Iago Cavalcanti

Iago Cavalcanti
Federal University of Pernambuco | UFPE · Laboratório de Imunopatologia Keizo Asami (LIKA)

Master of Pharmacy

About

72
Publications
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Introduction
I have experience in Pharmacy, with an emphasis on Pharmaceutical Nanotechnology, working on the following topics: Development and characterization of liposomes and polymeric nanoparticles, mechanism of cell endocytosis, cell capture, complement system activation, and antiproliferative activity tests with breast cancer cell lines.
Education
March 2018 - February 2020
Federal University of Pernambuco
Field of study
  • Pharmaceutical nanotechnology
March 2016 - February 2018

Publications

Publications (72)
Article
Bacterial infections have become a global public health problem in recent decades, mainly due to infections caused by Gram-negative bacteria with antibiotic resistance profiles, which were responsible for over 3 million deaths in 2019. Polymyxin B (PMB) and polymyxin E (PME or colistin) are cyclic cationic polypeptide antimicrobials that have re-em...
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Escherichia coli has been associated with the induction of colorectal cancer (CRC). Thus, combined therapy incorporating usnic acid (UA) and antibiotics such as ceftazidime (CAZ), co-encapsulated in liposomes, could be an alternative. Coating the liposomes with chitosan (Chi) could facilitate the oral administration of this nanocarrier. Liposomes w...
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The poly (isobutylcyanoacrylate) (PIBCA) nanoparticles stand out for being developed by biodegradable monomer and presenting simple techniques for obtaining them. Also, these nanoparticles allow their surface modification using polysaccharides that can act as a guiding agent assisting in encapsulated drug pharmacological activity. Therefore, this w...
Article
Introduction: Bee venom has therapeutics and pharmacological properties. Further toxicological studies on animal models are necessary due to the severe allergic reactions caused by this product. Method: Here, Caenorhabditis elegans was used as an in vivo toxicity model, while breast cancer cells were used to evaluate the pharmacological benefits...
Article
Isothermal titration calorimetry (ITC) is a technique for evaluating the thermodynamic profiles of connection between two molecules, allowing the experimental design of nanoparticles systems with drugs and/or biological molecules. Taking into account the relevance of ITC, we conducted, therefore, an integrative revision of the literature, from 2000...
Article
Methods An narrative literature review was carried out using the descriptors "Polypharmacy", "Pharmacological interactions", "Geriatrics" and "Antineoplastic agents", in the ScienceDirect, MEDLINE, and CAPLUS databases. Results One hundred and ten articles were identified, of which 82 were included in this review. The articles showed the importanc...
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Polysaccharides have been described as a successful alternative in developing nanosystems to reach specific sites. Levan is an exopolysaccharide with several biological activities, including immunostimulant, blood plasma substitute, and drug action prolonging agent. The present work aimed to develop poly-isobutyl cyanoacrylate (PIBCA) nanoparticles...
Article
Objective: To analyze the expressions of the social issue, mentioned by women diagnosed with malignant breast cancer. Methodology: This is a qualitative study, based on the critical-dialectic method. Results: From the diagnosis of breast cancer, the expression of the Social Question in the lives of these women intensifies, for several reasons; for...
Article
Aims: This study aimed to evaluate the gastroduodenal protective action of crude fraction extracted from P. caribaeorum mucus in Wistar rats. Main method: Initially, phytochemical screening was performed to measure secondary metabolites present in the extract. Subsequently, studies of gastroprotective action in Wistar rats were developed. The an...
Chapter
In this chapter, I discuss neurological tumors, bringing epidemiological data and talking about the main types of neurological cancers such as gliomas, neuroectodermal, and pituitary tumors. The treatment modalities for these types of tumors are mentioned, as well as some therapeutic protocols indicated for neurological tumors, and their administra...
