Husam Ghanim

Husam Ghanim
University at Buffalo, The State University of New York | SUNY Buffalo · Department of Medicine

About

193
Publications
8,350
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9,673
Citations
Citations since 2016
77 Research Items
4079 Citations
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600

Publications

Publications (193)
Article
Full-text available
Background Treatment with sodium-glucose transporter (SGLT)-2 inhibitors in patients with type 1 diabetes (T1DM) is associated with increased ketogenesis and diabetic ketoacidosis (DKA). The exact relationship between SGLT-2 inhibitors use in T1DM and ketogenesis is not fully understood. Patients and Methods In this single center, randomized, doub...
Article
Objective: Obesity in adolescent males is associated with lowering of total and free testosterone concentrations. Weight loss may increase testosterone concentrations. Design and Methods: We evaluated changes in sex hormones following bariatric surgery in 34 males (age range 14.6 – 19.8 years) with obesity. These participants were part of prospecti...
Article
Full-text available
Based on global estimates, almost 10% of adults have diabetes, of which 40% are estimated to also have chronic kidney disease (CKD). Almost 2 decades ago, treatments targeting the renin‐angiotensin system (RAS) were demonstrated to slow the progression of kidney disease. More recently, studies have reported the additive benefits of antihyperglycemi...
Article
Full-text available
Plasma free fatty acids (FFAs) are elevated in obesity and can induce insulin resistance via endoplasmic reticulum (ER) stress. However, it is unknown whether hepatic insulin resistance caused by the elevation of plasma FFAs is alleviated by chemical chaperones. Rats received one of the following i.v. treatments for 48 h: saline, intralipid plus he...
Article
Coronavirus disease 2019 (COVID-19) viral infection, like other infections, triggers an inflammatory response that is usually confined to the respiratory system. However, there is evidence that in a full-blown case, almost all systems of the body may be involved. In addition, there is the syndrome of cytokine storm, characterized by severe systemic...
Article
Aim: To investigate the mechanisms underlying improvements in blood pressure (BP) and congestive heart failure outcomes following treatment with dapagliflozin, a sodium-glucose co-transporter-2 inhibitor. Research design and methods: A total of 52 patients with type 2 diabetes (T2D) with an HbA1c of less than 8% participated in this prospective,...
Article
Background: The role of testosterone in improving sexual symptoms in men with hypogonadism is well known. However, recent studies indicate that testosterone plays an important role in several metabolic functions in males. Methods: Multiple Pubmed searches were conducted with use of terms, testosterone, insulin sensitivity, obesity, type 2 diabet...
Article
Full-text available
Obesity is associated with increased mortality as a result of several comorbidities which occur in tandem with the obese state. Chronic inflammation is well documented in obesity, and evidence from numerous studies support the notion that the increased inflammation in individuals with obesity accentuates the comorbidities seen in this condition. Th...
Article
The importance of glucose metabolic changes and inflammatory responses to these changes connect diabetes and Alzheimer’s disease (AD). The role intracellular insulin may have in this process could provide for alternative therapeutic approaches. In this study a novel cholesteryl ester based vesicle called a CholestosomeTM, that encapsulates payloads...
Article
Full-text available
Our previous work has shown that the ingestion of cream induces an increase in oxidative stress and other cellular and molecular indices of inflammation and atherosclerosis and that treatment with Vytorin for 6 weeks reduced and reversed majority of the effects of cream. However, it is not clear which component of Vytorin, simvastatin or ezetimibe,...
Article
Background: We have previously demonstrated that a 12-week addition of liraglutide to insulin therapy in patients with type 1 diabetes (T1DM) results in an improvement in glycemic control, weight loss and a reduction in systolic blood pressure (SBP). We now investigated effects of liraglutide treatments on glycemic control and adipose tissue metab...
