I Ketut Adnyana Adnyana

Bandung Institute of Technology | ITB · Pharmacology and Clinical Pharmacy

Atherosclerosis is a systemic disease, a combination of inflammatory conditions, endothelial dysfunction, and theaccumulation of lipids to form plaques in blood vessels. The inflammatory environment within the atherosclerotic lesion stimulates the lipoxygenase pathway of arachidonic acid metabolism, resulting in biosynthesis of the potent lipid inf...

Urgency: Effect of Centella asiatica (CA) and aerobic exercise on Amyloid beta-42 (Aβ42) and phosphorylated tau (p-tau) as biomarkers of dementia is not yet known. Objectives: This study aimed to analyze the effect of CA, aerobic exercise, and their combination on Aβ42 and p-tau in older women with dementia. Design: It was a 24-week randomized, dou...

Natural ingredients can have extraordinary potential as alternative medicines due to their accessibility and cost-effectiveness. Application of these ingredients should consider solubility and permeability, which determine the success of pharmaceutical characteristics formulation and biological activity indication. In this context, physical manipul...

Background: Eggshells are one of the most common culinary wastes, yet using eggshell membrane detritus in medical treatments remains largely unexplored. Objective: This study aims to assess the anti-inflammatory potential of eggshell membrane hydrolysate. Method: Eggshell membrane hydrolysate was prepared using acid-base hydrolysis. The intraplanta...

This study aimed to characterize chitin extracted from Indonesia mangrove crab (Scylla serrata) shells, as well as to assess its in vitro cytotoxic, antioxidant, and HMG CoA reductase inhibitory potentials. In silico molecular docking, molecular dynamic, and ADMET prediction analyses were also carried out. Chitin was extracted from mangrove crab sh...

Objectives Cucumis sativus L. (C. sativus) is vegetable commonly used for managing blood pressure and often consumed in combination with standard antihypertensive therapy, despite lack of scientific evidence supporting their use. Combination of herbs and standard medication could have positive or negative effects. Therefore, this study aimed to eva...

Objective: The study aimed to investigate the interactions between twelve extracellular enzymes and nuclear factor erythroid 2–related factor 2 (Nrf2) in the active site. Methods: The Zdock web server was accessed to perform molecular docking simulations for predicting interactions between the extracellular enzymes and the active site of Nrf2. The...

Context: Water kefir is a fermented beverage that is typically made in the home by inoculating a sugar-rich solution with a microbial community (water kefir grains). Several studies on the metabolite content and hepatoprotective effects of water kefir have been published, but carbon tetrachloride (CCl4)-induced acute liver injury has not been studi...

The liver is extremely vulnerable to damage because of its role in metabolism. Toxin, metabolic syndrome, alcohol, microorganisms, and autoimmune diseases can be the cause of liver damage. While different etiologies can cause liver disease, pathophysiologically, there are similarities in the role of free radicals, inflammatory mediators, and gut mi...

Context: The essential oil of the Ageratum conyzoides (100 mg/kg BW) previously demonstrated anti-neuropathic pain activity with various mechanisms of action. However, the safety data of this essential oil is unknown. Aims: To evaluate the acute and subchronic toxicity profile of the A. conyzoides essential oil. Methods: The acute toxicity study...

Aims: Obesity is a non-communicable disease whose prevalence continues to increase every year throughout the world. Obesity contributes to the emergence of several diseases such as type-2 diabetes mellitus, hypertension, cardiovascular disorders, cancer, and non-alcoholic fatty liver. A number of studies report that natural ingredients have the pot...

Obesity is defined as excessive and abnormal accumulation of fat in the body which can affect the health of the human body. Obesity is associated with several chronic diseases such as type-II diabetes mellitus, hypertension, lipid disorders, joint disorders, and non-alcoholic fatty liver disease (NAFLD). Management of obesity includes non-pharmacol...

Kesehatan adalah bidang program prioritas Pemprov Bali (2018-2023) dengan salah satu Pelayanan Pengobatan Tradisional Integrasi, dengan usaha mengangkat pengobatan usadha dapan berjalan seiring saling bahu membahu, isi mengisi dalam mewujudkan manusia Bali dengan Jana Kertih. Tujuan penulisan artikel ini adalah Pemprov Bali mengembangkan obat alami...

This study aims to determine the antiobesity activity of Calophyllum soulattri leaves extract (CSLE) on high fat diet-fed rats (HFD) and to predict the molecular docking and pharmacokinetics of selected compounds of Calophyllum soulattri to fat mass and obesity-associated protein (FTO). Daily body weight, organ, carcass fat (renal and anal), body m...

