Hung-Wen Chiu

Hung-Wen Chiu
Taipei Medical University | TMU · Graduate Institute of Medical Informatics

Doctor of Philosophy

About

112
Publications
12,659
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,451
Citations
Introduction
Artificial intelligence in bio-medicine Biomedical signal and image processing Biomedical data analysis

Publications

Publications (112)
Preprint
Objectives: Among trauma patients, it is crucial to avoid a delay in providing life-saving procedures owing to a missed diagnosis of a fracture. Unfortunately, missed rib fractures are common in such patients. Ribs have been found to be the locations with the most frequently missed fractures. As shown in previous studies, nearly 50% of rib fracture...
Article
Full-text available
Pneumonia and pulmonary edema are the most common causes of acute respiratory failure in emergency and intensive care. Airway maintenance and heart function preservation are two foundations for resuscitation. Laboratory examinations have been utilized for clinicians to early differentiate pneumonia and pulmonary edema; however, none can provide res...
Article
Full-text available
Parkinson’s disease (PD) is a progressive disorder of the nervous system that affects movement. Early prediction of PD can increase the chances of earlier intervention and delay the onset of the disease. Vocal impairment is one of the most important signs in the early stages of PD. Therefore, PD detection based on speech analysis and vocal patterns...
Article
Background and Objective COVID-19, a serious infectious disease outbreak started in the end of 2019, has caused a strong impact on the overall medical system, which reflects the gap in the volume and capacity of medical services and highlights the importance of clinical data ex-change and application. The most important concerns of medical records...
Article
Full-text available
Purpose Some predictive systems using machine learning models have been developed to predict sepsis; however, they were mostly built with a low percent of missing values, which does not correspond with the actual clinical situation. In this study, we developed a machine learning model with a high rate of missing and erroneous data to enable predict...
Article
The contribution of circulatory tau and β‐amyloid in Parkinson's disease (PD), especially the cognitive function, remains inconclusive. Extracellular vesicles (EVs) cargo these proteins throughout the bloodstream after they are directly secreted from many cells, including neurons. The present study aims to investigate the role of the plasma EV‐born...
Preprint
BACKGROUND During the COVID-19 pandemic, personal health records (PHRs) have enabled patients to monitor and manage their medical data without visiting hospitals and, consequently, minimize their infection risk. Taiwan’s National Health Insurance Administration (NHIA) launched the My Health Bank (MHB) service, a national PHR system through which in...
Article
Background: During the COVID-19 pandemic, personal health records (PHRs) have enabled patients to monitor and manage their medical data without visiting hospitals and, consequently, minimize their infection risk. Taiwan's National Health Insurance Administration (NHIA) launched the My Health Bank (MHB) service, a national PHR system through which...
Article
Background To identify the outcome-associated predictors and develop predictive models for patients receiving targeted temperature management (TTM) by artificial neural network (ANN). Methods The derived cohort consisted of 580 patients with cardiac arrest and ROSC treated with TTM between January 2014 and August 2019. We evaluated the predictive...
Article
Full-text available
Modern radiologic images comply with DICOM (digital imaging and communications in medicine) standard, which, upon conversion to other image format, would lose its image detail and information such as patient demographics or type of image modality that DICOM format carries. As there is a growing interest in using large amount of image data for resea...
Article
Background Accurate estimation of neurological outcomes after in-hospital cardiac arrest (IHCA) provides crucial information for clinical management. This study used artificial neural networks (ANNs) to determine the prognostic factors and develop prediction models for IHCA based on immediate preresuscitation parameters. Methods The derived cohort...
Article
Full-text available
In recent years, many types of research have continued to improve the environment of human speech and emotion recognition. As facial emotion recognition has gradually matured through speech recognition, the result of this study provided more accurate recognition of complex human emotional performance, and speech emotion identification will be deriv...
Article
Background: This study re-explored the predictive validity of Stroke Prognostication using Age and National Institutes of Health Stroke Scale (SPAN) index in patients who received different treatments for acute ischemic stroke (AIS) and developed machine learning-boosted outcome prediction models. Methods: We evaluated the prognostic relevance o...
