Hugo Mendieta Zerón

Autonomous University of Mexico State · Faculty of Medicine

Hyperglycemia, an abnormality that results from a breakdown of normal glucose control processes is also the result of molecular mechanisms to protect the insulin receptor? A hypothesis Abstract Background: Deficiency in either β-cell mass or function, or both, can lead to insufficient levels of insulin, resulting in hyperglycemia and diabetes melli...

Memorias del 10º Encuentro Internacional de Grupos y Semilleros de Investigación en Ciencias Básicas y Aplicadas llevado a cabo en julio del 2024 en la Institución Universitaria Colegio Mayor de Antioquia, Medellín, Colombia.

While it is true that there is no universal established definition for the concept of "obstetric hemorrhage" it is also true that its presentation as a complication constitutes a major public health challenge. This study was carried out from 2018 to 2022, at the "Mónica Pretelini Sáenz" Maternal Perinatal Hospital (HMPMPS). 27,381 patients were ana...

This research explores maternal-fetal heart rhythm coupling (MFHRC) in full-term and moderate preterm labor using high-resolution joint symbolic dynamics (HRJSD) to identify distinct heart rate patterns indicative of physiological system couplings during active labor stages. This study evidences that preterm labor exhibits unique MFHRC patterns com...

Hepcidin is a primary regulator of iron metabolism in the human body by promoting ferroportin degradation, hepcidin reduces intestinal iron absorption and its release from intracellular stores but regarding its role in the development of preeclampsia, information is scarce and contrasting. It is hypothesized that increased hepcidin may contribute t...

Breathing rate asymmetry (BRA) refers to the observed disparities in the acceleration and deceleration phases of human respiration. The techniques employed to assess BRA could also be utilized in exploring hypertensive disorders like pre-eclampsia, which is known to cause autonomic cardiorespiratory changes. This study explores features of complexi...

Background Pheochromocytoma is a rare disease, and its familial occurrence is quite uncommon. The aim of this paper is to report a three-generation phenotypical expression of a case familial occurrence of pheochromocytoma. Case presentation A 25-year-old female, with a history of adrenalectomy for pheochromocytoma, arrived at the shock room during...

Introduction Fetal heart rate variability (fHRV) is a tool used to investigate the functioning of the fetal autonomic nervous system. Despite the significance of preeclampsia, fHRV during the latent phase of labor has not been extensively studied. This study aimed to evaluate fetal cardiac autonomic activity by using linear and nonlinear indices of...

Resumen-En esta investigación se utilizó la metodología de Descubrimiento de Conocimiento en Bases de datos (KDD) y árboles de decisión, técnica de minería de datos para la obtención de los factores de mortalidad con mayor ganancia de información de una base de datos de un establecimiento médico del Estado de México que cuenta con la información de...

The first case of cerebral venous thrombosis, described in the past century, was identified in obstetric patients in 1825. The clinical manifestations represent a real diagnostic challenge due to the few recorded cases, the wide variety of possible clinical symptoms, and the diversity of medical conditions that cause it. In the past century, the et...

Introduction. Down Syndrome (DS) is the most common chromosomopathy. Cyclin B1 is a regulatory protein involved in mitosis. The aim was to determine the cyclin B1 relative expression in mothers of DS patients. Methods. In this cross-sectional study, mononuclear cells of peripheral blood were obtained from 40 mothers of confirmed DS patients and 40...

Introduction. Abdominal pain is a frequent reason for consultation in the emergency department , being the result of various pathologies, mostly of benign origin. However, the lack of timely identification and treatment can lead to significant complications. Objective. The purpose of this review is to deepen in the etiology of acute abdomen in pedi...

In Mexico, diabetes mellitus continues to be an important cause of mortality that could be reduced if patients could have timely and accurate information about their glucose concentrations. Glucose monitoring is a very useful tool to control blood glucose in the most optimal way possible and to avoid the complications that arise from blood glucose...

