Hugh Giffney

Hugh Giffney

PhD

About

14
Publications
1,124
Reads
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41
Citations
Introduction
Motivated to produce high-quality work and adaptable to the requirements of the job. Looking for a challenge.
Additional affiliations
September 2016 - September 2020
University College Dublin
Position
  • PhD Student
September 2016 - May 2019
University College Dublin
Position
  • Post-graduate Demonstrator
Description
  • I have accumulated over 1000 hours of teaching experience with undergraduate students, delivering laboratory practicals in the subjects of histology and veterinary anatomy.
September 2012 - September 2016
University College Dublin
Position
  • Student
Education
September 2012 - May 2016
University College Dublin
Field of study
  • Physiology

Publications

Publications (14)
Article
Inflammation is a pivotal pathological factor in colorectal cancer (CRC) initiation and progression, and modulating this inflammatory state has the potential to ameliorate disease progression. NR4A receptors have emerged as key regulators of inflammatory pathways that are important in CRC. Here, we have examined the effect of NR4A agonist, Cytospor...
Article
Full-text available
Adenosine is a purine nucleoside pivotal for homeostasis in cells and tissues. Stimulation of the adenosine receptors (AR) has been shown to regulate the nuclear orphan receptor 4A (NR4A1-3) family, resulting in attenuation of hyper-inflammatory responses in myeloid cells. The NR4A1-3 orphan receptors are early immediate response genes and transcri...
Article
Obesity represents one of the most significant public health challenges worldwide. Current clinical practice relies on body mass index (BMI) to define the obesity status of an individual, even though the index has long been recognized for its limitations as a measure of body fat. In normal BMI individuals, increased central adiposity has been assoc...
Article
Full-text available
Careful handling of the NMs (nanomaterials) in the research labs is crucial to ensure a safe working environment. As the largest university in the Ireland, UCD (University College Dublin) has invested significant resources to update researchers working with NMs. Due to sizes often <100 nm, the NMs including NPs (nanoparticles), harbor unprecedented...
Article
Hypoxia is a common and prominent feature of the microenvironment at sites of bacteria-associated inflammation in inflammatory bowel disease. The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing enzymes that regulate adaptive responses to hypoxia through controlling the activity of HIF and NF-κ...
Article
Full-text available
Dysregulation of inflammatory responses is a hallmark of multiple diseases such as atherosclerosis and rheumatoid arthritis. As constitutively active transcription factors, NR4A nuclear receptors function to control the magnitude of inflammatory responses and in chronic inflammatory disease can be protective or pathogenic. Within this study, we dem...

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Projects

Projects (2)
Project
Investigate the molecular mechanism involved in the adenosine upregulation of the Nuclear Orphan Receptors in myeloid cells.
Project
Aim 1: Characterisation of inflammatory gene expression profile, biochemical, lipidomic and proteomic parameters in an equine model of joint inflammation. Aim 2: Investigating the utility of novel nanoparticle based therapeutics in an equine model of joint inflammation.