Article
Context Dapagliflozin and other SGLT2 inhibitors are known to increase hematocrit possibly due to it diuretic effects and hemoconcentration. Objective Since type 2 diabetes is a pro-inflammatory state and since hepcidin, a known suppressor of erythropoiesis, is increased in pro-inflammatory states, we investigated the possibility that dapagliflozi...
Article
Context Adenosine 5’-monophosphate-activated protein kinase-α(AMPKα) is a mediator of exercise induced glucose uptake in skeletal muscle. Objective We evaluated whether the expression and phosphorylation of AMPKα are reduced in the skeletal muscle and adipose tissue in patients with hypogonadotropic hypogonadism(HH), and whether testosterone repla...
Article
Aims: Insulin has anabolic effects on skeletal muscle. However, there is limited understanding of the molecular mechanisms underlying this effect in humans. We evaluated whether the skeletal muscle expression of satellite cell activator Fibroblast growth factor 2 (FGF2) and muscle growth and differentiation factors are modulated acutely by insulin...
Article
Full-text available
Background One third of men with type 2 diabetes have subnormal free testosterone concentrations. We evaluated 1) whether bone mineral density (BMD) and bone strength is affected by gonadal status in type 2 diabetes, and 2) studied the effect of testosterone replacement on markers of osteoblast and osteoclast activity. Methods This is a secondary...
Article
Context: The intake of macronutrients as components of Western dietary pattern leads to oxidative stress and inflammation. Evidence acquisition: Data was largely retrieved from our previous and most recent work. Pubmed and Google scholar were searched for recent articles on the effect of macronutrients/dietary intake on inflammation, insulin res...
Article
Context Fibroblast growth factor (FGF)2 is an important stimulatory modulator of satellite cells in skeletal muscle. Satellite cells play a cardinal role in muscle growth and repair. Objective We evaluated whether skeletal muscle expression of FGF2 and muscle growth and differentiation factors are reduced in patients with hypogonadotropic hypogona...
Article
Glucocorticoids have been used as the major class of anti-inflammatory agents for over 60 years. However, they have well known side effects including weight gain, adiposity, muscle loss, osteoporosis and diabetogenicity. We have recently described the induction of specific pro-inflammatory genes by a single large dose of hydrocortisone (HC) in norm...
Article
Since liraglutide suppresses plasma glucagon concentrations and dapagliflozin increases glucagon concentrations, although both improve glycemia in patients with type 1 diabetes, we have now investigated whether they alter the concentrations of the two other products of the proglucagon gene, GLP-1 and GLP-2. Thirty patients with type 1 diabetes, tre...
Article
We have previously demonstrated that a 12-week addition of liraglutide to insulin therapy in patients with type 1 diabetes (T1D) results in an improvement in glycemic control, weight loss and a reduction in systolic blood pressure (SBP). We have now conducted a 6 month randomized study investigating effects of liraglutide in overweight and obese pa...
Article
Objective We tested the hypothesis that addition of GLP‐1 receptor agonists (GLP‐1RA) to insulin in c‐peptide positive patients with T1D will result in a reduction in hemoglobin A1C (HbA1c) with reduced insulin requirements and a rise in c‐peptide concentrations. Methods This is a retrospective analysis of 11 normal weight patients with T1D consec...
Article
Full-text available
A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to...
Article
One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty. The gonadotropin concentrations in these males are inappropriately normal; thus, these patients have hypogonadotropic hypo...
Article
We have previously demonstrated that a 12-week addition of liraglutide to insulin therapy in patients with type 1 diabetes (T1D) results in an improvement in glycemic control, weight loss and a reduction in systolic blood pressure (SBP). We have now conducted a 1 year randomized study investigating effects of liraglutide in patients with T1DM. All...
Article
Dapagliflozin and other SGLT2 inhibitors are known to increase hematocrit. One possible mechanism is glycosuria and polyuria and the loss of fluid from the vascular compartment. However, since type 2 diabetes is a pro-inflammatory state and since hepcidin, a known suppressor of erythropoiesis, is increased in pro-inflammatory states, we investigate...