Article
Full-text available
Personal health records (PHRs) have lots of benefits for things such as health surveillance, epidemiological surveillance, self-control, links to various services, public health and health management, and international surveillance. The implementation of an international standard for interoperability is essential to accessing personal health record...
Article
Full-text available
Despite the salient benefits of the intravenous tissue plasminogen activator (tPA), symptomatic intracerebral hemorrhage (sICH) remains a frequent complication and constitutes a major concern when treating acute ischemic stroke (AIS). This study explored the use of artificial neural network (ANN)-based models to predict sICH and 3-month mortality f...
Article
Objective: To investigate the prevalence and risk of subsequent dementia in subjects with sudden hearing loss during a 7-year follow-up period through comparisons with cohorts matched by sex, age group, and year of index date. Study design: A retrospective matched-cohort study. Setting: The Longitudinal Health Insurance Database 2000 (LHID2000...
Article
Objective: To develop artificial neural network (ANN)-based functional outcome prediction models for patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis based on immediate pretreatment parameters. Methods: The derived cohort consisted of 196 patients with AIS treated with intravenous thrombolysis between 2009 and 2017 at...
Chapter
In general, cerebrovascular diseases are composed of approximately 80% ischemic strokes. They are both expensive and time consuming while physicians take care of the acute ischemic stroke (AIS) patients. It is well-known that thrombolysis treatment in AIS patients can reduce disability and increase survival rate, however only one-half of patients h...
Article
Background Dementia is a syndrome that involves the deterioration of several higher mental functions in advanced age, and psoriasis is an autoimmune disease characterized by skin plaque. Epidemiological studies have indicated an association between dementia and psoriasis; however, to date, no studies in Asia have reported this association. Objecti...
Article
Full-text available
Osteoporosis and atrial fibrillation (AF) are common in post-menopausal women. Vitamin D and bisphosphonates are widely used to treat osteoporosis, and these may have different effects on the risk of AF.The goal of this study was to evaluate whether different agents for treating osteoporosis modulate the risk of AF in a population-based database.We...
Article
There is a typographical error in the International Classification of Disease Ninth Revision, Clinical Modification (ICD-9-CM) diagnostic code used for palmar hyperhidrosis. The published manuscript wrongly reports that the ICD-9-CM code used for palmar hyperhidrosis was 708.8 (which indicates a diagnosis of "Other specified urticaria"), when, in a...
Article
Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrit...
Article
Purpose: Palmar hyperhidrosis (PH) is excessive sweating of the palms resulting from sympathetic overactivity, and patients who undergo endoscopic thoracic sympathectomy (ETS) show reduced cardiac demand after 1 year and improved cerebral perfusion within 2-4 weeks. However, the long-term risks of major adverse cardiovascular events (MACE) followi...
Article
Full-text available
Background & aims Irritable bowel syndrome (IBS) manifests as chronic abdominal pain. One pathophysiological theory states that the brain–gut axis is responsible for pain control in the intestine. Although several studies have discussed the structural changes in the brain of IBS patients, most of these studies have been conducted in Western populat...
Article
Introduction: Sepsis increases the long-term incidence of ischemic stroke (IS). The chances for long-term IS in patients who are discharged after sepsis are unclear. Our aim was to demonstrate long-term risk chances of IS after septicemia discharge. We used a nomogram to identify those septicemia survivors with the higher risk of developing IS. M...
Conference Paper
Stroke is a serious health problem in many countries. About 20% of ischemia stroke involves carotid stenosis. Neck carotid ultrasound is fast, secure and convenient way to detect carotid artery stenosis. Carotid artery stenting (CAS) has become a popular treatment for cerebrovascular stenosis in recent years. However, CAS may also induce the occurr...