La Asociación Científica Latina A.C. (ASCILA) ha cumplido una vez más con la misión de acercar la investigación a nuevas generaciones, como ha sido el caso de su IX Congreso llevado a cabo en la Facultad de Medicina de la Universidad Autónoma del Estado de México. Claramente se pueden distinguir tres niveles en los trabajos que se presentan, 1) pr...

Introduction: Cycling is a physical activity, which is practiced recreationally and as a work activity. Its effects may extend to the regulation of the expression of proinflammatory cytokines in obesity; however, details should be studied in the clinical indicators associated with other chronic-degenerative diseases. Objective: To identify changes...

Resumen Es bien sabido que el ejercicio tiene beneficios en la salud, pero los mecanismos que ayudan a obtener dichos efectos pueden ser la clave en el desarrollo de estrategias terapéuticas para tratar la gran variedad de enfermedades metabólicas que se presentan como problemas de salud pública en la actualidad. Abstract It is a well known fact th...

Introduction During pregnancy, women experience metabolic changes that may induce insulin resistance, which can be traced to the blood glucose levels A number of factors may intervene in the metabolism of glucose in pregnant women; one of them is body composition. This factor is useful for studying metabolic diseases, for which the identification o...

Objectives Acute Kidney Injury (AKI) during pregnancy is a complication that poses a serious risk of life for the mother and the fetus. In most cases, the treatment considered in the first instance is pregnancy interruption with subsequent conventional treatment of AKI. The aim of this review is to describe the risks and benefits of using renal rep...

Introduction: There is a relationship between depression and sleep quality; however, the impact of the COVID-19 pandemic on this association is unknown, especially for those health workers who faced the pandemic. Therefore, we aimed to identify the association between depression and sleep quality in health workers who faced the COVID-19 pandemic. M...

Objective: To identify the influence of carbohydrate (CHO) intake on oxidative status among women with and without gestational diabetes mellitus (GDM). Materials and methods: A cross-sectional, observational and comparative study was carried out with two groups of 21 women each with and without GDM in the city of Toluca, Mexico, from January to...

Background Cardiorespiratory coupling (CRC) is a physiological phenomenon that reflects the mutual interaction between the cardiac and respiratory control systems. It is mainly associated with efferent vagal activity from the central autonomic network. Few studies have explored the autonomic changes of CRC in preeclampsia, a critical obstetric comp...

Liver rupture secondary to preeclampsia represents a complication that, if is not recognized early, can be fatal. Its presentation is rare, but very complex to treat, having options that are not clearly protocolized and usually derive from the experience of the surgeon who faces it. We present a case of liver rupture of a patient from Toluca, State...

Mining activity and intensive agriculture have negatively impacted the health of the ecosystems of Calimaya, Mexico. In this area, stone deposits have been exploited by intensive removal for more than 40 years, and intensive agriculture has been practiced for 25 years in which the use of pesticides is abused, a situation that represents a potential...

Beckwith-Wiedemann Syndrome (BWS) is a rare congenital disorder caused by alterations to the IGF2 gene. Its incidence has increased with the use of assisted reproduction techniques. We present a case of a patient with BWS who experienced anaphylactic shock during delivery, likely related to oxytocin use. Multidisciplinary management is necessary in...

Introduction Gestational diabetes mellitus (GDM) is underdiagnosed in Mexico. Early GDM risk stratification through prediction modeling is expected to improve preventative care. We developed a GDM risk assessment model that integrates both genetic and clinical variables. Research design and methods Data from pregnant Mexican women enrolled in the...

Background The autonomic nervous system of preterm fetuses has a different level of maturity than term fetuses. Thus, their autonomic response to transient hypoxemia caused by uterine contractions in labor may differ. This study aims to compare the behavior of the fetal autonomic response to uterine contractions between preterm and term active labo...

Existen diferentes criterios para el diagnóstico de diabetes mellitus gestacional (DMG); sin embargo, hoy en día son controversiales debido a que carecen de unanimidad. Es así que el objetivo de la presente investigación se basó en una revisión sistemática de los criterios diagnósticos de DMG en América Latina. Se realizó una búsqueda sistemática e...