Traditionally, Ageratum conyzoides is used to treat several inflammatory diseases, such as rheumatism and as wounds healing. This study aimed to evaluate the anti-inflammatory and antioxidant effects of 50% ethanol extract of A.conyzoides leaves. Anti-inflammatory assay was carried out in vivo using the 1% carrageenan induction method. The animals...

Athletes have a high need to maintain their performance to stay fit while performing a high training intensity and frequent exercise. It makes athletes have a high need for supplements. However, athletes are prohibited from taking supplements included in the doping category. The lowest risk of doping is herbal-based supplements. This study used a s...

This study aims to conduct a bibliometric analysis of the literature on sports nutrition as recovery published between 1964 and 2022. This study illustrates the structure and trends in sports nutrition publications by using scientific mapping and analyzing publication performance. This study identified the contributions of authors, journals, countr...

Weightlifting is a type of sport that demands beneficial complementary supplements. This is because of the highly intensive training and tight schedules, which requires the body to be maintained at the prime condition to avoid injury. Furthermore, supplements and natural products are needed to accelerate athletes' recovery and avoid doping. Cinnamo...

Hibiscus surattensis L. is a traditional medicinal plant often used for diabetes treatment in Indonesia, especially in Central Sulawesi. The leaves contain mainly kaempferol, morine, and trifolin which have various pharmacological effects, including high antioxidant properties and the potential to increase insulin secretion. Therefore, this study a...

In Indonesia, the sap of Angelica keiskei Koidzumi has been utilized traditionally as a blood-sugar reducer, nonetheless, its molecular mechanism still needs to be studied. This study aimed to isolate xanthoangelol (XA) from the yellow sap of A. keiskei planted in Mount Rinjani, Indonesia, and to investigate its mechanism by in silico and in vitro...

Background: Neuropathic pain has become a contributor to the global burden of illness. However, the currently available drugs exhibit inadequate pain relief and significant side effects. Our previous study demonstrated that the essential oil of Ageratum conyzoides had potent anti-neuropathic pain activity through opioid receptor activation. Precoc...

Diabetes mellitus in 2020 in the world was 422 million people, and 1,6 million deaths are directly attributed to diabetes each year. Diabetes mellitus is a disease characterized by increased levels of glucose in the blood due to impaired function of the pancreas gland in producing the hormone insulin. One of the mechanisms of action of the antidiab...

Neuropathic pain is a condition that caused by a lesion or somatosensory system disease. This condition affects to the general health of the human. However, the systematic review of the worldwide or the global burden of neuropathic pain is not available. The objective of the study was to review the neuropathic pain global burden including causes, p...

Electroencephalograph (EEG) is an alternative tool to detect brain abnormalities, but research on dementia patients is still limited. This study aimed to determine the differences in EEG waves with closed eyes between older women with dementia and non-dementia. This research uses a cross-sectional method. Examination of dementia using MMSE (Mini-Me...

Introduction: Menopausal women show some changes physically and psychologically. Decreased plasma estradiol, decreased sleep quality and cognitive function are some of the main problems in women with menopause. The purpose of this study was to determine the effect of aerobic exercises in the Menopausal woman. Methods: This study was conducted using...

Polypharmacy prescription very commonly occurs on patient’s prescription in every health facilities. Polypharmacy may increase the risk of Drug-drug Interactions (DDI’s) which mostly causes harm impact in the patient’s therapy. Drug interactions considered clinically significant if it increases the toxicity or decreases the effectiveness of therapy...

Highlights •Peperomia pellucida’ extracts accelerate normal healing process of alveolar bone. •Ethanol extract significantly increase trabecular thickness on tooth socket. •The extracts can increase fibroblast significantly in short term administration. •The extracts also can reduce the number of polymorphonuclear cells significantly. •Some phytoch...

Sunscreen is a cosmetic substance that has the ability to reflect or absorb sunlight actively. It can prevent skin irritation due to UV rays. One of the natural ingredients with a sunscreen effect is the Edible-nest swiftlet's (Aerodramus fuciphagus) nest (ESN). This study aimed to determine the value of the sun protective factor (SPF) of the ESN w...

α-mangostin, γ-mangostin, and xanthone are some of the marker compounds found in mangosteen (Garcinia mangostana Linn.) whose activity on several treatment targets including toward the peroxisome proliferator-activated receptor gamma (PPAR-γ) receptors, diphenyl peptidase 4 (DPP-4) enzyme, and aldose reductase enzyme is unknown. Although this plant...

Centella asiatica is known to improve cognitive function, but its influence on several domains of cognitive function in dementia women is still limited. This study aimed to determine the effect of Centella asiatica on cognitive function in women elderly with dementia. Screening for dementia used an MMSE questionnaire (Mini-Mental State Examination)...