Article
Full-text available
ABSTRACT Background: Empowering personal health records (PHRs) provides basic human right, awareness, and intention for health promotion. As health care delivery changes toward patient-centered services, PHRs become an indispensable platform for consumers and providers. Recently, the government introduced “My health bank,” a Web-based electronic me...
Article
Full-text available
Background: Empowering personal health records (PHRs) provides basic human right, awareness, and intention for health promotion. As health care delivery changes toward patient-centered services, PHRs become an indispensable platform for consumers and providers. Recently, the government introduced "My health bank," a Web-based electronic medical re...
Article
Full-text available
Background: Sepsis will induce stroke, new-onset atrial fibrillation (AF) increase ischemic stroke (IS) in in-hospitalization and long-term period after sepsis. Physicians must alert this condition and given suitable treatment. Aim: The associated of IS and new-onset AF in septicemia survivors after discharge have to be evaluated. Design: The inpat...
Article
Background and objective: Distinguishing cancer subtypes is critical for selecting the appropriate treatment strategy. Bioinformatics approaches have gradually taken the place of clinical observations and pathological experiments. However, these approaches are typically only used in gene expression profiling. Previous studies have primarily focuse...
Article
Full-text available
Background: Radiofrequency ablation (RFA) provides an effective treatment for patients who exhibit early hepatocellular carcinoma (HCC) stages or are waiting for liver transplantation. It is important to assess patients after RFA. The goal of this study was to build artificial neural network models with HCC-related variables to predict the 1-year...
Article
Full-text available
Background The incidence of stroke in pregnant women is low but trending upward. There are few studies of the topic in women of Asian ethnicity.AimWe aim to evaluate stroke risk in Asian women during and after pregnancy.DesignUsing the Taiwan National Health Insurance database (NHIRD), we designed a retrospective study that included 18-45-year-old...
Conference Paper
Disease of the heart accounts for 6% of all death. Heart sound is a routine in physical examination clinically, and is sensitive in detecting a subset of heart diseases. In the current study, we build up a model to classify heart sounds for preclinical screening. Heart sounds are recorded under uncontrolled environment, and each sample can range fr...
Article
Full-text available
Because stroke is the third leading disease that causes mortality in the world, the prevention of stroke from advanced carotid stenosis is an important issue. The carotid stent (CAS) is a less invasive to treat advanced carotid stenosis, but for high-risk patients it may cause some events after the procedure that reduces the benefit of stroke preve...
Conference Paper
Differences in cultural and the convenience of obtaining information expose a significant difference in the effectiveness of learning between Indigenous and non-Indigenous students. Indigenous students frequently misunderstand the content and examples provided by the teachers, and cultural constraint is an important factor in learning. This study c...
Article
Full-text available
Val66Met polymorphism on the brain-derived neurotrophic factor (BDNF) gene is associated with hippocampal pathology and impaired episodic memory. However, the influence of this polymorphism on working memory (WM) performance and patterns of brain activation is controversial. This study investigated the effects of BDNF Val66Met polymorphism on funct...
Article
Full-text available
Twenty-five to 40% of patients pass a spontaneous breathing trial (SBT) but fail to wean from mechanical ventilation. There is no single appropriate and convenient predictor or method that can help clinicians to accurately predict weaning outcomes. This study designed an artificial neural network (ANN) model for predicting successful extubation in...
Conference Paper
Gene expression profiles differ in different diseases. Even if diseases are at the same stage, such diseases exhibit different gene expressions, not to mention the different subtypes at a single lesion site. Distinguishing different disease subtypes at a single lesion site is difficult. In early cases, subtypes were initially distinguished by docto...
Article
Adjuvant chemotherapy (ACT) is used after surgery to prevent recurrence or metastases. However, ACT for non-small cell lung cancer (NSCLC) is still controversial. This study aimed to develop prediction models to distinguish who is suitable for ACT (ACT-benefit) and who should avoid ACT (ACT-futile) in NSCLC. We identified the ACT correlated gene si...
Article
Cell signaling pathway is an important facet of biological life. The integration of protein interaction and gene expression data is suitable to uncover the regulation of pathway. However, these methods are still confined to a partial region of large-scale genomics and whole-proteomics. In previous studies for this topic, researches usually focused...
