Hugo Salais-López

Hugo Salais-López
Universitat Jaume I | UJI · Predepartmental Medicine Unit

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5
Publications
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72
Citations

Publications

Publications (5)
Article
Full-text available
Motherhood entails increased motivation for pups, which become strong reinforcers and guide maternal behaviours. This depends on steroids and lactogens acting on the brain of females during pregnancy and postpartum. Since virgin female mice exposed to pups are nearly spontaneously maternal, the specific roles of endocrine and pup-derived signals in...
Article
Full-text available
Research of the central actions of prolactin is highly focused on females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived signalling in the male mouse brain, employing the immunostaining of phosphorylated signal transducer and activator of trans...
Data
Raw data for pSTAT5 analysis. Raw data of pSTAT5-ir density used for the statistical comparison of PRL-derived signalling among: (A) intact, PRL-supplmented males and ovariectomized, steroid-primed and PRL-supplemented females and (B) intact, PRL-supplemented males and castrated, PRL-supplemented males. (ZIP)
Preprint
Full-text available
Research of the central actions of prolactin is virtually restricted to females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived signalling in the male mouse brain, employing the immunostaining of phosphorylated signal transducer and activator of...
Article
Full-text available
Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care. By contrast, the role of prolactin in mice maternal behaviour remains unclear. This study aims at characterizing central prolactin activity patterns in female mice and...

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Projects

Projects (2)
Archived project
http://prometeo.labneurofun.com/index.php?lang=es The Prometeus’ Seminar is a meeting organised by the Lab of Functional Neuroanatomy (NeuroFun, research group 278 at UJI; PROMETEO2016/076) at the Universitat Jaume I (Castellón, Spain) and the Red Olfativa Española (ROE, Spanish Network for studies on Olfaction), of which the NeuroFun researchers are members. This Prometeus’ Seminar constitutes the Second Topic Series on Olfaction, an event devoted to promoting discussion on a subject related to olfaction and vomeronasal sensing. The meeting will be held at UJI, Castellón (Spain) in October 19-20, 2017. Research Topics This conference focuses on the common interests of both institutions. On the one hand we aim at attracting scientists interested in the neural basis of social behaviours. Given the preeminent role of chemical senses in the control of these behaviours in most experimental animals (e.g. rodents) this constitutes an opportunity for discussion for scientists interested in olfaction and vomeronasal sensing. In addition, there is growing evidence indicating that altered chemosensing can be related to several pathologies. For instance, it is quite established that neurodegenerative diseases such as Parkinson (PD) or Alzheimer (AD) course with hiposmia or anosmia, which is currently considered a “pre-clinical” symptom of the disease and can be, therefore, used for early diagnosis, thus allowing more effective therapies. In addition, it is not established yet whether neurological-psychiatric disorders characterised by deeply altered social behaviours (autism spectrum disorders, schizophrenia) might involve changes in chemosensing. The use of animal models of these disorders might contribute to clarifying this issue and, in doing so, to further understanding these disorders. You are invited to attend this fascinating meeting. Visit our webpage at: www.prometeo.labneurofun.com
Project
We have four main goals: 1. Understanding the role of prolactin (PRL) (and/or placental lactogens) and sexual steroids in the induction of full maternal behaviour in female mice: maternal aggression and fully motivated maternal care 2. Understanding what changes in gene expression occur in the different nodes of the sociosexual brain network to transform it in the maternal brain network 3. Analyse whether nonapeptidergic neurons on the BST/preoptic boundary are the target for the action of PRL 4. Analyse the effects of inactivating (or activating) these nonapeptidergic cells by means of DREADD technology on the expression of maternal behaviour in dams and virgin females 5. Study the role of pup-derived chemosignals in the expression of maternal behaviours