Composición corporal en mujeres con riesgo cardiovascular

Objective: Autoimmune polyglandular syndromes (APS) are endocrinopathies whose main characteristic is the loss of immune tolerance. The objective of this work was to report the APS prevalence in an Internal Medicine Service from Toluca, Mexico. Methods: This was a descriptive and retrospective study. Medical files from the service of Internal Medic...

Objective. Congenital diseases are hereditary disorders whose timely detection is vital for early treatment, thus avoiding serious consequences in the future. Material and methods. A retrospective study was made of suspected cases of congenital diseases detected through the neonatal screening in a third level hospital of Toluca, Mexico, from the te...

Currently, the gold standard for the diagnosis of SARS-CoV-2 infection is RT-PCR (reverse transcriptase PCR). In addition to its diagnostic function, it is an indirect indicator of the viral load that a patient has. Our knowledge of this new virus indicates that a high viral load is associated with a worse prognosis and a more severe clinical pictu...

Thyroid disease is one of the most frequent causes of gestational endocrinopathies. Deiodinases play an important role controlling the concentration of thyroid hormones at the tissue level and the homeostasis of thyroid hormones, on pregnant women; specifically, Deiodinase type 1 (D1) may control the TSH levels. To determine the serum levels of D1...

Electrohysterogram or uterine electromyogram (EHG) is a non-invasive record that has been shown to provide information about uterine electrical dynamics in labor. This study aimed to compare the irregularity and nonlinearity of uterine electrical dynamics at term and preterm labor using entropy-based methods. We analyzed a dataset of EHG recordings...

Background: Familial Medullary Thyroid Cancer (FMTC) is hereditary in 25% of cases. Patients with an inherited form of FMTC usually have a germline mutation in the RET proto-oncogene (10q11.2); these mutations generally occur in exons 10 (codons 618 and 620) and 11 (codons 630, 631, and 634). Methods: A narrative review of articles focused on the p...

SARS-CoV-2 leads to an inflammatory and fibrotic state in the lungs which can be the cause of death and even in those who survive cause a functional limitation. A male patient of 28 years with COVID-19 was treated with nitazoxanide 500 mg 6 hourly, ibuprofen 500 mg 8 hourly, levofloxacin 500 mg and vitamin D 4,000 IU 24 hourly, and pirfenidone (K-L...

La pandémie de la COVID-19 a causé des problèmes dans les domaines sanitaire et social, affectant sérieusement la perception du personnel de santé par la population générale. Une revue systématique d'articles scientifiques a été réalisée dans des bases de données telles que Pubmed, Scielo, Latindex et Google Scholar, bases de données de plaintes, r...

The identification of multiple risk factors that predispose to bleeding during the obstetric event, such as acquired hemophilia, which is a disorder that develops due to the generation of autoantibodies that inhibit coagulation factors, the objective interpretation of routine laboratory tests , the development of systematized thinking in diagnostic...

Objective: The aim of this study was to evaluate the seropositivity of rapid immunoglobulin G (IgG) and immunoglobulin M tests in patients recovered from coronavirus disease 2019 (COVID‑19). Background: Rapid severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) antigen‑detection tests can give results in less than 30 min to detect SARS‑CoV‑...

Background: Sheehan's syndrome (SS) occurs as result of ischemic pituitary necrosis due to postpartum hemorrhage. Objective: To calculate the approximate number of SS cases in Mexico and to determine an screening option. Methods: A search was performed in PubMed, Web of Science and Google Scholar of published papers in English, and Spanish using th...

Background: It is known that acceleration and deceleration patterns in heart rate variability (HRV) are asymmetrically distributed in healthy subjects. Accordingly, novel approaches for assessing the asymmetrical properties of HRV, such as the multiscale asymmetry (MSA), have been applied in the perinatal field. Objective: To study the asymmetry...

Objective. The world is facing a SARS-CoV-2 coronavirus pandemic. One of the greatest challenges of the current pandemic is its high speed of transmission, such that its global spread has caused more deaths than its predecessors along with the collapse of health services. Patients and methods. This retrospective, cross-sectional study performed on...

