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Publications (11)
Extracellular vesicles (EVs) are lipid bilayer vesicles with a diameter ranging from 30 to 150 nm, playing a crucial role in mediating cell-to-cell communication under both physiological and pathophysiological conditions. However, the clinical utilization of EVs is currently hindered by the challenge of monitoring them effectively in vitro and in v...
Previous studies have highlighted the antitumor effects of mesenchymal stem cell-derived extracellular vesi-cles (MSC-EVs), positioning them as a promising therapeutic avenue for cancer treatment. However, some researchers have proposed a bidirectional influence of MSC-EVs on tumors, determined by the specific tissue origin of the MSCs and the type...
ELife digest
Animals are made up of cells of different types, with each type of cell specializing on a specific role. But for the body to work properly, the different types of cells must be able to coordinate with each other to respond to internal and external stimuli. This can be achieved through signaling molecules, that is, molecules released by...
Acute Kidney Injury Endothelial cell injury is one of the specific features of acute kidney injury (AKI). In article number 2204626, Zongjin Li and co‐workers identify P‐selectin as a biomarker of ischemic AKI in endothelial cells and develop P‐selectin binding peptide‐engineered extracellular vesicles (PBP‐EVs) with imaging and therapeutic functio...
Nitric oxide (NO), as a gaseous therapeutic agent, shows great potential for the treatment of many kinds of diseases. Although various NO delivery systems have emerged, the immunogenicity and long-term toxicity of artificial carriers hinder the potential clinical translation of this gas therapeutics. Mesenchymal stem cells (MSCs), with the capaciti...
Endothelial cell injury plays a critical part in ischemic acute kidney injury (AKI) and participates in the progression of AKI. Targeting renal endothelial cell therapy may ameliorate vascular injury and further improve the prognosis of ischemic AKI. Here, P-selectin as a biomarker of ischemic AKI in endothelial cells is identified and P-selectin b...
Background
Chemotherapy is an effective anti-tumor treatment. Mesenchymal stem cells (MSCs), exerting therapy effect on injured tissues during chemotherapy, may be damaged in the process. The possibility of self-healing through long-range paracrine and the mechanisms are unclear.
Methods
Doxorubicin, a commonly used chemotherapy drug, was to treat...
Therapeutic angiogenesis with mesenchymal stem cells (MSCs) is promising for the clinical treatment of peripheral artery disease (PAD). However, the heterogeneous proangiogenic nature of MSCs is a key challenge in developing more effective treatments with MSCs for therapeutic angiogenesis purposes. Here, we propose to enhance the therapeutic functi...
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to stimulate regeneration in the treatment of kidney injury. Renal regeneration is also thought to be stimulated by the activation of Sox9+ cells. However, whether and how the activation mechanisms underlying EV treatment and Sox9+ cell-dependent regeneration intersect...