Chapter
In this chapter, I discuss the main cancers of the gastrointestinal tract, including cancers of the colon and rectum, stomach, esophagus, pancreas, biliary tract, gallbladder, liver, among others, addressing their epidemiological profiles, in addition to bringing some data about pathophysiology of each cancer. I also discuss the protocols used acco...
Chapter
This chapter deals with head and neck cancers, highlighting nasopharyngeal, squamous cell carcinomas, and salivary tumors. I bring epidemiological, pathophysiological data, staging, and the main therapeutic modalities. I also discuss some protocols indicated for the treatment of head and neck cancers, such as the FUP, EP, PG, PC, PCP, PFP, VNC prot...
Chapter
In this chapter, I discuss lung cancers, talking a little about their epidemiology, pathophysiology, and the main treatment modality for each type of lung cancer. I discuss non-small-cell and small-cell lung cancer, as well as malignant mesothelioma. Some protocols used in lung cancer were mentioned along with their infusion sequence, being cited p...
Chapter
In this chapter I discuss infusion therapy, what it is based on, when it is used, and what are its advantages and disadvantages in cancer treatment. I bring the classification of infusion types according to time, such as bolus infusion, rapid infusion and continuous infusion, and its purpose in the application of antineoplastic drugs. I discuss the...
Chapter
This chapter brings the main gynecological cancers such as cancers of the ovary, cervix, endometrium, and gestational trophoblastic neoplasia. I discuss the epidemiological profile of each cancer and bring some data on the pathophysiology, staging, and treatment modalities. The main chemotherapy protocols are also addressed, such as CABR, CAPBEV, C...
Chapter
In this first chapter, we discuss polypharmacy, its concept, and its use in chronic diseases. I emphasize the importance of polypharmacy in the treatment of patients with multimorbidities and its use in the treatment of cancer patients. I also discuss drug interactions that can occur in patients using polypharmacy, highlighting studies that bring d...
Chapter
In this chapter, I discuss breast cancer, bringing epidemiological data and talking a little about its pathophysiology, classification according to the molecular subtype, and the main therapeutic modalities of breast cancer. I discuss several chemotherapy protocols used in the treatment of adjuvant breast cancer, such as the AC, ACT, CMF, FEC, DAC,...
Chapter
In this second chapter, I approach cancer treatment, highlighting cytotoxic chemotherapy and biological therapy, classifying the therapies, and indicating the main drugs included in each anticancer therapy. In addition, I talk about combined therapy, which is based on the association of drugs with different mechanisms of action, promoting greater e...
Chapter
In this chapter I discuss cancers that affect the genitourinary tract, talking a little about the pathophysiology of cancers of the bladder, prostate, testicle, and kidney. I also bring epidemiological data for each cancer and cite the main protocols indicated for each cancer, bringing protocol efficacy data, as well as the infusion schedule for ea...
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Polymyxins were discovered in the 1940s and were used to treat infections caused by gram-negative bacteria. These molecules act by destroying the cell membrane through the destabilization of phospholipids and lipopolysaccharides (LPS). Due to adverse effects, such as nephrotoxicity and neurotoxicity, this class had seen limited use. However, with t...
Article
Pain is one of the main symptoms of cancer and the most difficult to control due to its complexity as it can involve physical, psychological, social, and spiritual aspects. We proposed to summarize the scientific knowledge already published related to the influence of spirituality on pain therapy in cancer patients. Articles were searched in PubMed...
Article
Introduction The main toxicity of cisplatin is nephrotoxicity, but more and more studies have highlighted and unveiled the mechanisms of cisplatin toxicity, and the neurotoxicity has been standing out. Objective We aimed to bring together the main studies that highlight the neurotoxicity of cisplatin in the treatment of cancer patients. Methods W...
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The discovery of antibiotics in the twentieth century made it possible to treat bacterial infections and revolutionized modern medicine. However, gradually, it is possible to perceive a decrease in the effectiveness of antimicrobial agents against pathogenic isolates, which, together with the low investment in the discovery and/or development of ne...
