Hubertus Maximilian Mehdorn

Hubertus Maximilian Mehdorn
University Medical Center Schleswig-Holstein | ukhs · of Neurosurgery

M.D. Ph.D.

About

570
Publications
38,677
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
19,680
Citations
Introduction
Many topics in neurosurgery and related disciplines have been studied in my career, trying to help young neuroscientists to develop their fields. Now, after retirement from active chairmanship late march 2015, I continue research mainly on neurorehabilitation and ethics of neurosciences, particularly spinal cord injury. Further clinical work is going on in private practice.
Additional affiliations
April 2015 - March 2020
University Medical Center Schleswig-Holstein
Position
  • Professor & Ret. Chairman
September 2008 - September 2014
Astana Medical University
Position
  • Professor
Description
  • Honorary Member Kasakh Neurosurgical Society
September 2006 - September 2006
Hangzhou First People's Hospital
Position
  • Professor
Education
October 1970 - July 1971
University of Zurich
Field of study
  • Medicine
February 1970 - July 1970
Université de Montpellier
Field of study
  • medicine
October 1966 - July 1972
Westfälische Wilhelms-Universität Münster
Field of study
  • Medicine

Publications

Publications (570)
Article
Zusammenfassung. Für das angemessene Fällen klinischer Urteile anhand neuropsychologischer Testverfahren ist die Güte der Testnormierung von zentraler Relevanz. Ziel der aktuellen Untersuchung ist es, unterschiedliche Klassifikationsmethoden für neuropsychologische Testleistungen zu vergleichen, um so die Güte der Normierung verbreiteter neuropsych...
Article
Full-text available
Objective: Generic psychosocial screening tools may not reflect the unique symptom profile of brain tumor patients (BTPs). The aim was to adapt the problem list of the Distress Thermometer (DT) for BTPs. Methods: First, items of low relevance for BTPs were identified on basis of retrospective analyses. Second, relevant yet missing problems were...
Article
Full-text available
Introduction: Occipital nerve stimulation (ONS) is used to treat therapy-resistant chronic migraine. Clinical use has resulted in a wide intraindividual and interindividual variation of clinical efficacy. The aim of this study was to analyze a potential relationship between sociodemographic variables, headache parameters, perceived sensory quality...
Article
Full-text available
Purpose: The craniometrics of head circumference (HC) and ventricular size are part of the clinical assessment of infants with hydrocephalus and are often utilized in conjunction with other clinical and radiological parameters to determine the success of treatment. We aimed to assess the effect of endoscopic third ventriculostomy (ETV) and shuntin...
Chapter
Intracranial space-occupying lesions, particularly glial tumors in eloquent areas, may challenge the neurosurgeon who aims at preserving most relevant neuropsychological functions while removing as much of the lesion as possible. It has been repeatedly questioned whether radical resection of gliomas is the method of choice because of their invasive...
Article
Introduction: The rate of intracranial hemorrhage (ICH) after deep brain stimulation (DBS) is between 1.5 and 6.1%, with prolonged deficits occurring in 0.4-2.5% of the patients. This retrospective study investigates whether the prophylactic administration of tranexamic acid (TA) to patients with abnormal platelet function detected preoperatively...
Article
Summary: Despite its extensive use, the construct validity of the Rey-Osterrieth Complex Figure Test (ROCFT) is still disputed. One of the main questions is whether executive functions contribute to the copy condition. In this study, healthy participants (n = 198) as well as patients with acquired brain damage (n = 161) were examined to determine w...
Article
The importance of international cooperation in neurosurgery incl. site visits to foreign hospitals is highlighted. The development of knowledge about function localization in brain surgery serves as an example. International cooperation led to modern day neurosurgery as shown e.g. in awake craniotomy.
Article
Full-text available
The significance of human biorepositories for modern medical research, particularly for comprehensive population-based genetic analyses, is constantly growing. While large and centralized institutions are usually considered best suited to meet the increasing demand for high-quality “biobanks,” most medical research institutions still host rather he...
