Huriye Erdogan

Bogazici University · Department of Chemistry

Cytochrome P450cam (CYP101Fe3+) regioselectively hydroxylates camphor. Possible hydroxylating intermediates in the catalytic cycle of this well-characterized enzyme have been proposed on the basis of experiments carried out at very low temperatures and shunt reactions, but their presence has not yet been validated at temperatures above 0°C during a...

A hybrid structure of a synthetic dendronized polymer, two different types of enzymes (superoxide dismutase and horseradish peroxidase), and a fluorescent dye (fluorescein) was synthesized. Thereby, a single polymer chain carried multiple copies of the two enzymes and the fluorescein. The entire attachment chemistry is based on UV/vis-quantifiable...

Herein, we report the in situ generation of poly(N-vinyl-2-pyrrolidone) (PVP)-stabilized palladium(0) nanoclusters and their catalytic activity in hydrogen generation from the methanolysis of ammonia-borane (AB). The PVP-stabilized palladium(0) nanoclusters with an average particle size of 3.2 +/- 0.5 nm were formed from the reduction of palladium(...

Cysteine glutathione peroxidases (CysGPxs) control oxidative stress levels by reducing hydroperoxides at the expense of cysteine thiol (-SH) oxidation, and the recovery of their peroxidatic activity is generally accomplished by thioredoxin (Trx). Corynebacterium glutamicum mycothiol peroxidase (Mpx) is a member of the CysGPx family. We discovered t...

Methionine sulfoxide reductases are conserved enzymes that reduce oxidized methionines in proteins, and play a pivotal role in cellular redox signaling. We have unraveled the redox relay mechanisms of methionine sulfoxide reductase A of the pathogen C. diphtheria (Cd-MsrA), and showed that this enzyme is coupled to two independent redox relay pathw...

Cancer is the uncontrolled growth of abnormal cells via malignant cell division and rapid DNA replication. While DNA damaging molecules can cause cancer, their role as anticancer drugs are very significant. For this purpose, the novel series of paraben substituted spermine bridged(dispirobino) cyclotriphosphazene compounds 2-6 were synthesized for...

The intermediates operating in the cytochrome P450 catalytic cycle have been investigated for more than half a century, fascinating many enzymologists. Each intermediate has its unique role to carry out diverse oxidations. Natural time course of the catalytic cycle is quite fast, hence, not all of the reactive intermediates could be isolated during...

Peroxiredoxins catalyze the reduction of peroxides, a process of vital importance to survive oxidative stress. A nucleophilic cysteine, also known as the peroxidatic cysteine, is responsible for this catalytic process. We used the Mycobacterium tuberculosis alkyl hydroperoxide reductase E (MtAhpE) as a model to investigate the effect of the chemica...

Zusammenfassung Enzyme vom Typ Cytochrom P450 (CYP) sind Monooxygenasen, die ein Häm enthalten und die die Hydroxylierung von nicht aktivierten C-H Bindungen sowohl stereo- als auch regioselektiv katalysieren. Der essentielle Schritt der Substratoxidation durch Cytochrom P450 ist die Insertion eines Sauerstoff-Atoms in das Substrat. Dieses Sauersto...

Catalysis Today j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / c a t t o d Hydrogen generation from the methanolysis of ammonia borane catalyzed by in situ generated, polymer stabilized ruthenium(0) nanoclusters a b s t r a c t Addressed herein is the detailed study on in situ generation of poly(N-vinyl-2-pyrrolidon...

With regards to the synthesis of L-Dopa (l-3,4-dihydroxy phenylalanine) two types of biosensors were designed by immobilizing tyrosinase on conducting polymers; polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT). PPy and PEDOT were synthesized electrochemically and tyrosinase immobilized by entrapment during electropolymerization. The k...

More attention has been paid to find new type renewable energy sources because of increasing concern about the environmental problems arising from the combustion of fossil fuels as energy sources. The development of new storage materials will facilitate the use of hydrogen as a major energy carrier. Several possibilities exist for &lsquo &lsquo sol...