Hsin-Yi Chen

Hsin-Yi Chen
Taipei Medical University | TMU · Graduate Institutes of Medical Sciences and Pharmacology

About

34
Publications
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1,524
Citations

Publications

Publications (34)
Article
Full-text available
Background Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them function in regulating the expression of autophagy-related genes. LncRNAs that directly act on the core autophagic proteins remain to be...
Article
Full-text available
The role of protein stabilization in cortical development remains poorly understood. A recessive mutation in the USP11 gene is found in a rare neurodevelopmental disorder with intellectual disability, but its pathogenicity and molecular mechanism are unknown. Here, we show that mouse Usp11 is expressed highly in embryonic cerebral cortex, and Usp11...
Article
Full-text available
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Lifestyle-related factors, such as diet, are associated with the development of CRC. Cumulating evidence indicates noticeable chemopreventive effects of phytochemicals on CRC, suggesting that drinking herbal tea potentially reduces the risk of distal colon cancer via...
Article
Full-text available
Precise noncoding RNA (ncRNA)-based network prediction is necessary to reveal ncRNA functions and pathological mechanisms. Here, we established a systemic pipeline to identify prognostic ncRNAs, predict their functions and explore their pathological mechanisms in lung adenocarcinoma (LUAD). After in silico and experimental validation based on evalu...
Article
Full-text available
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation has been identified as an HCC pro-metastatic activator associated with poor patient prognosis, but with a lack of targeting strategy. Here, we report that PSPC1, a nuclear substrate of PTK6, sequesters PTK6 in t...
Article
Full-text available
The BH3-only pro-apoptotic protein BIK is regulated by the ubiquitin–proteasome system. However, the mechanism of this regulation and its physiological functions remain elusive. Here, we identify Cul5-ASB11 as the E3 ligase targeting BIK for ubiquitination and degradation. ER stress leads to the activation of ASB11 by XBP1s during the adaptive phas...
Article
Full-text available
Cancer stemness drives tumor initiation, progression, metastasis, recurrence, and therapy resistance. However, mechanisms that potentiate the acquisition and maintenance of stemness fate of cancer cells remain incompletely understood. Here, we show that miR-103/107 stimulate multiple stem-like features in colorectal cancer, including expression of...
Article
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Metastasis is responsible for most cancer mortality, but its molecular mechanism has not been completely understood. In addition to coding genes and miRNAs, the contribution of long noncoding RNAs (lncRNAs) to tumor metastatic dissemination and the mechanisms controlling their expression are areas of intensive investigation. Here, we show that lncR...
Article
Full-text available
Cullin-RING ubiquitin ligases are the largest E3 ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. To date, eight members of the Cullin family proteins have been identified. In...
Article
Full-text available
Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. KLHL20 is a substrate-binding subunit of Cullin3 (Cul3) ubiquitin liga...
Article
The tumor suppressor protein PML is aberrantly degraded in multiple types of human cancers through mechanisms that incompletely understood. Here, we show that the phosphatase SCP1 and its isoforms SCP2/3 dephosphorylate PML at S518, thereby blocking PML ubiquitination and degradation mediated by the prolyl isomerase Pin1 and the ubiquitin ligase KL...
Article
Tracing the evolution of the bulk heterojunction structure, a dramatic promotion in the efficiency of polymer solar cells has been obtained in recent years. The active layer morphology of low-bandgap polymer solar cells is one of the critical factors for high-efficiency performance. In the past, the relationship between morphology improvement and t...
Article
Metastasis is responsible for most cancer deaths but it remains a poorly understood process. Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. DAPK downregulation or inactivation has been observed in a number of metastatic cancers through epigenetic, transcriptional, post-transcriptiona...
Chapter
Zinc oxide (ZnO), an n-type inorganic semiconductor, has been extensively utilized in polymer solar cells due to its salient characteristics such as low cost, non-toxicity, high stability, and good optoelectronic properties. Their one-dimensional counterparts, ZnO nanorods (NRs), are particularly attracting more and more attention in recent years....
Article
We review the recent developments and techniques applied to hybrid solar cells. Hybrid solar cells have progressed rapidly in the past few years. The highest efficiency of hybrid solar cells has exceeded 10 %, meeting the commercial requirement for production. In addition, their stability has been improved significantly using sandwiched structures...
Article
Sandwich-Structure Hybrid Solar Cells—Towards High Efficiency and Stability: The cover image illustrates a sandwich-structure hybrid solar cell. Solar cells made of organic materials suffer from lower efficiency and poor stability in comparison with their inorganic counterparts such as silicon. However, organic solar cells do possess many advantage...
Article
Full-text available
Enhanced photoelectrochemical (PEC) performances of Ga(2)O(3) and GaN nanowires (NWs) grown in situ from GaN were demonstrated. The PEC conversion efficiencies of Ga(2)O(3) and GaN NWs have been shown to be 0.906% and 1.09% respectively, in contrast to their 0.581% GaN thin film counterpart under similar experimental conditions. A low crystallinity...