Combined treatments against SARS-CoV-2 are emerging and some have taken into account the post-COVID-19 fibrosis. The aim of this survey was to report the experience of treating COVID-19 patients with pirfenidone, nitazoxanide (NTZ) and colchicine. It was a case series report of COVID-19 patients treated from December 2020 to March 2021, in a rural...

Background and Objective: GDM is associated with life-long adverse outcomes for mother and baby, and its incidence is increasing. Markers beyond clinical factors are needed to identify women at high risk and catalyze early preventive interventions. Our aim was to develop a risk assessment algorithm that integrates genetic and clinical variables. Me...

Background Type 2 diabetes mellitus (T2DM) leads to multiple chronic complications in the body including sensory functions. Aim The aim of this study was to determine the hearing threshold in middle-aged patients with T2DM and categorize it according to the presence or absence of hearing loss. Materials and Methods A prospective, cross-sectional...

Introduction: The adipose tissue secretes chemerin and omentin related to metabolic diseases. It has been reported that both proteins encoded by retinoic acid receptor responder protein 2 (RARRES2) and intelectin-1 (ITLN1) genes, respectively, are abnormally expressed in gestational diabetes mellitus (GDM). Aim: To evaluate the expression of these...

Rationale: Perimortem caesarean section (PMCS) is an emergency procedure performed in pregnant women over 20 weeks of gestation with cardiac arrest, in order to save the mother and the foetus, or only one of them. The objective of the review was to present clinical traits and evaluate survival of mothers and newborns as well as the complications fo...

Introduction: COVID-19 specifically affects the obstetric patient, due to the changes inherent to pregnancy such as diaphragmatic elevation, and as a result of this a worse adaptation to oxygen demands, so mechanical ventilation must be mastered to increase your survivability. Objective: To identify the attributable risk of protective mechanical ve...

Rheumatoid arthritis is a chronic inflammatory disease of an autoimmune nature whose etiology is still unknown and whose main target organ of affectation is the synovial membrane. It is documented that up to 90% of patients with this disease improve during pregnancy. During pregnancy huge hormonal changes are generated and the increase in free ster...

Introduction: The aim was to determine if one month taking BelAgeTM in the second trimester of pregnancy could reduce the risk of preeclampsia. Methods: From April 2019 to July 2020, a non-blinded, prospective, randomized, study was performed inviting women in the second trimester of pregnancy to take 3 g of BelAgeTM once daily for one month. The...

Introduction: The aim was to determine if one month taking BelAgeTM in the second trimester of pregnancy could reduce the risk of preeclampsia. Methods: From April 2019 to July 2020, a non-blinded, prospective, randomized, study was performed inviting women in the second trimester of pregnancy to take 3 g of BelAgeTM once daily for one month. The c...

El ciclismo se considera una actividad física de intensidad moderada debido al gasto energético que se puede lograr simplemente al practicarlo como una actividad recreativa o como forma de transporte, y también se considera un deporte de grado olímpico cuando se practica como ejercicio de alta intensidad. Esa misma versatilidad hace del ciclismo, u...

En el presente artículo se evaluarán las ventajas y desventajas del uso de la Telemedicina en México, con particular énfasis en los beneficios que traería al ofertar un sistema institucional gubernamental de atención por videoconsulta a las personas migrantes mexicanas, a los migrantes que transitan por nuestro país, a las comunidades más rezagadas...

Cuando nuestro sistema inmunitario no puede combatir una infección por el virus del papiloma humano (VPH) de alto riesgo, esta puede perdurar y transformar las células normales en anormales y posteriormente causar cáncer. El VPH de alto riesgo puede producir cambios celulares llamados precánceres cuando permanece e infecta las células de la vulva,...

Over the years, cancer treatment has focused on its eradication once it has been detected, however, it's common to find that a large number of neoplasms redevelop in patients, which reduces their quality and life expectancy when going through surgical treatments, chemotherapy and radiotherapy schemes once again. Several studies have been developed...

Currently, the COVID-19 pandemic is a huge threat to global health. Several treatments have been proposed for it as well as adjuvant treatments that can allow strengthening of the immune system when fighting the disease. In this work, we review the use of plasma as a treatment for COVID-19, evaluating their risks, benefits, previous use, and bioeth...