Article
BACKGROUND Patient-centered assessments and disease-adjusted patient-reported outcome measures (PROMs) are crucial in neuro-oncology. The Distress Thermometer (DT) is a well-accepted screening tool for cancer patients including a numerical rating scale (1–10, cut-offs indicating relevant distress ≥4–6) and 40 items describing possible problem categ...
Article
Full-text available
Background Fear of progression (FoP) is frequent in patients with cancer and of high clinical relevance. Despite the often devastating prognosis of brain cancer, FoP has not yet been assessed in neurooncological patients. Objective The aim of this study was thus the assessment of FoP and its clinical correlates. Methods In an ambulatory setting,...
Article
Purpose: Interpersonal factors are of major importance for cancer patients’ physical and mental health. Brain tumor patients rank amongst those cancer patients with the highest psychosocial burden. Changes in language, cognition, and personality pose specific risk factors for impeding interpersonal functioning in this patient group. Despite this, r...
Article
Background: Programming algorithms have never been tested for outcome. The EARLYSTIM study showed superior outcomes of deep brain stimulation of the subthalamic nucleus (STN-DBS) over best medical treatment in early Parkinson's disease (PD). Patients were programmed according to common guidelines but customized for each patient. Methods: Stimula...
Article
Objective: Generators implanted for deep brain stimulation must be replaced after several years. If a Kinetra generator is replaced by the Activa-PC, an adaptor will be required to attach it to the original extension cables. On the basis of our clinical impression that the battery life of the Active-PC generator was shorter when an adaptor was use...
Article
Objective: Patients suffering from aneurysmatic Subarachnoid Hemorrhage (SAH) may present with a variety of symptoms. The aim of this study is to evaluate the spectrum of misdiagnoses and to analyze the significance of delay of correct diagnosis on the clinical outcome. Methods: The data was collected prospectively from 2003 to 2013. Patients di...
Chapter
Full-text available
Historical development of Navy Hospital in Kiel/Germany from 19th Century to Civil use - becoming Dept. of Neurosurgery of Kiel University Medical Center
Article
Full-text available
Purpose: Social cognitive functions are of high clinical relevance. To date, little is known about social cognition in neurooncological patients and this domain is usually not included in standardized neurocognitive test batteries. Aim of this study was thus to assess whether social cognition could pose a useful contribution to the neurocognitive a...
Article
Full-text available
Purpose: To date, little is known about neuropsychiatric symptoms in patients with tumors within the cerebellopontine angle (CPA). These, however, might be of clinical relevance. Aim of this study was thus to assess possible impairment in cognition, elevation in mood symptoms, and fatigue in this specific patient group. Methods: Forty-five patients...
Article
Full-text available
Objective Whether intracerebral haemorrhage (ICH) associated with non‐vitamin K antagonist oral anticoagulants (NOAC‐ICH) has a better outcome compared to ICH associated with vitamin‐K antagonists (VKA‐ICH) is uncertain. Methods We performed a systematic review and individual patient data meta‐analysis of cohort studies comparing clinical and radi...
Article
Full-text available
OBJECTIVE: Whether intracerebral haemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin-K antagonists (VKA-ICH) is uncertain. METHODS: We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and rad...
Article
Objectives: Hydrocephalus can be defined as clinically symptomatic dilatation of the internal ventricular system at the expense of brain and blood volume. Shunt insertion is the mainstay of therapy for communicating hydrocephalus. One of the most frequently used valves is the programmable Codman Medos Hakim valve which enables the pressure level t...
Article
Objective Preoperative anxiety is frequent in neurosurgical patients and of high clinical relevance (e. g., associated with anestesiological requirements and surgery outcome). Little however is known about the quality of instruments for assessment of preoperative anxiety in this specific patient group and setting. This paper therefore focused on th...
Article
Objective Bad news refer to information which subjectively impedes a patient’s future prospects. Patients with intracranial tumours potentially face numerous bad news. This study assessed the patients’ perspective regarding the content of bad news, patients’ preferences for the communication of bad news, and clinical consequences of mismatch of pat...