Article
A single-longitudinal mode selection is realized in a linear-cavity tunable fiber laser constructed using a Faraday rotator mirror and a partial reflectance fiber Bragg grating as the cavity ends. At both tuning wavelengths of 1543.47 and 1557.52 nm, the measured optical signal-to-noise ratio is larger than 40 dB and a linewidth less than 1 MHz is...
Article
Protein–protein interactions (PPIs) and gene expression profiles interact with each other in the regulation of a pathway. Many studies have expressed the feasibility of deriving the pathway from the PPI network or gene expression information. However, previous researches are still limited to a small region of large-scale genomics and whole-proteomi...
Article
In general, around 80% of all strokes are ischemic. Take caring of the patients who have suffered an ischemic stroke is both expensive and time consuming. It is known that thrombolysis in patients with ischemic stroke can reduce the disability and increase the survival rate, however some patients still have poor outcomes. Therefore, to be able to p...
Article
Numerous cancer studies have combined gene expression experiments and clinical survival data to predict the prognosis of patients of specific gene types. However, most results of these studies were data dependent and were not suitable for other data sets. This study performed cross-laboratory validations for the cancer patient data from 4 hospitals...
Article
Biological pathways are the crucial biological mechanisms in living cells. The huge volume of genomics and proteomics data requires computational methods for predicting or reconstructing pathways. Thus, the application of protein-protein interaction (PPI) or gene expression methods is insufficient to discover meaningful pathways. The integration of...
Article
Full-text available
Slowing of average electroencephalography (EEG) frequency in Alzheimer's disease (AD) is well established, but whether EEG changes are able to reflect the severity of AD is uncertain. We attempt to establish quantitative EEG parameters that are suitable for evaluating AD in clinical practice. Ninety-five patients with newly diagnosed AD at differen...
Article
In the last decade, the use of data mining techniques has become widely accepted in medical applications, especially in predicting cancer patients' survival. In this study, we attempted to train an Artificial Neural Network (ANN) to predict the patients' five-year survivability. Breast cancer patients who were diagnosed and received standard treatm...
Article
Purpose: Previous studies had reported an increased prevalence of glaucoma in patients with obstructive sleep apnea (OSA). However, the risk of open-angle glaucoma (OAG) among patients with OSA remains unclear. Using a nationwide, population-based dataset in Taiwan, this study aimed to examine the prevalence and risk of OAG among patients with OSA...
Article
Full-text available
BACKGROUND AND PURPOSE:APOE4 is the best-documented genetic risk factor for sporadic AD. Previous research showed that APOE4 is associated with increased risk of occurrence and earlier onset of AD in a gene dose-dependent manner. However, the specific role of APOE4 in processing of brain functions requires further investigation. Investigators have...
Article
The aim of this study was to validate a specially designed electronic medical records (EMRs) questionnaire for use in Taiwan. Published reviews of national trends and EMRs characteristics from seven countries in the Americas, Oceania, Europe, and Asia were used to design the Google-based document. This questionnaire is intended for use by medical i...
Article
Objective: To prospectively investigate prediction of ADHD to anxiety disorders (ANXs) in a national sample of Taiwan. Method: From the Taiwan National Health Insurance Dataset (1997-2007), we collected 2,385 cases of new diagnoses of ADHD from 1999 to 2003 and 9,540 sex-, age- and index dates of the first diagnosis of ADHD-matched cohort contro...
Article
Child obesity is frequently associated with dysfunction of autonomic nervous system. Children in pubertal development were suggested to be vulnerable to autonomic nervous system problems such as decrease of heart rate variability from dysregulation of metabolic control. This study explored the influence of pubertal development on autonomic nervous...
Article
Full-text available
This study proposed a recognized system for electroencephalogram (EEG) data classification. In addition to the wavelet-based amplitude modulation (AM) features, the fuzzy c-means (FCM) clustering is used for the discriminant of left finger lifting and resting. The features are extracted from discrete wavelet transform (DWT) data with the AM method....