Article
Tuberculosis is an intracellular infectious disease caused by Mycobacterium tuberculosis, which mainly affects the lungs. Especially in patients infected by the Human Immunodeficiency Virus (HIV) or other immunosuppressed patients, tuberculosis is considered one of the infectious diseases with higher morbidity and mortality rates. Despite considera...
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Antimicrobial resistance (AMR) represents a critical obstacle to public health worldwide, due to the high incidence of strains resistant to available antibiotic therapies. In recent years, there has been a significant increase in the prevalence of resistant epidemic strains, associated with this, public health authorities have been alarmed about a...
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Objective: To evaluate the quality of life (QOL) of patients with breast cancer undergoing radiotherapy treatment. Methods: The current study is a descriptive quantitative approach that seeks to identify the QOL of breast cancer patients during their radiotherapy treatment. A convenience sample of 30 women undergoing radiotherapy for breast canc...
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Objectif: Déterminer la qualité de vie (QDV) des patientes atteintes du cancer du sein en traitement de radiothérapie. Méthodologie: La présente étude vise à mesurer, grâce à une approche quantitative descriptive, la QDV des patientes atteintes de cancer du sein traitées par radiothérapie. Un échantillon de commodité de 30 femmes en traitement de r...
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Background : Oncocalyxone A (oncoA) is a quinone extracted from the Cordia oncocalyx plant. This compound has pharmacological properties, such as anti-inflammatory, analgesic, and cytotoxic activities, among others. OncoA presents a similar chemical structure to doxorubicin, a drug used in cancer treatment, which possesses an intrinsic fluorescence...
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The pandemic COVID-19 has worried everyone due to the high mortality rate and the high number of people hospitalized with severe acute respiratory syndrome caused by SARS-CoV-2. Given the seriousness of this disease, several companies and research institutions have sought alternative treatment and/or prevention methods for COVID-19. Due to its vers...
Article
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O objetivo desse estudo foi realizar uma revisão da literatura sobre o uso da planta Lippia sidoides Cham no tratamento de infecções de faringe e cavidade oral. Dessa forma, realizou-se uma pesquisa da literatura a partir de artigos indexados em bibliotecas virtuais internacionais, Scientific Eletronic Library Online (SciELO), U.S. National Library...
Article
Introduction The established dose of chemotherapy is based on the values of the patient's body weight, where variations during treatment can increase the toxicity of chemotherapy, with the development of nephrotoxicity, among other toxicity profiles, as well as in cases of weight gain, patients may receive low doses and compromise the therapeutic r...
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Due to the deaths from infections caused by multidrug-resistant microorganisms worldwide, the World Health Organization considers antibiotic resistance to be a critical global public health problem. Bacterial resistance mechanisms are diverse and can be acquired through the overexpression of transmembrane proteins that are called efflux pumps, whic...
Article
Background Oncocalyxone A (oncoA) is a natural benzoquinone isolated from Cordia oncocalyx, which exhibits many biological activities such as anti-tumor, anti-inflammatory, antioxidant, and hypoglycemic. However, it presents renal, cardiac, and pulmonary toxicity, which can be a limiting factor. The encapsulation of oncoA in polymeric nanoparticles...
Article
Objective To evaluate the safety in the interchangeability of biosimilar products approved for cancer treatment from a pharmaceutical perspective. Methods A literature review was carried out using the descriptors “Biosimilar”, “Oncology Therapy”, “Interchangeable drugs” and “Biological Products”, in the Sciencedirect, MEDLINE, and CAPLUS databases...
Chapter
Vancomycin is a glycopeptide antibiotic used as a first-line for the treatment of serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA). It is one of the oldest antibiotics and has been used in the clinic for more than 50 years. Despite the benefits in the therapy of infections caused by antimicrobial-resistant microorgani...
Chapter
This chapter discusses about the diagnosis of cancer, emphasizing the importance of early diagnosis in cancer as well as the importance of tumor markers that help in the diagnosis of cancer. This chapter also focuses on the main tumor markers used in the clinic and their importance in diagnosing the type of cancer in which they are used. Some of th...