Article
Full-text available
Background: Neurosurgical brain tumour removal poses a unique threat for patients while also minimizing instrumental control. Thus, psychological processes utilized by patients in order to cope with surgery-related anxiety are of utmost importance. This is the first study to assess both nature and effectiveness of surgery-related coping efforts in...
Data
Die deutsche Version des SCOPA-Sleep Fragebogens zum Download
Article
Full-text available
Aim of the study was the cross-cultural adaptation and validation of the German version of the Scale for Outcomes in Parkinson’s disease-Sleep Scale (SCOPA-Sleep) for assessment of night-time sleep problems (NS) and daytime sleepiness (DS). Eighty-three patients with Parkinson’s disease completed the SCOPA-Sleep and a multitude of measures for asse...
Article
Background: Although subthalamic stimulation is a recognised treatment for motor complications in Parkinson's disease, reports on behavioural outcomes are controversial, which represents a major challenge when counselling candidates for subthalamic stimulation. We aimed to assess changes in behaviour in patients with Parkinson's disease receiving...
Article
Background: Nonrechargeable deep brain stimulation impulse generators (IGs) with low or empty battery status require surgical IG exchange several years after initial implantation. The aim of this study was to investigate complication rates after IG exchange surgery and identify risk factors. Methods: We retrospectively analyzed complications fol...
Chapter
Etwa 90% der Gliompatienten leiden unter neuropsychologischen Störungen, das heißt unter Veränderungen kognitiver Funktionen und/oder des affektiven Befindens infolge der Tumorerkrankung selbst bzw. ihrer Behandlung. Neuropsychologische Störungen haben eine ausgesprochen hohe Relevanz für Lebensqualität und Partizipation der Betroffenen. Der Beitra...
Article
Full-text available
We characterized health-related quality of life (HRQoL), cognitive, and functional status in newly diagnosed glioblastoma (GBM) patients receiving Tumor treating fields (TTFields) with temozolomide (TMZ) versus TMZ alone in a planned interim analysis of a randomized phase III trial [NCT00916409], which showed significant improvement in progression-...
Article
Objective: Nonrechargeable deep brain stimulation (DBS) generators must be replaced when the battery capacity is exhausted. Battery life depends on many factors and differs between generator models. A new nonrechargeable generator model replaced the previous model in 2008. Our clinical impression is that the earlier model had a longer battery life...
Article
Erythropoietin (Epo) exhibits promising neuroregenerative potential for spinal cord injury (SCI) and might be involved in other long-term sequelae, such as neuropathic pain development. The current studies investigated the time courses and spatial and cellular patterns of Epo and EpoR expression along the spinal axis after graded SCI. Male Long Eva...
Article
Full-text available
The aim of the study was to record movement-related single unit activity (SUA) in the human subthalamic nucleus (STN) during a standardized motor task of the upper limb. We performed microrecordings from the motor region of the human STN and registered kinematic data in 12 patients with Parkinson’s disease (PD) undergoing deep brain stimulation sur...
Article
Full-text available
Background: Cost reduction measures in medicine are gaining greater importance nowadays, especially in high-volume procedures such as laparoscopic appendectomy (LAE). Currently there are two common methods of dissecting the appendix from the caecal pole: linear stapler and endoloops. The endoloop is the cheaper device but can only be used in uncom...
Article
Background: The threshold current for inducing muscle contractions by stimulation of pyramidal tract fibres adjacent to the globus pallidus internus (GPi) is, besides microelectrode recordings for the determination of nuclear boundaries, currently the only neurophysiological marker for intraoperative refinement of the anatomically planned target p...
Article
Background: In aneurysmal subarachnoid haemorrhage cerebral vasospasm leads to clinical worsening and poor outcome. Interventional treatment with nimodipine might be a therapeutic option. Objective: To evaluate the clinical course of patients with different interventional treatment types. Methods: A retrospective, observational analysis was pe...
Article
Full-text available
Background Clinical outcome and mortality in intracerebral haemorrhage (ICH) associated with anticoagulant treatment is poor. Novel direct oral anticoagulant drugs (NOACs) are increasingly prescribed. Management of NOAC-associated ICH might be more challenging. The aim of this study was to compare the clinical and radiological course of ICH patient...
