensin (NTS) is involved in regulating the reproductive axis and is expressed at each level of this axis (hypothalamus–pituitary–gonads). This dependence on estrogen levels has been widely demonstrated in the hypothalamus and pituitary. We focused on confirming the relationship of NTS with estrogens and the gonadal axis, using...
Hydrocephalus is a central nervous system condition characterized by CSF buildup and ventricular hypertrophy. It is divided into two types: communicative and non-communicating hydrocephalus. Congenital hydrocephalus has been linked to several changes in the subcommissural organ (SCO). However, it is unclear whether these changes occur before or as...
Aquaporin 4 (AQP4) is a cerebral glial marker that labels ependymal cells and astrocytes’ endfeet and is the main water channel responsible for the parenchymal fluid balance. However, in brain development, AQP4 is a marker of glial stem cells and plays a crucial role in the pathophysiology of pediatric hydrocephalus. Gliogenesis characterization ha...
Hydrocephalus is a distension of the ventricular system associated with ventricular zone disruption, reactive astrogliosis, periventricular white matter ischemia, axonal impairment, and corpus callosum alterations. The condition's etiology is typically attributed to a malfunction in classical cerebrospinal fluid (CSF) bulk flow; however, this appro...
Resumen Enfermedad Alzheimer y diabetes mellitus, ¿enfermedad neuroendocrina? El presente documento se centra en estudiar la enfermedad de Alzheimer (EA) como una enfermedad neuroendocrina, puesto que hay evidencias que demuestran que personas con diabetes mellitus tipo 2 (DMT2) o tipo 1(DMT1) tienen un mayor riesgo de padecer EA con respecto a que...
Introduction:
The relationship between the entorhinal cortex and the hippocampus has been studied by different authors, who have highlighted the importance of grid cells, place cells, and the trisynaptic circuit in the processes that they regulate: the persistence of spatial, explicit, and recent memory and their possible impairment with ageing....
Resumen
Uso de antihipertensivos en la prevención del deterioro cognitivo y demencias La hipertensión arterial es un problema de salud pública que afecta a millones de personas en todo el mundo. El control de las cifras de presión arterial puede ser un factor importante en la prevención de enfermedades cardiovasculares. La hipertensión provoca una...
Introduction
The choroid plexuses, blood vessels, and brain barriers are closely related both in terms of morphology and function. Hypertension causes changes in cerebral blood flow and in small vessels and capillaries of the brain. This review studies the effects of high blood pressure (HBP) on the choroid plexuses and brain barriers.
Development...
The choroid plexus (ChP) is involved in the production of cerebrospinal fluid (CSF) and is intimately related to CSF physiopathology. Aquaporin-1 (AQP1) is the water channel directly implicated in CSF production and a potential therapeutic target in the management of CSF circulation disorders. Pathologies that present ventriculomegaly are associate...
Uso Terapéutico de los Cannabinoides en la Enfermedad de Parkinson. Revisión
La enfermedad de Parkinson es una enfermedad neurodegenerativa, compleja y crónica. Con ella se produce un deterioro progresivo del sistema nervioso central, en los pacientes que la padecen.Aunque en la actualidad no existe cura, existen muchísimas formas terapéuticas par...
Holoprosencephaly (HPE) is a birth defect that occurs during the first weeks of pregnancy and as a result the prosencephalon does not clearly divide in diencephalon, two halves of the telencephalon and lateral ventricles in the brain of the fetus and, in general, HPE is accompanied by facial defects. There are three main types of holoprosencephaly...
Introduction:
The choroid plexuses, blood vessels, and brain barriers are closely related both in terms of morphology and function. Hypertension causes changes in cerebral blood flow and in small vessels and capillaries of the brain. This review studies the effects of high blood pressure (HBP) on the choroid plexuses and brain barriers.
Developme...
Resumen Efectos de la castración perinatal y prepuberal sobre la amígdala cerebral La amígdala es considerada como el centro de las emociones y regulador de reacciones de agresividad, miedo y ansiedad. En humanos la amígdala se asocia con el aprendizaje emocional y la conducta social. La amígdala también juega un rol importante en la conducta sexua...
The non-canonical (non-classical) ligand of the Notch signaling pathway, Delta like-1 (DLK1) is expressed throughout fetal development, and is limited to few organs or tissues in adulthood.
Presently, DLK1 is the best studied non-classical ligand of Notch. In vitro, this gen acts inhibiting Notch whereas, in vivo, its action is unclear. The levels...
The choroid plexuses (ChP) are highly vascularized tissues suspended from each of the cerebral ventricles. Their main function is to secret cerebrospinal fluid (CSF) that fills the ventricles and the subarachnoid spaces, forming a crucial system for the development and maintenance of the CNS. However, despite the essential role of the ChP–CSF syste...
Previous work from our group has shown that structural lipids of Lipid Raft microdomains are altered in cortical areas of Parkinson’s disease (PD), even at early preclinical stages. These aberrations induce pathological protein rearrangements that are a potential trigger for aberrant signalling pathways, leading to cognitive decline that takes plac...
