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Hugo Josef Niggli

Hugo Josef Niggli
BioFoton · Research

Doctor of Philosophy

About

39
Publications
4,801
Reads
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766
Citations
Citations since 2016
2 Research Items
142 Citations
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201620172018201920202021202205101520
201620172018201920202021202205101520
201620172018201920202021202205101520
Additional affiliations
January 1993 - October 2016
BioFoton
Position
  • CEO

Publications

Publications (39)
Article
Full-text available
Bioelectromagnetic influence on the eyes of a group of 336 subjects with various vision disorders: amblyopia, myopia and hypermetropia were investigated with high-frequency black-white and color coronal discharge, infrared thermography and visual acuity measurements. The authors have performed registration of the biggest part of electromagnetic fie...
Article
Full-text available
This paper presents the results of evaluation of possible biophysical methods and approaches for registering of various non-ionizing radiation (NIR) wave types of the human body in the optic and electromagnetic range. Various types of NIR (electromagnetic waves, infrared radiation, thermo radiation, bioluminiscence) emitted from the human body were...
Article
Full-text available
This paper presents the results of evaluation of possible biophysical methods and approaches for registering of various non-ionizing radiation (NIR) wave types of the human body in the optic and electromagnetic range. Various types of NIR (electromagnetic waves, infrared radiation, thermo radiation, bioluminiscence) emitted from the human body were...
Article
Full-text available
This paper presents the results of evaluation of possible biophysical methods and approaches for registering various non-ionizing radiation (NIR) wave types of the human body in the electromagnetic range. Many types of NIR (electromagnetic waves, infrared radiation, thermo radiation, bioluminescence) emitted from the human body were reviewed. In pa...
Article
Full-text available
In recent years the low level analysis of ultra-weak photon emission in human cells is achieved using sophisticated Photomultiplier Technique (PMT). The basis of photonic measurements goes back to the theoretical finding of Einstein that a photon, which hits a metal plate, causes an electrical impulse. This current can be detected by single photon...
Article
Full-text available
As shown by the history of light, photons participate in most atomic and molecular interactions. Recent biophysical research has measured low light impulses, so-called biophotonic emission, in cells and biological tissue. It is reported throughout the world that all cells (plant, animal or human) emit a weak, so-called biophotonic radiation. Based...
Article
Full-text available
Photons participate in many atomic and molecular interactions and processes. Recent biophysical research has discovered an ultraweak radiation in biological tissues. It is now recognized that plants, animal and human cells emit this very weak biophotonic emission which can be readily measured with a sensitive photomultiplier system. UVA laser induc...
Chapter
In conclusion, a new highly sensitive method using UVA-laser induced delayed ultrawek luminescence in cultured mammalian cells is presented. Our results show evidence that this biological system is a new powerful non-invasive tool to determine biophysical changes within the cells. Future research will show whether this new biological detection syst...
Article
Photobiological research in the last decades has shown the existence of Delayed Luminescence in biological tissue, which presents an excitation spectrum with a peak within the UVA region and can be detected with sophisticated photomultiplier systems. Based on these findings, a new and powerful tool able to measure the UV-A-laser-induced Delayed Lum...
Article
The time resolved emission spectrum of delayed luminescence from human fibroblast and melanoma cells was measured. Noticeable differences both in the emission spectra, and in the time trend of the spectral components were found.
Article
The emission spectrum of ultraviolet A laser induced ultraweak delayed luminescence in cell cultures of mammalian cells depended on the temperature during irradiation and photonic measurements. A new method using a sophisticated photomultiplier system was developed in order to find differences between normal and tumor cells. The maximal peak of the...
Article
In our present studies, the time-resolved emission spectrum of delayed luminescence of cell cultures of human fibroblast and human melanoma have been measured using a sophisticated single photon device. Noticeable differences have been found both in the emission spectra, which are time dependent, and in the timing aspects of the different spectral...
Article
Full-text available
Photobiological research in the last 30 yr has shown the existence of ultraweak photon emission in biological tissue, which can be detected with sophisticated photomultiplier systems. Although the emission of this ultraweak radiation, often termed biophotons, is extremely low in mammalian cells, it can be efficiently increased by ultraviolet light....
Article
Yield of ultraweak photon emission in a cell culture model for biophotonic measurements using fibroblastic differentiation depended on the temperature of photonic measurement. The ultraweak photon emission of medium was significantly higher at 37 degrees C than at 25 degrees C and after UVB-irradiation this difference was even more pronounced. Whil...
Chapter
Photons participate in many atomic and molecular interactions and changes. Recent biophysical research has detected ultraweak photons or biophotonic emission in biological tissue. It is now established that plants, animals and human cells emit a very weak radiation which can be readily detected with an appropriate photomultiplier system. Although t...
Article
Photons participate in many atomic and molecular interactions and changes. Recent biophysical research has shown the induction of ultraweak photons in biological tissue. It is now established that plants, animal and human cells emit a very weak radiation which can be readily detected with an appropriate photomultiplier system. Although the emission...
