Hyeon Kim

• Bachelor of Science
• Korea Institute of Ocean Science and Technology

The present study describes the differentiation process of male germ cells in Octopus vulgaris, the morphology of sperm in the testis and spermatophore, and the sperm released after the spermatophoric reaction. During spermatogenesis, the male sperm cell gradually elongates from a round shape, with cytoplasm shifting toward the head and the acrosom...

Numerical analysis of a U-type solid oxide fuel cell stack was performed using computational fluid dynamics to investigate the effects of stack capacities and fuel/air utilization rates on the internal flow uniformity. The results indicated that increasing the fuel/air utilization rate improved the gas flow uniformity within the stack for the same...

Regulation of cell fate and lung cell differentiation is associated with Aminoacyl-tRNA synthetases (ARS)-interacting multifunctional protein 2 (AIMP2), which acts as a non-enzymatic component required for the multi-tRNA synthetase complex. In response to DNA damage, a component of AIMP2 separates from the multi-tRNA synthetase complex, binds to p5...

To investigate flow uniformity within individual unit cells in internal manifold-type solid oxide fuel cell stacks with respect to electrical capacity and stack height variations, numerical analyses using computational fluid dynamics techniques were conducted on SOFC stack models with capacities of 1 kWe, 2 kWe, and 3 kWe. The results of these calc...

Zinc (Zn) is an essential micronutrient in organisms and an abundant element in the Earth's crust. Trace amounts of Zn released from natural sources can enter aquatic ecosystems through weathering and erosion. Zn accumulates in organisms, and when its intracellular concentration exceeds a certain level, it can induce oxidative stress and trigger ox...

The larvae of the marine gastropod Lophocochlias parvissimus are meroplankton that spend part of their lives as plankton that disperse and drift in the water column before settling on the sea floor. Two individuals of L. parvissimus larvae were sampled by the Multiple Opening/Closing Net and Environmental Sensing System (MOCNESS) from the Central I...

Objectives: This study aimed to investigate the correlation of sarcopenic obesity with various cardiometabolic risk factors and fracture risk in middle-aged Korean women. Methods: In this cross-sectional study, the medical records of 1,775 women who had visited Pusan National University Hospital for routine health screenings from 2010 to 2016 we...

Nephrons are generally not distributed in the head kidney of teleost. Nonetheless, in this study, the nephron structure was identified in the head kidney of three species of Sebastes (Sebastes inermis, Sebastes schlegelii and Sebastes thompsoni). The kidney is Y shaped, with the development in the head kidney. The nephron structure was confirmed in...

This study aimed to develop hydrogels for tissue adhesion that are biocompatible, antioxidant, and antibacterial. We achieved this by using tannic acid (TA) and fungal-derived carboxymethyl chitosan (FCMCS) incorporated in a polyacrylamide (PAM) network using free-radical polymerization. The concentration of TA greatly influenced the physicochemica...

This study was performed to obtain information on the sex ratio, spawning period, and size at sexual maturity for fishery management of the largehead hairtail Trichiurus japonicus in Korean waters. The overall sex ratio (female, F; male, M) was 1:0.46 (n = 1274 females:589 males, 68.4% female) and as fish increased in length, the proportion of fema...

In this study, a simple approach was used for the synthesis of a water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate to evaluate its potential wound-healing properties. The HA-Q conjugation was confirmed by Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible spectrophotometry (UV-Vis), and nuclear magnetic resonanc...

E3L (RNA-binding protein E3) is one of the key IFN resistance genes encoded by VV and consists of 190 amino acids with a highly conserved carboxy-terminal double-stranded RNA-binding domain (dsRBD). PKR (dsRNA-dependent protein kinase) is an IFN-induced protein involved in anti-cell and antiviral activity. PKR inhibits the initiation of translation...

Hydrogels have emerged as a versatile platform for a numerous biomedical application due to their ability to absorb a huge quantity of biofluids. In order to design hydrogels, natural polymers are an attractive option owing to their biocompatibility and biodegradability. Due to abundance in occurrence, cost effectiveness, and facile crosslinking ap...

Cell-cultured meat, which is artificial meat made by in vitro cultivation of animal-derived cells, has attracted a lot of interest as a potential source of protein in the future. Porous hydrogels are crucial components that can be used as an artificial extracellular matrix (ECM) to provide cell growth for generating cultured meat. In this study, we...

In this review, we describe the genomic and physiological features of the yeast species predominantly isolated from Nuruk, a starter for traditional Korean rice wines, and Jang, a traditional Korean fermented soy product. Nuruk and Jang have several prevalent yeast species, including Saccharomycopsis fibuligera, Hyphopichia burtonii, and Debaryomyc...

KRAS mutations occur in a quarter of all human cancers. When activated in its GTP-bound form, RAS stimulates diverse cellular systems, such as cell division, differentiation, growth, and apoptosis through the activations of various signaling pathways, which include mitogen-activated protein kinase (MAPK), phosphoinositide 3 kinases (PI3K), and RAL-...

This study was performed to obtain information on the basic reproductive ecology and biological resource management of Buccinum osagawai. Samples were collected from August 2018 to October 2019 with a drum-shaped net at a depth of 150–250 m along the continental shelf in Jumunjin, on the east coast of Korea. The species showed gonochorism and a lac...

Bioactive materials exhibiting bone-like apatite formation are crucial for inducing the osteogenic potentials of bone cells in the bone tissue engineering field. Herein, we report the design and synthesis of bioactive phosphate-crosslinked sodium alginate-based (PSA) hydrogels for biomineralization using a calcium-free approach. The hydrogels produ...

