About
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Introduction
Additional affiliations
January 2000 - present
University of Chicago
Position
- Professor
January 1989 - present
January 1985 - December 1988
Projects
Projects (16)
Noncoding DNA - once called “junk” has revealed itself to be full of function (ENCODE). Technology development has allowed researchers to gather genome-scale data pointing towards complex regulatory regions, expression and function of noncoding RNA genes, and conserved elements. Variation in these regions has been tied to variation in biological function and human disease. This project tackles the problem of analyzing and clinically interpreting the data relating to
variation in and interactions between noncoding regions through computational biology. These outcome provides a ‘roadmap’ of disease mechanisms emerging from GWAS and further identify candidate therapeutic targets among downstream effectors of intergenic SNPs.
