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Ian Homer Y. Cua

Ian Homer Y. Cua
St. Luke's Medical Center Philippines · Institute of Digestive and Liver Diseases

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43
Publications
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1,529
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Publications

Publications (43)
Article
Purpose of review: There has been a deluge of scientific data since coronavirus disease 2019 (COVID-19) was first reported. The effects of COVID-19 on the digestive system are now increasingly well understood. This article aims to review the current data on the effects of COVID-19 on the digestive system with particular emphasis on preexisting dig...
Article
Budd Chiari syndrome (BCS) is a diverse disease with regard to the site of obstruction, the predisposing thrombophilic disorders and clinical presentation across the Asia-Pacific region. The hepatic vein ostial stenosis and short segment thrombosis are common in some parts of Asia-Pacific region, while membranous obstruction of the vena cava is com...
Article
Full-text available
Given the global health burden caused by the Coronavirus Disease 2019 (COVID‐19), there have been numerous studies aimed to understand its clinical course and to determine risk factors that may impact prognosis. Pre‐existing medical conditions are linked with COVID‐19 severity, particularly cardiometabolic diseases. Increasing evidence has also lin...
Article
There has been a shift towards the use of digital technology worldwide due to the COVID‐19 pandemic. People are advised to stay at home to maintain physical distancing and reduce risks of infection. Clinical services are put to minimum operations and routine endoscopic services have been inadvertently halted. With no definitive treatment of the vir...
Article
Full-text available
Metabolic associated fatty liver disease (MAFLD) is the principal worldwide cause of liver disease and affects nearly a quarter of the global population. The objective of this work was to present the clinical practice guidelines of the Asian Pacific Association for the Study of the Liver (APASL) on MAFLD. The guidelines cover various aspects of MAF...
Article
Full-text available
Background: The COVID-19 pandemic has caused disruption of routine gastroenterology practice which has resulted in the suspension of elective endoscopic procedures and outpatient consults. For the past months, the strategy was to mitigate infection risk for the healthcare team while still providing essential service to patients. A prolonged suspens...
Article
Full-text available
Although Coronavirus disease 2019 (COVID‐19) is primarily a respiratory disease, growing evidence shows that it can affect the digestive system and present with gastrointestinal (GI) symptoms. Various nutrition societies have recently published their guidelines in context of the pandemic, and several points emphasize the impact of these GI manifest...
Article
Full-text available
Asia has intermediate-to-high prevalence and high morbidity of hepatitis B virus (HBV) infection. The use of guideline-recommended nucleos(t)ide analogs with high barrier to resistance, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), is one of the key interventions for curbing HBV infection and associa...
Article
Full-text available
Background and aims COVID-19 is a dominant pulmonary disease, with multisystem involvement, depending upon comor-bidities. Its profile in patients with pre-existing chronic liver disease (CLD) is largely unknown. We studied the liver injury patterns of SARS-Cov-2 in CLD patients, with or without cirrhosis. Methods Data was collected from 13 Asian c...
Article
Background and aimsCOVID-19 is a dominant pulmonary disease, with multisystem involvement, depending upon comorbidities. Its profile in patients with pre-existing chronic liver disease (CLD) is largely unknown. We studied the liver injury patterns of SARS-Cov-2 in CLD patients, with or without cirrhosis.Methods Data was collected from 13 Asian coun...
Preprint
Full-text available
Background and Aims: COVID-19 is a dominant pulmonary disease, with multisystem involvement, depending upon co morbidities. Its profile in patients with pre-existing chronic liver disease (CLD) is largely unknown. We studied the liver injury patterns of SARS-Cov-2 in CLD patients, with or without cirrhosis. Methods: Data was collected from 13 Asian...
Article
Full-text available
The Coronavirus Disease 2019 (COVID‐19) is a respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has been classified as a pandemic by the World Health Organization in March 2020. Several studies have demonstrated that the gastrointestinal (GI) tract is also a potential route. As the pandemic is continu...
Article
Full-text available
Asia has an intermediate-to-high prevalence of and high morbidity and mortality from hepatitis B virus (HBV) infection. Optimization of diagnosis and initiation of treatment is one of the crucial strategies for lowering disease burden in this region. Therefore, a panel of 24 experts from 10 Asian countries convened, and reviewed the literature, to...