Chapter
In recent years more and more data have emerged linking the most radical resection to prolonged survival in patients harboring brain tumors. Since total tumor resection could increase postoperative morbidity, many methods have been suggested to reduce the risk of postoperative neurological deficits: awake craniotomy with the possibility of continuo...
Book
These proceeding cover new trends presented at the IV Congress of the International Society of Reconstructive Neurosurgery (ISRN), 2015. ISRN is an “open” multidisciplinary society that deals with advances in spine and peripheral-nerve reconstructive surgery, central nervous system revascularization (surgical, radio interventional), neuromodulation...
Article
Background: Deep brain stimulation (DBS) within or adjacent to the subthalamic nucleus (STN) currently represents the most common stereotactic procedure performed for Parkinson's disease. Better STN imaging is often regarded as a requirement for improving stereotactic targeting. But, remarkably enough, it is unclear whether there is a consensus ab...
Article
Full-text available
Background Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we termed “inverse signaling”. According to this hypothesis, soluble (s)-CXCL16 binds to the surface-expressed transmembrane (tm) -CXCL16,...
Chapter
Interview about how our mind is influenced by increasing media coverage and communication needs
Article
Introduction The treatment of glioblastoma multiforme (GBM) is a major challenge of neuro-oncology. Despite aggressive therapeutic strategies including surgery and radio-chemotherapy, median survival remains extremely low. This points to the urgent need for alternative treatment strategies such as immunotherapy. Immunological escape mechanisms, inv...
Article
Aggressive cancer cells show histological similarities to embryonic stem cells. As differentiated cells can re-acquire pluripotency and self-renewal by transfection with the transcription factors OCT4, SOX2, KLF4 and MYC, with Nanog as readout for success, we comprehensively investigated their occurrence and frequency in human astrocytomas of diffe...
Article
Question Low or empty battery status of non-rechargeable deep brain stimulation impuls generators (IG) requires a surgical IG exchange several years after initial implantation. Complications in patients undergoing DBS-Surgery are reported in the range between 7.6% and 25.3%. The aim of this study was to investigate the rate of complications after I...
Article
Myelomeningoceles (mmc) are clinically challenging CNS malformations. Although improvement in their management has been achieved with respect to antenatal diagnosis, prevention, and fetal surgery, the cellular mechanisms of damage in the neural placode are poorly understood. We aimed to identify cellular and molecular factors in lesion amplifying c...
Article
Objectives: Awake craniotomy is a well-established procedure in surgery of intracranial tumors in eloquent areas. However, sufficiently standardized instruments for the assessment of sensory-motor function before, during and after the operation are currently lacking, despite their importance for evaluation of operative outcome. Patients and metho...
Article
Full-text available
This study presents the first validation of the Brief Cognitive Status Exam (BCSE) against two other screening tools for cognitive impairment in patients with intracranial tumors. 58 patients and 22 matched healthy controls completed the BCSE, the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Patients were addit...
Article
Deep brain stimulation (DBS) has become one of the major therapy options for movement disorders including dystonia. This article should give a review of the current literature from a neurosurgical perspective. Since dystonia is a rare disease, only few studies on larger cohorts have been published, and very few randomized controlled studies are ava...
Article
Full-text available
Purpose: In patients with newly diagnosed glioblastoma that harbors a nonmethylated O(6)-methylguanine-DNA methyltransferase promotor, standard temozolomide (TMZ) has, at best, limited efficacy. The GLARIUS trial thus explored bevacizumab plus irinotecan (BEV+IRI) as an alternative to TMZ. Patients and methods: In this phase II, unblinded trial...
Chapter
Intracranial meningiomas are tumors arising from the covering cells of the arachnoid layer of the dura mater or from the intraventricular choroid plexus. While mostly benign tumors, they still represent a major challenge to neurosurgeons and other medical disciplines involved in their diagnostic and therapeutic management. Although this review inte...