Background: In Mexico, it is estimated that the adolescent population represents 29% of the population of childbearing age. The present study aimed to analyze the obstetric results of 3310 adolescent pregnant women attended in a third level hospital. Material and methods: All records of pregnant women aged 19 years or less up to the date of admissi...

The fetal autonomic nervous system responds to uterine contractions during active labor as identified by changes in the accelerations and decelerations of fetal heart rate (FHR). Thus, this exploratory study aimed to characterize the asymmetry differences of beat-to-beat FHR accelerations and decelerations in preterm and term fetuses during active...

Introduction: coronavirus pandemic has led to 1.8 million deaths worldwide as of May 1st, 2021. Nitazoxanide (NTZ) is currently being studied in several ambulatory clinical trials to control viral infections including SARS-CoV-2. This study evaluates the effect of treatment with NTZ compared to Hydroxychloroquine (HCQ) in hospitalized patients. Met...

OBJECTIVE: To evaluate the association of diastolic pressure (DBP) and metabolic variables in pregnant women. METHODOLOGY: Retrospecti­ve, cross­sectional study in full­term pregnant women, older than 25 years , with a single pregnancy, grouped by Body Mass Index (BMI). Li­pids , gluc ose and DBP were measured in all of them. Odds Ratio (95% CI), S...

Aim: To open the possibility of using vitamin D in cases of idiopathic lymphopenia. Background: In addition to its participation in the homeostasis of calcium and phosphorus, vitamin D has immunomodulatory mechanisms, so, its deficiency, apart from being associated with bone abnormalities, accompanies the development of certain autoimmune diseases....

A clinical case of a 24-year-old female is presented, in which data suggestive of an incomplete mole is detected by obstetric ultrasound of the first trimester, a first-trimester screening is carried out, reporting a fetus without structural alterations, an interruption of pregnancy is offered, same as the patient rejects so the pregnancy is contin...

Aseries of 1-sulfonyl-1,2,3-triazoles were prepared from diverse alkynes and p-toluenesulfonyl azide through copper catalyzed azide-alkyne cycloaddition. Antifungal activity evaluation of 1-sulfonyl-1,2,3-triazoles against genus Candida strains revealed a significant activity of two compounds containing 4-ClC6H4OCH2 and C6H4(CO)2NCH2 substituent gr...

Objetivo: evaluar el estado nutricional en población geriátrica hospitalizada.Metodología: Se incluyeron a todos los pacientes que ingresaron al servicio de Geriatría de un hospital de Tercer Nivel y se les aplicó el cuestionario Mini Nutritional Assessment (MNA).Resultados: Se evaluraon 175 pacientes, 87 hombres y 88 mujeres con promedios de edad...

Background: Gram-negative bacilli are primarily responsible for the most common pediatric infections. Frequently, Escherichia fergusonii is identified as E. coli because of its close genetic proximity. Objectives: We aimed at the isolation and identification of multi-resistant strains of E. fergusonii, affecting children under two months of age. Me...

Background: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, is not available and is not economically affordable for most patients. Objective: To report here a case of a pregnant woman 27 years of age with ALS, confirmed through electromyography. After spontaneous abortion and 88 da...

Background. Ultrasound has led to non-invasive neuromonitoring for surveillance and decision-making of aspects affecting the central nervous system. The aim was to determine the correlation between mean blood pressure and bilateral optic nerve sheath diameter, pulsatility index and mean flow rate of the middle cerebral artery in cases of preeclamps...

Background Nitazoxanide shows adequate in vitro activity against coronavirus. The aim of this study was to describe the behavior of coronavirus disease 2019 (COVID-19) in pregnant women treated with nitazoxanide. Methodology This cross-sectional study included the files of COVID-19 positive pregnant women treated with nitazoxanide 500 mg every 6 ho...

The emergent Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) could produce a maternal immune activation (MIA) via the inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal and adulthood mental illness and behavioral dysfunctions. However, so...