Hugo Ariel Alvarez

Hugo Ariel Alvarez
Universidad Nacional de La Plata | UNLP · Instituto de Física de Líquidos y Sistemas Biológicos (IFLYSIB)

PhD
Profesor Adjunto UNAJ - Jefe de Trabajos Prácticos UNLP

About

21
Publications
3,373
Reads
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276
Citations
Introduction
H. Ariel Alvarez currently works at the Instituto de Física de Líquidos y Sistemas Biológicos (IFLYSIB), as a Teaching Researcher from the Department of Biological Sciences (Faculty of Exact Sciences - National University of La Plata - UNLP). Ariel does research in Molecular Physics, Computational Physics and Biophysics at molecular, cellular and tissue levels, especially seeking the relationship between mechanical and signalling processes. He is also an Assistant Professor at UNAJ.
Additional affiliations
March 2017 - present
IFLYSIB - Universidad Nacional de La Plata
Position
  • Researcher
April 2014 - February 2017
Universidad Nacional de La Plata
Position
  • PostDoc Position

Publications

Publications (21)
Article
Full-text available
Introduction The peptide mastoparan 7 (MST7) triggered in human erythrocytes (rbcs) the release of ATP and swelling. Since swelling is a well-known inducer of ATP release, and extracellular (ATPe), interacting with P (purinergic) receptors, can affect cell volume (Vr), we explored the dynamic regulation between Vr and ATPe. Methods and Treatments...
Article
Objectives Familial chilblain lupus is a monogenic form of cutaneous lupus erythematosus caused by loss-of-function mutations in the nucleases TREX1 or SAMHD1. In a family without TREX1 or SAMHD1 mutation, we sought to determine the causative gene and the underlying disease pathology. Methods Exome sequencing was used for disease gene identificati...
Article
Full-text available
Two novel arginine-based surfactants, Bz-Arg-NHC10 and Bz-Arg-NHC12, were characterized with respect to surface properties and their interaction with human red-blood-cell (HRBC) membranes. The values for critical micellar concentration (CMC), the maximum surfactant adsorption at the air–liquid interface, and the area per molecule indicated better s...
Article
Crystallographic data comes from a space-time average over all the unit cells within the crystal, so dynamic phenomena do not contribute significantly to the diffraction data. Many efforts have been made to reconstitute the movement of the macromolecules and explore the microstates that the confined proteins can adopt in the crystalline network. We...
Article
Organs mainly attain their size by cell growth and proliferation, but sometimes also grow through recruitment of undifferentiated cells. Here we investigate the participation of cell recruitment in establishing the pattern of Vestigial (Vg), the product of the wing selector gene in Drosophila. We find that the Vg pattern overscales along the dorsal...
Preprint
Full-text available
Organs mainly attain their size by cell growth and proliferation, but sometimes also grow through recruitment of undifferentiated cells. Here we investigate the participation of cell recruitment in establishing the pattern of Vestigial (Vg), the product of the wing selector gene in Drosophila. We find that the Vg pattern overscales along the dorsal...
Preprint
Full-text available
Crystallographic data comes from a space-time average over all the unit cells within the crystal, so dynamic phenomena do not contribute significantly to the diffraction data. Many efforts have been made to reconstitute the movement of the macromolecules and explore the microstates that the confined proteins can adopt in the crystalline network. In...
Article
Multivalent design of glycosidase inhibitors is a promising strategy for the treatment of diseases involving enzymatic hydrolysis of glycosidic bonds in carbohydrates. An essential prerequisite for successful applications is the atomic level understanding of how outstanding binding enhancements are actually achieved with multivalent inhibitors. Her...
Article
Full-text available
Multivalent design of glycosidase inhibitors is a promising strategy for the treatment of diseases involving enzymatic hydrolysis of glycosidic bonds in carbohydrates. An essential prerequisite for successful applications is the atomic level understanding of how outstanding binding enhancements are actually achieved with multivalent inhibitors. Her...
Data
Modeling of ATPe and cell volume in MST7-stimulated rbcs. A data-driven mathematical model was built to account for the dynamic interaction between [ATPe] and relative cell volume (Vr) when rbcs are exposed to MST7. Fig A. Vr kinetics of MST7-exposed rbcs. Rbcs were incubated in 200 μL of isosmotic medium (300 mosM) and after 20 min cells were expo...
Article
Full-text available
Acetonitrile is widely utilized in scientific research, presenting an ideal solvent media for a large number of organic reactions. Its use at the industrial scale ranges from the production of molecules of pharmaceutical interest to photographic films. Additionally, certain enzyme based catalytic processes show great functionality in Acetonitrile m...
Article
Full-text available
Present knowledge obtained by molecular dynamics (MD) simulation studies regarding the dynamics of water, both in the vicinity of biological membranes and within the proteinaceous water channels, also known as aquaporins (AQPs), is reviewed. A brief general summary of the water models most extensively employed in MD simulations (SPC, SPC/E, TIP3P,...
Data
Full-text available
Fifty nanoseconds long HSA alpha-carbon root mean square displacement plot, and an schematic 2D representation of both Acetylsalicylic Acid and Myristic Acid, showing the topologies' construction.
Article
Full-text available
In this work, we present a study of the interaction between human serum albumin (HSA) and acetylsalicylic acid (ASA, C 9 H 8 O 4 ) by molecular dynamics simulations (MD). Starting from an experimentally resolved structure of the complex, we performed the extraction of the ligand by means of the application of an external force. After stabilization...
Chapter
Full-text available
Los estudiantes perciben los modelos de roles y métodos pedagógicos como anticuados y las disciplinas científicas como demasiado exigentes. La identificación del estudiante como futuro científico es entonces más difícil. En este contexto, es necesario mejorar la calidad, relevancia y atractivo de las estrategias de educación científica y tecnológic...
Book
Full-text available
Cero absoluto trata sobre varios fenómenos de la naturaleza presentados desde la Física, con el deseo de despertar la intriga por el mundo que nos rodea y llamar la atención acerca de los avances de la Física y sus aplicaciones tecnológicas. http://sedici.unlp.edu.ar/handle/10915/26346

Questions

Question (1)
Question
Concerning Molecular Dynamics simulations of protein crystals, the usual aproach to the problem concerns simulating in NVT ensemble. Why are these conditions prefered over NPT conditions?

Network

Cited By

Projects

Projects (6)
Project
Acá hay varias producciones de CPC Los Libros de Comunicación Pública de Ciencia escritos por docentes del Museo de Física de la UNLP y editados por el Instituto de Física de La Plata (IFLP) y CONICET. Presentaciones a congresos. Artículos varios