Conference Paper
Full-text available
Background Hepatic encephalopathy (HE) is one of the most common causes of hospitalization in patients with cirrhosis. It poses an increasingly recognized burden on the health care system and the patient‘s quality of life. Lactulose has been the standard pharmacologic treatment for overt HE for a long time. Recently, polyethylene glycol (PEG) elect...
Conference Paper
Full-text available
Background Optimal nutrition is paramount to the care of cirrhotic patients. Given the strong correlation of nutrition to various clinical outcomes, it is necessary to accurately assess the nutritional status of cirrhotic patients. In our knowing, there is no published material regarding cirrhosis and malnutrition in the Philippines. Hence, it woul...
Conference Paper
Full-text available
Background In the Philippines, data is limited on the characteristics of patients with hepatocellular carcinoma (HCC). Recent studies from other neighboring Asian countries suggests a change in trend in the epidemiology of HCC. This study aims to update the data, describe the etiology and clinical profile of patients with HCC at 2 tertiary referral...
Conference Paper
Full-text available
Background Spontaneous bacterial peritonitis (SBP) is a frequent complication seen among cirrhotic patients. The use of proton pump inhibitors (PPIs) has been suggested to be associated with a higher incidence of SBP. However, previous studies including case controls, cohorts, and meta-analyses provided conflicting conclusions. In light of newer st...
Article
Full-text available
Background: The population of Asia exceeds 4.4 billion people. Chronic hepatitis C virus (HCV) infection in Asia is characterized by specific distribution of genotypes, lack of access to specific therapeutic agents, relatively high cost of treatment, and lack of experienced healthcare providers. Clear consensus on the diagnosis, management, and mo...
Article
Full-text available
Purpose Selective internal radiation therapy or radioembolization (RE) shows efficacy in unresectable hepatocellular carcinoma (HCC) limited to the liver. This study compared the safety and efficacy of RE and sorafenib in patients with locally advanced HCC. Patients and Methods SIRveNIB (selective internal radiation therapy v sorafenib), an open-l...
Article
Unlabelled: The interaction between insulin resistance (IR), steatosis and genotype to fibrosis in chronic hepatitis C virus (HCV) infection has not been comprehensively assessed. We hypothesized that IR is a key mediator for the development of both steatosis and fibrosis in 346 untreated, nondiabetic patients solely infected with either genotype...
Article
The purpose of this study was to investigate whether combining percutaneous ethanol injection (PEI) with radiofrequency ablation in the management of hepatocellular carcinoma (HCC) in high-risk locations improves treatment outcomes. We compared the outcome of management of high-risk tumors with PEI and radiofrequency ablation (n = 50) or radiofrequ...
Article
Obesity is associated with impaired treatment responses in chronic hepatitis C. The aim of this study was to determine the relationship between the insulin resistance frequently seen in obese subjects and sustained virological response to anti-viral therapy (SVR) in patients with genotype 2 or 3 infection. Eighty-two patients were studied; 59 recei...
Article
To compare the effectiveness of modified automated and manual pulsed radiofrequency (RF) algorithms using internally cooled electrodes for hepatocellular carcinoma (HCC). Seventy-seven treatment-naive cirrhotic patients with 102 HCC (< or =4 cm) underwent 109 sessions of ultrasound-guided percutaneous RF ablation using a 17-gauge, 20-cm-long, singl...
Article
Unlabelled: The role of tumor necrosis factor alpha, interleukin 6, leptin, and adiponectin in the pathogenesis of hepatitis C virus (HCV)-associated insulin resistance (IR) remains controversial. We tested the hypothesis that these adipocytokines contribute to chronic HCV-associated IR and liver injury by first comparing their serum levels and ho...
Article
Hepatic steatosis has been associated with fibrosis, but it is unknown whether the latter is independent of the etiology of fat infiltration. We analyzed the relationship between clinical characteristics, insulin resistance (HOMA-R) and histological parameters in 132 patients with "viral" steatosis caused by genotype 3 chronic hepatitis C (CHC-3) a...
Article
Full-text available
Renal disease secondary to chronic hepatitis C virus (HCV) infection is infrequent but often life threatening and difficult to treat. Management is directed towards eradication of the virus. Combination therapy with interferon α or pegylated interferon α and ribavirin has been used successfully to induce recovery from membranoproliferative glomerul...
Article
This article reviews the nomenclature, clinical and histological basis for a diagnosis of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis, its natural history, pathophysiology and an approach to clinical management.

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