Peperomia pellucida (L.) Kunth has been studied as an anti-osteoporotic agent. However, there is no report about its estrogenic activity, which is important for its anti-osteoporotic activity. Thus, the aim of this research was to study the estrogenic potency of P. pellucida extracts. The estrogenic activity of P. pellucida extracts (n-hexane, ethy...

Context: Diabetes is a chronic health condition with insulin disturbance. Hibiscus surattensis L. is a medicinal plant and plays a pivotal role in diabetes. Aims: To evaluate the effect of H. surattensis leaves extract to increase insulin secretion and repair pancreatic tissue damage in streptozotocin (STZ)-induced diabetic mice. Methods: This rese...

Context: Diabetes is a chronic health condition with insulin disturbance. Hibiscus surattensis L. is a medicinal plant and plays a pivotal role in diabetes. Aims: To evaluate the effect of H. surattensis leaves extract to increase insulin secretion and repair pancreatic tissue damage in streptozotocin (STZ)-induced diabetic mice. Methods: This rese...

Background: Nowadays obesity recognized as chronic or non-communicable disease. Pathophysiology of obesity caused by an imbalance between energy intake and expenditure. Obesity was known to be a risk factor for the development of metabolic syndrome. The aim of this study is to evaluate activity of ethanol extract of red spinach (EERS) to prevent ob...

Accumulation of phosphorylated-tau and low levels of superoxide dismutase is associated with dementia affecting the quality of life in the elderly. This study aimed to determine differences in quality of life (QoL), phosphorylated-tau (p-TAU), and superoxide dismutase (SOD) plasma in women elderly with and without dementia. The research method was...

Keladi tikus (Typhonium flagelliforme (Lodd.) Blume) is an Indonesian medicinal plant that has various pharmacological properties. Zebrafish (Danio rerio) has been proposed as a model that can bridge the gap between cell assays and rodent assays. Evaluation of the toxic effects of natural products using the Zebrafish model can be assessed starting...

Lebah madu merupakan golongan serangga yang dapat menghasilkan madu. Produk madu ini dihasilkan dari nectar yang diolah oleh lebah madu sebagai cadangan makanan bagi koloni lebah madu. Komposisi kimia yang terkandung pada madu menjadikan produk alam ini memiliki manfaat yang banyak. Salah satunya adalah manfaat untuk meningkatkan stamina. Peningkat...

Objective: For evaluating the antibiotic resistance of Helicobacter pylori, the agar dilution method is the gold standard; however, using this method in daily practice is laborious. E-test has been proposed to be an uncomplicated method. This study was aimed at validating the E-test and detecting the presence of any bias between the agar dilution...

Background Neuropathic pain is one of the contributors to the global burdens of illness. At present many patients do not achieve satisfactory pain relief even with synthetic pain-killers. Taking this into consideration, it is necessary to search for natural product-derived alternative treatment with confirmed safety and efficacy. Ageratum conyzoide...

Garcinia mangostana Linn. or mangosteen through various parts of the plant and its contents are widely used as an alternative medicine for various diseases by assessing their pharmacological effects, including antidiabet ec, antihyperlipidemia, antiobesity, antioxidants, analgesic, anti-inflammatory, anticancer, antidepressant, antibacterial, renop...

Extracts of Peperomia pellucida [L.] Kunth have previously been demonstrated to have in vivo estrogenic-like effects, thereby functioning as an anti-osteoporotic agent. However, the compounds responsible for these effects have not yet been determined. Therefore, the aim of this study is to isolate and elucidate potential compounds with estrogenic a...

Dementia is increasing in the world which is a major cause of disability and dependence in the elderly. This causes the elderly can not do their daily activities so often live in a nursing home. It is important to know the factors associated with dementia to prevent and treat dementia with appropriate interventions. The objective of this study was...

Helicobacter pylori infects more than half the human population. However, the prevalence in Indonesia is low, as is the prevalence of gastric cancer. Hence, it could be instructive to compare these prevalence rates and their determining factors with those of countries that have high gastric cancer incidence. Ethnicity and genetic characteristics of...

The ethyl acetate fraction (EAF) of tamoenju (Hibiscus surattensis L.) leaves, used as a traditional antidiabetic agent in Central Sulawesi, has high inhibitory activity against α-glucosidase and dipeptidyl peptidase-4 (DPP-4). The aim of this study was to isolate the active compound of EAF that was carried out by step gradient polarity extraction,...

Antimicrobial resistance for Helicobacter pylori infection still become problem in Indonesia especially for metronidazole and clarithromycin resistance that is commonly used in the national regiment therapy. Finding a new antimicrobial agent against this bacterium is still a challenge to face. Propolis extract is well known substance which has anti...

Objective: For evaluating the antibiotic resistance of Helicobacter pylori, the agar dilution method is the gold standard; however, using this method in daily practice is laborious. E-test has been proposed to be an uncomplicated method. This study was aimed at validating the E-test and detecting the presence of any bias between the agar dilution m...