Chapter
This chapter covers the main therapeutic modalities for the treatment of cancer, covering cancer surgery and radiation therapy, as well as the types and classifications of radiation therapy, finally addressing conventional chemotherapy. Here, we present the main classes of antineoplastic chemotherapeutic agents that include alkylating agents, antim...
Chapter
In this chapter, we discuss what are the major receptors overexpressed in tumor cells and how these receptors have been widely tested as a targeted therapy in the treatment of cancer. We discuss the main classes of immunotherapy, including monoclonal antibodies, tyrosine kinase inhibitors, cancer vaccines, and checkpoint inhibitors, among others. D...
Chapter
This chapter defines what is pharmaceutical nanotechnology and what are the classifications of the nanosystems most used in the encapsulation of drugs, such as liposomes, polymeric nanoparticles, micelles, and solid lipid nanoparticles. This chapter also addresses the main functions of nanosystems in cancer, discusses briefly about their use in the...
Chapter
In this chapter, we discuss the discovery of cancer, with its first signs thousands of years ago. We also cover the concept of cancer, the difference between benign and malignant tumors, and the characteristics that differentiate one from the other. Epidemiological data are also covered in this chapter, providing data on the incidence rate worldwid...
Chapter
This chapter focuses on the pathophysiological characteristics of cancer, initially demonstrating how the normal cell division process takes place and the importance of cyclins in the cell division process. This chapter discusses the characteristics of neoplastic cells that differentiate them from tumor cells and the factors that trigger the develo...
Chapter
In this chapter, we bring up a discussion on the differences between conventional chemotherapy and target therapy, highlighting the benefits as well as the disadvantages of target therapy, compared to systemic chemotherapy that has been used for years in the treatment of cancer. We discuss the main eligibility criteria for the administration of the...
Article
Background Doxorubicin is a drug widely used for breast cancer treatment. It is known for its high cardiotoxicity, as a consequence of the free radicals production, which causes myocardial injury. As antioxidant vitamins act by inhibiting free radicals' production, could they be an alternative to inhibit doxorubicin's cardiotoxicity? This question...
Book
This work covers the pathophysiology of cancer, exploring the difficulty of optimal treatment due to the complexity and diversity of cancer types. The search for distinctive molecular biology characteristics of tumor cells is especially relevant in the identification of overexpressed receptors and proteins that can be used as a target for cancer tr...
Chapter
Bacterial biofilm is a form of life composed of bacterial cells adhered to surfaces immersed in a complex self-produced matrix of polysaccharides, extracellular DNAs, and proteins. The formation of biofilms is a regulated and complex process with continuous steps associated with complex mechanisms guided by chemical, physical and biological process...
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Due to the severity of infections caused by P. aeruginosa and the limitations in treatment, it is necessary to find new therapeutic alternatives. Thus, the use of silver nanoparticles (AgNPs) is a viable alternative because of their potential actions in the combat of microorganisms, showing efficacy against Gram-positive and Gram-negative bacteria,...
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Objetivo: A presente pesquisa objetiva caracterizar o perfil epidemiológico dos acidentes por animais peçonhentos na região Nordeste do Brasil. Metodologia: Estudo transversal, descritivo, com abordagem quantitativa sobre os acidentes com animais peçonhentos no Nordeste brasileiro no período de 2010 a 2019. Esta pesquisa consistiu em seis etapas, o...
Article
To inform about the impact of COVID-19 on cancer patients, a literature review was carried out, using the descriptors "COVID-19," "SARS-CoV-2," "Oncology," and "Coronavirus," in the Pubmed, Sciencedirect, and Scifinder databases. Fifty-three articles were included after analyzing the inclusion and exclusion criteria, being divided into five session...