Article
Full-text available
Metastasis is the major cause of poor prognosis in colorectal cancer (CRC), and increasing evidence supports the contribution of miRNAs to cancer progression. Here, we found that high expression of miR-103 and miR-107 (miR-103/107) was associated with metastasis potential of CRC cell lines and poor prognosis in patients with CRC. We showed that miR...
Article
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The size-dependent persistent photocurrent (PPC), which refers to a photocurrent persisting for a long time after the excitation light source is terminated, has been investigated in m-axial GaN nanowires (NWs) with diameters of 20–130 nm. These NWs possess polar side surfaces and thus exhibit strong surface band bending (SBB). With different diamet...
Article
Tumor hypoxia is associated with disease progression and treatment failure, but the hypoxia signaling mechanism is not fully understood. Here, we show that KLHL20, a Cullin3 (Cul3) substrate adaptor induced by HIF-1, coordinates with the actions of CDK1/2 and Pin1 to mediate hypoxia-induced PML proteasomal degradation. Furthermore, this PML destruc...
Conference Paper
In this paper, we investigate the soft iterative decoding technique for ternary recoding systems with run-length-limited (RLL) constraints. We employ a simple binary-to-ternary RLL encoder following the LDPC (low density parity check) encoder. In the decoder, the iteratively passing of soft information between the LDPC decoder and a detector is use...
Article
Full-text available
We propose two constructions for multilevel run-length-limited (RLL) block codes for which the rates are very close to the capacity. For each code construction, we propose a variation that has the advantage of low complexity of encoding and decoding. We conducted a simulation to see the combined effect of channel coding and our proposed RLL coding...
Article
Full-text available
We report on the photoconductivity study of the individual infrared-absorbing indium nitride (InN) nanowires. Temperature-dependent dark conductivity measurement indicates the semiconducting transport behavior of these InN nanowires. An enhanced photosensitivity from 0.3 to 14 is observed by lowering the temperature from 300 to 10 K. A calculated u...
Article
Full-text available
The size effects on both the photoconductivity and dark conductivity have been observed in m-axial GaN nanowires grown by chemical vapor deposition (CVD). For these nanowires with diameters at 50–130 nm, the products of carrier lifetime (τ) and mobility (μ) derived from the photocurrent measurements are typically at (2–8)×10−1 cm2/V, which are over...
Article
A new and general approach to achieving efficient electrically driven light emission from a Si-based nano p-n junction array is introduced. A wafer-scale array of p-type silicon nanotips were formed by a single-step self-masked dry etching process, which is compatible with current semiconductor technologies. On top of the silicon nanotip array, a l...
Conference Paper
Luby Trasform (LT) codes are regarded as packet-based codes which are useful for multicast communications. High Peak-to-Average Power Ratio (PAPR) is a notorious problem inherently existing in OFDM systems. In this paper, we propose to take the PAPR constraint into account in the encoding of LT codes for OFDM multicast systems. Substantial PAPR red...
Article
Full-text available
Breast tumor kinase (Brk), an Src-like nonreceptor tyrosine kinase, is overexpressed in breast cancer and several other cancer types. Our previous study indicates that Brk promotes cell migration and tumor invasion by phosphorylating the focal adhesion protein paxillin. Here, we report the identification of p190RhoGAP-A (p190) as a Brk substrate. B...
Article
We propose two techniques for the low-density parity-check (LDPC) coded partial response channel with run-length-limited (RLL) constraints. The first is a modification of the selective flipping technique so that side information is not needed. The second is based on the estimation of flipped bits for the selective flipping technique. The second tec...
Article
Full-text available
Huge photocurrent gains with a value of 10 000 detected in air and 100 000 detected in vacuum have been obtained from SnO2 nanowires. Unlike previous reports that emphasized on carrier trapping by charge oxygen molecules in metal oxide nanostructures, we point out that spatial separation of photoexcited electrons and holes due to built-in electric...
Article
Full-text available
Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anticancer therapeutic opportunity. Here, we report four anti-proliferative phytocompounds in Wedelia chinensis, an oriental herbal medicine, identified through their ability to modulat...
Article
Full-text available
An ultrahigh photocurrent gain has been found in the ultraviolet-absorbed GaN nanowires with m -directional long axis grown by chemical vapor deposition. The quantitative results have shown the gain values at 5.0×10<sup>4</sup>–1.9×10<sup>5</sup> of the GaN nanowires with diameters from 40 to 135 nm are near three orders of magnitude higher than th...
Article
Full-text available
Brk (for breast tumor kinase) is a nonreceptor tyrosine kinase containing SH3, SH2, and tyrosine kinase catalytic domains. Brk was originally identified from a human metastatic breast tumor, and its overexpression is frequently observed in breast cancer and several other cancer types. However, the molecular mechanism by which this kinase participat...

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