Article
Full-text available
Pyrimidine dimers participate as important factors in ultraviolet-induced lethality, mutagenicity and tumorgenicity. Substantial efforts have been made in recent years to understand the induction of pyrimidine photodimers and their repair in human skin cells exposed to low physiological fluences of UV-light. Dimers are known to be efficiently induc...
Chapter
Photons participate in many atomic and molecular interactions and changes. Recent biophysical research has shown the existence of photons in biological tissue and plants, animal and human cells emit a very weak radiation which can be readily detected with an appropriate photomultiplier system. Although the emission of this radiation is extremely lo...
Article
Since Hayflick's pioneering work in the early sixties, human diploid fibroblasts have become a widely accepted in vitro model system. Recently, Bayreuther and co-workers extended this experimental approach showing that fibroblasts in culture resemble, in their design, the hemopoietic stem-cell differentiation system. They found that the chemical ag...
Article
The rates of formation and excision of UVC light-induced cyclobutane-type pyrimidine photodimers were determined in cultures of foreskin-derived normal human fibroblasts in mitotic (MF) and mitomycin-C (MMC)-induced postmitotic fibroblasts (PMF). Characteristic morphological changes support the notion that MMC accelerates the differentiation pathwa...
Article
Photons participate in many atomic and molecular interactions and changes in the physical universe. In recent years sophisticated detection procedures for the measurement of ultraweak photons in a variety of different cells have been performed leading to the conclusion that plant, animal and human cells emit ultraweak photons. Using an extremely lo...
Article
I measured the induction of cytosine-cytosine dimer (C-C) densities after UV-C (less than 290 nm) and UV-B irradiation (290-320 nm) in the 2'-deoxy-[3H]cytidine labeled DNA of Cloudman S91 mouse melanoma cells using a new, sensitive high pressure liquid chromatography procedure. UV-B exposure resulted in 0.000034% C-C/J m-2 of the total cytosine ra...
Chapter
Practically all cells emit light at a steady rate from a few photons per cell per day to several photons per cell per second, which is readily detected with a sensitive photomultiplier placed with the cells in a dark chamber. It is widely accepted that at least a part of the emitted light results from radical reactions, but chromatin has also been...
Article
Since Hayflick’s pioneering work in the early sixties, human diploid fibroblasts have become a widely accepted in vitro model system for gerontological research. Most recently, Bayreuther and co-workers extended this experimental approach showing that fibroblasts in culture resemble in their design the hemopoietic stem-cell differentiation system....
Article
We compared the induction of pyrimidine dimer densities after UV-irradiation in mouse melanoma cells before and after treatment with cholera toxin. Treatment with cholera toxin stimulated tyrosinase activity up to 50-fold, leading to a marked, visually apparent increase in cellular melanin concentrations. Irradiation of treated and untreated cells...
Article
The formation and excision of UV-C light-induced cyclobutane-type pyrimidine photodimers were determined in cultures of human skin fibroblasts at time zero and several weeks following treatment with mitomycin C (MMC). Characteristic morphological changes of the fibroblasts and specific shifts in the [35S]methionine polypeptide pattern of total cell...
Article
The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
Article
Cyclobutane-type pyrimidine photodimers as well as the induction of ornithine decarboxylase (ODC) may serve as biochemical markers of the mutagenic and carcinogenic effects of ultraviolet light (UV). For this reason, it is important to compare the formation of pyrimidine dimers with the induction of ODC in human skin fibroblasts after irradiation w...
Article
— We compared artificial UV-sources such as germicidal- or sun-lamps with summer noon sunlight in Switzerland for selective efficiency in the induction of pyrimidine dimers in the DNA of human cells. In our studies we determined cytosine-thymine (C-T) as well as thymine-thymine dimer densities (T-T) by high pressure liquid chromatography in culture...
Article
The rate of cyclobutane-type pyrimidine photodimerization with 313 nm light was determined in confluent cultures of xeroderma pigmentosum cells of group A. A new method was developed for the determination of sodium borohydride reduced thymine-thymine (TT) and cytosine-thymine (CT) dirners by high pressure liquid chromatography. It was found that th...
Article
The formation and excision of 313-nm light-induced cyclobutane-type pyrimidine photodimers were determined in confluent cultures of human fibroblasts. A new method was developed for the resolution and determination of cytosine-thymine (CT) and thymine-thymine dimers (TT) by using sodium borohydride reduction and high-pressure liquid chromatography....
Article
The nucleosomal distribution of cis-syn cyclobutyl-type thymine photodimers was determined in normal human skin fibroblasts following irradiation with low doses of far-ultraviolet light at 254 nm and nearultraviolet light at 313 nm. The thymine photodimer concentrations were determined by high pressure liquid chromatography in acid hydrolysates of...
Article
Full-text available
Synopsis Acid phosphatase activity in tape-strip biopsies of human stratum corneum was determined using p-nitro-phenyl phosphate as substrate following skin treatment of healthy volunteers with different surfactants at various concentrations. As a short-term effect, enhanced reduction of acid phosphatase activity with stronger surfactants and highe...

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Projects (2)
Project
The importance of low Level radiation in plant, animal and human cells. Low Level detection using the ARETUSA Equipment.