Dopamine beta hydroxylase and p73 expression in the Compound Eyes of the Branchipus schaefferi and Artemia parthenogenetica. The anostraca Branchipus schaefferi belongs to the most endangered crustacean species in Europe. The Branchipus schaefferi inhabits small, temporary ponds with turbid water; the periods of desiccation are inundated with quies...
Choroid plexus (CP) has important physiological and pathological roles in Alzheimer disease (AD). The AD triple transgenic mouse model (3xTg-AD) is an animal model that mimics many critical hallmarks of the disease. The effects of high expression of human transgress on the CP function of 3xTg-AD mice were analyzed in this study. The confocal image...
Objective:
The aim of the present work was to make a comparative analysis of the cerebrospinal fluid levels of Tumor necrosis factor (TNFα) and aquaporin 1 (AQP1) in (i) healthy elder control, (ii) patients with mild cognitive impairment and, (iii) patients with idiopathic normal pressure hydrocephalus.
Patients and methods:
Samples of CSF were...
Prenatal and one-two month postnatal testos-terone influences human neural and behavioural development, since the prenatal and one-two month postnatal hormone environment clearly contributes to the development of sex-related variation in human behaviour, and plays a role in the development of the sexual brain and individual differences in behaviour...
Prenatal and one-two month postnatal testosterone influences human neural and behavioural development, since the prenatal and one-two month postnatal hormone environment clearly contributes to the development of sex-related variation in human behaviour, and plays a role in the development of the sexual brain and individual differences in behaviour...
Hydrocephalus is an accumulation of cerebrospinal fluid (CSF) with dilatation of brain ventricles
which can be either communicating or noncommunicating. Multiple pathophysiological mechanisms
underlie the appearance of hydrocephalus, which has many different causes including birth
defects, brain hemorrhage, infection, meningitis, tumor, or head inj...
El desarrollo de sistema olfativo y la diferenciación sexual del encéfalo, tanto en el hombre como en los animales, están estrechamente relacionados. Actualmente, se describe la imbricación entre la formación del sistema olfativo principal y la migración de las neuronas que sintetizan la hormona liberadora de gonadotrofinas (GnRF). Estas neuronas G...
The syndrome of inappropriate antidiuretic hormone (SIADH) is a disease characterized by hyponatremia and hyperosmolarity of urine where vasopressin and angiotensin II are implicated in the alteration of salt water balance and cardiovascular and blood pressure regulation. The aim of this study is to analyse the expression of substances related with...
Neuromyelitis optica is an inflammatory disease characterized by neuritis and myelitis of the optic nerve. Its physiopathology is connected with the aquaporin-4 water channel, since antibodies against aquaporin-4 have been found in the cerebrospinal fluid and blood of neuromyelitis optica patients. The seropositivity for aquaporin-4 antibodies is u...
Neuromyelitis optica is an inflammatory disease characterized by neuritis and myelitis of the optic nerve. Its physiopathology is connected with the aquaporin-4 water channel, since antibodies against aquaporin-4 have been found in the cerebrospinal fluid and blood of neuromyelitis optica patients. The seropositivity for aquaporin-4 antibodies is u...
Kallmann syndrome (KS) is a genetic disorder which combines hypogonadotropic hypogonadism and anosmia. Hypogonadism is characterized by the absence or reduced levels of gonadotropin-releasing hormone and anosmia due to olfactory bulb aplasia. KS treatment usually begins just before puberty, but brain sexual maturation occurs long before puberty nor...
Summary
Water channels. Aquaporins 1 and 4 in the central nervous system and its relation to the hydrocephalus.
Aquaporins are membrane-bound water channel and highly related to the development and resolution of brain edema. Aquaporin-1(AQP1) is highly expressed at the choroid plexus and is related to CSF production. Aquaporin-4 (AQP4) is a water c...
10:1-6 www.majorensis.es Majorensis ISSN 1697-5529 1 Los canales de agua. Acuaporinas 1 y 4 en el sistema nervioso central y su relación con la hidrocefalia. Recibido 20-Enero-2014; revisado 05-Febrero-2014; aceptado 17-Febrero-2014 Resumen Los canales de agua. Acuaporinas 1 y 4 en el sistema nervioso central y su relación con la hidrocefalia. Las...
Transporte del β-amilode a través de las barreras cerebrales y su posible implicación en el desarrollo de la enfermedad de Alzheimer.
Summary
β-amyloid transport through the brain barrier and its possible role in the development of Alzheimer's disease. The clearance of β-amyloid, through its accurate metabolism in the brain, is essential to preve...
The p73 proteins are present in different kinds of cells of the central nervous system, such as the choroid plexus, circumventricular structures and neuroepithelium. It has been reported that spontaneously hypertensive rats show ventricular dilation, changes in cerebrospinal fluid proteins and variations in the circumventricular structures such as...