Article
Hypothesis. In view of the reduction in post prandial glucose concentrations and an increase in insulin concentrations and the inhibition of post prandial endotoxemia and increases in TLR-4 and TLR-2 expression following the intake of fiber with a high fat high calorie meal (HFHC) in normal subjects, we hypothesized that a similar effect would be o...
Article
Aim: To investigate whether the intake of a meal suppresses ketogenesis in patients with type 1 diabetes. Methods: 30 patients with type 1 diabetes with no C-peptide, fasted overnight, were divided into 3 groups of 10 patients each. The first (group 1) continued the fast for 5 hours after arrival in our clinical research unit while the second (grou...
Article
Objective: Since morbid obesity is associated with congestive cardiac failure and hypertension, and gastric bypass surgery is followed by a reduction in blood pressure and a reduction in the risk of congestive cardiac failure, we hypothesized that weight loss following bariatric surgery in morbidly obese patients is associated with a decrease in pl...
Article
We have previously demonstrated that the addition of liraglutide to insulin significantly improves the glycemic control in patients with type 1 diabetes (T1D) with undetectable c-peptide. We have now investigated whether the addition of GLP-1 therapy to insulin in c-peptide positive patients with T1D will increase the c-peptide concentrations and i...
Article
AMP kinase is a key enzyme involved with energy regulation, the intake of macronutrients, the uptake of glucose and fatty acids by cells and the metabolic combustion of fatty acids. We hypothesized that in patients with hypogonadism associated with diabetes, its expression and activity are diminished since there is a quantitative and qualitative lo...
Article
Galectin-3 (gal-3) has recently been shown to mediate insulin resistance in mice. Its deletion leads to insulin sensitization while its excess is associated with insulin resistance. We, thus, undertook an investigation into its role in the reversal of insulin resistance in three human models of insulin sensitization: (1) 6 months following bariatri...
Article
PCSK9 is a major modulator of LDLc through internalization and endosomal degradation of LDL receptor. It has been shown that PCSK9 plasma levels predict CVD risk. Bariatric surgery is known to reduce both LDLc and CVD. However, its exact effect on circulating PCSK9 levels has not been fully investigated. We have now investigated the effect of stric...
Article
Since morbid obesity is associated with congestive cardiac failure and hypertension, and gastric bypass surgery is followed by a reduction in blood pressure and in the risk of congestive cardiac failure, we hypothesized that weight loss following Roux‐en‐Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in pla...
Article
While the use of incretins, including GLP-1 receptor agonists and PDD-IV inhibitors, is well established in the treatment of type 2 diabetes, many other aspects of these agents are yet to be discovered and utilized for their potential clinical benefit. These include the potential role of GLP-1 receptor agonists in the induction of weight loss, bloo...
Article
Aims: One third of males with type 2 diabetes have hypogonadism, characterized by low total and free testosterone concentrations. We hypothesized that this condition is associated with a compensatory increase in the expression of androgen receptors (AR) and that testosterone replacement reverses these changes. We also measured estrogen receptor an...
Article
Full-text available
Purpose We have previously demonstrated anti-inflammatory and antioxidant effects of exenatide. We have now hypothesized that exenatide also increases the plasma concentration of IL-1RA, an endogenous anti-inflammatory protein and modulates the Nrf-2-Keap-1-ARE system to induce key antioxidant enzymes to suppress inflammatory and oxidative stress....
Article
Background and aims: Inflammation and postprandial lipemia are associated with increased cardiovascular disease. We investigated whether ezetimibe and simvastatin combination, a lipid lowering combination of simvastatin and ezetimibe, exerts an anti-inflammatory effect in the fasting state and after dairy cream intake. Methods: Twenty obese pati...
Article
In view of the occurrence of diabetic ketoacidosis associated with the use of sodium-glucose transport protein-2 (SGLT2) inhibitors in patients with type 1 diabetes (T1DM) and the relative absence of this complication in patients treated with liraglutide in spite of reductions in insulin doses, we investigated the effect of liraglutide on ketogenes...