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The current pandemic COVID-19, caused by the SARS-CoV-2 virus, has been affecting thousands of people worldwide, promoting high numbers of deaths. With this, the world population is going through a process of changing habits, with social distance, improvement of hygiene techniques, to reduce the spread of the SARS-CoV-2 virus and, consequently, red...
Article
In response to the global outbreak caused by SARS-CoV-2, this article aims to propose the development of nanosystems for the delivery of hydroxychloroquine in the respiratory system to the treatment of COVID-19. Performed a descriptive literature review, using the descriptors "COVID-19", "Nanotechnology", "Respiratory Syndrome" and "Hydroxychloroqu...
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Introduction and objective: We verified the main hematological and biochemical alterations during the chemotherapy treatment for women with cervical cancer. Material and method: A retrospective, analytical and cross-sectional test was performed. The sample consisted of 39 medical records of women who underwent chemotherapy in the period from Janua...
Article
Zymomonas mobilis have characteristics that classify it as probiotic. Thus, this study aimed to evaluate the effect of regular consumption of fermented broth of this strain on the intestinal function of individuals with changes in intestinal transit. This is a randomized, descriptive and quantitative clinical trial, a sample composed of undergradua...
Article
A 40-year-old male with colorectal cancer, with an unbalanced hypercaloric diet, on his own initiative, to gain weight, without nutritional follow-up, during chemotherapy treatment with oxaliplatin protocols, without pharmaceutical guidance. When initiating new protocol, with oxaliplatin/irinotecan combination therapy, he presented symptomatology s...
Chapter
Staphylococcus aureus is a microorganism that presents several virulence factors besides the ability to acquire resistance to a large number of antibiotics. The clinical and indiscriminate use of methicillin allowed the appearance of methicillin-resistant S. aureus (MRSA), considered one of the leading causes of nosocomy infections, with high morta...
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Objective: Carry out a bibliographical survey about the use of nanoparticles in the delivery of natural products for the treatment of lung cancer. Methods: A bibliographic review was made using the descriptors “Nanoparticles”, “Biological Products” and “Lung Neoplasms”, through the databases ScienceDirect, PubMed and SciELO, in the period from 200...
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Aim: To demonstrate the relationship between religious/spiritual coping and hope in cancer patients undergoing chemotherapy. Method: This is a cross-sectional, descriptive study with a quantitative approach performed in a reference outpatient clinic in Caruaru, PE, between August and October 2017. A total of 82 cancer patients undergoing chemoth...
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Objective: to evaluate the main clinical symptoms associated with the toxic effects of antineoplastic therapy in women with breast cancer at a cancer treatment center in the city of Caruaru/PE. Methods: This is an analytical and transversal study with a quantitative approach, carried out between September and December 2017, whose data source was t...
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Objetivo: avaliar a opinião da equipe multiprofissional de atendimento ao paciente do Hospital Mestre Vitalino, Caruaru, PE, quanto à importância do cirurgião-dentista no ambiente hospitalar. Material e Métodos: trata-se de um estudo exploratório, descritivo, transversal, com abordagem quantitativa. Um questionário autoadministrado com 11 perguntas...
Article
Objective: identify the main adverse reactions presented by patients with HER2 positive breast cancer from an outpatient clinic specialized in chemotherapy in the city of Caruaru-PE, after the use of Trastuzumab. Methods: The data were obtained through the analysis of the medical records of the patients attended at the outpatient clinic from Januar...
Article
Objective: Identify the main adverse reactions presented by patients with HER2 positive breast cancer from an outpatient clinic specialized in chemotherapy in the city of Caruaru-PE, after the use of Trastuzumab. Methods: The data were obtained through the analysis of the medical records of the patients attended at the outpatient clinic from Janua...
Article
A manipulação dos agentes antineoplásicos é uma das atividades dos profissionais farmacêuticos, que se veem expostos constantemente a esses agentes nocivos a saúde humana. O grande papel da biossegurança é conferir proteção e segurança a esses profissionais com o intuito de diminuir os riscos de exposição ocupacional através da utilização de equipa...

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