Article
Full-text available
The chemokine CXCL12 (also termed SDF-1, stromal cell-derived factor-1) and its receptors CXCR4 and CXCR7 are known to play a pivotal role in tumor progression including glioblastomas (GBM). Previous investigations focused on the expression and functional roles of CXCR4 and CXCR7 in different GBM cell subpopulations, but comparative analysis in mat...
Article
Full-text available
After performing a decompressive craniectomy, a cranioplastic surgery is usually warranted. The complications of this reconstructive procedure may differ from the initial operation. The authors of this study report on their experience to define patient-specific and procedural risk factors for possible complications following cranioplasty influencin...
Article
Intracranial meningiomas are tumors arising from the covering cells of the arachnoid layer of the dura mater or from the intraventricular choroid plexus. While mostly benign tumors, they still represent a major challenge to neurosurgeons and other medical disciplines involved in their diagnostic and therapeutic management. Although this review inte...
Article
Full-text available
Background: The incidence of intracerebellar hemorrhages approaches 5-10% of all intracerebral hematomas. The clinical presentation varies from headaches and dizziness to rapid deterioration of consciousness to the point of coma in severe cases. In order to find some concrete criteria that could influence the prognosis of these patients, we perfor...
Article
BACKGROUND: Tumor Treating Fields (TTFields) are an anti-mitotic, electric-physical treatment modality. An interim analysis of the phase 3 trial comparing TTFields with maintenance temozolomide (TTFields/TMZ) showed superior progression free and overall survival compared to temozolomide alone (TMZ alone) in patients with newly diagnosed GBM. METHOD...
Article
Full-text available
Background: The ideal treatment strategy for low-grade gliomas (LGGs) is a controversial topic. Additionally, only smaller single-center series dealing with the concept of intraoperative magnetic resonance imaging (iMRI) have been published. Objective: To investigate determinants for patient outcome and progression-free-survival (PFS) after iMRI...
Article
Deep brain stimulation (DBS) in therapy for advanced Parkinson's disease (PD) is an accepted treatment. Infections of the system and other complications occasionally result in hardware removal and subsequent medical treatment alone for months. We have analyzed the clinical course of 15 patients requiring removal of at least parts of the DBS system,...
Article
The cytokine hormone erythropoietin (EPO) and the chemokine CCL3 are known to be produced in the brain under various pathological conditions. In this study, we investigated whether EPO and CCL3 influence on each other during neuroinflammation. We showed that EPO could reduce lipopolysaccharide (LPS)-induced CCL3 mRNA expression in rat cerebellar ne...
Conference Paper
Background: Occipital Nerve stimulation (ONS) is a treatment option for therapy-resistant chronic migraine. The precise effect of ONS onto the pathophysiology of migraine and the trigeminocervicale antinociceptive system remains unknown. In this study, the effect of ONS onto experimentally induced pain and antinociceptive reflexes in patients with...
Conference Paper
Background: Occipital Nerve stimulation (ONS) induces sensory experiences in the distribution area of occipital nerves and can be used for treating chronic migraine. The aim of this therapy is to activate antinociceptive mechanisms for preventing migraine. The relationship between cognitive and affective properties of the induced sensations and the...
Conference Paper
Aim: Occipital Nerve stimulation (ONS) is used for treating therapy-resistant chronic migraine. The relationship between stimulation parameters, induced sensations and the clinical efficacy of treating migraine is widely unknown to date. Therefore, the aim of this study is to evaluate the relationship beween stimulation parameters, sensations induc...
Article
Full-text available
A rare case of idiopathic temporomesial encephalocele in a 64 years old female is presented. The clinical symptoms of this adult patient were spontaneous rhinorrhea and headaches. A temporomesial encephalocele could be diagnosed and the cele was removed surgically in two operative procedures. In case of clinical symptoms like rhinorrhea a surgical...
Article
Full-text available
The Twist-1 transcription factor and its interacting protein Akirin-2 regulate apoptosis. We found that in glioblastomas, highly malignant brain tumors, Akirin-2 and Twist-1 were expressed in glial fi brillary acidic protein positive tumor regions as well as in tumor endothelial cells and infi ltrating macrophages / microglia. Temozolomide (TMZ) in...