Pola kehidupan masyarakat di dunia saat ini cenderung kembali ke alam termasuk dibidang obat-obatan. Keuntungan dari penggunaan obat tradisional adalah efek samping yang relatif kecil dibandingkan obat kimia. Salah satu tanaman obat yang digunakan masyarakat adalah ciplukan (Physalis peruviana L). Tanaman ini telah dimanfaatkan dalam pengobatan tra...

ABSTRAK Penurunan daya ingat dan ketidakmampuan dalam melakukan aktivitas sehari-hari menjadi salah satu alasan lansia dikirim ke panti wredha. Adapun tujuan penelitian ini untuk mengetahui hubungan faktor demografi dan demensia dengan kemandirian lansia dalam memenuhi aktivitas dasar dan instrumental di panti wredha. Desain penelitian ini adalah...

Introduction. The purpose of this study was to examine whether 6-week daily consumption of honey from Apis mellifera and Apis cerana species would affect performance and reduce blood lactate in futsal athletes. Subjects and Methods. In this study, 30 male futsal athletes volunteered to be subjects. A group of 15 futsal athletes volunteered for rand...

Angelica keiskei sap is used as a blood-sugar reducer in Indonesia, however its molecular mechanism has not yet been explored. 4-hydroxyderricin (4-HD) is one of the major components extracted from A. keiskei sap. The aim of this work was to isolate 4-HD from the sap of A. keiskei planted in Lombok, Indonesia, and to study in silico and in vitro me...

Duku’s mistletoe leaves (Dendrophtoe pentandra (L.) Miq) is a parasitic plant part with botanical insecticides quality. Preliminary test was done using phenolic extract test with FeCl 3 to know the content of the leaves’s phenolic compound and its toxicity effect. The effects of the toxicity were observed with Brine Shrimp Lethality Test (BSLT) met...

Obesity associated with several chronic diseases. Based on this condition, natural products use should be considered as alternative treatment. The objectives of this research are to evaluate effect of senna (Senna alexandrina Mill.) and pomegranate (Punica granatum L.) leaves extracts and its fractions on pro-inflammatory cytokines suppression of t...

Inhibition of α-glucosidase is a method used to identify bioactive secondary metabolite that has the potency to treat diabetic. The aim of this study was to evaluate the biochemical activity (i.e. antioxidant and inhibition of α-glucosidase) of four different types of Dendrophthoepentandra (L.) Miq leaves extract through the α-glucosidase inhibitor...

Uji aktivitas antioksidan yang dilakukan terhadap ekstrak methanol dari daun benalu duku hijau (Dendrophthoe pentandara (L.) Miq) dan daun benalu duku merah (Scurrula ferruginea (Jack) Danser) dengan menggunakan metode DPPH bertujuan untuk membandingkan aktivitas antioksidan antara kedua daun benalu duku yang berbeda warna tersebut. Daun benalu duk...

Objective This research aimed to investigate the mechanism of action of leaf extract and active subfraction from English wild sour or Hibiscus surattensis L., evaluating antioxidant activity, and determining phytochemical constituents that potential for treating various ailments such as diabetes and hepatitis. Background Antioxidant potential of e...

The aim of this study was to investigate the acute and subchronic toxicity of a film formulation that combines κ-Carrageenan and konjac glucomannan for soft capsule application. For the acute toxicity study, a dose of 2000 mg/kg body weight (bw) of the film suspension was administered orally to rats. The animals were observed for toxic symptoms and...

Peredaran obat ilegal dan penyalahgunaan obat pada komunitas Sekolah Dasar di Indonesia semakin masif dan memprihatinkan. Wujud inovasi untuk memproteksi siswa SD dari masalah tersebut yaitu melalui kolaborasi akademisi Institut Teknologi Bandung dengan profesional Balai POM di Palu berupa edukasi anti penyalahgunaan obat kepada siswa SD melalui me...

Uji fenolik ekstrak dilakukan dengan menggunakan FeCl 3 untuk mengetahui kandungan senyawa fenolik dari daun benalu duku hijau (Dendrophthoe pentandara (L.) Miq) dan daun benalu duku merah (Scurrula ferruginea (Jack) Danser) serta efek toksisitas telah diamati dengan metode Brine Shrimp Lethality Test (BSLT). Daun benalu duku diekstrak hingga diper...

Objective: This research elaborated role of alpha mangostin and xanthone on fasting blood glucose, insulin and langerhans islet in alloxan induced diabetic mice. Methods: Fasting blood glucose, insulin and langerhans islet test were conducted using male Mus musculus mice, divided into 10 groups randomly, which were normal, control (alloxan induced...