Background
Aquaporin-4 (AQP4) is a water channel mainly located in the ventricular ependymal cells (brain-CSF barrier), the sub-ependymal glia, glia limitans and in end-feet of astrocytes in at the blood–brain barrier (BBB).
Methods
In the present work, the expression of AQP4 in the cerebrospinal fluid (CSF) in control and congenital human hydroce...
Recibido 08-septimebre-2012; revisado 18-septiembre-2012; aceptado 26-septiembre-2012 Resumen La Hidrocefalia Congénita. Consideraciones sobre las vías menores de producción y reabsorción del líquido cefalorraquídeo. La hidrocefalia es una activa distensión del sistema ventricular cerebral debido a un mal funcionamiento en cualquier lugar del flujo...
Luteinizing hormone-releasing hormone (LHRH) neurons and fibers are located in the anteroventral hypothalamus, specifically in the preoptic medial area and the organum vasculosum of the lamina terminalis. Most luteinizing hormone-releasing hormone neurons project to the median eminence where they are secreted in the pituitary portal system in order...
It has been reported that spontaneously hypertensive rats (SHR) show ventricular dilation, changes in CSF proteins and variations in the circumventricular organs (CVO) such as: the subcommissural organ (SCO), the subfornical organ (SFO) and the area postrema (AP) which are located in the walls of the third and fourth ventricles. On the other hand,...
The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is a disease characterized by hyponatremia and hyperosmolality of urine, and where vasopressin, angiotensin II and catecholamines are implicated in salt water balance, cardiovascular and blood pressure regulation. Therefore, the aim of this study is to analyze the hypothalamic distribution...
High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebro-spinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeabili...
High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebro- spinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeabil...
Congenital hydrocephalus. Considerations on the minor pathways of cerebrospinal fluid production and reabsorption. Hydrocephalus is an active distension of the ventricular system due to a malfunction in any part
of the flow of cerebrospinal fluid, either at the point of production, within the ventricles or at the point
of absorption into the circul...
Catecholamine manifestation in the adrenal medulla of hypertensive mice (BPH/2).The hypertensive inbred mouse strain, BPH/2, has high blood pressure early in life, compared with its hypotensive BPL/1 and normotensive BPN/3 controls. The present study analyses, by immunohistochemistry in the adrenal medulla, the expression of catecholamine biosynthe...
The subcommissural organ (SCO) releases glycoproteins into the ventricular cerebrospinal fluid (CSF), where they form Reissner´s fibre (RF) and also secretes a CSF-soluble material different from RF-material. Pax6 is a transcription factor important for the regulation of cell proliferation, migration and differentiation
in the developing brain. In...
The subcommissural organ (SCO) is a cerebral structure, formed by an ependymal differentiation of the third ventricle and is composed of two layers of cells: the ependymal layer in contact with the ventricular light and the hypendymal layer just below the posterior commissure (PC). The subcommissural organ (SCO) functions are associated with the ci...
Reissner�s fibre (RF) is formed by the polymerization of the glycoprotein secreted by the subcommissural organ (SCO).The SCO also secretes soluble glycoprotein into the cerebrospinal fluid (CSF); variations in RF and SCO have been reported in hydrocephalus. On the other hand, hydrocephalus and other brain alterations have been described in p73 muta...
Summary
The expression in the brain of exogenously
administered genes has been proposed as an
alternative therapy for a large variety of hereditary
and acquired diseases of the SNC, and in particular
for those whose available treatment does not offer
complete recovery and can even have serious side
effects. There has been much research into gene
th...
Los músculos supernumerarios del pie, no son nombrados con frecuencia en los textos deanatomía, pero su presencia puede en ocasiones producir alteraciones en la biomecánica articular o compresión de los nervios plantares. Describimos la presencia de un músculo supernumerario bilateral, en un cadáver de un hombre adulto procedente del Departamento d...
In hydrocephalus alterations of the brain structures have been described, among them: cortical displacement, cerebrospinal fluid composition alterations and circumventricular structure variations are described and many of these variations could be cause or consequences of the hydrocephalus. The protein p73 is a member of a family of transcription f...
The adrenal medulla is composed mainly by chromaffin cells producing of hormones, being the main organ for converting the tyrosine aminoacid in the catecholamines adrenaline and noradrenalin. The cells of the adrenal medulla derive embryologically from neural crest, like neurons modified. The protein p73 is a member of a family of transcription fac...
The paraventricular hypothalamic nucleus (PVN) and supraoptic nucleus (SOP) are two brain structures closely related with hypothalamichypophyseal axis and play an important roll in the cardiovascular regulation and of the salt-water balance mechanism. The hormone vasopressin, well known for its pressor and antidiuretic effects, is primarily synthes...
The dorsal vagal complex (CVD) is formed by the nucleus tractus solitarii, (NTS), the dorsal motor
nucleus of the vagus nerve (NMDV) and the area postrema (AP).The CVD functions has been
connected with the cardiovascular regulations and is considered a relay centre for integrating central and
peripheral signals related to cardiovascular regulation....