Heat stimulation can promote osteoblast differentiation and bone formation. Combining photothermal therapy and chemotherapy is an effective strategy for treating rheumatoid arthritis (RA). Herein, we prepared chitosan/gelatin/β-glycerophosphate-melanin-methotrexate (CMM) hydrogel that could be used to perform simultaneous chemotherapy and photother...

To understand the habitat ecology of Tresus keenae, an infaunal bivalve, the microanatomical structure of the siphon and the method of siphonal sheath formation were described. The diameter of the incurrent siphon was approximately 1.2 times greater than that of the excurrent siphon. Several irregular tentacles developed inside the distal end of th...

In this work, doxorubicin (Dox)-encapsulated poly(vinyl caprolactam) (PVCL)-based three-dimensional nanogel networks were developed and were crosslinked with disulfide linkages. The nanogels degrade rapidly to low molecular weight chains in the presence of the typical intracellular concentration of glutathione. Doxorubicin (Dox) was successfully en...

We evaluated the Cre-lox and CRISPR-Cas9 systems as marker-recycling tools in Saccharomyces cerevisiae recombinants containing multiple-integrated expression cassettes. As an initial trial, we constructed rDNA-nontranscribed spacer- or Ty4-based multiple integration vectors containing the URA3 marker flanked by the loxP sequence. Integrants harbori...

RAS proteins play a role in many physiological signals transduction processes, including cell growth, division, and survival. The Ras protein has amino acids 188-189 and functions as GTPase. These proteins are switch molecules that cycle between inactive GDP-bound and active GTP-bound by guanine nucleotide exchange factors (GEFs). KRAS is one of th...

This study aims to investigate the effect of zinc on the sex ratio and intersexuality of Tegillarca granosa, a sequential hermaphroditic bivalve that undergoes sex change during the gonadal inactive stage. Groups of T. granosa in the gonadal inactive stage were first exposed to zinc under indoor aquarium conditions for 5 weeks, and then under wild...

An injectable nanocomposite hydrogel with tunable multifunctional properties such as cell adhesive, antibacterial, and hemostasis, was developed. The nanocomposite hydrogel consisted of natural non-animal fungal mushroom-derived carboxymethyl chitosan (F-CMCS), and tannic acid stabilized silver (TA-Ag) nanoparticles. The hydrogel showed shear-thinn...

We report on the gonadal structure abnormality and intersexuality found from a survey regarding the reproductive potential of the rock bream, Oplegnathus fasciatus, along the southern coast of Korea. In total, 448 samples were collected for histological analysis (total length 27.5±6.8 cm; total weight 522.9±385.6 g). The sex ratio (F:M) was 1:0.46...

Temperature is a pivotal key in fish physiology but is limited in determining blood bone biomarker as a stressor. In this study, fourteen blood biochemical markers were evaluated by employing clinical blood test methods to identify the causation between temperature and the levels of sensitivity for the given temperature in a red sea bream, Pagrus m...

Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage-associated molecular pattern molecules), such as AGEs, HMGB1, and S100/calgranulins, and as an innate immune sensor, can recognize microbial PAMPs (pathogen-associated molecular pa...

Aroma ester components produced by fermenting yeast cells via alcohol acetyltransferase (AATase)-catalyzed intracellular reactions are responsible for the fruity character of fermented alcoholic beverages, such as beer and wine. Acetate esters are reportedly produced at relatively high concentrations by non-Saccharomyces species. Here, we identifie...

Resistance to anticancer therapeutics occurs in virtually every type of cancer and becomes a major difficulty in cancer treatment. Although 5-fluorouracil (5FU) is the first-line choice of anticancer therapy for gastric cancer, its effectiveness is limited owing to drug resistance. Recently, altered cancer metabolism, including the Warburg effect,...

Samples were collected from the subtidal region of Jumunjin on the eastern coast of Korea in July 2020. A total of 338 mussels of shell height (SH) 20.8-149.8 mm were used for sex ratio analysis. The sex ratio (F:M) in the same population of mussel Mytilus coruscus was approximately 1:0.7. The sex ratio according to the class of SH was different. T...

Two genes encoding the probable α-L-arabinofuranosidase (EC 3.2.1.55) isozymes with 92.3% amino acid sequence identity, ABF51A and ABF51B, were found from the chromosomes 3 and 5 of Saccharomycopsis fibuligera KJJ81, the amylolytic yeast isolated from Korean wheat-based Nuruk, respectively. Each open reading frame consists of 1,551 nucleotides whic...

In this study, a four-cell stack of anode-supported planar solid oxide fuel cells (SOFCs) was designed and simulated to investigate the flow/heat transport phenomena and the performance of the SOFC stack. This SOFC stack was designed based on the external manifold types with one side open toward the cathode inlet and components such as base station...

This study was carried out to obtain information on the developmental biology and the management of biological resources of the abalone Haliotis gigantea in Korea. The sex ratio (female:male) in the present study was 1:1.7 and the proportion of females was 36.6% (n=106/290). Their gonadal structures displayed definitive seasonal changes which were...

In this analysis, a 3D mechanistic model is developed for two different designs of planar solid oxide fuel cell (SOFC) stack running on biogas. The stacks consist of 5 planar SOFCs each and the stack flow uniformity index criteria are employed to investigate the flow characteristics. The flow uniformity is analyzed at the stacks level as well as am...