Article
Background: Fiber intake is associated with a reduction in the occurrence of cardiovascular events and diabetes. Objective: To investigate whether the addition of fiber to a high fat-high Calorie (HFHC) meal prevents pro-inflammatory changes induced by HFHC meal. Design: Ten fasting normal subjects consumed HFHC meal with or without an additio...
Article
In view of the known vasodilatory effects of GLP-1, and exenatide, we investigated the effects of exenatide on vasoactive factors. We analyzed blood samples and mononuclear cells (MNC) from a previous study collected after a single dose and following 12 weeks of exenatide or placebo treatment on a series of 24 patients with T2DM. Following exenatid...
Article
Context: It is imperative that novel approaches to treatment of type 1 diabetes (T1D) are devised. Objective: The objective of the study was to investigate whether addition of dapagliflozin to insulin and liraglutide results in a significant reduction in glycemia and body weight. Design: This was a randomized clinical trial. Setting: The stu...
Article
ContextAs the syndrome of hypogonadotropic hypogonadism (HH) is associated with anaemia and the administration of testosterone restores haematocrit to normal, we investigated the potential underlying mechanisms. DesignRandomized, double-blind, placebo-controlled trial. Methods We measured basal serum concentrations of erythropoietin, iron, iron bin...
Article
Full-text available
Objective: To investigate whether addition of three different doses of liraglutide to insulin in patients with type 1 diabetes (T1D) results in significant reduction in glycemia, body weight, and insulin dose. Research design and methods: We randomized 72 patients (placebo = 18, liraglutide = 54) with T1D to receive placebo and 0.6, 1.2, and 1.8...
Conference Paper
Exenatide exerts ROS suppressive and anti-inflammatory effects and promotes the Nrf-2 dependent anti-oxidant genes (NQO-1, GST-1P and HO-1). This led us to hypothesize that exenatide and possibly other GLP-1 receptor agonists may be nephroprotective. We have, thus, investigated the evolution of albuminuria in 466 patients with type 2 diabetes who w...
Conference Paper
Full-text available
Exenatide exerts ROS suppressive and anti-inflammatory effects and promotes the Nrf-2 dependent anti-oxidant genes (NQO-1, GST-1P and HO-1). This led us to hypothesize that exenatide and possibly other GLP-1 receptor agonists may be nephroprotective. We have, thus, investigated the evolution of albuminuria in 466 patients with type 2 diabetes who w...
Conference Paper
Full-text available
In view of the occurrence of diabetic ketoacidosis associated with the use of SGLT2 inhibitors in patients with type 1 diabetes and absence of this complication in patients treated with liraglutide in spite of reductions in insulin doses, we investigated the effect of liraglutide on ketogenesis. Sixteen patients with inadequately controlled type 1...
Conference Paper
Full-text available
Liraglutide and SGLT2 inhibitors have a beneficial role in the management of type 1 diabetes (T1D). We have now investigated triple therapy using a sequential combination of insulin, liraglutide and dapagliflozin in such patients. Since treatment with SGLT-2 inhibitors in T1D is associated with increased risk of diabetic ketoacidosis (DKA), we have...
Conference Paper
Full-text available
We have recently demonstrated that the addition of liraglutide to insulin significantly improves the glycemic control in patients with type 1 diabetes (T1D). We have now conducted the first prospectively randomized study investigating whether the addition of dapagliflozin, a SGLT-2 inhibitor which induces glycosuria, to insulin and liraglutide woul...
Article
Full-text available
Objective: One-third of men with type 2 diabetes have hypogonadotropic hypogonadism (HH). We conducted a randomized placebo controlled trial to evaluate the effect of testosterone replacement on insulin resistance in men with type 2 diabetes and HH. Research design and methods: A total of 94 men with type 2 diabetes were recruited into the study...