Hyun Soo Lim

Chungnam National University | CNU · Department of Biomedical Engineering

As an emerging strategy in antitumor therapy, photodynamic therapy (PDT) has garnered significant attention in recent years for the treatment of various malignant tumors. This is due to its low side effects, superior spatial selectivity, and maximum preservation of normal tissue function. However, the hypoxic nature of tumors, continuous oxygen con...

Canine mammary sarcoma tumors (CMST) are the most aggressive tumors with poor prognosis in dogs. Due to inadequate treatment options for CMST, recent studies have focused on alternative treatment strategies. We previously determined the optimized protocol of 5-ALA-based photodynamic therapy (PDT) in canine liposarcoma. However, its molecular mechan...

Backgrounds Canine mammary gland tumors (CMGTs) are heterogeneous tumors and share many similar features with human breast cancer. Despite the improvement of current treatment options, new treatment modalities are required to effectively kill tumor cells without general toxicity in the treatment of CMGTs. Photodynamic therapy (PDT) is a promising m...

Canine mammary gland tumors (CMGTs) are heterogeneous disease and subclassified [sarcomas (S), carcinomas (C), and carcinosarcomas (CS)] according to histopathological differentiation. Photodynamic therapy (PDT) is a promising treatment strategy based on the use of a photosensitizer (PS) activated by light. However, the therapeutic potential of PDT...

The increasing use of lasers in photodynamic therapy (PDT) for the treatment of cancer requires a better understanding of the effects of different laser parameters on the results of PDT. To minimize thermal damage and optimize healing benefits, we compared pulse, burst pulse, and continuous wave (CW) laser irradiation modes in PDT treatment of lung...

Background Pseudomonas aeruginosa is one of the most life-threatening pathogens in nosocomial environments. This study aimed to explore whether photodynamic therapy using a 660 nm diode laser and Radachlorin is an effective in vitro inhibitor of P. aeruginosa and determine what energy density and rate of delivery are the most impactful. Methods Su...

MUHAMMED GULER, ALI FURKAN KAMANLI, MUSTAFA ZAHID YILDIZ, AYLA EREN OZDEMIR, HYUN SOO LIM

In cancer treatments photodynamic therapy, because of being a minimally invasive method and having no significant harmful side effect to the patient. This method begins with the administration of ALA-5 photosensitizer material prior to treatment in the tissue, which reacts chemically to the specific wavelength light. Dosimeter calculations determin...

US Food and Drug Administration (FDA) approved as a innovative cure for cancer, 1996. The effect is death of cancer cells through necrosis, apoptosis. Mainly the Continuous Wave mode (CW) use for PDT Laser. It sting, the question including itch, and etc. Reportedly, the increase of temperature with the perforated edema, ulcer, necrosis. The Thermal...

Long time ultrasound scan can cause a temperature rise in human tissue and affect the physical body. This is closely connected with patients` safety. So many researchers have been studied on this matter with animals such as mammals and experimental rat, because diagnostic ultrasound has been used many types of human organ to find disease. Therefore...

The frequency of diagnostic radiation examinations in medical institutions has recently increased to 220 million cases in 2011, and the annual exposure dose per capita was 1.4 mSv, 51% and 35% respectively, compared to those in 2007. The number of chest radiography was found to be 27.59% of them, the highest frequency of normal radiography. In this...

In this study, we attempted a comparative analysis of the dose and imaging difference between the deep inhalation (DI) and deep exhalation (DE) chest radiography of the same region. Healthy volunteers (n \(=\) 30; 27 men and 3 women) free of chest disease in their 20s, 30s, and 40s were selected as the subjects of this study. We employed an X-ray g...

The purpose of this study was to evaluate the usefulness of laser guidance to target tissue within the lung, while applying Percutaneous CT-guided Needle Biopsy(PCNB) using two lasers. 64 MDCT(Multi Detector Computed Tomography), Chest phantom which was inserted with tissue in Bolus, 20 Gauge needle for biopsy, Two Lasers were used. When the needle...

New design of the excitation light source that can stably generate light with center wavelengths of 450nm, 530nm, 632.8nm and white light for auto-fluorescence(AF) and photodynamic diagnosis(PDD) of cancer in clinics in a single system is presented in this study. The light source consists of Xenon Lamp (300W), light guide module including motorize...

The Purpose of this study was to evaluate by comparing the dose change and build up characteristic according to delay time in 30 days of glass dosimeter processed preheat and non preheat when measuring accumulation dose of radiation by using glass dosimeter over the long haul. For obtaining low dose with 0.1 mGy, 1 mGy and 5 mGy, we employed diagno...

Purpose: The purposes of this study were to measure the dose distribution of Photodynamic therapy(PDT) laser with 635 nm wavelength using GafChromic film. Method & Result: We made each output 300 J by changing mW and sec using the laser beam radiation mode such as C.W(Continuous Wave) mode, Pulse mode and Burst Pulse mode and measured the does at 0...

IGRT(Image Guided Radiation Therapy) in radiation therapy is a very useful technique in order to increase setup of patient and position reproducibility. Tomotherapy can increase accuracy of setup to take IGRT by MVCT, but it be for verified accuracy of Image guided, and MVCT occurs the exposure of patient. Through this study, IGRT accuracy of Tomot...

General application of continuous-wave (CW) laser irradiation modes in photodynamic therapy can cause thermal damage to normal tissues in addition to tumors. A new photodynamic laser therapy system using a pulse irradiation mode was optimized to reduce nonspecific thermal damage. In in vitro tissue specimens, tissue energy deposition rates were mea...

Effect of prenatal ultrasound diagnosis have serious damage for the possibility has been reported very low. Long time ultrasound scan can rise the temperature in body tissues and affect the physical. Changes in body temperature have been studied with ultrasound scan time. Fetal ultrasonography were evaluated without the influence of time. The findi...

As one of photo dynamic therapies, the existing LED photo irradiation method with 635 nm continuous wave has most frequently been used for acne treatment, it suffered from a low energy efficiency and generation of a large amount of heat in tissues requiring improvement measures. In this thesis, a LED photo irradiation system for acne treatment has...

Background and aims: This study demonstrated the development of a laser system for cancer treatment with photodynamic therapy (PDT) based on a 635 nm laser diode. In order to optimize efficacy in PDT, the ideal laser system should deliver a homogeneous nondivergent light energy with a variable spot size and specific wavelength at a stable output p...

This study aims at designing and evaluating light source devices that can stably generate light with various wavelengths in order to make possible PDD using a photosensitizer and diagnosis using auto-fluorescence. The light source was a Xenon lamp and filter wheel, composed of an optical output control through Iris and filters with several waveleng...

Photodynamic diagnosis (PDD) is a method to diagnose the possibility of cancer, both by the principle that if a photosensitizer is injected into an organic tissue, it is accumulated in the tissue of a malignant tumor selectively after a specific period, and by a comparison of the intensity of the fluorescence of normal tissue with abnormal tissue a...