Article
Full-text available
In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST an...
Article
Objectives: This study created a survival prediction model for liver cancer using data mining algorithms. Methods: The data were collected from the cancer registry of a medical center in Northern Taiwan between 2004 and 2008. A total of 227 patients were newly diagnosed with liver cancer during this time. Following a literature review, expert consu...
Conference Paper
The diagnosis of vasovagal syncope (VVS) is according to history, tilt table test and blood pressure change with postural stress. We collected 30 patients below 55 years-old, received tilt table test without pharmacological challenge from 2005 to 2010. Due to this disorder is the heterogeneity, multiple factor. The pathophysological pathway was not...
Article
Obstructive sleep apnea (OSA) is a major concern in modern medicine; however, it is difficult to diagnose. Screening questionnaires such as the Berlin questionnaire, Rome questionnaire, and BASH'IM score are used to identify patients with OSA. However, the sensitivity and specificity of these tools are not satisfactory. We aim to introduce an artif...
Conference Paper
This study established a survival prediction model for liver cancer using data mining technology. The data were collected from the cancer registration database of a medical center in Northern Taiwan between 2004 and 2008. A total of 227 patients were newly diagnosed with liver cancer during this time. With literature review, and expert consultation...
Article
The proliferation of communication and mobile computing devices and local-area wireless networks has cultivated a growing interest in location-aware systems and services. An essential problem in location-aware computing is the determination of physical locations. RFID technologies are gaining much attention, as they are attractive solutions to indo...
Article
Full-text available
The diagnosis of vasovagal syncope (VVS) is according to history, tilt table test and blood pressure change with postural stress. We collected 30 patients below 55 years-old, received tilt table test without pharmacological challenge from 2005 to 2010. Due to this disorder is the heterogeneity, multiple factor. The pathophysological pathway was not...
Article
Research on pathway has been much appealing for studying the biological biomarkers, cell mechanism, and cancer proliferation in recent years. Pathway has been typically related to human diseases for drug discovery especially for tumor-targeted therapy. Since the scanty of the knowledge about cancer-related pathways, further exploration is required....
Conference Paper
Short-term heart rate variability (HRV) analysis based on spectral methods has been widely applied to assessment of autonomic nervous system activities for many physiological and mental disorders. Recently, homecare devices designed for heart monitoring have attempted to include HRV analysis function. These homecare devices based on some microproce...
Conference Paper
Full-text available
Vasovagal syncope (WS) is diagnosed by medical history and confirmed by head-up tilt (HUT) test. In this study, we attempted to examine this controversy by evaluating heart rate variability and baroreceptor sensitivity in WS during upright posture. The WS subjects had lower total peripheral vascular resistance at baseline supine and HUT position. D...
Article
A lot of researches have proven that health education can help patients to maintain and improve their health. And it also shortens the time staying in hospital to save medication resource. Because the patients are willing to get healthcare knowledge to enhance the ability of self-care, they pay more attention to the health education. In Taiwan, the...
Article
Perioperative hypotension is associated with adverse outcomes in patients undergoing surgery. A computer-based model that integrates related factors and predicts the risk of hypotension would be helpful in clinical anesthesia. The purpose of this study was to develop artificial neural network (ANN) models to identify patients at high risk for posti...
Article
Pulse contour-derived cardiac output for continuous hemodynamic monitoring is becoming popular in critical care. However, the data regarding its reliability during acute hemodynamic instability are inconsistent. This study was conducted to determine whether pulse contour-derived cardiac output truly reflects rapid hemodynamic changes. Hemorrhagic s...
Article
Full-text available
a b s t r a c t Despite many previous studies on the association between hyperthyroidism and the hy-peradrenergic state, controversies still exist. Detrended fluctuation analysis (DFA) is a well recognized method in the nonlinear analysis of heart rate variability (HRV), and it has phys-iological significance related to the autonomic nervous system...
</