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Phase-separated membraneless organelles or biomolecular condensates play diverse functions in cells, however recapturing their characteristics using small organic molecules has been a challenge. In the present study, cell-lysate-based screening of 843 self-assembling small molecules led to the discovery of a simple organic molecule, named huezole,...
Immune potentiators, termed adjuvant, trigger early innate immune responses to ensure the generation of robust and long-lasting adaptive immune responses of vaccines. Here we present study that takes advantage of a self-assembling small molecule library for the development of a novel vaccine adjuvant. Cell-based screening of the library and subsequ...
Vaccine adjuvants are required for the generation of robust and long‐lasting immune responses of antigen vaccines. Screening of a newly constructed chemical library of self‐assembling molecules led to the rapid discovery of cholicamide (6), as a potent vaccine adjuvant. Just like viruses, the nanoassembly of cholicamide enters the cells and is reco...
Cell-based therapy is a promising approach to restoring lost functions to compromised organs. However, the issue of inefficient cell engraftment remains to be resolved. Herein, we take a chemical approach to facilitate cell engraftment by using self-assembling molecules which modify two cellular traits: cell survival and invasiveness. In this syste...
Depending on the substituents of asymmetric alkynes, the hydroiodination may proceed regio- or non-regioselectively while forming either the (E)- or the (Z)-isomer of the product or a mixture of the latter.